{"id":2241,"date":"2024-06-26T19:41:08","date_gmt":"2024-06-26T19:41:08","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/nf1-gene-mutations-disrupt-brain-cell-plasticity-and-motor-learning-in-mice\/"},"modified":"2024-06-26T19:41:08","modified_gmt":"2024-06-26T19:41:08","slug":"nf1-gene-mutations-disrupt-brain-cell-plasticity-and-motor-learning-in-mice","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/nf1-gene-mutations-disrupt-brain-cell-plasticity-and-motor-learning-in-mice\/","title":{"rendered":"Nf1 gene mutations disrupt brain cell plasticity and motor learning in mice"},"content":{"rendered":"<p>Nf1 mutation generates focal OPC hyperdensities. Immunohistochemistry of PDGFR? (green) revealed focal OPC hyperdensities (HD) in the OPC-specific Nf1-mutant mice (Nf1OPC-Het, or Nf1+\/fl;Pdgfra::Cre). Scale bar, 1 mm. Representative non-HD (blue outline) and HD (yellow outline) OPCs (PDGFR?, green) are shown on the right. Scale bar, 20 \u00b5m. Credit: Pan et al Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), are diseases caused by a defect in one or more genes, which can sometimes result in cognitive and motor impairments. Better understanding the neural underpinning of these disorders and how they <a class=\"read-more-link\" href=\"https:\/\/healthmedicinet.com\/nf1-gene-mutations-disrupt-brain-cell-plasticity-and-motor-learning-in-mice\/\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nf1 mutation generates focal OPC hyperdensities. Immunohistochemistry of PDGFR? (green) revealed focal OPC hyperdensities (HD) in the OPC-specific Nf1-mutant mice (Nf1OPC-Het, or Nf1+\/fl;Pdgfra::Cre). Scale bar, 1 mm. Representative non-HD (blue outline) and HD (yellow outline) OPCs (PDGFR?, green) are shown on the right. Scale bar, 20 \u00b5m. Credit: Pan et al Neurogenetic disorders, such as [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2241","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/2241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=2241"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/2241\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=2241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=2241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=2241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}