{"id":6685,"date":"2025-01-26T08:47:35","date_gmt":"2025-01-26T08:47:35","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-can-you-take-metformin-and-phentermine-together-in-2025\/"},"modified":"2025-01-26T08:47:35","modified_gmt":"2025-01-26T08:47:35","slug":"hmn-can-you-take-metformin-and-phentermine-together-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-can-you-take-metformin-and-phentermine-together-in-2025\/","title":{"rendered":"HMN: Can you take metformin and phentermine together? in 2025"},"content":{"rendered":"<p> Do you know  Can you take metformin and phentermine together??<br \/>\n<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Phentermine is an appetite suppressant that\u2019s FDA approved for weight loss. Metformin is FDA approved for treating Type 2 diabetes, although it\u2019s sometimes prescribed off-label for weight management.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Typically, phentermine and metformin aren\u2019t prescribed together unless an individual\u2019s obesity is related to diabetes, polycystic ovarian syndrome (PCOS), or metabolic syndrome.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Since both drugs can directly or indirectly affect blood glucose, they run the risk of causing hypoglycemia when taken together\u2014particularly by someone with otherwise normal blood sugar levels.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Which one works better for weight loss depends on your specific conditions and circumstances since they have different side effects, contraindications, drug interactions, warnings, and average prices.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label>In this article<\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Losing weight can be tough. And it can be even tougher for people who have Type 2 diabetes, which can impair weight loss. That\u2019s why it might seem natural to treat both obesity and diabetes simultaneously. For the past half-century, phentermine has been one of the most commonly prescribed weight loss drugs, and metformin has been one of the most popular diabetes medications\u2014and it\u2019s also prescribed off-label for weight reduction.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People who have been diagnosed with obesity and diabetes (or who just want faster results) might be wondering whether they can take them together to encourage weight loss. The answer isn\u2019t so simple. Here\u2019s what the experts say.<\/span><\/p>\n<h2 id=\"can-you-take-phentermine-and-metformin-together-for-weight-loss\"><span style=\"font-weight: 400;\">Can you take phentermine and metformin together for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You can take phentermine and metformin together, but there are limited situations when a healthcare provider would prescribe them together for weight loss.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWhile there are no drug-drug interactions between the two agents, the combination of metformin and phentermine is not one of the preferred or alternative agents formally indicated for weight management,\u201d say <\/span><a href=\"https:\/\/www.ketchum.edu\/directory\/diana-roman\"><span style=\"font-weight: 400;\">Diana Roman, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\"> and<\/span> <a href=\"https:\/\/www.ketchum.edu\/directory\/miriam-morkos\"><span style=\"font-weight: 400;\">Miriam B. Morkos, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\"> of<\/span> <a href=\"https:\/\/www.ketchum.edu\/\"><span style=\"font-weight: 400;\">Marshall B. Ketchum University<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That means it\u2019s usually only beneficial under close observation and when a person\u2019s obesity is complicated by another condition. \u201cI usually recommend a combination of metformin and phentermine for patients who have a combination of obesity with a body mass index (BMI) of more than 30 or a BMI of 27 with any of the following conditions: Type 2 diabetes, PCOS, or insulin resistance,\u201d says <\/span><a href=\"https:\/\/www.medicalofficesofmanhattan.com\/our-team\/dr-yoshua-quinones\/\"><span style=\"font-weight: 400;\">Yoshua Quinones, MD<\/span><\/a><span style=\"font-weight: 400;\">, board-certified internist with Medical Offices of Manhattan and contributor to <\/span><a href=\"https:\/\/www.labfinder.com\/\"><span style=\"font-weight: 400;\">LabFinder.com<\/span><\/a><span style=\"font-weight: 400;\">. \u201cMetformin will help with the cravings and sugar levels, while phentermine is an appetite suppressant.