This confocal image of a macrophage (a type of white blood cell in the immune system) differentiated from induced pluripotent stem cells shows that the human specific gene CHRFAM7A rearranges the actin cytoskeleton (green). Credit: University at Buffalo University at Buffalo researchers have found that the active form of a gene promotes a broad range of protective traits. The gene is found in 75% of the population and is known to protect against neurodegeneration. Now, UB researchers have found that this same gene enhances immune function, too. The new findings were published Read More
A shopper loads her car after shopping at a Walmart in Pittsburgh, Thursday, Feb. 22, 2018. Walmart announced Tuesday, April 30, 2024, is closing its health centers and virtual care service, as the retail giant has struggled to find success with the offerings. AP Photo/Gene J. Puskar, File) Walmart is closing its health centers and virtual care service after struggling to find success with the offerings, the U.S. retailer said Tuesday. The Bentonville, Arkansas-based company said that after managing the clinics it launched in 2019 and expanding its telehealth program, Read More
This is a story about proteins, how they malfunction, and what cells do to prevent that. Credit: Matt Perko, UC Santa Barbara Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts. A protein’s structure is critical to its function. Malformed proteins not only fail to carry out their tasks, they can accumulate and eventually gum up the inner workings of cells. As a result, misfolded proteins cause a variety of degenerative diseases, from Alzheimer’s and Parkinson’s to the blinding disease retinitis pigmentosa. Read More
Words have a direct impact on the formation of a child’s identity. By labeling children, for example categorizing them as “lazy” or “clever,” we may actually be doing them a disservice. We might see ourselves as benevolent architects of their future, but we might, involuntarily, be holding them back. There is a delicate balance between uplifting or helping a child to grow and condemning them. It is vital that we reflect on whether our words build bridges or barriers for the children who hear them. Labels: beyond praise and criticism Read More
On a narrow street lined with row houses and an auto body shop in the Kensington neighborhood of North Philadelphia, Marsella Elie climbs a home’s front steps and knocks hard on the door. A middle-aged man appears with a wary look on his face. “Hello, sir, how are you doing today?” asked Elie, wearing a royal-blue jacket embroidered with the city government’s Liberty Bell logo. “My name is Marsella. I’m working with the city. You heard about the overdoses that are going around in the neighborhood, right?” The man gives Read More
Dr. Ashraf Ibrahim in his laboratory at The Lundquist Institute. Credit: The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center A novel oral amphotericin B (MAT2203) developed by Matinas BioPharma for treatment of invasive mucormycosis (IM) and other deadly invasive fungal infections, has demonstrated encouraging results in a series of preclinical studies. The research, led by Lundquist Institute (TLI) Investigator Ashraf Ibrahim, Ph.D., has been published in the journal Antimicrobial Agents and Chemotherapy. The studies focused on MAT2203, an oral lipid nanocrystal formulation of amphotericin B, which has previously Read More
Use of publicly available large language models (LLMs) resulted in changes in breast imaging reports classification that could have a negative effect on patient management, according to a new international study published in the journal Radiology. The study findings underscore the need to regulate these LLMs in scenarios that require high-level medical reasoning, researchers said. LLMs are a type of artificial intelligence (AI) widely used today for a variety of purposes. In radiology, LLMs have already been tested in a wide variety of clinical tasks, from processing radiology request forms Read More
The disruption to the supply of a prescription medicine that helps people stop smoking may have led to thousands fewer people quitting each year in England, which will lead to avoidable deaths in future, suggests a new study led by UCL (University College London) researchers. Varenicline (also known as Champix) is one of the most effective treatments to help smokers quit. It works by reducing cravings for nicotine and easing withdrawal symptoms. But its distribution was paused in July 2021 in the UK and Europe as a precaution after higher Read More
Children who are recovering from severe pneumonia could safely switch from injectable to oral antibiotics earlier, allowing them to come home from hospital sooner. This is according to new results from the PediCAP clinical trial, presented April 29 at the ESCMID Global conference in Barcelona. The current World Health Organization (WHO) guidelines recommend that children with severe community-acquired pneumonia are treated for five days with an injectable antibiotic. This means children must stay in hospital for the full five days, even if they get better sooner. Longer hospital stays are Read More
New research from UNICEF Innocenti, produced in partnership with the University of Sheffield, New York University, City University New York and the Queensland University of Technology, explores the question of whether video games can contribute to the well-being of children, and if so, how? This research looked to the voices of the young, based on the scientific study of hundreds of children in six countries over many months. The report is titled “Digital Technology, Play and Child Well-Being.” The research found something remarkable: Digital games can indeed contribute to the Read More
Researchers highlight the significance of plant-based alternatives for disease treatment, as well as of advanced diagnostic tools through the development of metabolomics. Credit: Journal of Pharmaceutical Analysis Inflammatory bowel disease (IBD) is a common chronic gastrointestinal disorder and current treatment strategies can cause adverse effects. Thus, there is a need to identify alternative compounds to treat IBD. Similarly, the dose-related toxicity and efficacy of anticancer drugs needs to be monitored accurately to improve the treatment outcomes. Moreover, over the years, plant-based therapeutic compounds and traditional Chinese medicine formulas have gained Read More
If you’re preparing to register your child for summer sports camps and fall, team sports, Nirav Pandya, MD, orthopedic surgeon at UCSF Benioff Children’s Hospitals, has some suggestions for how to help your kids avoid common repetitive injuries. Kids who play a variety of sports, rather than specializing in one, at a young age tend to experience fewer injuries overall on average, Pandya says. That’s because specializing in a single sport when kids are young comes with risks. What should parents be thinking about as they make upcoming summer and Read More
The way religious beliefs and medical treatments intersect can really affect how people use medications and stick to their treatment plans. Lately, there’s been talk about “Halal pharmaceuticals,” which are drugs made to fit with Islamic beliefs. But a lot of health care providers in places like the Middle East don’t know much about what goes into these drugs or how they’re made. Scholars in Zarqa University, Jordan, have investigated what health care providers know, think, and feel about halal pharmaceuticals. The work is published in The Open Public Health Read More
