-
Credit: iScience (2024). DOI: 10.1016/j.isci.2024.109747 People on the autism spectrum are predisposed to Post-Traumatic Stress Disorder (PTSD), a new study from The Australian National University (ANU) and the University of Queensland has shown. The research also found PTSD can lead to the aggravation of core traits of autism such as repetitive behavior. The study, published in the journal iScience, showed that while generally PTSD is triggered by an extreme stress, a single mild stress can be enough to produce a traumatic memory in those with autism spectrum disorder (ASD). Senior Read More
-
In one of the first studies of its kind, UC Santa Barbara researchers have found that the immune status of postpartum mothers shifts with how she feeds her baby. According to a paper published in the journal Scientific Reports, certain inflammatory proteins—substances that are secreted as part of an immune response—peak at different times of day, correlating with whether the mothers breastfeed, pump or formula-feed their babies. “It’s a great study; there are so many unanswered questions about maternal health in the postpartum period,” said Amy Boddy, a human biologist Read More
-
Researchers at Boston Medical Center (BMC) have published findings in JAMA Pediatrics that show the hospital’s revised clinical guidelines for reporting substance-exposed newborns support family health. In May 2021, BMC revised its clinical guidelines to report suspected abuse after a child is born when there are tangible concerns about the parent’s ability to safely care for the child, rather than automatically filing Child Protective Services (CPS) reports for all cases of prescribed use of opioids or medication for opioid use disorder. This clinical guideline shift reduced reporting to CPS by Read More
-
The COVID-19 pandemic significantly increased interest in wearable health-monitoring devices among low-income Hispanic and Latine adults living in the U.S., a new Northwestern University study has found. While the pandemic highlighted the need for regular health monitoring, these groups often lack access to affordable health care and sometimes distrust existing health systems. Wearables, therefore, could provide a reliable, at-home alternative to traditional in-clinic health monitoring. But, although interest has increased, several barriers remain that prevent these groups from adopting wearable technologies. According to the researchers, tech companies historically have designed Read More
-
A study examining childhood maltreatment in Australia has revealed the shocking burden for Australians, estimating it causes up to 40% of common, life-long mental health conditions. The mental health conditions examined were anxiety, depression, harmful alcohol and drug use, self-harm and suicide attempts. Childhood maltreatment is classified as physical, sexual and emotional abuse, and emotional or physical neglect before the age of 18. Childhood maltreatment was found to account for 41% of suicide attempts in Australia, 35% for cases of self-harm and 21% for depression. The analysis, published in JAMA Read More
-
An estimated 321,566 children in the United States lost a parent to drug overdose from 2011 to 2021, according to a study published in JAMA Psychiatry. The rate of children who experienced this loss more than doubled during this period, from approximately 27 to 63 children per 100,000. The highest number of affected children were those with non-Hispanic white parents, but communities of color and tribal communities were disproportionately affected. The study was a collaborative effort led by researchers at the National Institutes of Health’s (NIH) National Institute on Drug Read More
-
A team of Dana-Farber Cancer Institute investigators discovered that a subset of myeloid and lymphoid leukemias depend on a molecular complex called PI3Kgamma for survival. The study provides both mechanistic and preclinical evidence supporting the rapid initiation of clinical trials for patients with acute myeloid leukemia (AML) to test an existing medicine that inhibits the complex, called eganelisib, both alone and in combination with the most used AML chemotherapy, cytarabine. The study was published in Nature. “Given what we’ve observed, we can move very quickly to take these medicines, which Read More
-
Starting people with opioid use disorder on extended-release, injectable naltrexone (XR-naltrexone) within five to seven days of seeking treatment is more effective than the standard treatment method of starting within 10–15 days, but requires closer medical supervision, according to results from a clinical trial published in JAMA Network Open. The findings suggest that this rapid treatment protocol could make XR-naltrexone more viable as a treatment option for opioid use disorder, which continues to take lives at an alarming rate. “When someone is ready to seek treatment for opioid use disorder, Read More
-
For children with neurogenic bladder, self-catheterization is associated with lower adherence to clean intermittent catheterization (CIC), according to a study recently published in the Journal of Pediatric Urology. Simran K. Sidhu, from Kuala Lumpur Hospital in Malaysia, and colleagues identified factors that could affect CIC compliance and examined the association between CIC compliance and short-term urological outcomes in children with neurogenic bladder due to spina bifida and caudal regression syndrome. The validated Intermittent Catheterization Adherence Scale was used to assess patient compliance with CIC among 50 patients aged 2 to Read More
-
METHOD study design. n?=?177 participants were allocated to the PDP intervention group and n?=?170 participants were allocated to the control group. DBS, dried blood spot finger-prick test. CGM, continuous glucose monitor. A Food Frequency Questionnaire (FFQ), accompanied by a dietary behavior survey, was administered. Anthropometry measures included waist circumference, hip circumference, height and body weight. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-02951-6 Personalized nutrition approaches can improve several key health metrics, including lower weight, lower cholesterol, better mood, improved gut health, lower heart disease risk, and better metabolic health. Improvements for Read More
-
Mount Sinai researchers took detailed pictures of the serotonin receptor and clinically-validated drug target 5-HT1A using cryo-electron microscopy to show how the psychedelics LSD and 5-MeO-DMT and a 5-HT1A-selective 5-MeO-DMT derivative (4-F, 5-MeO-PyrT) bind. The team further discovered that 4-F, 5-MeO-DMT has antidepressant effects in mouse models mediated by 5-HT1A, which potentially contribute to the therapeutic effects of psychedelics observed in clinical studies. Credit: Audrey Warren, Ph.D. candidate and Daniel Wacker. Ph.D., Assistant Professor of Pharmacological Science and Neuroscience at Icahn Mount Sinai Researchers at the Icahn School of Medicine Read More
-
UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep. This efficient memory occurs in a part of the brain that is crucial for learning and memory, and where Alzheimer’s disease begins. The discovery is published in the journal Nature Communications. Does this sound familiar? You go to the kitchen to fetch something, but when you get there, you forget what you wanted. This is your working memory failing. Working memory is defined as remembering some information for a short period while you Read More
-
Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.04.008 Tiny, dangerous, and easily transmitted hepatitis B virus (HBV) chronically affects about 296 million people and kills about 1 million every year. This stealthy virus invades the liver and remains largely asymptomatic until it culminates in cirrhosis or cancer. Most treatments try to inhibit the virus’s polymerase (pol) protein. But those treatments are lifelong and not curative. Now, researchers from the lab of Rockefeller’s Charles M. Rice have revealed never-before-seen mechanisms that may lead to new therapeutic approaches for HBV. They published the Read More
-
We’ve come a long way in terms of understanding that everyone thinks, interacts and experiences the world differently. In the past, autistic people, people with attention deficit hyperactive disorder (ADHD) and other profiles were categorized by what they struggled with or couldn’t do. The concept of neurodiversity, developed by autistic activists in the 1990s, is an emerging area. It promotes the idea that different brains (“neurotypes“) are part of the natural variation of being human—just like “biodiversity“—and they are vital for our survival. This idea is now being applied to Read More
-
Credit: Oxford University Press The last pandemic was bad, but COVID-19 is only one of many infectious diseases that emerged since the turn of this century. Since 2000, the world has experienced 15 novel Ebola epidemics, the global spread of a 1918-like influenza strain and major outbreaks of three new and unusually deadly coronavirus infections: SARS, MERS and, of course, COVID-19. Every year, researchers discover two or three entirely new pathogens: the viruses, bacteria and microparasites that sicken and kill people. While some of these discoveries reflect better detection methods, Read More
-
Credit: Pixabay from Pexels We feel ecological grief when we lose places, species or ecosystems we value and love. These losses are a growing threat to mental health and well-being globally. We all see news of environmental degradation and climate change impacts around the world. But environmental scientists, rangers, engineers, advocates and policymakers are at particular risk of ecological grief, due to their first-hand experience of environmental decline. Our author group has heard from colleagues about the impacts of coral bleaching, bushfires and floods on their work and the distress Read More
-
New research from a multi-disciplinary team at Trinity College Dublin suggests a “tailored vaccine” might hold the key to treating bacteria-driven flares of eczema in children. The work has been published in JCI Insight. The team has taken several leaps forward in understanding how the immune response works in cases of eczema driven by the common, troublesome Staphylococcus aureus bacterium, and in doing so they have identified new cellular targets for a vaccine. Eczema, also known as atopic dermatitis, affects up to one in four children in Ireland. Common symptoms Read More
-
Overall hypertension (a-c) and essential hypertension (d-f) hospitalization risk from 1-year, 2-year, and 3-year PM1 exposure. Credit: Science China Press Hypertension is among the leading cardiovascular diseases. Despite extensive research, evidence concerning the relationship between long-term exposure to ambient particulate matter and hypertension remains limited and inconsistent, particularly with regard to submicron particulate matter (PM1). While randomized controlled trials are considered the gold standard for causal inference, environmental epidemiological studies typically rely on observational data. Traditional approaches in observational studies are less effective than randomized controlled trials in fully controlling Read More
-
Credit: Respiratory Physiology & Neurobiology (2024). DOI: 10.1016/j.resp.2024.104265 Using a computational model representing the full respiratory tract, researchers from the University of Technology Sydney (UTS) have confirmed the safety of CPAP therapy, addressing concerns about potential damage to lung tissues due to high pressure or turbulent airflow. “CPAP works by increasing airway pressure to prevent the collapse of soft tissues during sleep that results in snoring and more seriously, interrupted breathing and daytime fatigue,” said lead researcher for the study Senior Lecturer of Mechanical Engineering Dr. Suvash Saha. “If not Read More
-
A team led by LDI senior fellow and Perelman School of Medicine faculty member Lauren Eberly at a Navajo Nation hospital in New Mexico has developed a simple intervention that increased the uptake of guideline-directed heart failure therapy drugs by 53%. Titled “Telephone-Based Guideline-Directed Medical Therapy Optimization in Navajo Nation: The Hózhó Randomized Clinical Trial,” the study is published in the April issue of JAMA Internal Medicine. “We found a 53% increase in the uptake of guideline-directed medical therapy to be a very significant effect,” said Eberly. “In some ways, Read More
-
Patients with lung cancer who were Asian/Pacific Islander, Black or Hispanic experienced a higher intensity of end-of-life care compared to white patients, according to a Northwestern Medicine population-based analysis published in the Journal of Clinical Oncology. “When we think about patients with cancer and end of life, there’s a lot of research that shows that most patients would prefer not to be in the hospital. Dying in the hospital or spending last days in the hospital is not associated with better outcomes, it’s not associated with higher quality of life, Read More
-
Unintended Cre recombination in all hematopoietic lineage cells in SM22?-Cre mice. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2315123121 Most of the time, our immune systems do a great job defending against infection and keeping our bodies running smoothly. Sometimes, though, our immune system actually makes things worse. Case in point—researchers from Japan have now shown that a naturally occurring immune signaling protein may be a key player in the development of an incurable form of lung disease. In a study published last month in PNAS, investigators Read More
-
Credit: Adam Connell/LLNL. In a new development for addressing future viral pandemics, a multi-institutional team involving Lawrence Livermore National Laboratory (LLNL) researchers has successfully combined an artificial intelligence (AI)-backed platform with supercomputing to redesign and restore the effectiveness of antibodies whose ability to fight viruses has been compromised by viral evolution. The team’s research—published in the journal Nature—showcases a novel antibody design platform comprising experimental data, structural biology, bioinformatics modeling, and molecular simulations—driven by a machine learning algorithm. The interagency team used the platform to computationally optimize an existing SARS-CoV-2 Read More
-
The sensor module, positioned on the thyrohyoid muscle, features a 45-degree pre-curved design and soft, waterproof encapsulation. Credit: Park et al A smart neckband allows wearers to monitor their dietary intake. Automatically monitoring food and fluid intake can be useful when managing conditions including diabetes and obesity, or when maximizing fitness. But wearable technologies must be able to distinguish eating and drinking from similar movements, such as speaking and walking. Chi Hwan Lee and colleagues propose a machine-learning enabled neckband that can differentiate body movements, speech, and fluid and food Read More
-