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s more on the conditions that may benefit from this combination therapy:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Type 2 diabetes<\/b><b>:<\/b><span style=\"font-weight: 400;\"> It\u2019s often best to treat obesity and Type 2 diabetes at the same time. <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413121006318\"><span style=\"font-weight: 400;\">Studies show<\/span><\/a><span style=\"font-weight: 400;\"> that obesity can trigger insulin resistance\u2014increasing the risk of developing Type 2 diabetes\u2014while <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7553667\/\"><span style=\"font-weight: 400;\">Type 2 diabetes can also contribute to obesity<\/span><\/a><span style=\"font-weight: 400;\">. If a patient has both and hasn\u2019t been able to lose weight with lifestyle changes, both medications might be necessary.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Polycystic ovary syndrome (PCOS)<\/b><span style=\"font-weight: 400;\">: This is a hormonal condition that affects women, and it can make the cells less responsive to insulin, <\/span><a href=\"https:\/\/www.cdc.gov\/diabetes\/risk-factors\/pcos-polycystic-ovary-syndrome.html\"><span style=\"font-weight: 400;\">causing insulin resistance<\/span><\/a><span style=\"font-weight: 400;\">. Studies have connected PCOS to an increased risk of both <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8984565\/\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2861983\/\"><span style=\"font-weight: 400;\">obesity<\/span><\/a><span style=\"font-weight: 400;\">, so it can be helpful to treat both insulin resistance and weight gain at the same time in patients with PCOS.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Metabolic syndrome:<\/b><span style=\"font-weight: 400;\"> This is actually <\/span><a href=\"https:\/\/www.nhlbi.nih.gov\/health\/metabolic-syndrome\"><span style=\"font-weight: 400;\">a group of conditions<\/span><\/a><span style=\"font-weight: 400;\">, which all can contribute to the development of Type 2 diabetes and cardiovascular disease. They include insulin resistance, high blood pressure (hypertension), obesity, high blood triglycerides, and low HDL cholesterol. Since it\u2019s a multi-faceted condition, metabolic syndrome might require a multi-pronged treatment approach.<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/academic.oup.com\/jcemcr\/article\/1\/1\/luac038\/6994175#\"><span style=\"font-weight: 400;\">One case study<\/span><\/a><span style=\"font-weight: 400;\"> examined the effects of phentermine, topiramate, metformin, and semaglutide on an adult male with severe obesity and prediabetes. When combined with a lower-calorie diet, the man saw a 32.5% reduction in total body weight. However, the researchers concluded that more research is necessary to evaluate combinations of weight loss medications.<\/span><\/p>\n<h3 id=\"what-about-dosages\"><span style=\"font-weight: 400;\">What about dosages?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cTo minimize the gastrointestinal side effects, I usually recommend starting with the lowest dose of metformin,\u201d Dr. Quinones says. He says that would be 500 mg once a day combined with 15 mg of phentermine. \u201cIf tolerated, we may go up in the dose. Metformin can go all the way to 2,000 mg a day and phentermine up to 37.5 mg per day.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The recommended dosage of metformin and phentermine can vary depending on the specific person, their conditions, and other circumstances. The most important thing is to always follow your healthcare provider\u2019s exact dosage instructions when taking both medications together.