{"id":4699,"date":"2024-11-28T20:31:30","date_gmt":"2024-12-10T04:49:23","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/?p=4699"},"modified":"2024-12-10T04:49:23","modified_gmt":"2024-12-10T04:49:23","slug":"hmn-what-it-is-incompatibility-and-complications-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-what-it-is-incompatibility-and-complications-in-2025\/","title":{"rendered":"HMN: What it is, incompatibility, and complications in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  What it is, incompatibility, and complications in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p>The Rhesus (Rh) factor is a protein on the surface of red blood cells, determining blood type as either positive or negative, which is crucial during pregnancy for compatibility between a pregnant person and their fetus.<\/p>\n<\/li>\n<li>\n<p>Rh incompatibility occurs when an Rh-negative pregnant person carries an Rh-positive fetus, potentially leading to hemolytic disease of the neonate (HDN), but it is rare, usually detected early, and treatable.<\/p>\n<\/li>\n<li>\n<p>Rh incompatibility is diagnosed through prenatal blood tests and, if detected, can be treated with Rh immunoglobulin (RhoGAM) injections to prevent the pregnant person from producing antibodies against the fetus\u2019s blood.<\/p>\n<\/li>\n<li>\n<p>Untreated Rh incompatibility can lead to serious complications for the newborn, but preventive treatments like RhoGAM significantly reduce these risks, making such complications rare in countries where the treatment is widely available.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">If you are pregnant or considering becoming pregnant, you may have heard of the Rh factor. You probably want to know if it\u2019s something you need to be concerned about, and you may be confused about what it actually is. This is common\u2014it\u2019s a bit of a confusing concept!<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here, we\u2019ll go through the ins and outs of Rh factor, including what it is, what causes it, who is at risk for complications, and what treatment options are available.\u00a0<\/span><\/p>\n<h2 id=\"what-is-rh-factor\"><span style=\"font-weight: 400;\">What is Rh factor?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Simply put, the Rhesus factor, or Rh factor, refers to a protein that\u2019s located on the surface of red blood cells. Some people are positive for this protein, while others are negative. During pregnancy, if a pregnant person is Rh negative, but their fetus is Rh positive, complications can occur. Thankfully, though,<\/span> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459353\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">this kind of blood type incompatibility is rare<\/span><\/a><span style=\"font-weight: 400;\">, it\u2019s usually caught early, and treatment is effective.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When you think of blood types, you usually think of the different letter types that identify the absence or presence of A or B antigens (Type O, Type A, and Type B, etc.). The Rh factor is another component that determines if your blood type is positive or negative. When you have this protein, you are considered positive. If you don\u2019t have this protein, you are negative. For example, if you are Type A positive, that means that you have A antigen blood and that your blood cells are positive for the Rh factor. If you are Type A negative, that means that your blood doesn\u2019t contain the Rh factor. The antigen type and Rh factor both determine if your blood is compatible with another person\u2019s blood\u2014either as a blood transfusion recipient or during pregnancy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rh factor isn\u2019t something to worry about in pregnancy unless a pregnant woman is Rh negative and her fetus is Rh positive. When this happens, Rh incompatibility between the fetus and the pregnant person can develop (also known as Rh alloimmunization), which can cause hemolytic disease of the neonate (HDN), a serious, but treatable complication.