A head-mounted device generates an ultra-low frequency ultralow magnetic field, known as an Extremely Low Frequency Magnetic Environment (ELF-ELME). Credit: Mikako Ito, Keiko Itano A head-mounted device that generates an ultra-low frequency ultra-low magnetic field has been found to improve the symptoms of four male patients diagnosed with major depressive disorder. Future trials using the device may offer a safe and noninvasive way of treating depression. The results were published in the Asian Journal of Psychiatry. The presence of a magnetic field with frequencies typically ranging from 0 to 300 Read More
-
Graphical abstract. Credit: Journal of Ethnopharmacology (2024). DOI: 10.1016/j.jep.2024.118149 In the Dai minority region of China, the Aspidopterys obcordata (Hei Gai Guan) has been used as a fork medicine for the treatment of urinary tract infections, cystitis, and urinary tract stones. Previous studies showed that the Aspidopterys obcordata fructo oligosaccharide (AOFOS) from Hei Gai Guan has inhibitory effects on the growth of calcium oxalate crystals of the kidney stones (also known as urolithiasis). However, the effects of plant polysaccharides on the prevention and treatment of kidney stones are poorly understood. Read More
-
Approximately 31,000 people are living with amyotrophic lateral sclerosis (ALS) in the United States, with an average of 5,000 new cases every year, according to the Centers for Disease Control and Prevention. ALS, commonly referred to as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects the nerve cells that make muscles work. As these nerve cells stop working, the brain loses its ability to control movement and trigger specific muscles—including the muscles needed for speaking. In a new publication in the Journal of Speech, Language, and Hearing Research, Read More
-
by KeAi Communications Co., Ltd. Comparisons of short-term outcomes between FRAS and ERAS. Credit: Huanghui Wu, et al In the 1990s, Dr. Henrik Kehlet introduced the concept of enhanced recovery after surgery (ERAS), pioneering multimodal surgical care. Initially applied to patients undergoing colonic surgery, ERAS has also been dedicated to developing multimodal perioperative care to improve patients’ recovery after major surgery through research, education, audit and implementation of evidence-based practice, aiming to close the “knowing-doing” gap. Representing a paradigm shift in perioperative care, ERAS challenges traditional practices, replacing them with Read More
-
New research from City, University of London and the University of Southampton highlights the importance of Healthy Start for low-income families and outlines several recommendations for local and national governments to improve uptake of the scheme. The study was led by Professor Christina Vogel, Director of the Centre for Food Policy at City, University of London. This work aimed to evaluate the Healthy Start scheme in England and understand how the scheme can be improved to reach more eligible families. The Healthy Start scheme was launched in 2006. It offers Read More
-
Smart toys with internet connections and AI-enabled robots, with capacities for sophisticated social interactions with children, are widely available today. This is no doubt driven by rapid development in Artificial Intelligence, with impacts being widely felt. Companies are looking to enhance productivity and revenue, while governments are considering safety measures in their AI strategies. Child-focused AI products include: Parents and professionals working with children may feel pressure to purchase these or other products as alternatives to in-person activities like play dates, therapy or games—or wonder about their usefulness and potential Read More
-
Study protocol. Gray and black horizontal bars represent sleep opportunities. Participants were admitted (horizontal dotted line) following a ?21-day at-home preadmittance phase of a 10-hour sleep opportunity per night (gray horizontal bars). Initial in-laboratory sleep opportunities (“Sleep Satiation”) were 16 h/d (12 h/night with 4-hour nap midday) followed by 10 h/d to ensure participants had no sleep debt at the time of baseline 24-hour sampling (blue dotted horizontal bar). Forced desynchrony protocol (“Sleep Restriction + Circadian Disruption”) was then initiated in which participants lived on a 28-hour day for approximately Read More
-
More and more of my friends are following the plant-based diet trend. Is that the same as going vegan? Is it healthy for you? What can I actually eat? ANSWER: Plant-based foods go beyond a “boring salad.” With a whole-food plant-based diet, we focus on eating foods that are primarily coming from plants and that occur in their natural state. Veganism also takes that into account but can incorporate other social and justice factors into that lifestyle. Certainly, it can be difficult to go 100% whole-food plant-based, especially if that’s Read More
-
Dr. Sherecce Fields, a clinical psychologist and professor in the Department of Psychological and Brain Sciences at Texas A&M University, says caffeine should be ingested in moderation and with caution. Credit: Michael Miller/Texas A&M AgriLife Marketing and Communications Whether it’s brewing a cup of coffee at home, ordering a specialty $6 latte from a local coffee shop or cracking open a Red Bull on the way to the gym, the consensus is clear: The prevalence of the caffeinated beverage industry continues to grow. According to the National Coffee Association’s Coffee Read More
-
Credit: Andrea Piacquadio from Pexels Dementia is often described as “the long goodbye.” Although the person is still alive, dementia slowly and irreversibly chips away at their memories and the qualities that make someone “them.” Dementia eventually takes away the person’s ability to communicate, eat and drink on their own, understand where they are, and recognize family members. Since as early as the 19th century, stories from loved ones, caregivers and health care workers have described some people with dementia suddenly becoming lucid. They have described the person engaging in Read More
-
“No use of substances” sign. Credit: Journal of Studies on Alcohol and Drugs Teenagers are less likely to drink, smoke or use drugs when their parents keep tabs on their activities—but not necessarily because kids are more likely to be punished for substance use, suggests a new study in the Journal of Studies on Alcohol and Drugs. Researchers found that contrary to common belief, parents’ “monitoring” does not seem to boost the odds of catching their kids using substances. However, when kids simply are aware that their parents are monitoring Read More
-
With half of individuals who use cannabis in pregnancy also using tobacco or nicotine products, OHSU researchers investigated the effects of using both substances on both mother and newborn health outcomes. Credit: OHSU In a new study, Oregon Health & Science University researchers report that combined cannabis and nicotine use during pregnancy is associated with significantly higher risk of poor health outcomes for newborns compared with use of either substance alone. The study, published in JAMA Network Open, found infants born to mothers who used both substances throughout pregnancy were Read More
-
If you’re one of the millions of Americans who have a penicillin allergy listed on your medical record, research suggests it’s highly likely that this label is inaccurate. Having a penicillin allergy label matters, as it can have a significant impact on patient care. For many people, it has resulted in higher costs for antibiotics, delays in getting care, and longer hospital stays. That’s why Anjeli Kalra, MD, an assistant professor in the Division of Allergy and Clinical Immunology at the University of Colorado Department of Medicine, is highlighting the Read More