Experimental treatment groups involving hepatocytes exposed to various doses of AAV, AAV* (AAV pre-treated with EP), or plasmids, with or without electric field pulse (EP) exposure (illustrations not drawn to scale). Credit: PLOS ONE (2024). DOI: 10.1371/journal.pone.0298866 In an effort to improve delivery of costly medical treatments, a team of researchers in electrical engineering at the University of Wisconsin–Madison has developed a stimulating method that could make the human body more receptive to certain gene therapies. The researchers exposed liver cells to short electric pulses—and those gentle zaps caused the Read More
America’s young people face a mental health crisis, and adults constantly debate how much to blame phones and social media. A new round of conversation has been spurred by Jonathan Haidt’s book “The Anxious Generation,” which contends that rising mental health issues in children and adolescents are the result of social media replacing key experiences during formative years of brain development. The book has been criticized by academics, and rightfully so. Haidt’s argument is based largely on research showing that adolescent mental health has declined since 2010, coinciding roughly with Read More
The benefits of physical fitness for kids spill over into their mental health, new research shows. Getting plenty of exercise may guard against depressive symptoms, anxiety and attention-deficit hyperactivity disorder (ADHD), a new study published April 29 in the journal JAMA Pediatrics found. And the more exercise, the better: Higher performance in cardiovascular activities, strength and muscular endurance were each associated with even greater protection against mental health issues. The findings arrive as America continues to grapple with a surge in mental health diagnoses among children and adolescents. The new Read More
All women should start getting mammograms every other year beginning at age 40, the nation’s top panel of preventive health experts announced Tuesday. About 20% more lives can be saved from breast cancer by moving the regular screening age up to age 40, rather than starting at age 50, the U.S. Preventive Services Task Force (USPSTF) estimates. The task force based its recommendation partly on increasing rates of breast cancer in younger women. “More women in their 40s have been getting breast cancer, with rates increasing about 2 percent each Read More
Chicken with potatoes, carrot-and-cabbage salad: it looks like a detox meal, but it’s the menu at a school cafeteria in Rio de Janeiro, Brazil, which is seeking new ways to fight childhood obesity. Nearly one-third of children in Brazil are obese, an epidemic city health officials and community leaders are seeking to address in innovative ways, enlisting school cafeterias and taking their message of healthful eating to the street. “Cake? There’s no cake here,” laughs cook Neide Oliveira as she chops onions for the 650 students of Burle Marx public Read More
For her study, Selvarathinam leveraged the fact that worms have similarities in their genes to humans and predictable behaviors that are easy to study. She proceeded to optimize an experi-mental protocol that aimed to link the mental illness schizophrenia to neurodegenerative disease using worm behavior. Credit: UT Arlington As an undergraduate student in The University of Texas at Arlington’s Honors College, Hannah Selvarathinam knew she wanted to conduct research. Near the end of her first year at UTA, the Keller native reached out to the lab of biology Assistant Professor Read More
by KeAi Communications Co., Ltd. The Effect of cyclosporine and its analog NIM-811 on tissue injury. Credit: Liver Research (2024). DOI: 10.1016/j.livres.2024.02.002 During hepatic surgery or liver transplantation, the liver is vulnerable to ischemia-reperfusion injury (IRI), especially when vessels are compressed to control bleeding or during periods of ischemia. The hallmark of IRI is mitochondrial dysfunction, which generates reactive oxygen species, and cell death through necrosis or apoptosis. Cyclosporine (CsA), a well-known immunosuppressive agent that inhibits calcineurin, provides the additional effect of inhibiting the mitochondrial permeability transition pore (mPTP), hence Read More
Flow diagram of this study. Flow diagram shows the analytic process of the DRIA predictive value in multiple ICI-treated cohorts. DRIA, DNA damage response-related immune activation; ICIs, immune checkpoint inhibitors; GI, gastrointestinal; MSS, microsatellite-stable. Credit: Cancer Biology & Medicine (2024). DOI: 10.20892/j.issn.2095-3941.2023.0303 Despite significant progress in treating gastrointestinal (GI) cancers through surgical resection, chemotherapy, radiotherapy, and targeted therapy, the objective response rate (ORR) for immune checkpoint inhibitor (ICI) therapy remains low. Common biomarkers such as PD-L1 expression, tumor mutational burden (TMB), and microsatellite instability (MSI) often lack predictive precision or Read More
Variant definition, splitting and classification as border or ectopic. Credit: Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01618-2 A new study by neuroscientists at Florida State University has revealed brain differences that may explain why humans demonstrate a variety of cognitive abilities and behaviors. The research, conducted by a multi-institution team led by FSU Associate Professor of Psychology and Neuroscience Caterina Gratton and research technician Ally Dworetsky, shows that two forms of individual differences may predict cognitive abilities, explain behavioral differences and even pinpoint biomarkers of brain disease. “We discovered that in addition Read More
Graphical Abstract. Credit: SLEEP (2023). DOI: 10.1093/sleep/zsad233 Sleep apnea and low oxygen levels while sleeping are associated with epilepsy that first occurs after 60 years of age, known as late-onset epilepsy, according to a new study published in Sleep. The link was independent of other known risk factors for late-onset epilepsy and sleep apnea including hypertension and stroke. The findings may help to better understand the relationship between sleep disorders and late-onset epilepsy, as well as identify potential targets for treatment. “There’s increasing evidence that late-onset epilepsy may be indicative Read More
Women are 40% more likely to experience depression in perimenopause than those who aren’t experiencing any menopausal symptoms, finds a new study led by UCL researchers. The research, published in the Journal of Affective Disorders, provides a meta-analysis of seven studies involving 9,141 women from across the world (including Australia, U.S., China, Netherlands and Switzerland), to understand whether different stages of the menopause were associated with different risk of depression. Perimenopause usually occurs around three to five years before the onset of menopause. During this stage, women’s estrogen and progesterone Read More
Autistic young adults face many barriers to employment and often struggle to reconcile their hopes and expectations for a future career during vocational planning. Credit: Shelly Silva/University of Delaware With graduation season around the corner, many autistic high school and college seniors may feel a unique tension between their hopes (what is possible) and their expectations (what is probable) when it comes to their future careers. Autistic youth face so many barriers to employment that one-third of young adults on the autism spectrum are not employed in their twenties. Those Read More
