{"id":291400,"date":"2023-05-21T21:30:27","date_gmt":"2023-05-21T21:30:27","guid":{"rendered":"https:\/\/nybreaking.com\/menopause-drug-that-switches-off-hot-flushes-could-be-available-by-the-end-of-the-year\/"},"modified":"2023-05-21T21:30:27","modified_gmt":"2023-05-21T21:30:27","slug":"by-the-end-of-the-year-a-menopause-medication-that-switches-off-hot-flashes-might-be-accessible","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/i\/by-the-end-of-the-year-a-menopause-medication-that-switches-off-hot-flashes-might-be-accessible\/","title":{"rendered":"By the end of the year, a menopause medication that &#8220;switches off&#8221; hot flashes might be accessible."},"content":{"rendered":"<div style=\"margin-bottom:20px;\"><img width=\"634\" height=\"434\" src=\"https:\/\/nybr.b-cdn.net\/wp-content\/uploads\/2023\/05\/Menopause-drug-that-switches-off-hot-flushes-could-be-available.jpg\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"An anti-menopausal drug that &#039;turns off&#039; hot flashes in just days could be available by the end of the year (file image)\" decoding=\"async\" loading=\"lazy\" srcset=\"https:\/\/nybr.b-cdn.net\/wp-content\/uploads\/2023\/05\/Menopause-drug-that-switches-off-hot-flushes-could-be-available.jpg 634w, https:\/\/nybr.b-cdn.net\/wp-content\/uploads\/2023\/05\/Menopause-drug-that-switches-off-hot-flushes-could-be-available-300x205.jpg 300w\" sizes=\"auto, (max-width: 634px) 100vw, 634px\" title=\"Menopause drug that &#039;switches off&#039; hot flushes could be available by the end of the year 16\"><\/div>\n<div id=\"js-article-text\" wp_automatic_readability=\"84.03743315508\">n<\/p>\n<h2>Menopausal drug that &#8216;turns off&#8217; hot flashes in just days could be available by year&#8217;s end after being approved in the US as a lifeline for hundreds of thousands of women unable to take hormone replacement therapy<\/h2>\n<p>n<\/p>\n<ul class=\"mol-bullets-with-font\">n<\/p>\n<li class=\"class\"><strong>The first non-hormonal drug for menopause, called fezolinetant, acts on the brain<\/strong><\/li>\n<p>n<\/p>\n<li class=\"class\"><strong>Women reported a reduction in hot flash severity and better sleep quality <\/strong><\/li>\n<p>n<\/ul>\n<p>n<\/p>\n<p class=\"author-section byline-plain\">By Xantha Leatham Deputy Science Editor for The Daily Mail <\/p>\n<p>n<\/p>\n<p class=\"byline-section\"><span class=\"article-timestamp article-timestamp-updated\"> <span class=\"article-timestamp-label\">Updated:<\/span> <time datetime=\"2023-05-21T22:30:27+0100\">    22:30 BST, 21 May 2023 <\/time><\/span> <\/p>\n<p>n<\/p>\n<p> <!-- ad: https:\/\/mads.dailymail.co.uk\/v8\/de\/health\/none\/article\/other\/para_top.html --> <!-- CWV --><!--[if !IE]><!--> <link href=\"https:\/\/www.dailymail.co.uk\/static\/mol-fe\/static\/mol-fe-async-bundle\/6.50.5\/articleDefer.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/><!--<![endif]--><!--[if IE]>n<link href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/1.17.0\/registration--.css\" media=\"screen\" rel=\"stylesheet\" type=\"text\/css\" \/>n<![endif]--><!--[if !IE]><!--><link href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/17.16.0\/registration--.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/><!--<![endif]--><!--[if IE]>n<link href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/1.17.0\/all-ie8-9--.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/>n<link href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/1.17.0\/all1-ie8-9--.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/>n<![endif]--><!--[if !IE]><!--><link href=\"https:\/\/www.dailymail.co.uk\/static\/mol-fe\/static\/mol-fe-sync-bundle\/8.31.2\/desktop.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/><link href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/17.16.0\/all--.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/><link href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/17.16.0\/all1--.css\" media=\"all\" rel=\"stylesheet\" type=\"text\/css\" \/><!--<![endif]--><!--[if gte IE 8]><!