{"id":6879,"date":"2025-02-03T11:21:09","date_gmt":"2025-02-03T11:21:09","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-side-effects-in-2025-3\/"},"modified":"2025-12-23T14:46:14","modified_gmt":"2025-12-23T14:46:14","slug":"hmn-caplyta-latuda-differences-similarities-side-effects-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-caplyta-latuda-differences-similarities-side-effects-in-2025\/","title":{"rendered":"HMN: Caplyta  , Latuda Differences, similarities &#038; side effects in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, similarities &#038; side effects in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Caplyta contains the active ingredient lumateperone and is used to treat schizophrenia and bipolar depression in adults, including both bipolar I and bipolar II disorder. Latuda (lurasidone) is approved for use in adults and can also be used in pediatric patients for some indications. It is used to treat schizophrenia and bipolar depression but is only FDA approved for bipolar I disorder.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Caplyta is an oral capsule and can be taken with or without food. Caplyta is available as a brand-name drug only. Latuda is an oral tablet that must be taken with at least 350 calories of food to ensure proper absorption. Latuda is available in both brand-name and generic formulations.\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Both Caplyta and Latuda have similar side effects, drug interactions, and warnings. It\u2019s important to consult your healthcare provider for more information and medical advice about your condition and treatment.\u00a0<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Caplyta (lumateperone) and <\/span><span style=\"font-weight: 400;\">Latuda<\/span><span style=\"font-weight: 400;\"> (lurasidone) are brand-name second-generation antipsychotics. Both medicines are approved by the Food and Drug Administration (FDA) to treat schizophrenia and bipolar depression. Because they belong to the same class of drugs, they work the same way\u2014by blocking certain dopamine and serotonin receptors and activating other receptors. Although Caplyta and Latuda are both classified as second-generation antipsychotics, they are not exactly the same. These medicines have some similarities, and some differences, too. Continue reading to learn more about Caplyta and Latuda.<\/span><\/p>\n<h2 id=\"caplyta-vs-latuda-key-differences\"><span style=\"font-weight: 400;\">Caplyta vs. Latuda: Key differences<\/span><\/h2>\n<p><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/24692-antipsychotic-medications\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Antipsychotic medications<\/span><\/a><span style=\"font-weight: 400;\"> are used to treat conditions related to psychosis (a group of symptoms involving a disconnection from reality), such as <\/span><span style=\"font-weight: 400;\">schizophrenia<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">bipolar disorder<\/span><span style=\"font-weight: 400;\">, delirium, and other mental health conditions. These medications are generally prescribed by psychiatrists. There are two types of antipsychotics:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>First-generation antipsychotics<\/b><span style=\"font-weight: 400;\">, also known as <\/span><span style=\"font-weight: 400;\">typical antipsychotics<\/span><span style=\"font-weight: 400;\">, were the first types of antipsychotic medicines to be developed. These drugs, which include Haldol (<\/span><span style=\"font-weight: 400;\">haloperidol<\/span><span style=\"font-weight: 400;\">) and others, are not as commonly used to treat psychosis due to their side effects now that newer drugs with less extensive side effects are available.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Second-generation antipsychotics<\/b><span style=\"font-weight: 400;\">, or <\/span><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><span style=\"font-weight: 400;\">, are now the preferred drugs for the treatment of psychosis because they have fewer side effects than first-generation antipsychotics. In addition to Caplyta and Latuda, drugs in this class include <\/span><span style=\"font-weight: 400;\">Abilify<\/span><span style=\"font-weight: 400;\"> (aripiprazole), <\/span><span style=\"font-weight: 400;\">Geodon<\/span><span style=\"font-weight: 400;\"> (ziprasidone), <\/span><span style=\"font-weight: 400;\">Risperdal<\/span><span style=\"font-weight: 400;\"> (risperidone), Zyprexa (<\/span><span style=\"font-weight: 400;\">olanzapine<\/span><span style=\"font-weight: 400;\">), <\/span><span style=\"font-weight: 400;\">Rexulti<\/span><span style=\"font-weight: 400;\"> (brexpiprazole), Saphris (asenapine), <\/span><span style=\"font-weight: 400;\">Seroquel<\/span><span style=\"font-weight: 400;\"> (quetiapine), <\/span><span style=\"font-weight: 400;\">Vraylar<\/span><span style=\"font-weight: 400;\"> (cariprazine), and others.<\/span><\/li>\n<\/ul>\n<p><b> <\/b><b>Latuda vs. risperidone<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Caplyta is a brand-name drug with no generic version available. Latuda is available in brand name as well as generic lurasidone. Caplyta is FDA approved for use in adult patients only. In contrast, Latuda can be used in adults as well as older children and adolescents, depending on the use. While Caplyta can be taken with or without food, Latuda should always be taken with food\u2014at least 350 calories\u2014for optimal absorption.