{"id":6659,"date":"2025-01-05T04:51:33","date_gmt":"2025-01-05T04:51:33","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-comparing-nsaids-for-pain-relief-in-2025\/"},"modified":"2025-01-05T04:51:33","modified_gmt":"2025-01-05T04:51:33","slug":"hmn-comparing-nsaids-for-pain-relief-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-comparing-nsaids-for-pain-relief-in-2025\/","title":{"rendered":"HMN: Comparing NSAIDs for pain relief in 2025"},"content":{"rendered":"<p> Do you know Comparing NSAIDs for pain relief?<br \/>\n<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs), but there are significant differences between the two drugs.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Toradol is prescription only and used in moderate to moderately severe pain. It can only be given orally after at least one injectable dose, and total treatment is limited to 5 days.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Ibuprofen is available both over-the-counter and by prescription, and it is best suited for mild to moderate pain.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen carry a significant risk of gastrointestinal irritation and damage, especially with repetitive or prolonged use.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">There are many health conditions where taking NSAID drugs is not recommended. These include pregnancy, renal disease, or those with pre-existing bleeding disorders.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label>In this article<\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen are two nonsteroidal anti-inflammatory drugs indicated for the treatment of pain and inflammatory conditions. Nonsteroidal anti-inflammatory drugs, commonly known as NSAIDS, are commonly used to treat muscle pain, arthritis, menstrual pain, and migraines, among other conditions. NSAIDs are also used as antipyretics to lower body fevers. NSAIDs work by inhibiting an enzyme known as cyclooxygenase, or COX for short. There are different COX enzymes that play a role throughout the body, and COX is important in the processes of inflammation and fever. While Toradol (ketorolac)\u00a0 and ibuprofen are both NSAIDs, there are some important differences between them, and different recommendations for when they are appropriate.<\/span><\/p>\n<h2 id=\"what-are-the-main-differences-between-toradol-and-ibuprofen\"><span style=\"font-weight: 400;\">What are the main differences between Toradol and ibuprofen?<\/span><\/h2>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Main differences of Toradol versus ibuprofen<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drug (NSAID)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drug (NSAID)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/p>\n<p><b>Or<\/b><\/p>\n<p><b>What is the brand name?<\/b><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">ketorolac<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Motrin, Advil<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet, injectable solution<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet, oral chewable tablet, oral capsule, oral suspension, injectable solution<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30 mg IV\/IM q6h (max 120 mg\/ day) followed by 20 mg orally, then 10 mg orally every 4-5 hours(max 40 mg\/ day). Combined systemic therapy should not exceed 5 days)\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">400 mg by mouth every 4-6 hours as needed (max 3,200 mg\/ day)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">5 days<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Short-term (less than one week)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adolescents 17 years or older, adults<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Infants, children, adolescents, and adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"conditions-treated-by-toradol-and-ibuprofen\"><span style=\"font-weight: 400;\">Conditions treated by Toradol and ibuprofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen may belong to the same major drug class, but they are quite different in how they are accessed and utilized.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Toradol is a prescription-only NSAID indicated for the short-term treatment of moderate or moderately severe pain that requires analgesia at the opioid level. It is also used off-label to treat migraines that have not been responsive to first-line treatments. Toradol treatment should begin with an intramuscular or intravenous dose or series of doses. This can be followed by oral therapy. It is important that the total duration of treatment with Toradol does not exceed 5 days at a time.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ibuprofen is both an over-the-counter (OTC) and prescription NSAID pain reliever used for a broader variety of conditions. These include mild to moderate pain, moderate to severe pain (as an adjunct to opioid treatment), arthritic conditions, dysmenorrhea, fever, and migraine. It is also used off-label in conditions such as frostbite, cystic fibrosis, gout, and pericarditis.\u00a0<\/span><\/p>\n<h2 id=\"is-toradol-or-ibuprofen-more-effective\"><span style=\"font-weight: 400;\">Is Toradol or ibuprofen more effective?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen have been compared directly for a few different indications. Researchers <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133820\/\"><span style=\"font-weight: 400;\">compared the efficacy<\/span><\/a><span style=\"font-weight: 400;\"> of a 5-day treatment of oral ibuprofen, ketorolac, and diclofenac for acute, in a clinical trial evaluating nonradicular lower back pain. Results were very similar between the three drugs, with no one drug showing a clear advantage in pain relief. The intravenous forms of both drugs were <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38849734\/\"><span style=\"font-weight: 400;\">compared in a separate trial<\/span><\/a><span style=\"font-weight: 400;\"> looking at perioperative pain control following open abdominal hysterectomy surgery. Patient satisfaction ratings were slightly higher in the ketorolac group, but pain scores were found to be similar.