{"id":5467,"date":"2024-10-16T20:31:30","date_gmt":"2024-12-10T03:28:10","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/?p=5467"},"modified":"2024-12-10T03:28:10","modified_gmt":"2024-12-10T03:28:10","slug":"hmn-does-zoloft-make-you-tired-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-does-zoloft-make-you-tired-in-2025\/","title":{"rendered":"HMN: Does Zoloft make you tired in 2025?"},"content":{"rendered":"<p>\n<br \/>Do you know:  Does Zoloft make you tired? in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Fatigue is a potential side effect of Zoloft, but it\u2019s less common than with other antidepressants.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Zoloft fatigue is usually temporary and only lasts a few weeks. It decreases as your body adjusts to the medication. Taking Zoloft in the evening may help reduce daytime sleepiness.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Zoloft makes some people more energetic because it treats symptoms of depression, including tiredness.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/sertraline-marketed-zoloft-information\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Zoloft (sertraline)<\/span><\/a><span style=\"font-weight: 400;\"> is a selective serotonin reuptake inhibitor (SSRI), a type of antidepressant that is <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=fe9e8b7d-61ea-409d-84aa-3ebd79a046b5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FDA approved to treat<\/span><\/a><span style=\"font-weight: 400;\"> major depressive disorder, panic disorder, panic attacks, <\/span><span style=\"font-weight: 400;\">obsessive-compulsive disorder<\/span><span style=\"font-weight: 400;\"> (OCD), premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder, and social anxiety disorder. Fatigue is a <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/215133s000lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">potential side effect of Zoloft<\/span><\/a><span style=\"font-weight: 400;\">, but it\u2019s less common than with other antidepressants. In fact, Zoloft actually gives some people an energy boost because it alleviates symptoms of depression, including tiredness. Read on to learn more about how common it is for Zoloft to make you feel sleepy, how long to expect this side effect to last, and what to do if you are dealing with fatigue.<\/span><\/p>\n<h2 id=\"does-zoloft-make-you-tired\"><span style=\"font-weight: 400;\">Does Zoloft make you tired?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">About 10% of patients will experience drowsiness from Zoloft, says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/jack-drescher-504b2612\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Jack Drescher, MD<\/span><\/a><span style=\"font-weight: 400;\">, psychiatrist and past president of the <\/span><a href=\"https:\/\/www.ourgap.org\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Group for the Advancement of Psychiatry<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Increased fatigue is a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5548844\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">common side effect of antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, but Zoloft is less likely to make you tired than many. \u201cOther SSRIs, like <\/span><span style=\"font-weight: 400;\">Paxil<\/span><span style=\"font-weight: 400;\">, are more commonly sedating compared to Zoloft,\u201d says Bryan Bruno, MD, psychiatrist and medical director at <\/span><a href=\"https:\/\/www.midcitytms.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mid City TMS<\/span><\/a><span style=\"font-weight: 400;\">, a medical center focused on treating depression in New York, New York. Overall, Zoloft has fewer side effects than other types of antidepressants, such as <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547689\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">tricyclic antidepressants or monoamine oxidase inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> (MAOIs).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Still, Zoloft can sometimes cause symptoms of sleepiness and fatigue, especially when you first start taking it. \u201cIf it occurs, the fatigue tends to last for a few weeks at the start of treatment, gradually improving, but for some people, it may last longer,\u201d explains Dr. Bruno. More often, Zoloft provides a much-needed energy boost. \u201cZoloft can actually improve energy levels, especially when low energy is a symptom of depression,\u201d Dr. Bruno says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf the medicine is working the way it is supposed to, it should not diminish energy levels,\u201d agrees Dr. Drescher. \u201cOn the contrary, a person with low energy levels from depression may experience an increase in energy with Zoloft or other antidepressants.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other common side effects<\/span><span style=\"font-weight: 400;\"> of sertraline include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Digestive issues like diarrhea, heartburn, indigestion, or constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleep problems such as insomnia, trouble falling asleep, or difficulty staying asleep<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Teeth grinding or jaw clenching<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased or increased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain or weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lightheadedness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erectile dysfunction<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased sex drive<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Most of these possible side effects dissipate within the first week or two of starting the medication.