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-caplyta-vs-latuda-key-differences\"><span class=\"title\">Compare Caplyta vs. Latuda key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is lumateperone, but there is no generic available.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Lurasidone\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral capsules: <\/span><span style=\"font-weight: 400;\">10.5 mg, 21 mg, and 42 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets: <\/span><span style=\"font-weight: 400;\">20 mg, 40 mg, 60 mg, 80 mg, and 120 mg<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">42 mg by mouth once daily<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Schizophrenia: 40 to 160 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bipolar depression: 20 to 120 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Latuda should always be taken with at least 350 calories of food for optimal absorption.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults and adolescents 13\u201317 years old for schizophrenia<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adults and pediatric patients 10\u201317 years old for bipolar depression<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"caplyta-vs-latuda-conditions-treated\"><span style=\"font-weight: 400;\">Caplyta vs. Latuda: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both medications are approved by the FDA for the treatment of <\/span><span style=\"font-weight: 400;\">schizophrenia<\/span><span style=\"font-weight: 400;\"> as well as bipolar depression. For bipolar depression, either drug can be used alone (this is called monotherapy) or along with a mood stabilizer such as lithium or divalproex (this is called adjunctive, or add-on, therapy). Note that Caplyta is FDA approved for bipolar I or <\/span><span style=\"font-weight: 400;\">bipolar II<\/span><span style=\"font-weight: 400;\"> disorder, while Latuda is FDA approved for bipolar I disorder.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-caplyta-vs-latuda-conditions-treated\"><span class=\"title\">Compare Caplyta vs. Latuda conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Schizophrenia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults only)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults and adolescents 13\u201317 years old)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Depressive episodes associated with bipolar\u00a0 disorder (bipolar depression)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults only) for <\/span><span style=\"font-weight: 400;\">bipolar I or bipolar II disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (for use in adults and pediatric patients 10\u201317 years when used as the only treatment; for use in adults only when used along with lithium or divalproex\/valproate); for bipolar I disorder\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"is-latuda-better-than-caplyta\"><span style=\"font-weight: 400;\">Is Latuda better than Caplyta?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is no data directly comparing the two drugs. However, a <\/span><a href=\"https:\/\/www.cambridge.org\/core\/journals\/european-psychiatry\/article\/efficacy-and-tolerability-of-fdaapproved-atypical-antipsychotics-for-the-treatment-of-bipolar-depression-a-systematic-review-and-network-metaanalysis\/9DEFC4464EBB6E4730A1D89654C6F2AB\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">review<\/span><\/a><span style=\"font-weight: 400;\"> of many clinical studies looked at five atypical antipsychotics, including Caplyta and Latuda, among others. The researchers found that all five antipsychotics were more effective than placebo (inactive medicine). Latuda ranked second, and Caplyta ranked third in terms of efficacy. Caplyta had higher rates of sleepiness as a side effect than Latuda. However, Caplyta was associated with lower rates of weight gain than placebo and the other antipsychotics. Caplyta was ranked second for best-tolerated medication, and Latuda was ranked third.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Only a healthcare provider can determine the best treatment option for your condition, considering individual factors such as symptoms, medical conditions, medical and family history, potential side effects, and drug interactions.\u00a0<\/span><\/p>\n<h2 id=\"caplyta-vs-latuda-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Caplyta vs. Latuda: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most commercial health insurance plans and Medicare prescription plans offer coverage for Caplyta and Latuda. However, copays and out-of-pocket costs will vary by plan. Insurance plans generally charge less for generic drugs, so lurasidone is likely to be more affordable than Latuda. Choosing the brand-name drug may result in a higher cost, or it may not be covered at all. You can contact your insurance plan for the most recent information on pricing estimates of each medication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For people without insurance, a one-month supply of Caplyta costs about $2,144. However, you can use a free <\/span><span style=\"font-weight: 400;\"> prescription discount card<\/span><span style=\"font-weight: 400;\"> to pay a lower cost of $1,608 monthly.