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While pain relief may be similar, Toradol and ibuprofen differ in their profile of adverse effects, especially <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23163547\/\"><span style=\"font-weight: 400;\">gastrointestinal effects<\/span><\/a><span style=\"font-weight: 400;\">. NSAIDs are known to cause gastrointestinal irritation and damage, and this effect appears to worsen with long-term and consistent use. Both Toradol and ibuprofen inhibit both the COX-1 and COX-2 pathways, with COX-1 receptors being much more predominant in the gastrointestinal tract. Despite that similarity, Toradol appears to be more harsh and linked to more damage to the intestinal tract than ibuprofen. This is one reason why Toradol use is specifically limited to 5 days at a time. Both drugs should be taken with food to help offset some of the acidity and irritation caused by these drugs. This could be an important factor when choosing between Toradol and ibuprofen for pain relief.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is not intended to be medical advice, and only your healthcare professional can decide which of these is right for you. They may take into account your ability to get a first-dose injection with Toradol, which is typically done in the provider\u2019s office. This is not necessary with ibuprofen. Another factor to consider is how long you expect treatment to be needed. Toradol must be discontinued after 5 days even if the pain has not been resolved. Ibuprofen can be used longer than 5 days, though you want to keep the duration as short as possible to avoid unwanted adverse events.<\/span><\/p>\n<h2 id=\"coverage-and-cost-comparison-of-toradol-vs-ibuprofen\"><span style=\"font-weight: 400;\">Coverage and cost comparison of Toradol vs. ibuprofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Prescription drug insurance plans do typically cover the generic version of Toradol, known as ketorolac, as well as ibuprofen. Plans may impose quantity limits per fill. For example, because Toradol is only to be used for 5 days, many plans will only cover 5 days at a time. Should another treatment be needed at a later time, a separate prescription refill would need to be filled. Both NSAID drugs are available generically and typically available on the lower copay tier. The price you pay may be affected by deductibles or other factors with your insurance plan.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Luckily, whether you are insured or uninsured, you can always find the lowest possible cash price of either drug at <\/span><a href=\"http:\/\/singlecare.com\"><span style=\"font-weight: 400;\">SingleCare.com<\/span><\/a><span style=\"font-weight: 400;\">. SingleCare will also let you know what <\/span><span style=\"font-weight: 400;\">Toradol<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">ibuprofen<\/span><span style=\"font-weight: 400;\"> cost at your nearby pharmacies up front. This saves you from calling or going door to door to find the best price.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Toradol vs. ibuprofen costs<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">20, 10 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 800 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typical Medicare copay<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$15+<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$5+<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$16<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$7<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"common-side-effects-of-toradol-vs-ibuprofen\"><span style=\"font-weight: 400;\">Common side effects of Toradol vs. ibuprofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen are both NSAID pain-relieving drugs. Because they belong to the same drug class, their side effects are similar but may vary in rate of occurrence and severity. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=337afb4f-789f-4cac-817a-e4286664a71e\"><span style=\"font-weight: 400;\">Toradol<\/span><\/a><span style=\"font-weight: 400;\"> comes with a boxed warning from the Food and Drug Administration (FDA) due to its risk for gastrointestinal bleeding, gastric perforation, and peptic ulcers. There is also a risk of cardiovascular thrombotic events due to the effect on blood platelets. This can lead to heart attacks and strokes, which can be fatal. Abdominal pain and dyspepsia are the adverse events that occur most commonly with Toradol use.<\/span><\/p>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=e17f9b41-cac3-5613-e053-2a95a90ab909\"><span style=\"font-weight: 400;\">Ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> carries a similar FDA-boxed warning for thrombotic events and gastrointestinal risks as Toradol. Nausea, abdominal pain, and heartburn are the most common side effects of ibuprofen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other side effects of NSAID drugs which can occur with either Toradol or ibuprofen use include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site irritation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rashes<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not intended to be a complete risk of all adverse events that can occur with Toradol or ibuprofen. You should consult your pharmacist or healthcare provider for more information.<\/span><\/p>\n<h2 id=\"drug-interactions-of-toradol-vs-ibuprofen\"><span style=\"font-weight: 400;\">Drug interactions of Toradol vs. ibuprofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen should be avoided with other NSAIDs as their concomitant use can increase the risk for serious adverse events. This can include aspirin, Aleve (naproxen), and diclofenac. NSAIDs should be used very cautiously with blood-thinning agents, as this can result in an inability to form blood clots when needed. This includes warfarin, aspirin, and heparin. NSAIDs can also diminish the effect of hypertensive medications such as ACE inhibitors, which could allow your blood pressure to increase. ACE-inhibitors include lisinopril, captopril, and fosinopril, to name a few.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If a patient is on a diuretic, specifically furosemide or hydrochlorothiazide, the effects of the diuretic may be decreased by Toradol and ibuprofen. Patients, especially those with a history of renal disease, should be monitored closely for renal failure. NSAIDs can increase lithium levels for patients taking lithium. Patients taking ketorolac in addition to medications for seizures may also experience an increase in seizure activity while on ketorolac.