{"id":6679,"date":"2025-01-22T22:30:52","date_gmt":"2025-01-22T22:30:52","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-can-you-take-phentermine-and-wellbutrin-together-for-weight-loss-in-2025\/"},"modified":"2025-01-22T22:30:52","modified_gmt":"2025-01-22T22:30:52","slug":"hmn-can-you-take-phentermine-and-wellbutrin-together-for-weight-loss-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-can-you-take-phentermine-and-wellbutrin-together-for-weight-loss-in-2025\/","title":{"rendered":"HMN: Can you take phentermine and wellbutrin together for weight loss? in 2025"},"content":{"rendered":"<p> Do you know  Can you take phentermine and wellbutrin together for weight loss??<br \/>\n<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Wellbutrin (bupropion) is a brand-name antidepressant, while phentermine is a generic appetite suppressant that\u2019s approved for weight management in people with a high body mass index (BMI).<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Doctors may prescribe Wellbutrin with phentermine to people who have both depression and obesity, but careful monitoring is required.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Taking Wellbutrin and phentermine with each other may cause serious interactions, potentially raising the risk of seizures and serotonin syndrome.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label>In this article<\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Around 65% of adults in the United States say willpower alone is not enough to lose weight and keep it off with lifestyle changes, according to a Pew Research survey from 2024. That means there are millions of people looking to weight loss drugs for help. One such drug is <\/span><span style=\"font-weight: 400;\">phentermine<\/span><span style=\"font-weight: 400;\"> (brand name: <\/span><span style=\"font-weight: 400;\">Adipex<\/span><span style=\"font-weight: 400;\">). If you\u2019re taking <\/span><span style=\"font-weight: 400;\">Wellbutrin<\/span><span style=\"font-weight: 400;\"> (bupropion) for depression and are considering weight loss medication, you may wonder whether phentermine is safe.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s what you should know if you\u2019re considering taking both medications together.\u00a0<\/span><\/p>\n<h2 id=\"can-you-take-phentermine-and-wellbutrin-together-for-weight-loss\"><span style=\"font-weight: 400;\">Can you take phentermine and Wellbutrin together for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cIt is not recommended to combine phentermine and Wellbutrin together for weight management because there is a drug-drug interaction between the two agents,\u201d say <\/span><a href=\"https:\/\/www.ketchum.edu\/directory\/diana-roman\"><span style=\"font-weight: 400;\">Diana Roman, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.ketchum.edu\/directory\/miriam-morkos\"><span style=\"font-weight: 400;\">Miriam B. Morkos, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\"> of<\/span> <a href=\"https:\/\/www.ketchum.edu\/\"><span style=\"font-weight: 400;\">Marshall B. Ketchum University<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">More specifically, \u201cWellbutrin is associated with an increased seizure risk and should not be combined with other agents that may increase seizure risk, such as phentermine.\u201d It can also cause a condition called <\/span><span style=\"font-weight: 400;\">serotonin syndrome<\/span><span style=\"font-weight: 400;\">, which can be potentially life-threatening.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The problem for some people is that obesity and depression may occur simultaneously. Studies have demonstrated <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7449839\/\"><span style=\"font-weight: 400;\">a reciprocal connection<\/span><\/a><span style=\"font-weight: 400;\"> between major depressive disorder and weight gain. In fact, people with obesity have a 55% higher chance of developing depression, while people diagnosed with depression have a 58% higher chance of developing obesity, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20194822\/\"><span style=\"font-weight: 400;\">according to a study from 2020<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But according to <\/span><a href=\"https:\/\/www.medicalofficesofmanhattan.com\/our-team\/hannah-cohan-np\/\"><span style=\"font-weight: 400;\">Hannah Cohan<\/span><\/a><span style=\"font-weight: 400;\">, a board-certified nurse practitioner with the Medical Offices of Manhattan, \u201cIt\u2019s safer to explore other weight loss options, such as <\/span><span style=\"font-weight: 400;\">Zepbound<\/span><span style=\"font-weight: 400;\"> (tirzepatide) or <\/span><span style=\"font-weight: 400;\">Ozempic<\/span><span style=\"font-weight: 400;\"> (semaglutide), which can be used alongside Wellbutrin without the same risk of serotonin-related complications.\u201d <\/span><span style=\"font-weight: 400;\">Qsymia<\/span><span style=\"font-weight: 400;\"> (phentermine\/topiramate) and <\/span><span style=\"font-weight: 400;\">Contrave<\/span><span style=\"font-weight: 400;\"> (bupropion\/naltrexone) without Wellbutrin may be safer options purely for weight management.<\/span><\/p>\n<p><b>RELATED: <\/b><b>Contrave vs. phentermine<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Some people actually report <\/span><span style=\"font-weight: 400;\">weight loss while taking Wellbutrin<\/span><span style=\"font-weight: 400;\">, so if you give it some time, you may find that phentermine isn\u2019t necessary. Regardless, it\u2019s extremely important to consult a healthcare provider about the best options for any specific case of obesity or depression. And \u201cif a decision is made by a provider to combine the two agents, it is important to exercise caution and monitor therapy,\u201d say Drs. Roman and Morkos.