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Without insurance, a one-month supply of brand-name Latuda will cost about $1,859 out of pocket. However, using a free <\/span><span style=\"font-weight: 400;\"> coupon<\/span><span style=\"font-weight: 400;\"> will drop the cost to about $1,374, depending on the pharmacy. You\u2019ll pay as little as $20 if your healthcare provider prescribes generic lurasidone instead of Latuda.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-caplyta-vs-latuda-cost-coverage\"><span class=\"title\">Compare Caplyta vs. Latuda cost &amp; coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 42 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 20 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b> cost*<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$1,700<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1,374 for brand-name Latuda; $19 for generic lurasidone<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">* Cost at the time of publication. Drug costs fluctuate and vary by pharmacy.<\/span><\/p>\n<h2 id=\"caplyta-vs-latuda-side-effects\"><span style=\"font-weight: 400;\">Caplyta vs. Latuda side effects<\/span><\/h2>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534115\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Extrapyramidal symptoms<\/span><\/a><span style=\"font-weight: 400;\"> (EPS) are a group of movement disorders often caused by antipsychotic drugs. There are various types of movement problems, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dystonia<\/b><span style=\"font-weight: 400;\">: Involuntary muscle contractions resulting in abnormal posture and repetitive movements. Dystonia can affect the back, pelvis, stomach, neck, jaw, eyes, face, and tongue.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Akathisia: <\/b><span style=\"font-weight: 400;\">A feeling of restlessness and an urge to move. People with akathisia may cross their legs repetitively or shift back and forth from one foot to the other.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Parkinsonism<\/b><span style=\"font-weight: 400;\">: Symptoms of Parkinsonism may include shaking, stiffness, a slow and shuffling gait, stooped posture, imbalance, and difficulty standing up from a sitting position.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tardive dyskinesia (TD)<\/b><span style=\"font-weight: 400;\">: Involuntary movements that affect the face and tongue, like grimacing, lip smacking, and blinking.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Common side effects of Caplyta include sleepiness, dizziness, dry mouth, and nausea. Caplyta can also cause fertility problems in both males and females. You should consult your healthcare provider if this is a concern.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects of Latuda include nausea, vomiting, drowsiness, and EPS. Latuda can also increase prolactin levels. This may cause men to have swollen breast tissue or erectile dysfunction. In women, this may cause breast milk secretion, even in those who are not breastfeeding. It may also cause your menstrual cycle to go away.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Less often, serious side effects may occur. Individuals with symptoms of an allergic reaction, such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat, should seek emergency medical attention.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The table below provides more information about side effects. Note that for Latuda, the frequency is a range, which can vary by dose. This is not a full list of side effects, and others may occur. Consult your healthcare provider or pharmacist for more information about side effects.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-caplyta-vs-latuda-side-effects\"><span class=\"title\">Compare Caplyta vs. Latuda side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7\u201311%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">EPS<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies by condition, from 1.3 to 6.7%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6\u201322%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7\u201313%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6\u20139%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness or sedation\u00a0\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">24%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8\u201326%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4\u20136%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dry mouth\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4\u20136%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Agitation\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3\u201310%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Anxiety<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3\u20137%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=db730b06-6351-47fd-8183-e61e61bbead5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Caplyta<\/span><\/a><span style=\"font-weight: 400;\"> (DailyMed), <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=afad3051-9df2-4c54-9684-e8262a133af8\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Latuda<\/span><\/a><span style=\"font-weight: 400;\"> (DailyMed)<\/span><\/p>\n<h2 id=\"caplyta-and-latuda-drug-interactions\"><span style=\"font-weight: 400;\">Caplyta and Latuda drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Caplyta or Latuda, tell your healthcare provider about all the medications you take, including prescription medications, over-the-counter drugs, vitamins, and supplements. Certain medications can affect how Caplyta and Latuda are processed in the body, and Caplyta and Latuda can affect other medications. Some drugs should be avoided, while others may require a dosage adjustment. You should also avoid grapefruit and grapefruit juice while taking Caplyta and Latuda. Talk to your healthcare provider about drug interactions and how they may affect you.