<\/span><\/p>\n<h2 id=\"taking-metformin-with-phentermine-side-effects-and-warnings\"><span style=\"font-weight: 400;\">Taking metformin with phentermine: Side effects and warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You\u2019ll notice that each of the conditions listed in the section above is related to insulin resistance and elevated blood glucose. In those cases, it\u2019s technically possible to take both drugs together since they both can lower blood sugar. For people who don\u2019t have one of the specific conditions listed above, however, taking phentermine and metformin together might cause certain side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPhentermine is a stimulant that releases norepinephrine, a neurotransmitter from the hypothalamus. This release in norepinephrine results in appetite suppression and satiety,\u201d Drs. Roman and Morkos say. This reduced weight and caloric intake <\/span><a href=\"https:\/\/pro.aace.com\/files\/obesity\/toolkit\/phentermine_patient_info.pdf\"><span style=\"font-weight: 400;\">may lower blood glucose<\/span><\/a><span style=\"font-weight: 400;\">. At the same time, \u201cMetformin decreases the production of glucose by the liver, a process called gluconeogenesis, and also decreases intestinal absorption of glucose and increases insulin sensitivity.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For people with otherwise normal glucose, this dual decrease in blood sugar may cause hypoglycemia. Characterized by abnormally low blood sugar, <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/diseases\/11647-hypoglycemia-low-blood-sugar\"><span style=\"font-weight: 400;\">hypoglycemia<\/span><\/a><span style=\"font-weight: 400;\"> can cause dizziness, confusion, increased heart rate, shaking, sweating, chills, and anxiety. In extreme cases, it can be life-threatening, leading to seizures, loss of consciousness, disorientation, and blurred vision. That\u2019s why <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/085128s065lbl.pdf\"><span style=\"font-weight: 400;\">phentermine\u2019s label<\/span><\/a><span style=\"font-weight: 400;\"> lists insulin and oral hypoglycemic drugs under its interactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For this reason, anyone taking phentermine and metformin should monitor their blood sugar carefully and follow their healthcare provider\u2019s instructions exactly. If you experience any symptoms of hypoglycemia while taking these drugs together, consult your healthcare provider immediately. And always inform your healthcare provider about any other medical conditions you have or other drugs and supplements you\u2019re taking to avoid interactions with <\/span><span style=\"font-weight: 400;\">phentermine<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">metformin<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"is-metformin-or-phentermine-better-for-weight-loss\"><span style=\"font-weight: 400;\">Is metformin or phentermine better for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279038\/\"><span style=\"font-weight: 400;\">a roundup of studies examining the effectiveness<\/span><\/a><span style=\"font-weight: 400;\"> of various weight loss medications, phentermine patients saw an average 4.4% weight loss over 28 weeks\u2014although doctors might not always prescribe it for that long. Metformin, when prescribed to people without diabetes or prediabetes, only showed an average weight loss of around 2%. That said, there are a few factors that may determine which of these two is better for particular situations.<\/span><\/p>\n<h3 id=\"drug-class\"><span style=\"font-weight: 400;\">Drug class<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both drugs might help you lose weight, but only phentermine is approved by the Food and Drug Administration as a weight loss drug. Metformin is only approved for Type 2 diabetes, although some people also lose weight while taking it. Per Drs. Roman and Morkos, \u201cmetformin is considered a weight-neutral agent but can cause modest weight loss; thus, metformin may be used \u2018off-label\u2019 by some clinicians for weight loss if the more preferred agents are not affordable or not appropriate for a specific patient.