<\/span><\/p>\n<h2 id=\"what-causes-rh-incompatibility\"><span style=\"font-weight: 400;\">What causes Rh incompatibility?<\/span><b>\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">If you have a negative blood type and you are exposed to Rh positive blood, via pregnancy or blood transfusion, you begin to produce antibodies against the Rh positive blood. Although blood doesn\u2019t typically mix between the expectant mother and the fetus during pregnancy, Rh antibodies can cross the placenta. Additionally, blood mixing may occur during medical procedures like<\/span> <a href=\"https:\/\/www.acog.org\/womens-health\/faqs\/the-rh-factor-how-it-can-affect-your-pregnancy\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">amniocentesis, chorionic villus sampling, or during labor and delivery<\/span><\/a><span style=\"font-weight: 400;\">. If your Rh-negative blood is exposed to your fetus\u2019s Rh-positive blood, a phenomenon called alloimmunization occurs, where you begin to produce anti-Rh antibodies.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">When this happens, your antibodies may become harmful to your fetus. \u201cThe antibodies from the immune response of the patient can pass to the fetus and destroy the red blood cells [of the fetus], leading to fetal anemia,\u201d explains<\/span> <a href=\"https:\/\/www.northwell.edu\/find-care\/find-a-doctor\/maternal-fetal-medicine\/dr-fouad-atallah-md-11517468\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fouad Atallah, MD,<\/span><\/a><span style=\"font-weight: 400;\"> a board-certified physician in obstetrics and maternal-fetal medicine subspecialist at Staten Island University Hospital in New York.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This response may be weak at the beginning of pregnancy or during a first pregnancy. \u201cFetal anemia may not occur until later in pregnancy or in the subsequent pregnancy,\u201d Dr. Atallah explains.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the American College of Obstetricians and Gynecologists (ACOG), it is not usually until a second pregnancy (or a pregnancy that has occurred after a miscarriage) that Rh incompatibility becomes a concerning issue. This is because maternal antibody numbers are much higher during second, third, and subsequent pregnancies, increasing the risk to the fetus. The incompatibility may cause early pregnancy complications like miscarriage or ectopic pregnancy.<\/span><\/p>\n<h2 id=\"who-is-at-risk-for-rh-incompatibility\"><span style=\"font-weight: 400;\">Who is at risk for Rh incompatibility?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cIn an Rh alloimmunized pregnant individual [a pregnant person who is already Rh sensitized], it is the fetus and\/or newborn and not the pregnant person who is at risk for hemolytic disease,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/alex-juusela-md-mph-facog\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Alex Juusela, MD, MPH<\/span><\/a><span style=\"font-weight: 400;\">, a board-certified OB-GYN at<\/span> <a href=\"https:\/\/obgyn.med.wayne.edu\/fellowships\/mfm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Wayne State University<\/span><\/a><span style=\"font-weight: 400;\">. Even then, the severity of the disease is variable. \u201cIt can range from mild breakdown of red blood cells (hemolysis) to severe fetal\/neonatal anemia requiring blood transfusion(s) and even medically indicated preterm delivery,\u201d says Dr. Juusela.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Again, it\u2019s important to keep in mind that Rh factor only becomes an issue if the pregnant individual is Rh negative and their gestating fetus is Rh positive.