-
Lab tests of counterfeit oxycodone (Oxycontin) pills seized by police in Rhode Island in 2022 found 99.3% also contained dangerous fentanyl. It was typically mixed with another potentially deadly drug, xylazine. Both drugs make overdose more likely and more fatal, experts note. As too many American families have tragically come to know, “counterfeit prescription pills have been associated with adverse outcomes, including fatal overdose,” said a team of researchers led by Dr. Rachel Wightman. She’s associate professor of epidemiology and emergency medicine at Brown University in Providence, RI. Wightman’s team Read More
-
Planters peanut products sold at Publix and Dollar Tree in five states are being recalled due to the risk of Listeria contamination, maker Hormel announced. The products are Planters Honey Roasted Peanuts (4 ounces) and Planters Deluxe Lightly Salted Mixed Nuts (8.75 ounces). So far, there have been no reports of illness linked to the recalled products, the company said. “The products were shipped to Publix distribution warehouses in Florida, Georgia, Alabama and North Carolina and to Dollar Tree distribution warehouses in South Carolina and Georgia,” the company said in Read More
-
Emergency departments nationwide are overcrowded and overtaxed, but a new study suggests artificial intelligence (AI) could one day help prioritize which patients need treatment most urgently. Using anonymized records of 251,000 adult emergency department (ED) visits, researchers at UC San Francisco evaluated how well an AI model was able to extract symptoms from patients’ clinical notes to determine their need to be treated immediately. They then compared the AI analysis with the patients’ scores on the Emergency Severity Index, a 1–5 scale that ED nurses use when patients arrive to Read More
-
An illustration of the model fitting and prediction process. We first fitted context maintenance and retrieval to pilot data to obtain a parameter set ? that could capture pilot participants’ free-recall patterns. We preregistered these parameters and then used them in our live experiment in combination with the experimental participants’ recalls to predict post-cue recall behavior, that is, demonstrating the ability of the model to generalize over (1) a different group of subjects and (2) a different period of recall. Credit: Psychological Science (2024). DOI: 10.1177/09567976231215298 A computer model developed Read More
-
Researchers have discovered a protein marker to help identify cells able to repopulate in patients with damaged blood vessels. Their findings, recently published in Circulation, could lead to new therapies for people with endothelial dysfunction, a type of disorder that contributes to coronary artery disease that may occlude with plaque and lack ability to carry sufficient blood into the heart tissue causing a heart attack. “This study is the first to establish that a single, prospective marker identifies vascular clonal repopulating endothelial cells (CRECs),” said Chang-Hyun Gil, Ph.D., MS, assistant Read More
-
Through the endocytic pathway, the interaction of endorepellin and Neurexin physiologically triggers autophagy and appropriately modulates the differentiation of neural stem cells into neurons as a blocker, which is necessary for normal neural tube closure. Credit: Science China Press Neural tube defects (NTDs) rank as the second most prevalent congenital malformation in humans, impacting the central nervous system development in approximately 1 in every 1,000 live births. Over 300 genes, including the HSPG2 gene, are implicated in NTDs in mice. However, a considerable clinical hurdle remains in discerning pathogenic mutations Read More
-
A recent review article provides critical insights into the management of acute agitation in reproductive-age females and during pregnancy within the emergency departments (EDs). The study emphasizes the importance of considering the safety of psychotropic medications in this demographic population, given the potential risks to both the patient and the fetus. Agitation in the emergency department is not uncommon and can stem from various causes, including psychiatric disorders, substance abuse, and other medical conditions. When a pregnant patient exhibits signs of agitation, the situation becomes more complex due to potential Read More
-
Sedentary lifestyle puts strain on young hearts. Credit: University of Jyväskylä According to a recent Finnish study, high levels of sedentary behavior and physical inactivity from childhood strain the heart in adolescence. High cardiac workload predicts heart failure and other heart diseases. In light of the findings, increasing moderate and vigorous physical activity from childhood onwards is particularly important in preventing heart diseases. In a collaborative study by the Faculty of Sport Sciences at the University of Jyväskylä and the Institute of Biomedicine at the University of Eastern Finland, sedentary Read More
-
Rural Americans are less likely to initiate care for substance use disorders and to receive ongoing care compared with those who live in urban areas, according to a new study. When they do access care, people who live in less populated areas are more likely to have to go outside their provider network to receive treatment, which comes with higher out-of-pocket costs, found a team of researchers at The Ohio State University College of Public Health. Their study appears in the journal Health Services Research. “One thing that’s really striking Read More
-
TP53 inactivation initiates ordered genomic evolution. (A) The Lowe et al. group applied the KPCLOH reporter mouse model harboring both mutated Kras (mKate fluorescence) and intact Tp53 [GFP fluorescence, defined as DP cells (yellow)] and sporadic p53 inactivation resulted in the disappearance of GFP signal [defined as SP cells (red)]. This model allows for simultaneously monitoring TP53 status, genome evolution, and cellular phenotypes in vivo. Cartoon presentation is partially adopted15. (B) The Curtis’s group utilized human gastric organoids (HGOs) combined with CRISPR-Cas9 technology to generate TP53?/? HGOs (left panel) and Read More
-
Project ECHO continues to bridge health care gaps, especially in rural communities. Credit: University of Missouri More Americans suffer from chronic pain than diabetes, heart disease, and cancer combined. Yet, a shortage of pain medicine specialists persists, causing many pain sufferers to seek care in primary care settings. Researchers from the University of Missouri School of Medicine have found that an innovative tele-mentoring program can help address reliance on opioids in the management of pain, with potential benefits for patients, families and communities. “Claims Data Analysis of Provider-to-Provider Tele-mentoring Program Read More
-
A study led by Senthil Sambandam, M.D., found that using robotic equipment in total knee replacement surgeries often costs more but may result in better outcomes for some patients. Credit: UT Southwestern Total knee replacements performed with the help of a surgical robot have better outcomes on average than similar surgeries performed manually but can cost significantly more, a new study by UT Southwestern Medical Center researchers shows. The findings, published in Archives of Orthopaedic and Trauma Surgery, could help doctors and patients make more educated decisions on which option Read More
-