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So for someone who just wants to lose weight, phentermine might be the better choice. But for someone whose obesity stems from Type 2 diabetes, metformin might be more helpful.<\/span><\/p>\n<h3 id=\"side-effects\"><span style=\"font-weight: 400;\">Side effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Phentermine and metformin each have possible adverse effects that might determine whether they\u2019re viable or desirable for certain people. Some of the most common <\/span><span style=\"font-weight: 400;\">side effects of phentermine<\/span><span style=\"font-weight: 400;\"> are dry mouth, insomnia, headaches, dizziness, and constipation. A few of <\/span><span style=\"font-weight: 400;\">metformin\u2019s most common side effects<\/span><span style=\"font-weight: 400;\"> include diarrhea, nausea, vomiting, flatulence, weakness, indigestion, and abdominal discomfort.<\/span><\/p>\n<h3 id=\"contraindications\"><span style=\"font-weight: 400;\">Contraindications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For certain populations, taking one of these drugs might actually be dangerous, as they each have contraindications. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=ff620c0b-aa99-4f63-9526-d094cedc8d19&amp;type=display\"><span style=\"font-weight: 400;\">Phentermine\u2019s contraindications<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of heart disease or heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Currently taking or have taken a monoamine oxidase inhibitor (MAOI) in the past 14 days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperthyroidism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Uncontrolled anxiety or agitated state<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of drug abuse<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A hypersensitivity to the sympathomimetic amines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy (since weight loss may harm the fetus)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding (since it\u2019s unclear if phentermine is excreted in human milk)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">And patients <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/lookup.cfm?setid=2c6eb3db-d27e-4b25-b5f3-2a4473dae97f\"><span style=\"font-weight: 400;\">should not take metformin if they have<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe renal impairment<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypersensitivity to metformin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acute or chronic metabolic acidosis<\/span><\/li>\n<\/ul>\n<h3 id=\"other-warnings\"><span style=\"font-weight: 400;\">Other warnings<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Phentermine is classified by the Drug Enforcement Administration as a <\/span><a href=\"https:\/\/www.deadiversion.usdoj.gov\/schedules\/orangebook\/orangebook.pdf\"><span style=\"font-weight: 400;\">Schedule IV controlled substance<\/span><\/a><span style=\"font-weight: 400;\"> because of its similarity to amphetamines and its risk of dependence and misuse. It\u2019s typically only prescribed short-term.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Plus, \u201clike any other stimulant, phentermine may cause cardiovascular side effects, which include an increase in heart rate, blood pressure, and heart arrhythmia,\u201d Dr. Quinones says. \u201cThis is why it\u2019s important to talk to your primary care doctor about risks and benefits.\u201d The drug label also advises against drinking alcohol while taking phentermine and says it may impair the ability to drive or operate machinery.