A survey commissioned by King’s College London, and carried out by YouGov, has found that 65% of people across the U.K. are worried about access to palliative and end of life care, and 41% think there is too little NHS resource allocated to palliative care. The survey of 2,164 adults across the U.K. was commissioned by the Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care at King’s to explore people’s knowledge and experiences of palliative and end of life care. The data was released ahead of yesterday’s debate by Read More
Credit: Pediatric Neurology (2024). DOI: 10.1016/j.pediatrneurol.2024.03.008 TRAF7 syndrome, or CAFDADD syndrome, is a neurological and developmental disease that causes a wide variety of clinical manifestations, such as cardiac, facial and digital abnormalities and developmental delay. Now, a study published in Pediatric Neurology provides a better understanding of the clinical, genetic and functional characteristics of CAFDADD syndrome, which is caused by the TRAF7 gene. The paper will contribute to a better understanding of this disease and the improvement of medical care and clinical management of patients. The study was co-led by Read More
Evidence mapping bubble plot of exercise-based interventions for long-term conditions (LTCs). Y-axis: number of participants included in the selected systematic review. X-axis: categorization of exercise intervention effect. Credit: eClinicalMedicine (2024). DOI: 10.1016/j.eclinm.2024.102599 A new study looking at health data from the last 20 years has highlighted the benefits of exercise programs for individuals living with long-term health conditions. Drawing on a comprehensive overview of published evidence spanning 39 different long-term conditions—and encompassing 990 randomized controlled trials and more than 900,000 patients—the research underscores the fundamental role of exercise in enhancing Read More
Researchers from the University of California San Diego have revealed new trends in drug consumption that shed light on how people are adapting to the evolving risks associated with unregulated drug use in the United States. The findings could help policymakers and public health officials better tailor interventions to meet the needs of vulnerable populations and reduce the public health burden of substance-related harm. The study was published in Drug and Alcohol Dependence. Since the early 2010s, deaths from accidental overdoses have been on the rise in the United States Read More
Morphological changes of human corneal endothelial cells after UV-A exposition. Credit: Aging (2024). DOI: 10.18632/aging.205761 A new research paper titled “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure” has been published on the cover of Aging. In this new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi (1948-2024), and Koji Kitazawa from Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Read More
The American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF) has published “Clinical Practice Guideline: Age-Related Hearing Loss” in Otolaryngology–Head and Neck Surgery. This clinical practice guideline (CPG) sheds lights on a global public health problem affecting approximately 466 million people worldwide and identifies quality improvement opportunities and provide clinicians trustworthy, evidence-based recommendations regarding the identification and management of age-related hearing loss (ARHL) in patients 50 years and older. “Age-related hearing loss is underdiagnosed and undertreated despite being the most common sensory deficit in the aging population. With almost 50% Read More
Key milestones in NET diagnostics and therapeutics. 64Cu DOTATATE indicates copper-64 DOTA-Tyr3-octreotate; 68Ga DOTATATE, gallium-68 DOTA-Tyr3-octreotate; 77Lu DOTATATE, lutetium-177 DOTA-Tyr3-octreotate; GEP, gastroenteropancreatic; GI, gastrointestinal; NET, neuroendocrine tumor; PET, positron emission tomography. Credit: CA: A Cancer Journal for Clinicians (2024). DOI: 10.3322/caac.21840 Newly updated guidelines on neuroendocrine tumors developed by an expert at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborators provide clinicians with the latest recommendations for staging and management of these rare but increasingly diagnosed tumors. The guidelines, developed for the American Read More
Clonal hematopoiesis is a phenomenon caused by mutations in hematopoietic stem cells and can lead to blood cancer. We now know that it occurs also in people with normal blood counts, where it is associated with an increased risk of life-threatening atherosclerotic cardiovascular disease. A research team at the Medical University of Vienna has now developed a genetic testing procedure to detect clonal hematopoiesis, which, when used in combination with an ultrasound examination of the carotid artery, allows to identify patients at high cardiovascular risk. The study was published in Read More
BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. Left: GDH1-dependent glutamine metabolic remodeling upon BET inhibition. Right: “Synthetic lethality” targeting OXPHOS and BET proteins extends the survival of HCC-bearing mice. Credit: Wen Mi, Jianwei You, Liucheng Li, Lingzhi Zhu, Xinyi Xia, Li Yang, Fei Li, Yi Xu, Junfeng Bi, Pingyu Liu, Li Chen, Fuming Li Primary hepatocellular carcinoma (HCC), the major type of liver cancer, is a leading cause of worldwide cancer-related death. End-stage liver cancer patients have limited treatment options due to the lack of druggable Read More
Overview of a National Dashboard of State- and Territory-Level COVID-19 Policies Aimed at Post–Acute Care Settings The date filter allows for daily selection of dates from March 1, 2020, to July 1, 2022. A slider is included under the date selection box for viewing policy progression throughout the pandemic. The health care settings filter consists of 4 checkboxes, allowing for the selection of target health care settings (general health care settings, nursing homes, home health care agencies, and both). Comprehensive definitions are found in the eTable in Supplement 1. The Read More
Cost-effectiveness acceptability curve (CEAC) showing the probability of early GDM diagnosis and treatment being cost-effective among women with risk factors for hyperglycemia in pregnancy for different ceilings of willingness-to-pay (WTP) compared with usual care for composite adverse pregnancy outcome. Credit: eClinicalMedicine (2024). DOI: 10.1016/j.eclinm.2024.102610 New research led by Western Sydney University has shown that treatment of gestational diabetes from early pregnancy can not only reduce birth complications among babies and mothers, but can also reduce health costs by up to 10%. Published in eClinicalMedicine, the new study explored whether treatment Read More
A Monash University sexual health expert has warned that an unintended consequence of Australia’s migration rules could compromise Australia’s goal to end the HIV epidemic by 2030. Associate Professor Jason Ong, of the Melbourne Sexual Health Center (MSHC), at Monash University’s School of Translational Medicine, says some people living with HIV are choosing cheaper, suboptimal antiretroviral treatment (ART) out of fear that their applications for permanent residency (PR) will be rejected. This is because they must show their medical spending will not total more than $51,000 over 10 years—a requirement, Read More