<\/span> <a href=\"https:\/\/www.acog.org\/womens-health\/faqs\/the-rh-factor-how-it-can-affect-your-pregnancy\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Rh factor is an inherited trait<\/span><\/a><span style=\"font-weight: 400;\"> and can only be passed on if one of the parents is Rh positive. So, if both parents are Rh negative, there is no chance that they will have a Rh positive baby. The main concern is if you are a pregnant person who is Rh negative, your partner is Rh positive, and you have an Rh-positive fetus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here is a chart to clarify Rh factor inheritance and in what circumstances it may become an issue.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><strong><span class=\"title\">Risk for Rh incompatibility <\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Rh positive<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rh positive<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rh positive<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Low<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Low<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Rh positive<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Could be either Rh positive or Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Low, because pregnant parent is also positive<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Rh positive<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Could be either Rh positive or Rh negative<\/span><\/td>\n<td><span style=\"font-weight: 400;\">High risk if fetus is Rh negative<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"what-is-the-rh-factor-test\"><span style=\"font-weight: 400;\">What is the Rh factor test?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here\u2019s the good news: Rh factor is something that your healthcare provider will monitor for during pregnancy with routine prenatal tests. Any issues with Rh factor are usually caught early, which increases the likelihood of successful treatment.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Typically, there are two screening tests that are performed to determine your risk of Rh incompatibility. The first is a simple blood test to determine if the mother\u2019s blood is Rh negative. If they are a Rh negative mother, then another test will be performed to find out if they have already formed antibodies against Rh factor.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cRh incompatibility during pregnancy is typically diagnosed through a blood test (antibody screen),\u201d says<\/span> <a href=\"https:\/\/www.northwell.edu\/find-care\/find-a-doctor\/maternal-fetal-medicine\/dr-matthew-justin-blitz-md-11371137\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Matthew J. Blitz, MD,<\/span><\/a><span style=\"font-weight: 400;\"> director of clinical research, maternal-fetal medicine at Northwell Health. \u201cThe test checks for the presence of Rh antibodies in the pregnant person\u2019s blood, which indicates that they have been sensitized to the Rh factor and are at risk for Rh incompatibility.\u201d This test is usually performed during your first prenatal visit in the first trimester and then again around 28 weeks.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">And what happens if antibodies are found? \u201cIf Rh antibodies are detected, additional testing may be done to determine the severity of the Rh incompatibility and the potential risk to the fetus,\u201d Dr. Blitz explains. This may include measuring the levels of antibodies in the pregnant person\u2019s blood and performing tests like ultrasounds to monitor the fetus for signs of anemia.<\/span><\/p>\n<h2 id=\"rh-incompatibility-treatment\"><span style=\"font-weight: 400;\">Rh incompatibility treatment<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Rh incompatibility treatment varies depending on where you are in your pregnancy and what your antibody levels are. \u201cIf Rh incompatibility is detected early in pregnancy and the pregnant parent has not yet produced significant levels of Rh antibodies, treatment may involve administering a medication called Rh immune globulin (RhoGAM or RhIg),\u201d says Dr. Blitz. \u201cRhoGAM is a blood product that can prevent the expectant parents\u2019 immune system from producing antibodies against the Rh factor in the fetus\u2019s blood.