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-caplyta-vs-latuda-drug-interactions\"><span class=\"title\">Compare Caplyta vs. Latuda drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Clarithromycin<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ritonavir<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Voriconazole\u00a0<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inhibitors<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diltiazem\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Erythromycin\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Fluconazole\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Verapamil<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inhibitors\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Phenytoin<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifampin\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Strong CYP3A4 inducers\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bosentan<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Efavirenz\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Modafinil<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nafcillin\u00a0<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Moderate CYP3A4 inducers<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"caplyta-and-latuda-drug-warnings\"><span style=\"font-weight: 400;\">Caplyta and Latuda drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Caplyta or Latuda, tell your healthcare provider about any medical conditions you have, including if you are pregnant, trying to become pregnant, or breastfeeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both Caplyta and Latuda have a boxed warning, also called a <\/span><span style=\"font-weight: 400;\">black box warning<\/span><span style=\"font-weight: 400;\">, which is the most serious warning required by the FDA. The warnings state that:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Older adults with dementia-related psychosis have an increased risk of death if they take antipsychotic medication. People with dementia-related psychosis should take neither Caplyta nor Latuda.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">As seen in short-term studies, antidepressants may increase the risk of suicidal thoughts and behaviors, especially in children and young adults. Patients of any age who take Caplyta or Latuda should be closely monitored for changes in mood and behavior or suicidal thoughts and behaviors.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other warnings for both drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Neuroleptic malignant syndrome (NMS) is potentially fatal and has been reported with antipsychotic medications. Be alert to signs and symptoms of rigid muscles, high fever, delirium, and kidney failure. Emergency medical help is required for NMS.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">To minimize the risk of TD, healthcare professionals focus on prescribing the lowest effective dose of medicine. Patients who take Caplyta or Latuda will be monitored for movement disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Because metabolic changes like high blood sugar, <\/span><span style=\"font-weight: 400;\">high cholesterol<\/span><span style=\"font-weight: 400;\">, and weight gain may occur, people who take Caplyta or Latuda will be monitored for any changes.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients who take Caplyta or Latuda will also have blood cell counts monitored. If there is a significant decrease in white blood cells, the medication may have to be stopped, under the guidance of a healthcare provider.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Caplyta and Latuda can cause <\/span><span style=\"font-weight: 400;\">orthostatic hypotension<\/span><span style=\"font-weight: 400;\">. This means that your blood pressure drops when standing up. Healthcare providers may monitor patients\u2019 heart rate and <\/span><span style=\"font-weight: 400;\">blood pressure<\/span><span style=\"font-weight: 400;\"> while they\u2019re taking Caplyta or Latuda, especially if they have certain medical conditions like heart disease. Because Caplyta or Latuda can cause these effects, as well as drowsiness and instability, patients who take these medications may be at risk for fainting, falls, and fractures.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">When taking Caplyta or Latuda, avoid alcohol, and do not drive or operate machinery until you know how the medication affects you.\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Caplyta and Latuda should be used cautiously in people with a history of seizures. Let your healthcare provider know if you have ever had a seizure.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Both drugs may make you more sensitive to hot temperatures. 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