--><link rel=\"stylesheet\" type=\"text\/css\" media=\"screen\" href=\"https:\/\/www.dailymail.co.uk\/static\/mol-fe\/static\/mol-fe-fff\/2.4.1\/styles\/fff.css\" \/><!--<![endif]--><!--[if IE 8]>nn<![endif]--><!--[if IE 9]>nn<![endif]--><!--[if IE]>nn<![endif]--><!--[if !IE]> --><!--<![endif]--><!-- SiteCatalyst code version: H.20.3.n    Copyright 1997-2009 Omniture, Inc. More info available atn    http:\/\/www.omniture.com --><!-- End SiteCatalyst code version: H.20.3. --><!--[if IE]>nn<![endif]--><!--[if !IE]> --><!--<![endif]--><!--[if IE]>n  n  <noscript><link rel=\"stylesheet\" href=\"https:\/\/www.dailymail.co.uk\/static\/gunther\/gunther-2159\/video_bundle--.css\"><\/noscript>n  n<![endif]--><!--[if !IE]> --><link rel=\"preload\" href=\"https:\/\/www.dailymail.co.uk\/static\/videoplayer\/6.21.1\/styles\/mol-fe-videoplayer.min.css\" as=\"style\" onload=\"this.rel=\" stylesheet=\"\" \/><noscript><link rel=\"stylesheet\" href=\"https:\/\/www.dailymail.co.uk\/static\/videoplayer\/6.21.1\/styles\/mol-fe-videoplayer.min.css\" \/><\/noscript>  <!-- <![endif]-->   <!-- CWV --><\/p>\n<p>n<\/p>\n<div itemprop=\"articleBody\" wp_automatic_readability=\"63.736384439359\">n<\/p>\n<p class=\"mol-para-with-font\">By the end of the year, an anti-menopausal drug could be available that &#8220;turns off&#8221; hot flashes in just days.<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">The &#8216;game-changing&#8217; drug, called fezolinetant, acts directly on the brain and could be a lifeline for hundreds of thousands of women unable to take hormone replacement therapy (HRT).<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">Earlier this month, the US approved fezolinetant, the first non-hormonal menopause drug. <\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">Its makers describe it as a therapy &#8220;based on our understanding of the biology behind hot flashes.&#8221; <\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">The drug works by blocking a brain protein called neurokinin 3, which plays a role in regulating body temperature in menopausal women. <\/p>\n<p>n<\/p>\n<div class=\"artSplitter mol-img-group\" style=\"style\" wp_automatic_readability=\"8\">n<\/p>\n<div class=\"mol-img\">n<\/p>\n<div class=\"image-wrap\"> <\/div>\n<p>n<\/p>\n<p> <noscript> <img decoding=\"async\" loading=\"lazy\" id=\"i-7fe0f86204efa495\" src=\"https:\/\/nybr.b-cdn.net\/wp-content\/uploads\/2023\/05\/Menopause-drug-that-switches-off-hot-flushes-could-be-available.jpg\" height=\"434\" width=\"634\" alt=\"An anti-menopausal drug that &#039;turns off&#039; hot flashes in just days could be available by the end of the year (file image)\" class=\"blkBorder img-share\" title=\"Menopause drug that &#039;switches off&#039; hot flushes could be available by the end of the year 13\"><\/noscript> <\/div>\n<p>n<\/p>\n<p class=\"imageCaption\">An anti-menopausal drug that &#8216;turns off&#8217; hot flashes in just days could be available by the end of the year (file image)<\/p>\n<p>n<\/p><\/div>\n<p>n<\/p>\n<div class=\"artSplitter mol-img-group\" style=\"style\" wp_automatic_readability=\"10\">n<\/p>\n<div class=\"mol-img\">n<\/p>\n<div class=\"image-wrap\"> <img decoding=\"async\" loading=\"lazy\" id=\"i-91bf59b974efad05\" src=\"https:\/\/nybr.b-cdn.net\/wp-content\/uploads\/2023\/05\/1684705415_933_Menopause-drug-that-switches-off-hot-flushes-could-be-available.jpg\" height=\"423\" width=\"634\" alt=\"The &#039;groundbreaking&#039; drug, called fezolinetant, could be a lifeline for hundreds of thousands of women unable to take hormone replacement therapy (HRT) (file image)\" class=\"blkBorder img-share\" style=\"max-width:100%\" title=\"Menopause drug that &#039;switches off&#039; hot flushes could be available by the end of the year 14\"><\/div>\n<p>n<\/p>\n<p> <noscript> <img decoding=\"async\" loading=\"lazy\" id=\"i-91bf59b974efad05\" src=\"https:\/\/nybr.b-cdn.net\/wp-content\/uploads\/2023\/05\/1684705415_933_Menopause-drug-that-switches-off-hot-flushes-could-be-available.jpg\" height=\"423\" width=\"634\" alt=\"The &#039;groundbreaking&#039; drug, called fezolinetant, could be a lifeline