\u201d Rh immunoglobulin shots are typically administered at 28 weeks of pregnancy to an Rh-negative parent, and then again within 72 hours after delivery to an Rh-positive infant.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Treatment is different if Rh incompatibility is detected later in pregnancy or if the pregnant person has already produced high levels of Rh antibodies. In this case, treatment will involve closely monitoring the fetus for signs of anemia and other complications, such as jaundice or anemia. \u201cTreatment may include phototherapy (light therapy) or blood transfusions,\u201d Dr. Blitz says.\u00a0<\/span><\/p>\n<h2 id=\"complications-associated-with-rh-incompatibility\"><span style=\"font-weight: 400;\">Complications associated with Rh incompatibility<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Thankfully, the risks of complications from Rh incompatibility are greatly reduced with preventive RhoGAM treatment. But if Rh incapability isn\u2019t treated or if treatment isn\u2019t successful, serious complications and health problems can result in newborns. \u201cRh alloimmunization is the leading cause of hemolytic disease of the fetus\/newborn,\u201d explains Dr. Juusela. \u201cThis is a condition characterized by fetal anemia of varying degrees and can range from mild anemia to severe anemia with elevated bilirubin levels, hydrops, heart failure, growth restriction, and fetal death.\u201d<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Again, preventing complications in the first place is the goal and is widely successful, reminds Dr. Atallah. But if the treatment fails, there are ways that the fetus can be treated to prevent the most serious complications. \u201cThe treatment, in that case, would be to transfuse the fetus in cases of severe anemia,\u201d he says. \u201cOften, multiple transfusions are required.\u201d Most of these fetuses will survive, unless they develop hydrops (fluid build-up in their body) or anemia in early pregnancy, which reduces survival rate, according to Dr. Atallah.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If your pregnancy is impacted by Rh factor, you can be assured that you\u2019ll be carefully monitored. \u201cGiven the potential for fetal anemia, the pregnancy should be considered high-risk and be monitored closely,\u201d Dr. Atallah says. Newborns of untreated or treatment resistant Rh-incompatible pregnancies are very closely monitored for signs of jaundice or anemia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Luckily, it\u2019s rare for infants to develop complications from Rh incompatibility because of the effectiveness of preventive treatments. In countries where treatment is given widely, the incidences of Rh incompatibility complications have been reduced to 2.5 per every 100,000 births.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have any further questions about Rh factor, or if you are concerned that it might impact a current or future pregnancy, reach out to an OB-GYN or other medical professional.<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 8.2089 20.5098 8.05745C19.6147 7.90601 18.6945 8.05596 17.8938 8.48379C17.093 8.91162 16.4569 9.59313 16.0852 10.4214C15.7135 11.2497 15.6273 12.178 15.84 13.0606C14.2094 12.9781 12.6144 12.5536 11.1587 11.8145C9.70287 11.0754 8.41885 10.0383 7.39 8.7706C7.02914 9.40077 6.83952 10.1144 6.84 10.8406C6.83872 11.515 7.00422 12.1792 7.32176 12.7742C7.63929 13.3691 8.09902 13.8763 8.66 14.2506C8.00798 14.2329 7.36989 14.0579 6.8 13.7406V13.7906C6.80489 14.7355 7.13599 15.6497 7.73731 16.3786C8.33864 17.1074 9.17326 17.6062 10.1 17.7906C9.74326 17.8992 9.37288 17.9564 9 17.9606C8.74189 17.9576 8.48442 17.9342 8.23 17.8906C8.49391 18.7034 9.00462 19.4137 9.69107 19.9228C10.3775 20.4318 11.2056 20.7142 12.06 20.7306C10.6172 21.8659 8.83588 22.4855 7 22.4906C6.66574 22.4917 6.33174 22.4717 6 22.4306C7.87443 