England striker Beth Mead was sidelined by an ACL injury. A groundbreaking project was launched Tuesday in the English Women’s Super League to study anterior cruciate ligament injury prevention. Players unions the Professional Footballers’ Association (PFA) and FIFPRO have joined forces with Nike and Leeds Beckett University to provide funding. Research suggests such injuries are two to six times more likely to occur in women than men but there is little understanding about how to reduce their frequency in professional women footballers. The WSL clubs participating in the three-year study Read More
The WHO said Tuesday it was being frequently updated by Washington about the bird flu outbreak in the United States—the only country so far where dairy cows have been infected. Earlier this month, US authorities said a person working on a dairy farm in Texas was recovering from bird flu after having been exposed to cattle. “We have been receiving information and we have been receiving almost daily updates,” said Wenqing Zhang, head of the global influenza program at the World Health Organization. “The response update has been updated routinely Read More
As the battle over abortion continues to rage in the courts and American politics, a new report estimates that one in every four U.S. women will undergo the procedure during their lifetime. The study was issued by the Guttmacher Institute, a research and policy organization focused on sexual and reproductive health that supports access to abortion. Researchers there surveyed nearly 6,700 U.S. women who accessed clinical abortion care at 56 non-hospital facilities in 21 states between June 2021 and July 2022. That’s just prior to the Dobbs decision overturning Roe Read More
The EU’s drug watchdog urged Tuesday that anti-COVID jabs be updated before another round of vaccinations to counter a new variant of the virus, which is still claiming thousands of lives. The most widely circulating COVID variant worldwide is now JN.1, having overtaken the XBB family that is the target of the most recent vaccines, the European Medicines Agency said. The Amsterdam-based watchdog’s emergency task force said it has “recommended updating COVID-19 vaccines to target the new variant JN.1 for the 2024-2025 vaccination campaign” the EMA said. Some 4,500 COVID Read More
Social connectedness, a feeling of belonging at school and in the community, can play an important role in suicide prevention among high-risk teens, new research from the University of Oregon finds. Teachers, social workers, and even neighbors and community members all can make a difference in vulnerable teens’ lives, said Lauren Berny, a doctoral candidate in prevention science at the UO’s College of Education and research fellow at UO’s Prevention Science Institute. She is the lead author of two recent studies that found caring connections with adults and peers can Read More
The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens, T cell migration and infiltration, and T cell recognition and cytotoxicity. The cGAS-STING pathway also regulates tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, B cells, and cancer-associated fibroblasts (CAFs). Credit: Cancer Biology & Medicine (2024). DOI: 10.20892/j.issn.2095-3941.2023.0440 Cancer immunotherapy, which leverages the body’s immune system to target tumors, has emerged as a pivotal strategy in oncology. This paradigm shift from conventional Read More
Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0 Considered the most aggressive type of brain cancer, glioblastoma grows rapidly, destroying healthy tissue. Globally, approximately 300,000 people are diagnosed each year with glioblastoma. Glioblastoma is a type of cancer affecting glial cells, which connect nerve cells and support brain function. “It tends to be a tumor that also tends to grow and invade the brain,” says Dr. Alfredo Quinones-Hinojosa, a neurosurgeon at Mayo Clinic. “Sometimes it can be slow and steady, but it tends to grow very fast.” Despite significant advances in Read More
For people with HIV (PWH), semaglutide is effective for metabolic dysfunction-associated steatotic liver disease (MASLD), according to a research letter published online April 30 in the Annals of Internal Medicine. Jordan E. Lake, M.D., from UTHealth Houston, and colleagues designed a pilot study to examine the effect of semaglutide on magnetic resonance imaging-proton density fat fraction-quantified intrahepatic triglycerides (IHTG) in PWH and MASLD. Eligible participants were aged 18 years or older and had suppressed HIV-1 RNA while using antiretroviral therapy. The per-protocol analysis included 49 of 51 participants with central Read More
Long-term outcomes following a hospitalization for atrial fibrillation or flutter. Credit: European Heart Journal (2024). DOI: 10.1093/eurheartj/ehae204 Of patients admitted to hospital for atrial fibrillation (AF) in Australia and New Zealand, 45% die within a decade, according to University of Queensland research. A team led by Dr. Linh Ngo from UQ’s Faculty of Medicine analyzed data from more than 250,000 patients admitted for AF and atrial flutter—a closely related condition—to all public and most private hospitals in Australia and New Zealand between 2008 and 2017. The results are published in Read More
When COVID-19 caused significant economic disruptions, thousands of people around the world experienced sudden shocks to their financial situation through reduced earnings or job losses. Now economic researchers at the University of South Australia have examined the mental health effects on people who experienced immediate or expected financial setbacks during the height of the pandemic. The paper is published in the journal Economics & Human Biology. Data gathered from China, Japan and South Korea during the early phases of the pandemic revealed that the severe economic shocks induced by COVID-19 Read More
Single-cell atlas of GATA3+ lymphocytes across human allergic diseases. a, Left, schematic of the generation of a single-cell GATA3+ lymphocyte atlas. Data sets from the indicated human diseases were processed, and cells expressing GATA3 were extracted and integrated with Harmony. Right, uniform manifold approximation and projection (UMAP) of integrated, annotated GATA3+ lymphocytes. b, Heatmap of the top 100 differentially expressed genes for each cluster (minimum log2(fold change) of 0.5 and Padjusted < 0.05), with key genes annotating the highlighted clusters. c, Joint density plot of TCF7 and LEF1 expression in Read More
Deciding to have an abortion is a deeply personal choice, and so is what comes next: determining the type of abortion that’s best for you. UBC Ph.D. student Kate Wahl wants to help Canadians navigate that decision. She’s developed It’s My Choice, Canada’s first interactive website aimed at helping people identify the abortion option that best fits their values and circumstances. She is also lead author of an article on the development of the decision aid now published in the Journal of Medical Internet Research. Hosted by the Society of Read More
Single trial structure presented simultaneously to Demonstrators and Observers within the same dyad. Credit: Communications Psychology (2024). DOI: 10.1038/s44271-024-00069-6 An individual’s experience of pain from medical treatment can be heightened by witnessing other people’s responses to the same treatment, with this negative experience subsequently spreading to others, scientists have discovered. You may have heard of the placebo effect—a beneficial effect produced by a patient’s positive beliefs about a treatment. The “nocebo” effect describes the opposite, where negative expectations about treatment can cause harmful side effects. New research, published recently in Read More