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metformin, in rare cases, may <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9368510\/\"><span style=\"font-weight: 400;\">cause a condition called lactic acidosis<\/span><\/a><span style=\"font-weight: 400;\">, in which the body produces more lactic acid than it can process. In severe cases, this condition can be life-threatening. However, this occurs primarily <\/span><a href=\"https:\/\/www.fda.gov\/media\/96771\/download\"><span style=\"font-weight: 400;\">in patients with severe renal impairment<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"average-cost\"><span style=\"font-weight: 400;\">Average cost<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Neither drug is extremely expensive, but all other things equal, even small differences in price can make one medication more appealing to some. The average out-of-pocket cost of phentermine is $51 for 30, 37.5 mg tablets, while metformin\u2019s average price is $170 for 60, 500 mg tablets.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With free SingleCare coupons, however, you can get a 30-day supply of phentermine for as low as $8, or a 30-day supply of metformin for $4.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"metformin-vs-phentermine-comparison\"><span class=\"title\">Metformin vs. phentermine: Comparison<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Biguanide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anorectic<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage and forms<\/span><\/td>\n<td><span style=\"font-weight: 400;\">850\u20131,000 mg twice per day, or 1,000\u20132,000 mg per day for extended-release<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15\u201337.5 mg once per day<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headaches<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Risks\/restrictions to consider<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of lactic acidosis\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastrointestinal issues<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Not for people with severe kidney impairment<\/span><\/li>\n<\/ul>\n<\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\"> May lead to abuse or dependence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Increased risk of hypoglycemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">\u00a0Increased risk of cardiovascular issues<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$170 for 60, 500 mg tablets.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$51 for 30, 37.5 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare coupon<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Get coupon<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Get coupon<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Learn more<\/span><\/td>\n<td><span style=\"font-weight: 400;\">More metformin details<\/span><\/td>\n<td><span style=\"font-weight: 400;\">More phentermine details<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Phentermine and metformin are two drugs that can help patients lose weight, although they aren\u2019t always the best combination. For anyone who has obesity coupled with Type 2 diabetes, PCOS, metabolic syndrome, or another condition that causes insulin resistance, healthcare providers might prescribe them together. For others, the combination of phentermine and metformin could cause severe side effects, so you should only take them together when prescribed and monitored by a healthcare provider.\u00a0<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 8.2089 20.5098 8.05745C19.6147 7.90601 18.6945 8.05596 17.8938 8.48379C17.093 8.91162 16.4569 9.59313 16.0852 10.4214C15.7135 11.2497 15.6273 12.178 15.84 13.0606C14.2094 12.9781 12.6144 12.5536 11.1587 11.8145C9.70287 11.0754 8.41885 10.0383 7.39 8.7706C7.02914 9.40077 6.83952 10.1144 6.84 10.8406C6.83872 11.515 7.00422 12.1792 7.32176 12.7742C7.63929 13.3691 8.09902 13.8763 8.66 14.2506C8.00798 14.2329 7.36989 14.0579 6.8 13.7406V13.7906C6.80489 14.7355 7.13599 15.6497 7.73731 16.3786C8.33864 17.1074 9.17326 17.6062 10.1 17.7906C9.74326 17.8992 9.37288 17.9564 9 