23.6409 10.0588 24.2833 12.29 24.2806C13.8297 24.2966 15.3571 24.0056 16.7831 23.4247C18.2091 22.8437 19.505 21.9845 20.5952 20.8971C21.6854 19.8097 22.548 18.516 23.1326 17.0915C23.7172 15.667 24.012 14.1403 24 12.6006C24 12.4306 24 12.2506 24 12.0706C24.7847 11.4854 25.4615 10.768 26 9.9506Z\"\/>\n  <\/g>\n  <g id=\"linkedin\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M10.4092 25.75H6.08646V13.1473H10.4092V25.75ZM8.24784 11.3829C7.65167 11.3829 7.07993 11.1528 6.65838 10.7431C6.23682 10.3335 6 9.77783 6 9.19847C6 8.61911 6.23682 8.06349 6.65838 7.65382C7.07993 7.24415 7.65167 7.014 8.24784 7.014C8.5644 6.97911 8.88498 7.0096 9.18858 7.10346C9.49218 7.19732 9.77196 7.35244 10.0096 7.55867C10.2472 7.76489 10.4374 8.01757 10.5675 8.30015C10.6977 8.58274 10.765 8.88886 10.765 9.19847C10.765 9.50808 10.6977 9.8142 10.5675 10.0968C10.4374 10.3794 10.2472 10.632 10.0096 10.8383C9.77196 11.0445 9.49218 11.1996 9.18858 11.2935C8.88498 11.3873 8.5644 11.4178 8.24784 11.3829ZM26 25.75H21.6772V18.9866C21.6772 17.2922 21.0576 16.186 19.487 16.186C19.001 16.1894 18.5276 16.3376 18.1309 16.6105C17.7341 16.8834 17.433 17.2679 17.268 17.7123C17.1553 18.0414 17.1064 18.388 17.1239 18.7345V25.736H12.8012C12.8012 25.736 12.8012 14.2816 12.8012 13.1333H17.1239V14.9117C17.5166 14.2495 18.0878 13.704 18.7759 13.3338C19.4639 12.9637 20.2429 12.783 21.0288 12.8112C23.9107 12.8112 26 14.6176 26 18.4965V25.75Z\"\/>\n  <\/g>\n  <g id=\"share\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M21.4994 23.9007H8.47991V10.9629H11.8416C12.6131 9.96349 13.5086 9.14204 14.5419 8.49857H7.9977C6.89552 8.49857 6 9.38848 6 10.4837V24.3799C6 25.4752 6.89552 26.3651 7.9977 26.3651H21.9816C23.0838 26.3651 23.9793 25.4752 23.9793 24.3799V14.2898L21.4994 16.1175V23.9007Z\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M10.0574 22.2921C12.9437 14.4472 17.4696 12.8249 19.7704 12.5305V15.8574L26.4524 10.9287L19.7704 6V8.10154C9.04478 9.01198 10.0574 22.2921 10.0574 22.2921Z\"\/>\n  <\/g>\n  <g id=\"youtube\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M16.0644 9H16.1756C17.2032 9.00375 22.4098 9.04125 23.8136 9.41878C24.238 9.53399 24.6247 9.75858 24.9351 10.0701C25.2455 10.3816 25.4688 10.7691 25.5825 11.1939C25.7087 11.6689 25.7975 12.2977 25.8575 12.9465L25.87 13.0765L25.8975 13.4015L25.9075 13.5315C25.9888 14.6741 25.9988 15.7442 26 15.9779V16.0717C25.9988 16.3142 25.9875 17.4568 25.8975 18.6469L25.8875 18.7781L25.8762 18.9081C25.8137 19.6232 25.7212 20.3332 25.5825 20.8557C25.4691 21.2807 25.246 21.6684 24.9355 21.98C24.6251 22.2915 24.2382 22.516 23.8136 22.6309C22.3635 23.0209 16.8519 23.0484 16.0881 23.0496H15.9106C15.5243 23.0496 13.9267 23.0421 12.2516 22.9846L12.0391 22.9771L11.9304 22.9721L11.7166 22.9634L11.5028 22.9546C10.1153 22.8934 8.79392 22.7946 8.18514 22.6296C7.76072 22.5148 7.37392 22.2906 7.06347 21.9792C6.75303 21.6679 6.52984 21.2805 6.41628 20.8557C6.27752 20.3345 6.18501 19.6232 6.12251 18.9081L6.11251 18.7769L6.10251 18.6469C6.04081 17.7998 6.00663 16.951 6 16.1017L6 15.9479C6.0025 15.6792 6.0125 14.7504 6.08001 13.7253L6.08876 13.5965L6.09251 13.5315L6.10251 13.4015L6.13001 13.0765L6.14251 12.9465C6.20251 12.2977 6.29127 11.6677 6.41753 11.1939C6.5309 10.7689 6.754 10.3812 7.06446 10.0697C7.37492 9.75811 7.76182 9.53365 8.18639 9.41878C8.79517 9.25627 10.1165 9.15626 11.5041 9.09376L11.7166 9.08501L11.9316 9.07751L12.0391 9.07375L12.2529 9.065C13.4426 9.02672 14.6328 9.00547 15.8231 9.00125H16.0644V9ZM14.0005 13.0128V19.0356L19.1971 16.0254L14.0005 13.0128Z\"\/>\n  <\/g>\n  <g id=\"instagram\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M21.34 9.46C21.1027 9.46 20.8707 9.53038 20.6733 9.66224C20.476 9.79409 20.3222 9.98151 20.2313 10.2008C20.1405 10.4201 20.1168 10.6613 20.1631 10.8941C20.2094 11.1269 20.3236 11.3407 20.4915 11.5085C20.6593 11.6764 20.8731 11.7906 21.1059 11.8369C21.3387 11.8832 21.5799 11.8595 21.7992 11.7687C22.0185 11.6778 22.2059 11.524 22.3378 11.3267C22.4696 11.1293 22.54 10.8973 22.54 10.66C22.54 10.3417 22.4136 10.0365 22.1885 