for hundreds of thousands of women unable to take hormone replacement therapy (HRT) (file image)\" class=\"blkBorder img-share\" title=\"Menopause drug that &#039;switches off&#039; hot flushes could be available by the end of the year 15\"><\/noscript> <\/div>\n<p>n<\/p>\n<p class=\"imageCaption\">The &#8216;groundbreaking&#8217; drug, called fezolinetant, could be a lifeline for hundreds of thousands of women unable to take hormone replacement therapy (HRT) (file image)<\/p>\n<p>n<\/p><\/div>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">A large study published this year found that taking the pill once a day for 12 weeks reduced the frequency of hot flashes by about 60 percent in women with moderate or severe symptoms, compared with a 45 percent decrease in those taking a placebo. got.<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">Women also reported a reduction in hot flash severity and better sleep quality. <\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">&#8220;This is going to be a complete blockbuster drug,&#8221; said Professor Waljit Dhillo, an endocrinologist at Imperial College London.<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">&#8220;It&#8217;s like a switch.  Within a day or two the hot flashes disappear \u2013 it&#8217;s amazing how well these drugs work.<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">&#8220;It will completely change for many women.&#8221;<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">Fezolinetant, made by the Japanese company Astellas Pharma, is now under review by the European Medicines Agency. <\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">A decision is expected this year, followed by the UK several months later. <\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">The drug does not affect estrogen levels &#8211; which drop sharply during menopause &#8211; so will not address symptoms of fatigue and mood swings the way HRT does. <\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">But HRT isn&#8217;t for everyone, including people with a history of breast or ovarian cancer.<\/p>\n<p>n<\/p>\n<p class=\"mol-para-with-font\">&#8216;If you can&#8217;t take HRT, there aren&#8217;t many really effective options,&#8217; says Professor Annice Mukherjee, a consultant endocrinologist at Coventry University.  &#8220;Women need options.&#8221;<\/p>\n<p>n<\/p><\/div>\n<p>n<\/p>\n<p>            <!-- ad: https:\/\/mads.dailymail.co.uk\/v8\/de\/health\/none\/article\/other\/inread_player.html --><\/p>\n<p>n<\/p>\n<div class=\"column-content cleared\">n<\/p>\n<div class=\"shareArticles\">n<\/p>\n<h3 class=\"social-links-title\">Share or comment on this article: <\/h3>\n<p>n<\/p>\n<\/div>\n<\/div>\n<p>n<\/p>\n<p>            <ad-slot position=\"smart_feed\"><\/ad-slot><ad-slot position=\"after_article\"><\/ad-slot><\/div>\n<p>n<\/p>\n<p>Menopause drug that &#8216;switches off&#8217; hot flushes could be available by the end of the year<\/a><\/p>\n<p>n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>n Menopausal drug that &#8216;turns off&#8217; hot flashes in just days could be available by year&#8217;s end after being approved in the US as a lifeline for hundreds of thousands of women unable to take hormone replacement therapy n n The first non-hormonal drug for menopause, called fezolinetant, acts on the brain n Women reported <a class=\"read-more-link\" href=\"https:\/\/healthmedicinet.com\/i\/by-the-end-of-the-year-a-menopause-medication-that-switches-off-hot-flashes-might-be-accessible\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-291400","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/291400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/comments?post=291400"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/posts\/291400\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/media?parent=291400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/categories?post=291400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/i\/wp-json\/wp\/v2\/tags?post=291400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}