Graphical abstract . Credit: Journal of Nuclear Medicine (2024). DOI: 10.2967/jnumed.123.267175 A novel investigational PET imaging agent can rapidly and accurately visualize lesions in clear cell renal cell cancer (ccRCC) patients according to new research published in the May issue of The Journal of Nuclear Medicine. The results of the study suggest that the agent 68Ga-DPI-4452 (Debio 0328) is superior to standard CT imaging in the context of ccRCC. It also allows for significantly faster imaging and, in the future, could be utilized as part of a theranostic pair. ccRCC Read More
-
Firefighters may have an increased risk of prostate cancer due to on-the-job chemical exposures, according to new research from the University of Arizona Mel and Enid Zuckerman College of Public Health and University of Michigan in collaboration with fire service partners and researchers around the country through the Fire Fighter Cancer Cohort Study. Prostate cancer is the leading incident cancer among U.S. males. Firefighters are diagnosed with prostate cancer at a rate 1.21 times higher than the general population, possibly because of chemical exposures including smoke and firefighting foam during Read More
-
A cesarean section is an important surgical intervention that can save the lives of mother and baby. Cesarean sections are essential in complicated labors such as prolonged or obstructed labor or if the baby is distressed. The World Health Organization says that while “every effort should be made to provide a cesarean section to women in need,” country cesarean rates should range between 10% and 15%. In South Africa rates are much higher in both public and private sector hospitals. In public hospitals, cesareans accounted for 28.8% of all births Read More
-
General overview of the study. Credit: Nature Machine Intelligence (2024). DOI: 10.1038/s42256-024-00807-9 Researchers at Mass General Brigham have harnessed the technology behind foundation models, which power tools like ChatGPT, to discover new cancer imaging biomarkers that could transform how patterns are identified from radiological images. Improved identification of such patterns can greatly impact the early detection and treatment of cancer. The research team developed their foundation model using a comprehensive dataset consisting of 11,467 images of abnormal radiologic scans. Using these images, the model was able to identify patterns that Read More
-
Distribution of non-P42 MOG-IgG in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset. Credit: Journal of Neurology, Neurosurgery & Psychiatry (2024). DOI: 10.1136/jnnp-2023-332851 Blindness and paralysis are often the devastating consequences of little-known disease myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). An Australian research collaboration is looking to change this, making huge strides in understanding the condition which could lead to better outcomes in the future. Often referred to as a cousin of MS due to shared symptoms, MOGAD is an autoimmune condition where the body attacks a protein in the Read More
-
Diagram and performance of the deep learning-based algorithm for identifying patients with active AF or paroxysmal AF at the time of TTE. Credit: npj Digital Medicine (2024). DOI: 10.1038/s41746-024-01090-z An artificial intelligence program developed by investigators in the Smidt Heart Institute and their Cedars-Sinai colleagues can detect a type of abnormal heart rhythm that can go unnoticed during medical appointments, according to a new study. The study’s findings, published in npj Digital Medicine, suggest AI could one day be employed to analyze images from a common imaging test called an Read More
-
How do we know whether newly minted doctors have what it takes to prevent patient deaths? After completing residency training, graduating physicians typically take board certification exams at the time they enter practice—but surprisingly little is known about the ability of these standard tests to predict the things that count the most in a doctor’s performance, such as how likely their patients are to survive or to avoid a return trip to the hospital. A new study, published May 6 in JAMA, found that internal medicine patients of newly trained Read More
-
Genetic engineering of S. boulardii to express mSA handle on the cell surface for attachment of ECM-specific targeting ligands. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-48128-0 Inflammatory bowel disease (IBD) is a complex condition that requires individualized care to meet the needs of the patient’s current disease state. With available medications sometimes causing serious side effects or losing their efficacy over time, many researchers have been exploring new, more targeted ways of delivering medications or other beneficial compounds, such as probiotics. To address pitfalls in IBD treatment and drug delivery, the Read More
-
Variation of short tandem repeat associated with thyroid disease in humans. A newly identified intergenic repeat-Alu contraction or sequence variant may be a frequent cause of compensated congenital hypothyroidism and multinodular goiter (MNG) through disruption of a thyroid-specific non-coding regulatory mechanism. TF, transcription factor. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01723-9 A team of researchers from the University of Chicago, in collaboration with the Free University of Brussels and the University of Washington, have uncovered a genetic mutation in a non-coding region of DNA that alters the regulation of the thyroid, Read More
-
In a study carried out by experts in child development at the University of York, researchers have found that pre-school children actively select, shape and create their own experiences to match their genetic tendencies. The researchers looked at how genes and the environment work together to shape the brain development of children between the ages of two and four. They found that rather than being passive recipients of the environment around them—such as the behavior and likes and dislikes of their parents—they also had a strong say in creating their Read More
-
In January 2024 alone, more than 280 anti-LGBTQ+ bills were introduced in the U.S. As this type of legislation and policies are becoming more prevalent across the country, a paper from researchers at Rice University concludes that the negative effects are felt profoundly not just by members of the LGBTQ+ community but by those who work in roles supporting them. The article “Understanding and Addressing the Health Implications of Anti?LGBTQ+ Legislation” is published in a recent edition of Occupational Health Science. The study is an anthology of expert opinions and Read More
-
Graphical abstract. Credit: Cell Metabolism (2024). DOI: 10.1016/j.cmet.2024.04.015 Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development. The fasting regime reduces the development of liver cancer in mice with pre-existing liver inflammation. The researchers identified two proteins in liver cells that are jointly responsible for the protective effect of fasting. An approved drug can Read More
-
Weekly depression in the U.S. for 2020 as measured using LBMHA, and compared to Gallup polling for sadness during the same period of time. The central lines represent the average. The higher the line, the more depression or sadness, respectively. Credit: Sid Mangalik A study that used artificial intelligence (AI) and social media posts to assess the rates of depression and anxiety in nearly half of American counties found that the AI-generated measurements produced more reliable assessments than population surveys. Led by Stony Brook University researchers in collaboration with computer Read More
-
