{"id":1570,"date":"2024-06-14T16:06:05","date_gmt":"2024-06-14T16:06:05","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/researchers-unveil-impact-of-east-asian-gene-variant-on-type-2-diabetes-risk\/"},"modified":"2024-06-14T16:06:05","modified_gmt":"2024-06-14T16:06:05","slug":"researchers-unveil-impact-of-east-asian-gene-variant-on-type-2-diabetes-risk","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/researchers-unveil-impact-of-east-asian-gene-variant-on-type-2-diabetes-risk\/","title":{"rendered":"Researchers unveil impact of east Asian gene variant on type 2 diabetes risk"},"content":{"rendered":"<p>Metabolic seahorse assays revealed alterations in glycolysis function and oxidative phosphorylation in the presence of the PAX4 p.Arg192His or p.Tyr186X variants. Credit: Nature Communications (2023). DOI: 10.1038\/s41467-023-41860-z It was earlier discovered that a variation in the PAX4 gene specifically predisposes East Asians to a higher risk of developing type 2 diabetes (T2D), increasing lifetime risk by up to 1.8 times. A new study, now published in the journal Nature Communications, reveals for the first time how an East Asian-specific PAX4 gene variant, R192H, impacts the development and function of beta <a class=\"read-more-link\" href=\"https:\/\/healthmedicinet.com\/researchers-unveil-impact-of-east-asian-gene-variant-on-type-2-diabetes-risk\/\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metabolic seahorse assays revealed alterations in glycolysis function and oxidative phosphorylation in the presence of the PAX4 p.Arg192His or p.Tyr186X variants. Credit: Nature Communications (2023). DOI: 10.1038\/s41467-023-41860-z It was earlier discovered that a variation in the PAX4 gene specifically predisposes East Asians to a higher risk of developing type 2 diabetes (T2D), increasing lifetime risk [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1570","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/1570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=1570"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/1570\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=1570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=1570"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=1570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}