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This list of interactions is not intended to be all-inclusive. Please consult your prescriber or pharmacist for a complete list of potential drug interactions.<\/span><\/p>\n<h2 id=\"warnings-of-toradol-and-ibuprofen\"><span style=\"font-weight: 400;\">Warnings of Toradol and ibuprofen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The FDA\u2019s boxed warning for Toradol also encompasses warnings for patients with a history of bleeding disorders or who already have an active bleed. Giving Toradol in this condition is high risk and should be avoided. Patients who have renal impairment or a history of renal disease should not take Toradol. Toradol should not be used in labor and delivery due to adverse effects on fetal circulation and the inhibition of uterine contractions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">NSAIDs generally should be avoided in patients with renal dysfunction, including Toradol and ibuprofen. Make sure to tell your healthcare provider if you have a history of kidney disease. Before taking NSAIDs. Because some strengths of ibuprofen can be purchased without a prescription, be sure to read the label warnings completely before taking. NSAIDs can also lead to new or worsening hypertension, fluid retention, and skin reactions.\u00a0<\/span><\/p>\n<h2 id=\"frequently-asked-questions-about-toradol-vs-ibuprofen\"><span style=\"font-weight: 400;\">Frequently asked questions about Toradol vs. ibuprofen<\/span><\/h2>\n<h3 id=\"what-is-toradol\"><span style=\"font-weight: 400;\">What is Toradol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Toradol (ketorolac) is a prescription nonsteroidal anti-inflammatory drug indicated for the treatment of moderate to moderately severe pain requiring opioid analgesia.\u00a0<\/span><\/p>\n<h3 id=\"what-is-ibuprofen\"><span style=\"font-weight: 400;\">What is ibuprofen?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Ibuprofen is a generic nonsteroidal anti-inflammatory drug available both in prescription and OTC strengths. Ibuprofen has a broader range of approved uses including <\/span><span style=\"font-weight: 400;\">mild to moderate pain, moderate to severe pain (as an adjunct to opioid treatment), arthritic conditions, dysmenorrhea, fever, and migraines.\u00a0<\/span><\/p>\n<h3 id=\"are-toradol-and-ibuprofen-the-same\"><span style=\"font-weight: 400;\">Are Toradol and ibuprofen the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Toradol and ibuprofen are both nonsteroidal anti-inflammatory drugs, but they are not quite the same. Toradol is prescription only and is generally used for more moderate to severe pain. It can only be given orally following an intravenous or intramuscular administration. Ibuprofen can be accessed with or without a prescription and is generally used for mild to moderate pain conditions.<\/span><\/p>\n<h3 id=\"is-toradol-or-ibuprofen-better\"><span style=\"font-weight: 400;\">Is Toradol or ibuprofen better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Data from clinical studies suggests that Toradol and ibuprofen are similar in their ability to provide pain relief. Prescribers may consider other factors such as length of treatment needed or the ability to provide the first dose via injection when determining which medication is best for their patient.<\/span><\/p>\n<h3 id=\"can-i-use-toradol-or-ibuprofen-while-pregnant\"><span style=\"font-weight: 400;\">Can I use Toradol or ibuprofen while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">NSAID drugs are generally discouraged in pregnancy due to the platelet inhibition they cause and the risk of bleeding. NSAIDs can also negatively affect the renal health of the fetus. Toradol is contraindicated in the third trimester of pregnancy as well as during labor and delivery. Ibuprofen use is also contraindicated in the third trimester. Use of any NSAID prior to the third trimester should only be done if the benefits far outweigh the risks.\u00a0<\/span><\/p>\n<h3 id=\"can-i-use-toradol-or-ibuprofen-with-alcohol\"><span style=\"font-weight: 400;\">Can I use Toradol or ibuprofen with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">NSAID drugs like Toradol and ibuprofen are linked to an <\/span><a href=\"https:\/\/www.niaaa.nih.gov\/health-professionals-communities\/core-resource-on-alcohol\/alcohol-medication-interactions-potentially-dangerous-mixes#:~:text=Nonsteroidal%20anti%2Dinflammatory%20drugs%20(NSAIDs,alcohol%20significantly%20increases%20the%20risk.\"><span style=\"font-weight: 400;\">increased risk of gastrointestinal bleeding<\/span><\/a><span style=\"font-weight: 400;\">. Combining NSAIDs with alcohol increases that risk even more. In fact, just one drink per day while taking NSAIDs can increase your risk of GI bleeding by up to 37%.<\/span><\/p>\n<h3 id=\"what-is-the-otc-equivalent-of-toradol\"><span style=\"font-weight: 400;\">What is the OTC equivalent of Toradol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is no exact equivalent to Toradol available over the counter. However, some lower-dose NSAIDs are available without a prescription. These include Aleve (naproxen), Motrin or Advil (ibuprofen), and aspirin. 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Key takeaways Toradol and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs), but there are significant differences between the two drugs. Toradol is prescription only and used in moderate to moderately severe pain. It can only be given orally after at least one injectable dose, and total treatment [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-6659","post","type-post","status-publish","format-standard","hentry","category-wiki"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/6659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=6659"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/6659\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=6659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=6659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=6659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}