17.9606C8.74189 17.9576 8.48442 17.9342 8.23 17.8906C8.49391 18.7034 9.00462 19.4137 9.69107 19.9228C10.3775 20.4318 11.2056 20.7142 12.06 20.7306C10.6172 21.8659 8.83588 22.4855 7 22.4906C6.66574 22.4917 6.33174 22.4717 6 22.4306C7.87443 23.6409 10.0588 24.2833 12.29 24.2806C13.8297 24.2966 15.3571 24.0056 16.7831 23.4247C18.2091 22.8437 19.505 21.9845 20.5952 20.8971C21.6854 19.8097 22.548 18.516 23.1326 17.0915C23.7172 15.667 24.012 14.1403 24 12.6006C24 12.4306 24 12.2506 24 12.0706C24.7847 11.4854 25.4615 10.768 26 9.9506Z\"\/>\n  <\/g>\n  <g id=\"linkedin\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M10.4092 25.75H6.08646V13.1473H10.4092V25.75ZM8.24784 11.3829C7.65167 11.3829 7.07993 11.1528 6.65838 10.7431C6.23682 10.3335 6 9.77783 6 9.19847C6 8.61911 6.23682 8.06349 6.65838 7.65382C7.07993 7.24415 7.65167 7.014 8.24784 7.014C8.5644 6.97911 8.88498 7.0096 9.18858 7.10346C9.49218 7.19732 9.77196 7.35244 10.0096 7.55867C10.2472 7.76489 10.4374 8.01757 10.5675 8.30015C10.6977 8.58274 10.765 8.88886 10.765 9.19847C10.765 9.50808 10.6977 9.8142 10.5675 10.0968C10.4374 10.3794 10.2472 10.632 10.0096 10.8383C9.77196 11.0445 9.49218 11.1996 9.18858 11.2935C8.88498 11.3873 8.5644 11.4178 8.24784 11.3829ZM26 25.75H21.6772V18.9866C21.6772 17.2922 21.0576 16.186 19.487 16.186C19.001 16.1894 18.5276 16.3376 18.1309 16.6105C17.7341 16.8834 17.433 17.2679 17.268 17.7123C17.1553 18.0414 17.1064 18.388 17.1239 18.7345V25.736H12.8012C12.8012 25.736 12.8012 14.2816 12.8012 13.1333H17.1239V14.9117C17.5166 14.2495 18.0878 13.704 18.7759 13.3338C19.4639 12.9637 20.2429 12.783 21.0288 12.8112C23.9107 12.8112 26 14.6176 26 18.4965V25.75Z\"\/>\n  <\/g>\n  <g id=\"share\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M21.4994 23.9007H8.47991V10.9629H11.8416C12.6131 9.96349 13.5086 9.14204 14.5419 8.49857H7.9977C6.89552 8.49857 6 9.38848 6 10.4837V24.3799C6 25.4752 6.89552 26.3651 7.9977 26.3651H21.9816C23.0838 26.3651 23.9793 25.4752 23.9793 24.3799V14.2898L21.4994 16.1175V23.9007Z\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M10.0574 22.2921C12.9437 14.4472 17.4696 12.8249 19.7704 12.5305V15.8574L26.4524 10.9287L19.7704 6V8.10154C9.04478 9.01198 10.0574 22.2921 10.0574 22.2921Z\"\/>\n  <\/g>\n  <g id=\"youtube\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M16.0644 9H16.1756C17.2032 9.00375 22.4098 9.04125 23.8136 9.41878C24.238 9.53399 24.6247 9.75858 24.9351 10.0701C25.2455 10.3816 25.4688 10.7691 25.5825 11.1939C25.7087 11.6689 25.7975 12.2977 25.8575 12.9465L25.87 13.0765L25.8975 13.4015L25.9075 13.5315C25.9888 14.6741 25.9988 15.7442 26 15.9779V16.0717C25.9988 16.3142 25.9875 17.4568 25.8975 18.6469L25.8875 18.7781L25.8762 18.9081C25.8137 19.6232 25.7212 20.3332 25.5825 20.8557C25.4691 21.2807 25.246 21.6684 24.9355 21.98C24.6251 22.2915 24.2382 22.516 23.8136 22.6309C22.3635 23.0209 16.8519 23.0484 16.0881 23.0496H15.9106C15.5243 23.0496 13.9267 23.0421 12.2516 22.9846L12.0391 22.9771L11.9304 22.9721L11.7166 22.9634L11.5028 22.9546C10.1153 22.8934 8.79392 22.7946 8.18514 22.6296C7.76072 22.5148 7.37392 22.2906 7.06347 21.9792C6.75303 21.6679 6.52984 21.2805 6.41628 20.8557C6.27752 20.3345 6.18501 19.6232 6.12251 18.9081L6.11251 18.7769L6.10251 18.6469C6.04081 17.7998 6.00663 16.951 6 16.1017L6 15.9479C6.0025 15.6792 6.0125 14.7504 6.08001 13.7253L6.08876 13.5965L6.09251 13.5315L6.10251 13.4015L6.13001 13.0765L6.14251 12.9465C6.20251 12.2977 6.29127 11.6677 6.41753 11.1939C6.5309 10.7689 6.754 10.3812 7.06446 10.0697C7.37492 9.75811 7.76182 9.53365 8.18639 9.41878C8.79517 9.25627 10.1165 9.15626 11.5041 9.09376L11.7166 9.08501L11.9316 9.07751L12.0391 9.07375L12.2529 9.065C13.4426 9.02672 14.6328 9.00547 15.8231 9.00125H16.0644V9ZM14.0005 13.0128V19.0356L19.1971 16.0254L14.0005 13.0128Z\"\/>\n  <\/g>\n  <g id=\"instagram\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M21.34 9.46C21.1027 9.46 20.8707 9.53038 20.6733 9.66224C20.476 9.79409 20.3222 9.98151 20.2313 10.2008C20.1405 10.4201 20.1168 10.6613 20.1631 10.8941C20.2094 11.1269 20.3236 11.3407 20.4915 11.5085C20.6593 11.6764 20.8731 11.7906 21.1059 11.8369C21.3387 