{"id":5334,"date":"2024-10-24T20:31:30","date_gmt":"2024-12-10T03:38:41","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/?p=5334"},"modified":"2024-12-10T03:38:41","modified_gmt":"2024-12-10T03:38:41","slug":"hydroxyzine-what-you-need-to-know-for-safe-use","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hydroxyzine-what-you-need-to-know-for-safe-use\/","title":{"rendered":"Hydroxyzine: What you need to know for safe use"},"content":{"rendered":"<p><\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Hydroxyzine is an antihistamine with anticholinergic and sedative properties used to treat itchiness from allergies, tension, and anxiety disorders.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Melatonin is a dietary supplement used to manage circadian rhythm sleep disorders and insomnia.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">There are mixed opinions on whether or not hydroxyzine and melatonin should be taken together. <\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Older adults, pregnant people, breastfeeding people, and those with liver, lung, and heart conditions should avoid taking melatonin and hydroxyzine together or individually without consulting a healthcare professional. <\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Melatonin and hydroxyzine should also not be combined with anti-anxiety medications, additional antihistamines, and other sedative medications.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">If your healthcare provider has deemed it safe for you to take hydroxyzine and melatonin, follow their dosing guidelines and let them know if you\u2019re experiencing any severe side effects.\u00a0<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label>In this article<\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Hydroxyzine<\/span><span style=\"font-weight: 400;\">, sold under the brand name Vistaril, is a prescription antihistamine drug that healthcare providers prescribe to treat anxiety disorders, nausea, and itching.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Melatonin is a hormone naturally made in the body. It is not a type of medication but a <\/span><a href=\"https:\/\/www.nccih.nih.gov\/health\/melatonin-what-you-need-to-know\"><span style=\"font-weight: 400;\">dietary supplement<\/span><\/a><span style=\"font-weight: 400;\"> that may help regulate sleep-wake cycles, insomnia, and circadian rhythm sleep disorders.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While some healthcare providers say it\u2019s safe to take them together, others heavily advise against this combination. If your healthcare provider approves taking melatonin and hydroxyzine together, it\u2019s important to understand the side effects, potential drug interactions, and dosing schedule of this combination of medications.\u00a0<\/span><\/p>\n<h2 id=\"can-you-take-hydroxyzine-and-melatonin-together\"><span style=\"font-weight: 400;\">Can you take hydroxyzine and melatonin together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to <\/span><a href=\"https:\/\/www.linkedin.com\/in\/francis-shih-a69161\/\"><span style=\"font-weight: 400;\">Francis Shih, MD<\/span><\/a><span style=\"font-weight: 400;\">, a psychiatrist and medical director of <\/span><a href=\"https:\/\/neurowellnessspa.com\/about\/care-team\/\"><span style=\"font-weight: 400;\">Neuro Wellness Spa<\/span><\/a><span style=\"font-weight: 400;\"> in Manhattan Beach, California, it is safe to take the prescription drug hydroxyzine and melatonin together, but you should consult with your healthcare provider before starting treatment. \u201cHydroxyzine and melatonin both cause drowsiness,\u201d he says. \u201cWhen taken together, they may cause excess sleepiness or dizziness, so dosing should be under the supervision of a physician.\u201d<\/span><\/p>\n<p><a href=\"https:\/\/www.linkedin.com\/in\/claudia-cometa-pharmd\/\"><span style=\"font-weight: 400;\">Claudia Cometa, PharmD<\/span><\/a><span style=\"font-weight: 400;\">, a pharmacist and the CEO and executive health consultant of Peace Advocacy Group of Clearwater, Florida, believes this combination should be avoided entirely. \u201cWhile many people do take multiple medications to treat a single condition, such as insomnia, this practice is not widely recommended or supported by medical literature,\u201d she says. \u201cThe additive effects of medications that affect the central nervous system, such as hydroxyzine and melatonin, can result in drowsiness, dizziness, and confusion.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are also instances where certain people within a certain age group or who are living with certain medical conditions should avoid mixing the antihistamine medication hydroxyzine and the supplement melatonin entirely.\u00a0<\/span><\/p>\n<h3 id=\"older-adults\"><span style=\"font-weight: 400;\">Older adults<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While Dr. Cometa advises against the use of the combination of this drug and supplement, she says it\u2019s especially unsafe for older adults. \u201cCombinations like this should be especially avoided in the elderly population due to the high risk of falls as well as patients with glaucoma and urinary retention,\u201d she says.<\/span><\/p>\n<h3 id=\"certain-health-conditions\"><span style=\"font-weight: 400;\">Certain health conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It may also be unsafe for people with certain medical conditions to use melatonin and hydroxyzine together.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPeople with lung, liver, and kidney disease should seek consultation from a physician or health care professional before taking hydroxyzine and melatonin together,\u201d Dr. Shih says. \u201cBreathing problems, dizziness, confusion, and falling can occur with at-risk individuals.\u201d<\/span><\/p>\n<h3 id=\"dosage\"><span style=\"font-weight: 400;\">Dosage<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking this drug and supplement combination, your healthcare provider can guide you on a safe dosing schedule. If hydroxyzine and melatonin can be safely taken together, Dr. Shih says that they should be started at the lowest dosages under the supervision of a healthcare provider. \u201c<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=81f9d88f-c50b-4c6a-a25b-46fa162a503e\"><span style=\"font-weight: 400;\">Hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\"> starts at 10 milligrams (mg) in tablet form and lower in liquid form,\u201d he says. \u201cMelatonin dosages typically start at 1-2 mg.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ultimately, your healthcare provider can determine whether or not this drug combination is safe for you, so it\u2019s best to consult them for any questions regarding the dosages of hydroxyzine and melatonin.<\/span><\/p>\n<h2 id=\"are-there-benefits-of-taking-hydroxyzine-and-melatonin-at-the-same-time\"><span style=\"font-weight: 400;\">Are there benefits of taking hydroxyzine and melatonin at the same time?