{"id":1839,"date":"2024-06-21T22:57:58","date_gmt":"2024-06-21T22:57:58","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/slowing-inflammation-may-boost-immunotherapys-effectiveness-against-advanced-lung-cancer\/"},"modified":"2024-06-21T22:57:58","modified_gmt":"2024-06-21T22:57:58","slug":"slowing-inflammation-may-boost-immunotherapys-effectiveness-against-advanced-lung-cancer","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/slowing-inflammation-may-boost-immunotherapys-effectiveness-against-advanced-lung-cancer\/","title":{"rendered":"Slowing inflammation may boost immunotherapy\u2019s effectiveness against advanced lung cancer"},"content":{"rendered":"<p>In a clinical trial of patients with NSCLC treated with anti\u2013PD-1, mitigating persistent IFN-I and inflammation with a JAK inhibitor decreased terminal differentiation of CD8 T cells and expanded fate-flexible CD8 T cell progenitors in responding patients. Patients with progressive disease had high baseline inflammation that minimally changed with JAK1 inhibition. Credit: Science (2024). DOI: 10.1126\/science.adf1329 Adding an anti-inflammatory drug to anti-PD1 checkpoint inhibitor immunotherapy has shown great promise as a new strategy against advanced lung cancer, based on results from a small clinical trial led by investigators at the <a class=\"read-more-link\" href=\"https:\/\/healthmedicinet.com\/slowing-inflammation-may-boost-immunotherapys-effectiveness-against-advanced-lung-cancer\/\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a clinical trial of patients with NSCLC treated with anti\u2013PD-1, mitigating persistent IFN-I and inflammation with a JAK inhibitor decreased terminal differentiation of CD8 T cells and expanded fate-flexible CD8 T cell progenitors in responding patients. Patients with progressive disease had high baseline inflammation that minimally changed with JAK1 inhibition. Credit: Science (2024). DOI: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1839","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/1839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=1839"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/1839\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=1839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=1839"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=1839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}