9.81147C21.9635 9.58643 21.6583 9.46 21.34 9.46ZM25.94 11.88C25.9206 11.0503 25.7652 10.2294 25.48 9.45C25.2257 8.78313 24.83 8.17928 24.32 7.68C23.8248 7.16743 23.2196 6.77418 22.55 6.53C21.7727 6.23616 20.9508 6.07721 20.12 6.06C19.06 6 18.72 6 16 6C13.28 6 12.94 6 11.88 6.06C11.0492 6.07721 10.2273 6.23616 9.45 6.53C8.78168 6.77665 8.17693 7.16956 7.68 7.68C7.16743 8.17518 6.77418 8.78044 6.53 9.45C6.23616 10.2273 6.07721 11.0492 6.06 11.88C6 12.94 6 13.28 6 16C6 18.72 6 19.06 6.06 20.12C6.07721 20.9508 6.23616 21.7727 6.53 22.55C6.77418 23.2196 7.16743 23.8248 7.68 24.32C8.17693 24.8304 8.78168 25.2234 9.45 25.47C10.2273 25.7638 11.0492 25.9228 11.88 25.94C12.94 26 13.28 26 16 26C18.72 26 19.06 26 20.12 25.94C20.9508 25.9228 21.7727 25.7638 22.55 25.47C23.2196 25.2258 23.8248 24.8326 24.32 24.32C24.8322 23.8226 25.2283 23.2182 25.48 22.55C25.7652 21.7706 25.9206 20.9497 25.94 20.12C25.94 19.06 26 18.72 26 16C26 13.28 26 12.94 25.94 11.88ZM24.14 20C24.1327 20.6348 24.0178 21.2637 23.8 21.86C23.6403 22.2952 23.3839 22.6884 23.05 23.01C22.7256 23.3405 22.3332 23.5964 21.9 23.76C21.3037 23.9778 20.6748 24.0927 20.04 24.1C19.04 24.15 18.67 24.16 16.04 24.16C13.41 24.16 13.04 24.16 12.04 24.1C11.3809 24.1123 10.7246 24.0109 10.1 23.8C9.68578 23.6281 9.31136 23.3728 9 23.05C8.66809 22.7287 8.41484 22.3352 8.26 21.9C8.01586 21.2952 7.88044 20.6519 7.86 20C7.86 19 7.8 18.63 7.8 16C7.8 13.37 7.8 13 7.86 12C7.86448 11.3511 7.98295 10.7079 8.21 10.1C8.38605 9.67791 8.65626 9.30166 9 9C9.30381 8.65617 9.67929 8.3831 10.1 8.2C10.7096 7.98004 11.352 7.86508 12 7.86C13 7.86 13.37 7.8 16 7.8C18.63 7.8 19 7.8 20 7.86C20.6348 7.86728 21.2637 7.98225 21.86 8.2C22.3144 8.36865 22.7223 8.64285 23.05 9C23.3777 9.30718 23.6338 9.68273 23.8 10.1C24.0223 10.7089 24.1373 11.3518 24.14 12C24.19 13 24.2 13.37 24.2 16C24.2 18.63 24.19 19 24.14 20ZM16 10.87C14.9858 10.872 13.995 11.1745 13.1527 11.7394C12.3103 12.3043 11.6544 13.1062 11.2676 14.0438C10.8809 14.9813 10.7807 16.0125 10.9798 17.0069C11.1789 18.0014 11.6682 18.9145 12.3861 19.631C13.1039 20.3474 14.018 20.835 15.0129 21.0321C16.0077 21.2293 17.0387 21.1271 17.9755 20.7385C18.9123 20.35 19.7129 19.6924 20.2761 18.849C20.8394 18.0056 21.14 17.0142 21.14 16C21.1413 15.3251 21.0092 14.6566 20.7512 14.033C20.4933 13.4093 20.1146 12.8428 19.6369 12.3661C19.1592 11.8893 18.5919 11.5117 17.9678 11.2549C17.3436 10.9982 16.6749 10.8674 16 10.87ZM16 19.33C15.3414 19.33 14.6976 19.1347 14.15 18.7688C13.6023 18.4029 13.1755 17.8828 12.9235 17.2743C12.6714 16.6659 12.6055 15.9963 12.734 15.3503C12.8625 14.7044 13.1796 14.111 13.6453 13.6453C14.111 13.1796 14.7044 12.8625 15.3503 12.734C15.9963 12.6055 16.6659 12.6714 17.2743 12.9235C17.8828 13.1755 18.4029 13.6023 18.7688 14.15C19.1347 14.6976 19.33 15.3414 19.33 16C19.33 16.4373 19.2439 16.8703 19.0765 17.2743C18.9092 17.6784 18.6639 18.0454 18.3547 18.3547C18.0454 18.6639 17.6784 18.9092 17.2743 19.0765C16.8703 19.2439 16.4373 19.33 16 19.33Z\"\/>\n  <\/g>\n<\/svg>                            <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Do you know: What it is, incompatibility, and complications in 2025 Key takeaways The Rhesus (Rh) factor is a protein on the surface of red blood cells, determining blood type as either positive or negative, which is crucial during pregnancy for compatibility between a pregnant person and their fetus. Rh incompatibility occurs when an Rh-negative [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4699","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/4699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=4699"}],"version-history":[{"count":1,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/4699\/revisions"}],"predecessor-version":[{"id":6166,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/4699\/revisions\/6166"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=4699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=4699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=4699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}