The genome-wide significant bipolar disorder (BPD) signal at the FADS1/2/3 cluster shares the same genetic etiology with 27 of the 33 metabolites tested, including arachidonic acid. (A) Regional association plot centered on the FADS1/2/3 locus depicting the BPD (top) and arachidonic acid (bottom) signals. The BPD sentinel variant, rs174592, is indicated. (B) Stacked bar plot depicting posterior probabilities of H0 (no causal variant), H1 (causal variant for BPD only), H2 (causal variant for metabolite only), H3 (2 distinct causal variants), and H4 (1 shared causal variant) returned by Coloc. Credit: Read More
For patients with solid tumors, assignment to an experimental group in trials of investigational drugs yields significant survival gains, according to a review published online April 30 in the Annuals of Internal Medicine. Renata Iskander, from McGill University in Montreal, and colleagues estimated progression-free survival and overall survival advantage of assignment to experimental groups in randomized trials of investigational drugs for six solid tumors. A total of 128 trials with 141 comparisons of a new drug and comparator were included in the sample, with 47,050 patients. The researchers found that Read More
California struck up a new deal with Amneal Pharmaceuticals on April 29 to bolster the state’s supply of the opioid overdose-reversing medication naloxone at a much lower price for schools, police departments and others trying to ease the toll of fentanyl. The deal would put the price tag for a two-dosage pack of FDA approved naloxone, often known by the brand name Narcan, at $24, a 40% drop from the current purchase price, state officials said at a news conference Monday. That lower price will allow the state’s health agencies Read More
Overview of strategies for cancer treatment avoiding Darwinian selection of resistant clones. In a development in cancer research, scientists are exploring new therapeutic strategies that move beyond traditional cytotoxic treatments, which have historically targeted uncontrolled cell proliferation. “These conventional methods often result in the survival of resistant cancer cells, ultimately leading to tumor progression and treatment failures,” said correspondent author of the study, professor Jan Brábek from the Faculty of Science, Charles University. In response, researchers are now focusing on alternative approaches aimed at modifying cancer cell behavior to prevent Read More
There is no risk for new-onset seizure incidence for individuals receiving a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine versus placebo, according to a review published online April 29 in JAMA Neurology. Ali Rafati, M.D., from Iran University of Medical Sciences in Tehran, and colleagues conducted a systematic literature review to identify studies examining seizure incidence among SARS-CoV-2 vaccine recipients versus those receiving placebo. Based on six randomized clinical trials (63,521 vaccine and 54,919 placebo recipients), the researchers found that during a 28-day follow-up after injection, there was no Read More
A Tennessee mother, Monica Kelly, was around 13 weeks pregnant when, according to a lawsuit filed against the state of Tennessee, doctors gave her the devastating news that her baby had Patau syndrome. The genetic disorder causes serious developmental defects and often results in miscarriage, stillbirth, or death within one year of birth. Continuing her pregnancy, doctors told her, could put her at risk of infection and complications that include high blood pressure, organ failure, and death. But they said they could not perform an abortion due to a Tennessee Read More
Image of a murine white pulp of the spleen, in which large amounts of B cells (B220, blue) and dendritic cells (CD11c, green) can be found. The red pulp is highlighted by myeloid cell staining (SIRP?, red). Credit: Technische Universität Dänemark (DTU) / Urs Michael Mörbe While previous studies have investigated the function of the protein Bcl6 in dendritic cells—in some cases with varying results—a new study published in Nature Communications has sought to harmonize the sometimes contradictory data with an in-depth analysis. Dendritic cells are part of our innate Read More
Buzzwords describing the digital dating scene are all over social media. Have you been ghosted? Is someone orbiting you? Are you being breadcrumbed? While these dating patterns may not be new, the words to describe them continue to evolve. As a psychotherapist, I see firsthand the impact these experiences can have on mental health. Given the sheer number of people using dating apps—53% of American 18-to-29-year-olds and 37% of 30-to-49-year-olds—it’s likely you have some first- or secondhand exposure to this world. If you’re curious about the latest psychological research on Read More
Physicians are increasingly seeing cases of syphilis that do not present with typical symptoms, such as rash or skin ulcers, according to a new report presented last week at the 2024 Epidemic Intelligence Service Conference in Atlanta. Instead, patients are presenting with headaches or disruptions in their vision or hearing, said a team co-led by Amy Nham, Pharm.D., M.P.H. Nham is a first-year epidemic intelligence service officer assigned to the Chicago Department of Public Health. Nham and two co-authors gave an overview of these “neurologic, ocular, and otic (NOO)” forms Read More
X-chromosome inactivation varies across different areas of brains. Here, fluorescent imaging data from a mouse reveal where the father’s X chromosome is most active (white) and least active (blue). Credit: Eric Szelenyi A study in mice suggests how chromosome inactivation may protect girls from a type of autism disorder inherited from their father’s X chromosome. Females inherit two copies of the X chromosome, one from their mother and one from their father. Because cells do not need two copies, the cells inactivate one copy early in embryonic development, a well-studied Read More
Dr. Raul Yhossef Tito-Tadeo, first author and postdoc at the Raes Lab (left) and Professor Dr. Jeroen Raes, PI and Vice-Director at VIB-KU Leuven Center for Microbiology and Rega Institute, Faculty of Medicine, KU Leuven. (Right). Credit: VIB For the first time, researchers from VIB-KU Leuven, UZ Leuven, Janssen Pharmaceutica and multiple international collaborators have introduced quantitative methods and extensive confounder control to discover microbiome biomarkers in colorectal cancer development. While multiple microbial taxa have been put forward as potential cancer-associated biomarkers in the past, this new study uncovers obscured Read More
NIH-led study finds genetic markers that explain up to 12% of the differences between two people’s blood pressure. Credit: Darryl Leja, National Human Genome Research Institute National Institutes of Health researchers and collaborators have discovered over 100 new regions of the human genome, also known as genomic loci, that appear to influence a person’s blood pressure. Results of the study also point to several specific genomic loci that may be relevant to iron metabolism and a type of cellular receptor known as adrenergic receptors. The study, published in Nature Genetics, Read More