11.8832 21.5799 11.8595 21.7992 11.7687C22.0185 11.6778 22.2059 11.524 22.3378 11.3267C22.4696 11.1293 22.54 10.8973 22.54 10.66C22.54 10.3417 22.4136 10.0365 22.1885 9.81147C21.9635 9.58643 21.6583 9.46 21.34 9.46ZM25.94 11.88C25.9206 11.0503 25.7652 10.2294 25.48 9.45C25.2257 8.78313 24.83 8.17928 24.32 7.68C23.8248 7.16743 23.2196 6.77418 22.55 6.53C21.7727 6.23616 20.9508 6.07721 20.12 6.06C19.06 6 18.72 6 16 6C13.28 6 12.94 6 11.88 6.06C11.0492 6.07721 10.2273 6.23616 9.45 6.53C8.78168 6.77665 8.17693 7.16956 7.68 7.68C7.16743 8.17518 6.77418 8.78044 6.53 9.45C6.23616 10.2273 6.07721 11.0492 6.06 11.88C6 12.94 6 13.28 6 16C6 18.72 6 19.06 6.06 20.12C6.07721 20.9508 6.23616 21.7727 6.53 22.55C6.77418 23.2196 7.16743 23.8248 7.68 24.32C8.17693 24.8304 8.78168 25.2234 9.45 25.47C10.2273 25.7638 11.0492 25.9228 11.88 25.94C12.94 26 13.28 26 16 26C18.72 26 19.06 26 20.12 25.94C20.9508 25.9228 21.7727 25.7638 22.55 25.47C23.2196 25.2258 23.8248 24.8326 24.32 24.32C24.8322 23.8226 25.2283 23.2182 25.48 22.55C25.7652 21.7706 25.9206 20.9497 25.94 20.12C25.94 19.06 26 18.72 26 16C26 13.28 26 12.94 25.94 11.88ZM24.14 20C24.1327 20.6348 24.0178 21.2637 23.8 21.86C23.6403 22.2952 23.3839 22.6884 23.05 23.01C22.7256 23.3405 22.3332 23.5964 21.9 23.76C21.3037 23.9778 20.6748 24.0927 20.04 24.1C19.04 24.15 18.67 24.16 16.04 24.16C13.41 24.16 13.04 24.16 12.04 24.1C11.3809 24.1123 10.7246 24.0109 10.1 23.8C9.68578 23.6281 9.31136 23.3728 9 23.05C8.66809 22.7287 8.41484 22.3352 8.26 21.9C8.01586 21.2952 7.88044 20.6519 7.86 20C7.86 19 7.8 18.63 7.8 16C7.8 13.37 7.8 13 7.86 12C7.86448 11.3511 7.98295 10.7079 8.21 10.1C8.38605 9.67791 8.65626 9.30166 9 9C9.30381 8.65617 9.67929 8.3831 10.1 8.2C10.7096 7.98004 11.352 7.86508 12 7.86C13 7.86 13.37 7.8 16 7.8C18.63 7.8 19 7.8 20 7.86C20.6348 7.86728 21.2637 7.98225 21.86 8.2C22.3144 8.36865 22.7223 8.64285 23.05 9C23.3777 9.30718 23.6338 9.68273 23.8 10.1C24.0223 10.7089 24.1373 11.3518 24.14 12C24.19 13 24.2 13.37 24.2 16C24.2 18.63 24.19 19 24.14 20ZM16 10.87C14.9858 10.872 13.995 11.1745 13.1527 11.7394C12.3103 12.3043 11.6544 13.1062 11.2676 14.0438C10.8809 14.9813 10.7807 16.0125 10.9798 17.0069C11.1789 18.0014 11.6682 18.9145 12.3861 19.631C13.1039 20.3474 14.018 20.835 15.0129 21.0321C16.0077 21.2293 17.0387 21.1271 17.9755 20.7385C18.9123 20.35 19.7129 19.6924 20.2761 18.849C20.8394 18.0056 21.14 17.0142 21.14 16C21.1413 15.3251 21.0092 14.6566 20.7512 14.033C20.4933 13.4093 20.1146 12.8428 19.6369 12.3661C19.1592 11.8893 18.5919 11.5117 17.9678 11.2549C17.3436 10.9982 16.6749 10.8674 16 10.87ZM16 19.33C15.3414 19.33 14.6976 19.1347 14.15 18.7688C13.6023 18.4029 13.1755 17.8828 12.9235 17.2743C12.6714 16.6659 12.6055 15.9963 12.734 15.3503C12.8625 14.7044 13.1796 14.111 13.6453 13.6453C14.111 13.1796 14.7044 12.8625 15.3503 12.734C15.9963 12.6055 16.6659 12.6714 17.2743 12.9235C17.8828 13.1755 18.4029 13.6023 18.7688 14.15C19.1347 14.6976 19.33 15.3414 19.33 16C19.33 16.4373 19.2439 16.8703 19.0765 17.2743C18.9092 17.6784 18.6639 18.0454 18.3547 18.3547C18.0454 18.6639 17.6784 18.9092 17.2743 19.0765C16.8703 19.2439 16.4373 19.33 16 19.33Z\"\/>\n  <\/g>\n<\/svg>\t\t\t\t\t\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Do you know Can you take metformin and phentermine together?? Key takeaways Phentermine is an appetite suppressant that\u2019s FDA approved for weight loss. Metformin is FDA approved for treating Type 2 diabetes, although it\u2019s sometimes prescribed off-label for weight management. Typically, phentermine and metformin aren\u2019t prescribed together unless an individual\u2019s obesity is related to diabetes, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6685","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/6685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=6685"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/6685\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=6685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=6685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=6685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}