Reduced interaction between p53 and MDM2 following SARS-CoV-2 spike protein overexpression in cancer cells. Credit: Oncotarget (2024). DOI: 10.18632/oncotarget.28582 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein. In-silico analysis previously suggested that SARS-CoV-2 spike interacts with p53 directly but this putative interaction has not been demonstrated in cells. In this new study, researchers Shengliang Zhang and Wafik S. El-Deiry from Brown Read More
-
Testing of peanut products leads to fears of possible listeria contamination and recalls in five states. Credit: Planters Hormel Foods’ recall of two Planters peanut and mixed nuts products at two retailers in five states due to possible contamination with potentially deadly listeria doesn’t surprise Northeastern University food policy expert Darin Detwiler. He says peanuts are at particular risk of being contaminated with the food-borne bacteria that causes listeria due to the way they are harvested, handled and stored. But Detwiler, an associate teaching professor, says recalls could be reduced Read More
-
Group-based interventions have the potential to address HIV-related stigma among adolescents living with the virus, finds a recent study from researchers at the Brown School at Washington University in St. Louis and Makerere University in Uganda. HIV stigma is a major barrier to all aspects of the HIV care continuum. However, few HIV stigma reduction interventions exist, especially those targeting adolescents. To address these gaps, a research group led by Proscovia Nabunya, an assistant professor at the Brown School, pilot tested the Suubi4Stigma cluster randomized clinical trial, to address stigma Read More
-
Emma Kuhn, from Flinders University Environmental Health, demonstrates a wall swab method used to assess the absence or level of methamphetamine contamination – used to assess whether remediation action is required. Credit: Flinders University A new Flinders University study has found less than 10% of suspected methamphetamine contamination in residences are reported to council environmental health officers (EHOs), raising further concerns more regulations are needed to manage safety and health in the community. The paper, “An Investigation into the Prevalence of Methamphetamine Related Enquiries to Local Government Environmental Health Officers,” Read More
-
In a study published online April 17 in the European Archives of Oto-Rhino-Laryngology, different grading methods for vestibular endolymphatic hydrops (EH) and the severity of hearing loss are compared in Meniere disease (MD). Zhihao Han, from the Beijing Friendship Hospital, and colleagues compared correlations between different grading methods of vestibular EH and the severity of hearing loss in MD in a retrospective study of 30 patients with MD. Patients underwent inner-ear magnetic resonance gadolinium-enhanced imaging using three-dimensional-real inversion recovery sequences and pure-tone audiometry. EH levels were evaluated according to classification Read More
-
Ultraviolet (UV) radiation used for outdoor recreational purposes can be associated with photokeratitis, according to a brief report published online May 2 in JAMA Ophthalmology. Julia Y.Y. Chan, M.B.B.S., from the Chinese University of Hong Kong, and colleagues describe a case series of photokeratitis associated with a single UV radiation display at an outdoor event. The case series included eight patients. The researchers reported that the mean time of UV display exposure was 3.00 hours, and symptoms presented at a mean 8.88 hours after the exposure. During the exposed period, Read More
-
The integration of biomarkers and patient-reported outcomes (PROs) improves prediction of interstitial cystitis (IC)/bladder pain syndrome, according to a study published online April 24 in Urology. Laura E. Lamb, Ph.D., from the Oakland University William Beaumont School of Medicine in Rochester, Michigan, and colleagues generated a machine learning predictive classification model (the Interstitial Cystitis Personalized Inflammation Symptom score), which uses PRO and cytokine levels, and then compared it to a challenger model. The machine learning model was based on 1,264 urine samples (536 IC and 728 age-matched controls) with corresponding Read More
-
Mean peak height velocity (cm/year) vs. mean age at peak height velocity (years) for cohorts of diverse ancestral backgrounds. Yellow and purple lines represent a linear model fit to APHV?~?PHV?×?sex. Credit: Genome Biology (2024). DOI: 10.1186/s13059-023-03136-z A genetic link between height growth during puberty and long-term health in adulthood has been identified by a new study from the University of Surrey and the University of Pennsylvania published in Genome Biology. Researchers found that being taller early in puberty and growing quickly in height during this period is linked to a Read More
-
A new study that followed a cohort of more than 110,000 people establishes significant disparities in the risk of anal cancer for people with HIV and for men who have sex with men with HIV, depending on the region of the country they live in. It’s known that people with HIV have the highest risk of anal cancer, said lead author Ashish A. Deshmukh, Ph.D., co-leader of the Cancer Control Research Program at MUSC Hollings Cancer Center. But this study, published in the Journal of the National Cancer Institute, is Read More
-
Correlation between transcriptomic age and other epigenetic aging predictors. Credit: Aging (2024). DOI: 10.18632/aging.205758 A new research paper titled “Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients” has been published in Aging. Research into aging has grown substantially with the creation of molecular biomarkers of biological age that can be used to determine age acceleration. Concurrently, nuclear magnetic resonance (NMR) assessment of biomarkers of inflammation and metabolism provides researchers with new ways to examine intermediate risk factors for chronic disease. In this new study, Read More
-
In a fast-paced digital age where patients can open their test results as soon as they are available, what happens when a patient reads through complicated results without a physician there to help them understand what it all means? And what happens when a patient misinterprets bad news as good news, or vice versa? It’s a scenario Benjamin Vipler, MD, confronted after his mom received her colonoscopy results on her health system’s patient portal. Like many patients, she opened up her results before meeting with her clinician, and tried to Read More
-
Some of the final work of a late University of Virginia School of Medicine scientist has opened the door for life-saving new treatments for solid cancer tumors, including breast cancer, lung cancer and melanoma. Prior to his sudden death in 2016, John Herr, Ph.D., had been collaborating with UVA Cancer Center’s Craig L. Slingluff Jr., MD, to investigate the possibility that a discovery from Herr’s lab could help treat cancer. Eight years of research has borne that idea out: Herr’s research into the SAS1B protein could lead to “broad and Read More
-
First linked to mutations in the CHD7 gene in 2004, CHARGE syndrome is a rare genetic disorder occurring in approximately 1 in 8,500 to 15,000 births. According to the National Institute of Health (NIH), CHARGE syndrome is an acronym for coloboma of eyes (C), heart disease (H), atresia of the choanae (A), retarded growth and mental development (R), genital anomalies (G), and ear malformations and hearing loss (E). Diagnosis is often challenging because this disorder manifests differently across individuals. A recent study published in Clinical Case Reports explored the detection Read More