Atherosclerosis is a condition affecting the cardiovascular system. If atherosclerosis occurs in the coronary arteries (which supply the heart) the result may be angina pectoris, or in worse cases a heart attack. Credit: Wikipedia/CC BY 3.0 Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease. The study has been published in Circulation. Atherosclerosis is characterized by a narrowing of arterial walls and can increase risk of coronary Read More
Microscopic view of a hypothalamus brain section. The third ventricle (black) is visible. The red dots show the receptor. The nuclei are blue. Credit: Albert Ricken, Leipzig University The rapidly escalating prevalence of overweight and obesity poses a significant medical challenge worldwide. In addition to people’s changing lifestyles, genetic factors also play a key role in the development of obesity. Scientists at Leipzig University and Heinrich Heine University Düsseldorf have now identified a new regulator of eating behavior. The findings have been published in Signal Transduction and Targeted Therapy. “Our Read More
Axial chest CT scans at (A) visit one and (B) visit two at the level of the takeoff of the right middle bronchus of a participant with 1.2 annual percentage quantitative interstitial abnormality progression. The female participant was 62 years old at visit one and 67 years old at visit two and a current smoker at both visits, with a 47.5 pack-year history at visit two. This participant had four subsequent acute respiratory disease (ARD) events and three subsequent severe ARD events. Credit: Radiological Society of North America (RSNA) Smokers Read More
Forest plot with smoking quantity variables on the y-axis and the causal estimate from the MR with placental weight as the outcome on the x-axis. The colors indicate the results for the different studies and the fixed effect meta-analysis. Credit: BMC Pregnancy and Childbirth (2024). DOI: 10.1186/s12884-024-06431-0 A new study from the University of Bergen and the University of Exeter shows that pregnant women who quit smoking may prevent an abnormal mismatch between the weight of the placenta and the growth of the fetus. The researchers in Bergen and Exeter Read More
Credit: Pavel Danilyuk from Pexels Researchers led by Queen Mary University of London have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person’s blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants. The study, published in Nature Genetics, is one of the largest such genomic studies of blood pressure to date, including data from over 1 Read More
Credit: Cell Metabolism (2024). DOI: 10.1016/j.cmet.2024.03.016 New research from the University of Aberdeen could lead to the development of medication for disease that affects 1 in 4 people worldwide but is currently untreatable. The study, which is published in Cell Metabolism was carried out by an international team of scientists, led by Professor Lora Heisler from the University of Aberdeen Rowett Institute and Dr. Fiona Murray from the University’s Institute of Medical Sciences. More than 400,000 individuals’ genes were studied from the UK Biobank, and researchers discovered that variants in Read More
Crystal structure of compound Mpro61 bound by the SARS-CoV-2 main protease . Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2320713121 A combination of two antiviral compounds may be a promising alternative to Paxlovid when treating COVID-19 in immunocompromised patients, according to Karen S. Anderson, Ph.D., professor of pharmacology and of molecular biophysics & biochemistry at Yale School of Medicine. People who are infected with SARS-CoV-2, the virus that causes COVID-19, currently have two options approved by the Food and Drug Administration (FDA) for antiviral treatment. The more Read More
IMT treatment prevents diet-induced obesity and improves glucose homoeostasis. Credit: Nature Metabolism (2024) DOI: 10.1038/s42255-024-01038-3 Researchers at Karolinska Institutet may have found a new way to treat obesity and related disorders by targeting the cells’ mitochondria. A study published in Nature Metabolism shows that a specific class of drugs that block mitochondrial function can reverse diet-induced obesity, fatty liver and diabetes in mice. Mitochondria are essential for human health, as they process the nutrients in the food we eat and harvest the energy needed for various processes in the cell. Read More
Credit: Anna Shvets from Pexels A team of neuroscientists from Universidad Politécnica de Madrid and Queen Sofia Foundation Alzheimer Center, both in Spain, has found that so-called superagers maintain memory as they grow older because they do not experience a decline in the integrity of their white brain matter. In their study, published in The Journal of Neuroscience, the group conducted multiple tests with 100 octogenarian volunteers over a 10-year span. Prior research and anecdotal evidence suggest that as people grow older, they tend to lose neurological function—thinking skills decline, Read More
Lab-grown human nephron progenitor cells. Credit: Biao Huang/Li Lab In a study published in Cell Stem Cell, USC scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney’s filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments. “By enhancing our capability to grow NPCs from human stem cells, we create a new avenue for understanding and combating congenital kidney diseases and cancer,” said corresponding and lead author Zhongwei Li, an assistant professor of medicine, Read More
scRNA sequencing of day 11 VM progenitors patterned by F5L6.13 and CHIR99021. Credit: Development (2024). DOI: 10.1242/dev.202545 Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson’s disease, pointing toward a new approach for a disease with no cure and few effective treatments. The researchers used an antibody to selectively activate a receptor in a molecular signaling pathway to develop dopaminergic neurons. These neurons produce dopamine, a neurotransmitter critical to brain health. Researchers around the world have been Read More
When SARS-CoV-2 breaks through the first layer of neutralizing and binding antibodies, T cells and memory B cells shield us from symptomatic and severe disease. Credit: NUS Yong Loo Lin School of Medicine As COVID-19 becomes endemic, an important group of people who continue to require vaccination is future birth cohorts of children. Yet, in the face of everchanging variants, as well as the waning of antibodies with time after each dose, key questions remain: What is the threshold of immune response against SARS-CoV-2 needed to protect against COVID-19 and Read More
Inhibitory control brain activity increases from baseline to follow-up in the iHUD group compared with the HC group. a,b, Right aPFC (a) and right dlPFC (b) activity during successful versus failed stops showed significant increases from baseline to follow-up in the iHUD group compared with the HC group. Credit: Nature Mental Health (2024). DOI: 10.1038/s44220-024-00230-4 In line with their previous work, researchers from the Icahn School of Medicine at Mount Sinai showed that individuals with heroin use disorder have lower activity in the anterior and dorsolateral PFC when performing an Read More
Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI176390 A multi-institutional team of investigators has discovered that targeting a specific protein interaction within immunosuppressive breast cancer cells may increase antitumor immune responses in otherwise difficult to treat solid tumors, according to recent findings published in the Journal of Clinical Investigation. “Our findings uncover a novel strategy for targeting immunosuppressive OTUD4-CD73 proteolytic axis in treating immune-suppressive breast cancers with the inhibitor ST80,” said Bin Zhang, MD, Ph.D., the Johanna Dobe Professor of Cancer Immunology and a co-corresponding author of the study. “Immune-cold” Read More
Relative proportions of intact and defective viral genomes measured longitudinally in A) untreated acute infection for 2 years B) late (chronic) treated infection for 1 year and C) early (acute) treated infection for 1 year. Credit: eLife (2024). DOI: 10.7554/eLife.96617.1 A study has compared the development of HIV reservoirs—locations in the body where the virus persists in a latent state—between patients who receive either early or late medical interventions. The findings highlight the importance of timely treatments for managing the virus. The research, published today as a reviewed preprint in Read More
Action potentials from dozens of individual neurons recorded in mouse postsubiculum. Credit: Adrian Duszkiewicz. Brain cells can be broadly divided into two categories: inhibitory and excitatory neurons. Excitatory neurons are cells that support the generation of electrical impulses in postsynaptic neurons, thus prompting the activation of cells in specific brain regions. Inhibitory neurons, on the other hand, contribute to inhibiting these electrical impulses and thus reducing activity in specific brain regions. The balance between inhibition and excitation contributes to the healthy functioning of the brain. While the neurobiological processes underpinning Read More
Supramolecular drug with on-demand reversibility. Credit: Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02209-z Researchers at the University of Sydney and University of Geneva have developed a new anticoagulant, whose anticlotting action can be rapidly stopped “on demand.” The result could lead to new surgical and post-operative drugs that minimize the risk of serious bleeding. The research team applied a completely new method to discover the molecule. The anticoagulant combines a short protein molecule (a peptide) from a tsetse fly—a blood-feeding insect—with a second, synthesized peptide. The bonds holding the two peptides together Read More
Early-life BMI trajectories categorized by tertiles of childhood cognitive function Simple line graphs connecting mean predicted values of BMI z-score at various ages across early life based on tertile of childhood cognitive function at age 10 years. Highest tertile of childhood cognitive function is indicated by blue lines, intermediate tertile is indicated by green lines, and lowest tertile is indicated by red lines. (A) NSHD, NCDS, and BCS70 adjusted for sex only. (B) NSHD, NCDS, and BCS70 adjusted for parents’ BMI, child’s birthweight, childhood socioeconomic status, and childhood household overcrowding. Read More
Kaplan–Meier curves of overall survival in patients diagnosed with cancer in the prison and general populations in England between Jan 1, 2012 and Dec 31, 2017. Credit: The Lancet Oncology (2024). DOI: 10.1016/S1470-2045(24)00035-4 Cancer patients diagnosed in English prisons do not receive the same level of curative treatment as those in the general population, meaning they are at increased risk of death. A study led by King’s College London, University of Surrey and University College London, shows that patients with cancer face several barriers to diagnosis in prison and once Read More
Complex Regional Pain Syndrome (CRPS) is a chronic and debilitating pain disorder, typically considered lifelong with limited treatment options. Now, new research finds that early detection and effective treatment can lead to significant recovery within 18 months, offering hope to millions of people worldwide. The findings are published in The Lancet Neurology journal. Led by NeuRA’s Centre for Pain IMPACT and conducted in partnership with the University of South Australia, the findings could deliver life-changing outcomes for people with CRPS, with up to 80% of patients recovering within the first Read More
The “birds and the bees.” The “facts of life.” Whatever you call it, many parents dread discussing sex and sexuality with their teenagers. They may be embarrassed, or worried that they don’t understand some concepts. In some countries, cultural norms may mean it’s considered inappropriate for adults and adolescents to talk about sex. However, these are conversations worth having. A large body of research has shown that teens who openly discuss sex and sexuality with their parents reduce their risky sexual behavior, leading to improved reproductive health. It’s also important Read More
Frequent teen vaping might boost the risk of exposure to lead and uranium, potentially harming brain and organ development, suggests research published online in the journal Tobacco Control. The findings underscore the need for implementation of regulations and prevention efforts targeting teens, emphasize the researchers. Vaping is popular with teens. In 2022, an estimated 14% of US high school students—around 2.14 million—and more than 3% of middle school students—around 380,000—reported vaping in the preceding month, note the researchers. Certain metals have been identified in e-cigarette aerosols and liquids. Their absorption Read More
Running, cycling, or swimming—if you regularly exercise, you’re well on track for a long and healthy life, as new research from the University of South Australia finds that an increased cardio fitness level will reduce your risk of death from any cause. Published in the British Journal of Sports Medicine, the study found that for every 1-MET increase in cardiorespiratory fitness—the amount of energy used for quiet sitting—a person can reduce their risk of death by 11%–17%, and specifically, their risk of heart disease by 18%. Comprising 26 systematic reviews Read More
Credit: Wikimedia Commons Inhaling the synthetic opioid fentanyl may cause potentially irreversible brain damage (toxic leukoencephalopathy), warn doctors in the journal BMJ Case Reports, after treating a middle-aged man found unresponsive in his hotel room after snorting the drug. Leukoencephalopathy refers to inflammation and damage to the brain’s white matter—the network of nerve fibers that enable the exchange of information and communication between different areas of the brain’s gray matter. Toxic leukoencephalopathy is a sudden or longstanding neurological syndrome, which has been reported after heroin inhalation, known as “chasing the Read More
Compared with people without opioid use disorder, those with opioid use disorder were less likely to receive palliative care in clinics and in their homes, and were dying at younger ages of causes other than opioid use, according to new research published in Canadian Medical Association Journal. “The majority of conversations about the opioid crisis focus on the high number of opioid toxicity deaths. The unfortunate reality is that people with opioid use disorder are dying young from other causes as well,” says author Dr. Jenny Lau, medical director of Read More