<\/span><\/p>\n<h2 id=\"what-you-should-know-about-taking-wellbutrin-and-phentermine-together\"><span style=\"font-weight: 400;\">What you should know about taking Wellbutrin and phentermine together<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Even though there are specific instances when healthcare providers might prescribe Wellbutrin and phentermine together, they\u2019re usually not combined. That\u2019s because they can have some fairly serious drug interactions. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Increased risk of seizures: <\/b><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/018644s043lbl.pdf\"><span style=\"font-weight: 400;\">Wellbutrin\u2019s drug label<\/span><\/a><span style=\"font-weight: 400;\"> includes a warning that the drug is associated with seizures in 0.4% of people who take 450 mg per day\u2014and that can increase tenfold for people who take 600 mg per day. Phentermine can also cause seizures, so taking them together increases the risk, especially for anyone who has a preexisting seizure disorder.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Serotonin syndrome<\/b><span style=\"font-weight: 400;\">: \u201cWellbutrin works by increasing dopamine and norepinephrine levels in the brain, but can also affect serotonin indirectly,\u201d Cohan says. \u201cOn the other hand, phentermine is an appetite suppressant that works by increasing the release of norepinephrine and inhibiting serotonin uptake. When combined, the risk of serotonin syndrome, a potentially life-threatening condition, increases, as both medications can influence serotonin levels in the brain.\u201d<\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Serotonin might be the body\u2019s \u201cfeel good\u201d chemical, but <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/17687-serotonin-syndrome\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\"> may cause nausea, vomiting, diarrhea, and tremors when it\u2019s mild or high blood pressure, racing heart rate, seizures, and fainting when it\u2019s more severe.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is why it\u2019s absolutely crucial to only take phentermine and Wellbutrin together if a healthcare provider has prescribed it and they\u2019re monitoring your condition. Always consult with a healthcare provider about any medications or supplements you\u2019re currently taking before beginning treatment, and always follow their instructions exactly.<\/span><\/p>\n<h3 id=\"what-about-dosages\"><span style=\"font-weight: 400;\">What about dosages?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Most of the time, patients will not take these medications together. In those cases, the typical <\/span><span style=\"font-weight: 400;\">phentermine dosage<\/span><span style=\"font-weight: 400;\"> is 15\u201337.5 mg per day. The <\/span><span style=\"font-weight: 400;\">standard dosage for Wellbutrin<\/span><span style=\"font-weight: 400;\"> SR is 150 mg twice daily or 150\u2013300 mg once daily (in the morning) for the extended-release Wellbutrin XL. The exact dosage a healthcare provider prescribes will depend on the patient\u2019s specific condition, concurrent medications, medical history, and more.<\/span><\/p>\n<h2 id=\"side-effects-of-phentermine-and-wellbutrin\"><span style=\"font-weight: 400;\">Side effects of phentermine and Wellbutrin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Keep in mind that the risk of certain side effects of phentermine and Wellbutrin may be amplified if you take them together. It\u2019s good to evaluate each drug\u2019s adverse effects too, since some of them might be deal-breakers. For example, dry mouth, insomnia, headaches, and <\/span><span style=\"font-weight: 400;\">constipation<\/span><span style=\"font-weight: 400;\"> are common side effects of both <\/span><span style=\"font-weight: 400;\">Wellbutrin<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">phentermine<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"phentermine-and-wellbutrin-contraindications\"><span style=\"font-weight: 400;\">Phentermine and Wellbutrin contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are certain people who\u2014because of an existing condition, other medications, allergies, or life circumstances\u2014shouldn\u2019t take a medication. For example, Wellbutrin is contraindicated for anyone who is:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diagnosed with a seizure disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taking other drugs that contain bupropion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diagnosed with bulimia or anorexia nervosa<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Undergoing an abrupt discontinuation of alcohol or sedatives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taking a monoamine oxidase inhibitor (MAOI) or has taken one within 14 days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic to bupropion<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Phentermine is contraindicated for anyone who has or is:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of heart disease or heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taken a monoamine oxidase inhibitor (MAOI) in the past 14 