{"id":6514,"date":"2024-12-13T08:43:13","date_gmt":"2024-12-13T08:43:13","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-lisinopril-and-cialis-interaction-what-to-know-in-2025\/"},"modified":"2024-12-20T13:56:45","modified_gmt":"2024-12-20T13:56:45","slug":"hmn-lisinopril-and-cialis-interaction-what-to-know-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-lisinopril-and-cialis-interaction-what-to-know-in-2025\/","title":{"rendered":"HMN: Lisinopril and Cialis interaction: What to know in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Lisinopril and Cialis interaction: What to know in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Lisinopril is an ACE inhibitor used to treat high blood pressure. Cialis is a PDE5 inhibitor used to treat erectile dysfunction and symptoms of an enlarged prostate in men.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Cialis and lisinopril are typically safe to take together. The main contraindication to Cialis is nitrates, which can cause an unsafe drop in blood pressure.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">While rare, there is a risk of blood pressure decreasing when taking Cialis and lisinopril, which may lead to dizziness, lightheadedness, and fainting.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">The most common starting dose for lisinopril is between 2.5 and 10 mg daily. The typical starting dose for Cialis when treating erectile dysfunction is 10 mg as needed. A 5 mg dose is often used to treat benign prostatic hyperplasia (BPH).<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Cialis<\/span><span style=\"font-weight: 400;\"> (tadalafil) is a <\/span><span style=\"font-weight: 400;\">phosphodiesterase 5 (PDE5) inhibitor<\/span><span style=\"font-weight: 400;\"> used to treat erectile dysfunction (ED) and symptoms of enlarged prostate. Like Viagra (sildenafil), another common PDE5 inhibitor, Cialis works by relaxing the blood vessels and improving blood flow. <\/span><span style=\"font-weight: 400;\">Lisinopril<\/span><span style=\"font-weight: 400;\"> is an<\/span> <span style=\"font-weight: 400;\">angiotensin-converting enzyme (ACE) inhibitor<\/span><span style=\"font-weight: 400;\">. It\u2019s a prescription drug used to treat hypertension (high blood pressure) and works by causing the blood vessels to widen so that blood can move more freely. In general, Cialis and lisinopril can be taken together safely.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Can you take Cialis with lisinopril?<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cialis and lisinopril are generally safe to take together.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">\u201cLisinopril and Cialis may be taken together, but you should be aware of the potential risks and monitor for them,\u201d explains Dr. Christina Bookwalter, Pharm.D., a clinical pharmacist with the Veterans Health Administration. \u201cWhen these drugs are taken together, there is a risk of blood pressure decreasing, which may cause dizziness, lightheadedness, and fainting.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Other blood pressure medications, such as alpha blockers, may also interact with Cialis and cause blood pressure to drop suddenly.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Lisinopril should not be taken with aliskiren, another type of antihypertensive in the direct renin inhibitor class. Taking lisinopril and aliskiren together may increase the risk of kidney problems, hypotension (low blood pressure), and high potassium levels in the blood.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Diuretics, over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs), and lithium also carry risks when taken with lisinopril. Dr. Brookwalter cautions that a healthcare professional should monitor anyone taking one of these medications with lisinopril.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Nitrates, which are taken for chest pain (angina), are the main medications to avoid when taking Cialis and other PDE5 inhibitors. Mixing Cialis with nitrates, such as nitroglycerin, nitrofurantoin, and isosorbide, carries the most risk because it can lead to such a severe drop in blood pressure that it can cause a fatal heart attack or stroke.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">It is also important to note that many conditions that lisinopril is used to treat \u2013 including heart disease, clogged blood vessels, high blood pressure, and diabetes \u2013 can also cause erectile dysfunction.\u00a0<\/span><\/p>\n<h2 id=\"what-happens-if-you-take-lisinopril-and-cialis-together\"><span style=\"font-weight: 400;\">What happens if you take lisinopril and Cialis together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Common side effects of lisinopril include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metallic taste in mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cloudy urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive fatigue<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Serious side effects, although rare, may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood potassium (hyperkalemia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low white blood cell counts (leukopenia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling under the skin (angioedema)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Erectile dysfunction<\/span><span style=\"font-weight: 400;\"> is a very rare side effect of lisinopril, occurring in less than 1% of patients.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">\u201cIt\u2019s a well-tolerated medicine,\u201d says Dr. Paul Pavlov, MD, a family doctor at North Bay Family Medical Clinic in Biloxi, Mississippi. \u201cThe most serious side effect is angioedema. That\u2019s where you have a very severe allergic reaction where your throat and tongue swell and it becomes a medical emergency.