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If your healthcare provider deems it safe to take hydroxyzine and melatonin together, this medication and supplement combination could improve your sleep quality. \u201cIf an individual does not respond to either hydroxyzine or melatonin alone at a safe maximum dose, taking them together can be a safe alternative to stronger prescription medication for sleep,\u201d Dr. Shih says. \u201cNeither medication is considered addictive or habit forming.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, Dr. Cometa says that someone taking melatonin for sleep troubles may benefit more from taking this dietary supplement with a different antihistamine to avoid unwanted side effects. \u201cI would recommend a second-generation antihistamine, such as cetirizine or loratadine, rather than hydroxyzine,\u201d she says.<\/span><\/p>\n<h2 id=\"hydroxyzine-and-melatonin-interactions\"><span style=\"font-weight: 400;\">Hydroxyzine and melatonin interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">With the mixed opinions on the safety and efficacy of mixing hydroxyzine and melatonin, it\u2019s important to discuss their potential risks, including interactions and side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201c[Hydroxyzine and melatonin] interactions include all sedating medications, such as <\/span><span style=\"font-weight: 400;\">opioids<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">anti-anxiety medications<\/span><span style=\"font-weight: 400;\">, and additional <\/span><span style=\"font-weight: 400;\">antihistamines <\/span><span style=\"font-weight: 400;\">and <\/span><span style=\"font-weight: 400;\">insomnia <\/span><span style=\"font-weight: 400;\">medications,\u201d says Dr. Cometa. \u201cHydroxyzine should not be used in patients with cardiac conditions or elderly patients. In addition, poor kidney function could affect an individual\u2019s ability to excrete, or get rid of, the medication and prolong its effects.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In regards to melatonin interactions, Dr. Shih says the dietary supplements can interact with alcohol, sedatives, opioids, antihistamines, antihistamines, anticoagulants, contraceptives, and psychiatric medications. \u201cMelatonin should also be avoided during pregnancy, while breastfeeding, or if you have epilepsy or liver disease,\u201d he says.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to their possible interactions, hydroxyzine and melatonin have their own individual side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to Dr. Shih, potential side effects of hydroxyzine include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty urinating\u00a0<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.nami.org\/about-mental-illness\/treatments\/mental-health-medications\/types-of-medication\/hydroxyzine-vistaril\/\"><span style=\"font-weight: 400;\">Rare severe side effects of hydroxyzine<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reaction (difficulty breathing, hives, swelling of your lips, tongue, or face)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Unsafe heart rhythm<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Priapism (an erection that does not go away after four hours)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acute generalized exanthematous pustulosis (AGEP), a type of skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serotonin syndrome (a life-threatening drug reaction that occurs from having too much serotonin in your body)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Additionally, Dr. Shih lists the following as possible adverse effects of the supplement melatonin:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in sleep patterns<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you\u2019re experiencing any interactions or serious side effects, please reach out to your healthcare provider as soon as possible for medical care.\u00a0<\/span><\/p>\n<h2 id=\"how-long-after-taking-hydroxyzine-can-you-take-melatonin\"><span style=\"font-weight: 400;\">How long after taking hydroxyzine can you take melatonin?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no specific or preferred dosing guidelines for taking melatonin and hydroxyzine. To get safe dosage or dosing scheduling guidance for these treatments, Dr. Shih recommends speaking with your healthcare provider for medical advice and additional information.<\/span><\/p>\n<h2 id=\"what-medications-should-you-not-mix-with-hydroxyzine-or-melatonin\"><span style=\"font-weight: 400;\">What medications should you not mix with hydroxyzine or melatonin?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As previously mentioned, certain medications should never be taken with hydroxyzine or melatonin. According to Dr. Cometa, these include additional sedative medications, such as opioids, anti-anxiety medications, additional antihistamines, and additional insomnia medications.<\/span><\/p>\n<h2 id=\"what-sleep-aids-can-i-take-with-hydroxyzine-or-melatonin\"><span style=\"font-weight: 400;\">What sleep aids can I take with hydroxyzine or melatonin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to Dr. Cometa, it\u2019s difficult to determine which sleep aids are safe to take with hydroxyzine or melatonin. \u201cThere are very few classes of medications that are recommended by the American Academy of Sleep Medicine due to the side effect profile of most sedating medications,\u201d she says. \u201cTherefore, caution must be exercised in choosing to take more than one sleep aid at a time.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When it comes to taking hydroxyzine and melatonin, healthcare providers have mixed opinions on whether they\u2019re safe together. That said, it\u2019s important to be aware of the potential risks and contact your healthcare provider if you have any questions or concerns about the combination. \u201cHydroxyzine and melatonin are generally considered safer alternatives to prescription sleep aids, but they still have risks,\u201d Dr. Shih says. \u201cConsultation with a healthcare provider is advised.\u201d<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 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Melatonin is a dietary supplement used to manage circadian rhythm sleep disorders and insomnia. There are mixed opinions on whether or not hydroxyzine and melatonin should be taken together. Older adults, pregnant people, breastfeeding [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5334","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/5334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=5334"}],"version-history":[{"count":1,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/5334\/revisions"}],"predecessor-version":[{"id":5741,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/5334\/revisions\/5741"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=5334"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=5334"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=5334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}