-
BBN induces changes in the mucosa of mice. Credit: bioRxiv (2023). DOI: 10.1101/2023.08.17.553533 In collaboration with University Hospital Basel, researchers from ETH are investigating the early stages of bladder cancer. Their findings show that future research should also focus on mechanical changes in tumor tissue. Dagmar Iber is Professor of Computational Biology at ETH’s Department of Biosystems Science and Engineering in Basel. Her research group uses a combination of lab experiments and computer modeling to investigate how cells organize themselves into organs and other complex, three-dimensional tissue structures based on Read More
-
Researchers from FAU’s Schmidt College of Medicine conducted a study to assess the perceived risk of harm associated with weekly cannabis use in a sample of 20,234 women ages 18 to 49 by disability status. Credit: Alex Dolce, Florida Atlantic University A growing number of states and territories in the United States have legalized medical and recreational cannabis use. As such, recreational cannabis has been associated with a lower perception of risk of harm in the general U.S. population. However, in women of childbearing age, evidence has shown that cannabis Read More
-
A sharp rise in exposures to synthetic cannabis products among youth—some leading to hospitalization—highlights the need for increased education around the dangers of exposure and increased focus on safe storage and packaging, according to pediatricians and researchers at Nationwide Children’s Hospital and the Central Ohio Poison Center. A new study conducted by researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital and the Central Ohio Poison Center examined trends in calls to poison centers across the country for exposures to Read More
-
Credit: Mary Ann Liebert, Inc A new study published in Population Health Management, which builds on previous work in the journal, describes the Academic Payvider model, a joint approach to care and coverage aimed at reforming the relationship between payers and providers to enhance value-based care. “There is an undeniable need for reformation of the relationship between health care payers and providers,” states Erika Harness, MHA, from the Sidney Kimmel Medical College at Thomas Jefferson University, and co-authors of the study. The Payvider model is one promising approach, with the Read More
-
On behalf of the Swedish Gender Equality Agency, researchers Lena Dahlberg and Mariam Kirvalidze have done a scoping review of informal caregiving and loneliness. More specifically, the report examines loneliness in spousal caregivers aged 65 years and older, the factors that increase the risk of loneliness in this group, the consequences of loneliness, and how they themselves experience loneliness. Loneliness is associated with low well-being and poor health. The report indicates that loneliness among spousal caregivers can involve emotional loneliness within the relationship with their partner, especially if the partner Read More
-
In 1682 children followed up from age 11 to 24 years, increased sedentariness from childhood through young adulthood caused excessive heart enlargement, irrespective of obesity or hypertensive category. Light physical activity effectively reversed the risk of premature heart damage. Credit: Andrew Agbaje. An increase in sedentary time from childhood causes progressing heart enlargement, a new study shows. However, light physical activity could reduce the risk. The study was conducted in collaboration among the Universities of Bristol, Exeter and Eastern Finland, and the results were published in the European Journal of Read More
-
A small, implantable cardiac pump that could help children await heart transplants at home, not in the hospital, has performed well in the first stage of human testing. The pump, a new type of ventricular assist device, or VAD, is surgically attached to the heart to augment its blood-pumping action in individuals with heart failure, allowing time to find a donor heart. The new pump could close an important gap in heart transplant care for children. In a feasibility trial of seven children who received the new pump to support Read More
-
For patients with high clinical suspicion of giant cell arteritis (GCA), color Doppler ultrasound of the temporal artery as a first-line diagnostic tool can avoid the need for other diagnostic tests, according to a study published online May 7 in the Annals of Internal Medicine. Guillaume Denis, M.D., from the Center Hospitalier Rochefort in France, and colleagues assessed a diagnostic strategy for GCA using color Doppler ultrasound of the temporal artery as a first-line diagnostic test, temporal artery biopsy (TAB) as a secondary test, and physician expertise as the reference Read More
-
by Vanessa G. Sánchez, KFF Health News Families of people with intellectual and developmental disabilities say Gov. Gavin Newsom is reneging on a scheduled raise for the workers who care for their loved ones, and advocates warn of potential lawsuits if disability services become harder to get. Citing California’s budget deficit, the Democratic governor wants to save around $613 million in state funds by delaying pay increases for a year for about 150,000 disability care workers. The state will forgo an additional $408 million in Medicaid reimbursements, reducing funding by Read More
-
The air inside all personal vehicles is polluted with harmful flame retardants—including those known or suspected to cause cancer—according to a new study published in Environmental Science & Technology. Car manufacturers add these chemicals to seat foam and other materials to meet an outdated federal flammability standard with no proven fire-safety benefit. “Our research found that interior materials release harmful chemicals into the cabin air of our cars,” said lead author Rebecca Hoehn, a scientist at Duke University. “Considering the average driver spends about an hour in the car every Read More
-
The systems, circuit and molecular levels of a memory trace. Credit: Nature Reviews Neuroscience (2024). DOI: 10.1038/s41583-024-00799-w A study published in Nature Reviews Neuroscience by an international team including the Woolcock’s Dr. Rick Wassing examined research into sleep disorders over more than two decades to prove a good night’s sleep is the perfect remedy for emotional distress. Nothing we haven’t known forever, some would argue, but Dr. Wassing who has spent the past two years on the project says there’s much more to it than that. “What we have done Read More
-
Flexible probe characteristics. A) Photograph of the multi-layer probe with overall dimensions and a close-up showing the distribution of the electrode sites at the tip of the probe. B) Impedance spectrum of an unused probe. C) Voltage-drop at the electrodes during biphasic pulsing in vitro over a period of 16 weeks with more than 10 billion stimulation pulses. D) Scanning electron microscopy images of the probe exposed to the pulsing test in (B). E) Scanning electron microscopy images of a probe explanted after 55 weeks in vivo. Credit: Advanced Healthcare Read More
-
Graphical abstract. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114112 Neurons are important, but they are not everything. Indeed, it is “cartilage,” in the form of clusters of extracellular matrix molecules called chondroitin sulfates, located in the outside nerve cells, that plays a crucial role in the brain’s ability to acquire and store information. A study published in Cell Reports describes a new mechanism of brain plasticity, or how nerve connections change in response to external stimuli. The paper is titled “Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory Read More