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Dr. Pavlov estimates that 98% of his patients do just fine on lisinopril.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">\u201cYou worry about a few minor side effects with lisinopril, primarily metallic taste in the mouth, which is like 2-5% of patients, or the rarer side effect of angioedema, which is about one in 1,000.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Common side effects of Cialis include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upset stomach<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heartburn<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Facial flushing and hot flashes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stuffy nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle aches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Back pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Serious side effects, although very rare, may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in hearing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hearing loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vision loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reaction<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Erection lasting more than four hours<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">If a patient is having chest pain or shortness of breath going up two flights of stairs, they may need to use caution before taking Cialis and being sexually active, according to Dr. Justin Dubin, MD, a urologist and men\u2019s health specialist in South Florida and co-host of the <\/span><i><span style=\"font-weight: 400;\">Man Up Podcast<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Dr. Dubin says that while Cialis and other erectile dysfunction meds, such as Levitra (vardenafil), do not cause heart attacks, men who have not had an active sex life in a while may take these drugs and suddenly, they\u2019re motivated to have sex. \u201cTheir bodies are not used to straining themselves so much, so it\u2019s the active sex that they haven\u2019t done in a while that causes the heart attack,\u201d he explains. Dr. Dubin recommends that patients who have heart issues or lack physical stamina seek medical advice from a cardiologist or primary healthcare provider before starting Cialis.<\/span><\/p>\n<h2 id=\"how-long-after-taking-lisinopril-can-i-take-cialis\"><span style=\"font-weight: 400;\">How long after taking lisinopril can I take Cialis?<\/span><\/h2>\n<p><b>\u00a0<\/b><span style=\"font-weight: 400;\">It is generally safe to take lisinopril and Cialis at the same time.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">The max dose for Cialis is 20 milligrams (mg) as needed. Most men take 5 or 10 mg daily.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">For benign prostatic hyperplasia (BPH), the typical Cialis dosage is 5 or 10 mg.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">An advantage of Cialis is it can last up to 36 hours. This is why Cialis is referred to as the \u201cweekend pill.\u201d A man can take one Cialis on a Friday evening, and he should be able to achieve a firm erection during sexual activity over the next few days. \u201cYou can set it and forget it,\u201d Dr. Pavlov says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Lisinopril is typically given in dosages ranging from 5 to 40 mg, but the usual dose is 10 to 20 mg once daily. It is also used as a combination drug with hydrochlorothiazide, a diuretic.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">\u201cThat combination does better as far as lowering blood pressure, as opposed to one or the other,\u201d Dr. Pavlov says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Both Cialis and lisinopril can be taken in the morning or at night, and neither need to be taken with food.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<h2 id=\"is-it-safe-to-take-cialis-with-lisinopril\"><span style=\"font-weight: 400;\">Is it safe to take Cialis with lisinopril?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For most people, it is safe to mix lisinopril with Cialis. The drugs treat different conditions. Lisinopril is for high blood pressure, and Cialis is for erectile dysfunction or benign prostatic hyperplasia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Because both Cialis and lisinopril can lower blood pressure, these drugs might cause severe hypotension together. This is uncommon, but together, the drugs can lead to an increased risk of side effects, including dizziness, fainting, lightheadedness, blurry vision, and fatigue.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Taking Cialis will not affect the effectiveness of lisinopril and vice versa.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">\u201cThere\u2019s no benefit to taking them both together,\u201d Dr. Pavlov says. \u201cYou take one for blood pressure, and you take the other for either erectile dysfunction or prostatic enlargement.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Dr. Dubin echoes Dr. Pavlov. \u201cI don\u2019t think there\u2019s much of a synergistic component here,\u201d Dr. Dubin explains. \u201cI think you\u2019re getting the benefit of getting good erections and getting blood pressure control.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">However, Dr. Dubin says there is limited data showing that better blood pressure control may improve erections. \u201cWe do know that having good blood pressure control is very important for good erectile function,\u201d he says.<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 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Cialis is a PDE5 inhibitor used to treat erectile dysfunction and symptoms of an enlarged prostate in men. Cialis and lisinopril are typically safe to take together. 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