Natural scenery typically conjures up positive emotions and a sense of well-being for most individuals. A new study by INSEAD shows that verdant views can also nudge people to pick healthier food. Published in Communications Psychology, the study suggests that spending time in a natural setting, such as walking in a park (vs. on city streets), or simply viewing greenery outside the window (vs. an urban view), leads people to make healthier food choices afterward. “Our studies suggest that it was not the urban view that led to unhealthy food Read More
by Alexa St. John This electron microscope image made available by the U.S. National Institutes of Health shows a human T cell, in blue, under attack by HIV, in yellow, the virus that causes AIDS. Three women who were diagnosed with HIV after getting “vampire facial” procedures at an unlicensed New Mexico medical spa are the first believed to have contracted the virus through a cosmetic procedure using needles, according to federal health officials. Credit: Seth Pincus, Elizabeth Fischer, Austin Athman/National Institute of Allergy and Infectious Diseases/NIH via AP, File Read More
The social psychologist Jonathan Haidt‘s new book The Anxious Generation delivers an urgent call for action. Haidt argues that the evidence is in. Teenagers’ widespread use of smartphones is causing a mental health crisis. Individual, collective and legislative action is required to limit their smartphone access. Haidt begins his book with an allegory. Imagine someone offered you the opportunity to have your 10-year-old child grow up on Mars, even though there is every reason to believe that radiation and low gravity could greatly disrupt healthy adolescent development, leading to long-term Read More
“Charlie” is an eight-year-old child with autism. Her parents are worried because she often responds to requests with insults, aggression and refusal. Simple demands, such as being asked to get dressed, can trigger an intense need to control the situation, fights and meltdowns. Charlie’s parents find themselves in a constant cycle of conflict, trying to manage her and their own reactions, often unsuccessfully. Their attempts to provide structure and consequences are met with more resistance. What’s going on? What makes Charlie’s behavior—that some are calling “pathological demand avoidance”—different to the Read More
Philips has been battling a series of crises over its DreamStation machines for sleep apnoea, a disorder in which breathing stops and starts during sleep. Dutch medical device maker Philips said Monday it had reached a $1.1 billion deal to settle US lawsuits over faulty sleep machines that have dogged the company. The company’s shares initially soared more than 45 percent in Amsterdam on news of the settlement, which was less onerous than feared by some shareholders, before ending the trading day up just over 28 percent. Philips has been Read More
With current physical and financial barriers to accessing care, people with mental health conditions may turn to artificial intelligence (AI)-powered chatbots for mental health relief or aid. Although they have not been approved as medical devices by the U.S. Food and Drug Administration or Health Canada, the appeal to use such chatbots may come from their 24/7 availability, personalized support and marketing of cognitive behavioral therapy. However, users may overestimate the therapeutic benefits and underestimate the limitations of using such technologies, further deteriorating their mental health. Such a phenomenon can Read More
A new study examining the role of aspirin in breast cancer treatment reveals critical issues related to health equity and aging that have broad implications for cancer and other disease intervention trials, say researchers from Georgetown University’s Lombardi Comprehensive Cancer Center. They outline their concerns in an editorial accompanying the study’s findings published April 29 in JAMA. The study, called the Alliance trial, was launched after researchers noted that breast cancer survivors taking aspirin as part of another clinical trial for cardiovascular disease lived longer. To confirm the observation, a Read More
Countries returned to the negotiating table Monday for one last push to conclude an international agreement on how to handle future pandemics, with the most likely outcome being a slimmed-down accord that shelves some of the thorniest issues. The 194 countries in the World Health Organization have come to its Geneva headquarters for a do-or-die round of negotiations after a two-year effort to seal a landmark accord on prevention, preparedness and response hit a deadline last month with no concrete wording agreed. The goal of the talks, which run until Read More
Five years of UniSC-led research into the pesky problem of picky eating by children suggests that therapists should focus more on empowering parents to ease family angst at the dinner table. The collaborative research led by Dr. Laine Chilman of the University of the Sunshine Coast also highlighted the effectiveness of an online coaching intervention for parents to improve children’s mealtime behaviors. Dr. Chilman, an occupational therapy academic who graduated this month with her Ph.D., said the findings were novel because previous research focused on how to fix picky eating Read More
Clever bio-inks that sit inside the human body and restore damaged neurons could cure a whole swathe of diseases in the next 20 years: conditions that have baffled scientists and clinicians for centuries. Think blindness, deafness, chronic pain, epilepsy, motor neuron disease, and Parkinson’s disease. According to University of South Australia materials engineer Associate Professor Matthew Griffith, these “incurable” diseases are all linked to misfiring neurons that humans have not been able to control. However, new technology being developed by Dr. Griffith and his team at UniSA’s Future Industries Institute Read More
Gathering data only takes 60 seconds of the infant sucking on the modified pacifier. Credit: University of California San Diego A modified pacifier and AI algorithms to analyze the data it produces could determine if newborns are learning the proper mechanics of nursing, a recent study shows. Specifically, the researchers from the University of California San Diego measured if babies are generating enough suckling strength to breastfeed and whether they are suckling in a regular pattern based on eight independent parameters. The results, published in the April 18 online edition Read More
Across the U.S., there are over 8 million student-athletes in high school and college. Engaging in sports can contribute to physical, mental, and social benefits, and coaches can play a key role in student-athletes’ continued participation in sports. A study led by UNC Greensboro’s Dr. Tsz Lun (Alan) Chu, published in Sport, Exercise, and Performance Psychology, examines how multiple aspects of a young athlete’s identity, including gender and race, may relate to their perceptions of their coaches and mental health. “There have been quite a few studies on this topic Read More
Two new studies from the Fairbanks School of Public Health on Indiana University’s Indianapolis campus examined the link between health behaviors, the built environment, and the health status of America’s largest cities. Using data from the American Fitness Index spanning from 2018 to 2022, the researchers determined that the maximum percentage of residents with good health status was 70 percent. The American Fitness Index is an American College of Sports Medicine initiative that quantitatively measures the overall health and fitness level of the 100 largest cities by population in the Read More