days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperthyroidism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of drug abuse<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A hypersensitivity to the sympathomimetic amines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant or breastfeeding<\/span><\/li>\n<\/ul>\n<h3 id=\"other-warnings\"><span style=\"font-weight: 400;\">Other warnings<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Wellbutrin has a boxed warning, also called a <\/span><span style=\"font-weight: 400;\">black box warning<\/span><span style=\"font-weight: 400;\">, because of its potential for suicidal thoughts and behavior\u2014especially in children, teenagers, and young adults. Wellbutrin\u2019s label also warns of high blood pressure and seizures and recommends prescribing with caution for anyone who has renal or hepatic impairment. Alcohol may also interact with Wellbutrin, and the effects it can have on pregnancy are unclear.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But phentermine has its own set of warnings. It\u2019s \u201ca sympathomimetic agent chemically related to amphetamines, a drug known for its high abuse potential. Consequently, prolonged use of phentermine may increase the risk of developing drug dependency,\u201d Drs. Roman and Morkos say. That\u2019s why the Drug Enforcement Administration has classified it as a Schedule IV <\/span><a href=\"https:\/\/www.deadiversion.usdoj.gov\/schedules\/orangebook\/c_cs_alpha.pdf\"><span style=\"font-weight: 400;\">controlled substance<\/span><\/a><span style=\"font-weight: 400;\">. Plus, it may also cause primary pulmonary hypertension or valvular heart disease, which is why people with existing or previous cardiovascular conditions should avoid it. The <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d1d74574-9ebc-45fc-86e9-8cbd59acacd4\"><span style=\"font-weight: 400;\">drug label<\/span><\/a><span style=\"font-weight: 400;\"> also advises against <\/span><span style=\"font-weight: 400;\">drinking alcohol while taking phentermine<\/span><span style=\"font-weight: 400;\"> and says it may impair the ability to drive or operate machinery.<\/span><\/p>\n<h3 id=\"average-cost\"><span style=\"font-weight: 400;\">Average cost<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If your healthcare provider gives you a choice between these prescription drugs\u2014and the side effects, contraindications, and warnings aren\u2019t an issue\u2014then it might come down to price. Fortunately, neither drug is particularly pricey, and there are some steep discounts available.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The average out-of-pocket cost of phentermine is $51 for 30, 37.5mg tablets, while the average cost of Wellbutrin SR is $558 for 60, 150 mg tablets. But with SingleCare coupons, you can get a 30-day supply of phentermine for as low as $8, or a 30-day supply of generic bupropion SR for as low as $4.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"phentermine-vs-wellbutrin-comparison\"><span class=\"title\">Phentermine vs. Wellbutrin: Comparison<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anorectic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antidepressant<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage and forms<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15\u201337.5 mg once per day<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Wellbutrin SR: 150 mg twice daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin XL: 150\u2013300 mg once daily (in the morning)\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea\/vomiting<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Risks\/restrictions to consider<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">May lead to abuse or dependence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of hypoglycemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of cardiovascular issues<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of suicidal thoughts\/behaviors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of high blood pressure<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance*<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$51 for 30, 37.5mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$558 for 60, 150 mg tablets of brand-name Wellbutrin SR; $103 for generic bupropion HCL ER (SR)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare cost*<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Get coupon<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Get coupon<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Learn more<\/span><\/td>\n<td><span style=\"font-weight: 400;\">More phentermine details<\/span><\/td>\n<td><span style=\"font-weight: 400;\">More Wellbutrin details<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*Cost at the time of publication. Drug prices fluctuate and vary by location.<\/span><\/h5>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Taking phentermine with Wellbutrin is rarely a safe option since it can increase the risk of seizures and serotonin syndrome. But for certain people who have both major depressive disorder and obesity, this combination might be viable. Just be sure to consult your healthcare provider about your options, and always follow their directions exactly when taking either or both of these drugs for obesity management. <\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 8.2089 20.5098 8.05745C19.6147 7.90601 18.6945 8.05596 17.8938 8.48379C17.093 8.91162 16.4569 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