-
Researchers from Griffith University’s National Center for Neuroimmunology and Emerging Diseases (NCNED) have made a discovery that could bring relief to those struggling with long COVID. In a world-first finding, they’ve identified a way to restore the faulty function of ion channels on immune cells using a well-known drug typically used for other medical purposes. The breakthrough, published in the journal Frontiers in Immunology, builds on previous research showing long COVID patients share similar issues with ion channels as those with chronic fatigue syndrome (also known as myalgic encephalomyelitis or Read More
-
Results of voxel-based morphometry and cerebellar activation related to the presentation of the aversive US. A, gray matter voxel-based morphometry (contrast “control group?>?cerebellar group”). US-related cerebellar activation (contrast “US post CS+?>?no-US post CS?” during fear acquisition training) in (B) healthy controls and (C) cerebellar patients collapsed over early and late fear acquisition blocks. Credit: eneuro (2024). DOI: 10.1523/ENEURO.0365-23.2023 For a long time, the fact that the cerebellum plays an important role in regulating our emotions—such as when processing fear—has been ignored. Professor Melanie Mark from Ruhr-University Bochum and Professor Dagmar Read More
-
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI176640 Why do some people with COVID-19 experience little more than a sniffle while others end up on a ventilator? And among critically ill patients, why do some eventually recover while others do not? A new study has unveiled clues for helping scientists predict who is most at risk for severe COVID-19, and among those who experience severe disease, who is most likely to survive. The researchers published their findings in the Journal of Clinical Investigation on May 1. The study drew on Read More
-
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI170118 B-cells infiltrating the lungs may be responsible for one of the most common complications in lung transplantation, which can lead to rejection, according to a study published in the Journal of Clinical Investigation. Roughly 2,500 people receive lung transplants each year, according to the U.S. Department of Health and Human Services, and they are one of few treatment options available for people experiencing end-stage respiratory failure, according to the National Institutes of Health. Ischemia/reperfusion injury—the damage caused by cell death following the Read More
-
A, Percentages of late-preterm and full-term newborns treated with antibiotics in different levels of care and total in Sweden. B, Number of antibiotic-days per 1,000 live births in late-preterm and full-term newborns in different levels of care and total in Sweden. C, Late-preterm and full-term newborns with early-onset sepsis, rate per 1,000 live births by year in different levels of care and total in Sweden. Credit: JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.3362 Newborns in Sweden are given antibiotics for suspected sepsis to an unjustified extent. This is according to a Read More
-
Credit: Adapted from Advanced Materials Technologies (2024). DOI: 10.1002/admt.202302155 A research team led by Professor Sohee Kim of the Department of Robotics and Mechatronics Engineering in the Daegu Gyeongbuk Institute of Science & Technology has successfully developed three-dimensional retinal electrodes that resemble convex Braille. By stimulating the remaining normal nerve cells in the retina, the electrodes are expected to be used to partially restore vision to patients with blindness. The study’s findings were published on March 24 in Advanced Materials Technologies. One of the main causes of blindness is damage Read More
-
Epithelial MHCII is required for mucosal retention of Cr-specific TH cells, prolonged colonocyte STAT3 activation and crypt protection. Credit: Nature (2024). DOI: 10.1038/s41586-024-07288-1 Intestinal epithelial cells line the inner wall of the gut, creating a barrier against dangerous bacteria like enteropathogenic E. coli that seek to attach to and destroy this barrier. Such pathogens pose significant risks to human health, including infant deaths due to diarrhea, particularly in developing countries. A study published in the journal Nature, led by Carlene Zindl, Ph.D., and C. Garrett Wilson in the research group Read More
-
Researchers have discovered how mutations in the MAGEL2 gene — the cause of the syndrome — give rise to truncated and non-functional proteins that accumulate in the cell nucleus and, thus, could aggravate the symptoms of those affected by the pathology. Credit: Journal of Medical Genetics (2024). DOI: 10.1136/jmg-2024-109898 Mutations in the MAGEL2 gene, which cause Schaaf-Yang syndrome (SYS)—an ultra-rare disease that affects neuronal and cognitive development—generate truncated, non-functional proteins that tend to accumulate in the cell nucleus. Moreover, this progressive accumulation of abnormal proteins could cause a toxic effect Read More
-
Gut bacteria metabolite holds potential in combating inflammatory bowel disease. Credit: Chiharu Nishiyama from Tokyo University of Science, Japan Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health. Any disturbance in the gut microbiota can, therefore, have a systemic impact. Intestinal microbes metabolize dietary components into beneficial fatty acids (FAs), supporting metabolism and maintaining host body homeostasis. Metabolites originating from polyunsaturated fatty acids (PUFAs), influenced by gut microbes such as Lactobacillus plantarum, exhibit potent effects on inflammation Read More
-
This unique setup created a layer of mucus exposed to the air for easy access during experiments. The researchers used a magnetic wire and powerful magnets to study the properties of the mucus without disturbing it. Credit: Cai and Braunreuther et al. As much as we might not want to think about it, mucus is everywhere in our bodies. It coats our airways and our digestive systems and serves as a first line of defense against pathogens, a habitat for our microbiomes, and a conveyor belt for our insides to Read More
-
Cryo-soft X-ray tomography 3D reconstructions of segmented mitochondria (brown) in the cytoplasm around the nucleus (blue) in herpes simplex virus type 1 infected cell. Credit: Maija Vihinen-Ranta Researchers at the University of Jyväskylä have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell. The new information could help to understand the interaction between herpesvirus and host cells and develop new viral treatments. Herpesviruses cause significant diseases but are also promising candidates for oncolytic therapy. HSV-1 infection depends on nuclear DNA replication, transcription Read More
-
TRTpred, a sensitive in silico predictor of tumor-reactive clonotypes. Credit: Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02232-0 Using artificial intelligence, Ludwig Cancer Research scientists have developed a powerful predictive model for identifying the most potent cancer-killing immune cells for use in cancer immunotherapies. Combined with additional algorithms, the predictive model, described in the current issue of the journal Nature Biotechnology, can be applied to personalized cancer treatments that tailor therapy to the unique cellular makeup of each patient’s tumors. “The implementation of artificial intelligence in cellular therapy is new and may be Read More