<\/span><\/p>\n<h2 id=\"why-does-zoloft-make-you-tired\"><span style=\"font-weight: 400;\">Why does Zoloft make you tired?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The reason that Zoloft and other <\/span><span style=\"font-weight: 400;\">SSRIs<\/span><span style=\"font-weight: 400;\"> may make you tired is because of the chemical changes they produce in your brain. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554406\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">SSRIs work by blocking serotonin reabsorption<\/span><\/a><span style=\"font-weight: 400;\">, which increases serotonin levels in your body and brain. \u201cSerotonin is widely known for its effect on mood, but it also plays a role in memory, anger, fear, appetite, stress, addiction, sexual pleasure, and sleep,\u201d explains <\/span><a href=\"https:\/\/www.linkedin.com\/in\/andrew-newhouse-pharmd-981680100\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Andrew Newhouse, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, director clinical pharmacy at <\/span><a href=\"https:\/\/www.sedgwick.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sedgwick<\/span><\/a><span style=\"font-weight: 400;\">. \u201cIncreased levels of serotonin can cause fatigue, which is what is seen with many SSRIs.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, insomnia is a common side effect of Zoloft. When you have trouble sleeping, it can cause daytime drowsiness or tiredness, explains <\/span><a href=\"https:\/\/www.linkedin.com\/in\/thomas-so-10943584\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Thomas So, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, senior manager of the Consumer Drug Information Group at<\/span><a href=\"http:\/\/www.fdbhealth.com\/\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">First Databank<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<\/p>\n<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span><\/p><\/div>\n<p>\t<\/span><\/p>\n<h2 id=\"managing-zoloft-fatigue\"><span style=\"font-weight: 400;\">Managing Zoloft fatigue<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For most people, Zoloft fatigue and other side effects will go away <\/span><span style=\"font-weight: 400;\">after the initial acclimation period. If it persists for you, don\u2019t worry. You have options, such as these strategies:<\/span><\/p>\n<ul>\n<li aria-level=\"1\"><b>Ask your provider if you should take Zoloft in the evening. <\/b><span style=\"font-weight: 400;\">The most intense side effects of Zoloft tend to peak <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7008964\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">between 4 and 10 hours<\/span><\/a><span style=\"font-weight: 400;\"> after taking it. \u201cIf Zoloft makes you feel tired or fatigued, you should take it in the evening before bed,\u201d Dr. So says. After taking Zoloft before bedtime, it reaches its highest levels in the blood while you are asleep, possibly leading to fewer side effects when you\u2019re awake.\u201d<\/span><\/li>\n<li aria-level=\"1\"><b>Ask about adjusting the dosage.<\/b><span style=\"font-weight: 400;\"> If the dose is too high, it could increase the risk of side effects. If it\u2019s too low, it may not alleviate symptoms of depression. Both can cause tiredness.<\/span><\/li>\n<li aria-level=\"1\"><b>Switch to a different antidepressant.<\/b><span style=\"font-weight: 400;\"> If side effects of the medication are interrupting your daily life, work with your healthcare provider to change medications. \u201cIf fatigue continues even if taken at night, it might be reasonable to try a different antidepressant that acts in a different way,\u201d Dr. Drescher notes. \u201c<\/span><span style=\"font-weight: 400;\">Wellbutrin<\/span><span style=\"font-weight: 400;\">, for example, is a more activating antidepressant.\u201d<\/span><\/li>\n<li aria-level=\"1\"><b>Practice good <\/b><b>sleep hygiene<\/b><span style=\"font-weight: 400;\">. You can try strategies like avoiding daytime napping, making sure your bedroom is dark and cool, or adjusting the thermostat before bed.<\/span><\/li>\n<li aria-level=\"1\"><b>Consider starting an exercise routine.<\/b><span style=\"font-weight: 400;\"> Daily exercise, such as walking, can boost energy levels for some people.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Finding the right antidepressant and dosage is a process. Work with your healthcare team until you find the right balance between alleviating your symptoms and minimizing side effects.<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/p>\n<h2 id=\"when-to-see-your-healthcare-provider\"><span style=\"font-weight: 400;\">When to see your healthcare provider<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When you start taking Zoloft, you should schedule check-ins with your prescriber or primary care provider every few weeks to discuss side effects and dosage. Most providers start with a lower dose and increase if needed, depending on how you respond to the medication. \u201cIt would be reasonable to inform your provider at these appointments as soon as any side effects are noticed so that the dose or medication can be adjusted,\u201d Dr. Newhouse recommends.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf after several weeks of taking Zoloft, your tiredness or fatigue is not improving or if these effects are impairing your ability to drive safely, it would be time to talk to your doctor,\u201d Dr. So says.\u201cYour doctor will help decide whether you should continue taking Zoloft, add other medications with Zoloft to help with the tiredness or fatigue, or change to a different <\/span><span style=\"font-weight: 400;\">antidepressant<\/span><span style=\"font-weight: 400;\">.\u201d In other words, you should never hesitate to reach out to a healthcare professional for medical advice and support when starting a new antidepressant 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