{"id":6991,"date":"2025-02-03T11:59:10","date_gmt":"2025-02-03T11:59:10","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-rexulti-and-alcohol-what-you-should-know-in-2025\/"},"modified":"2025-02-03T11:59:10","modified_gmt":"2025-02-03T11:59:10","slug":"hmn-rexulti-and-alcohol-what-you-should-know-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-rexulti-and-alcohol-what-you-should-know-in-2025\/","title":{"rendered":"HMN: Rexulti and alcohol: What you should know in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Rexulti and alcohol: What you should know in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Rexulti is an atypical antipsychotic prescribed for the treatment of major depressive disorder, schizophrenia, and agitation associated with Alzheimer\u2019s disease.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Anyone taking any kind of antipsychotic medication should be careful to avoid alcohol as much as possible because it can worsen their symptoms and side effects, leading to central nervous system depression.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">People taking Rexulti should be especially careful because the drug stays in the body for more than 12 days.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">While some drugs have a shorter half-life than Rexulti and may offer some flexibility for people who wish to consume alcohol, most experts recommend avoiding alcohol completely in combination with any psychiatric medication.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">People with major depressive disorder (MDD) sometimes need to add an antipsychotic medication to their treatment plan. <\/span><span style=\"font-weight: 400;\">Rexulti<\/span><span style=\"font-weight: 400;\"> (brexpiprazole) is commonly prescribed alongside other antidepressants to help people with MDD better manage <\/span><span style=\"font-weight: 400;\">symptoms of depression<\/span><span style=\"font-weight: 400;\"> in adults. As an atypical antipsychotic, Rexulti is also <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/205422s009lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">approved by the Food and Drug Administration (FDA)<\/span><\/a><span style=\"font-weight: 400;\"> to treat schizophrenia in people ages 13 and older, as well as agitation associated with Alzheimer\u2019s disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019ve been prescribed Rexulti, your healthcare provider may have advised you not to drink alcohol while taking the drug. Many of us take that advice with a grain of salt, assuming that \u201cnot drinking\u201d means not drinking excessively. But what about Rexulti: Should you literally not drink at all while taking it, or just moderate your intake? Here\u2019s what you should know about mixing Rexulti with alcohol.\u00a0<\/span><\/p>\n<h2 id=\"can-you-drink-on-rexulti\"><span style=\"font-weight: 400;\">Can you drink on Rexulti?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cMost people taking any type of psychiatric medication should try to avoid alcohol entirely, or at least greatly minimize their intake,\u201d said <\/span><a href=\"https:\/\/siliconpsych.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Alex Dimitriu, MD<\/span><\/a><span style=\"font-weight: 400;\">, psychiatrist, sleep medicine specialist, and founder of Menlo Park Psychiatry &amp; Sleep Medicine in California.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPsychiatric medications like Rexulti cause central nervous system (CNS) depression,\u201d according to Dr. Dimitriu, which means your nervous system slows down to a potentially dangerous level. This effect can be magnified when you combine Rexulti with alcohol, <\/span><a href=\"https:\/\/medlineplus.gov\/alcohol.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">which is also a central nervous system depressant<\/span><\/a><span style=\"font-weight: 400;\">. Additionally, mixing Rexulti with alcohol can not only increase adverse side effects but prevent it from working as intended to improve your symptoms, according to the <\/span><a href=\"https:\/\/www.nami.org\/about-mental-illness\/treatments\/mental-health-medications\/types-of-medication\/brexpiprazole-rexulti\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">National Alliance on Mental Illness<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Can this really happen with just one glass of wine or a couple of beers? Unfortunately, yes. Rexulti stays in your system for an unusually long time, and <\/span><a href=\"https:\/\/www.mytoolboxgenomics.com\/about-us\/erika-gray\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Erika Gray, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, cofounder of Toolbox Genomics, says people should exercise extreme caution when combining it with alcohol because the combination could be more dangerous than when mixing alcohol with other similar drugs.<\/span><\/p>\n<h2 id=\"what-happens-if-you-drink-alcohol-with-rexulti\"><span style=\"font-weight: 400;\">What happens if you drink alcohol with Rexulti?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When you mix Rexulti with alcohol, the chances of experiencing CNS depression are higher than when you take Rexulti by itself. According to Dr. Dimitriu, common symptoms of CNS depression include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sedation (i.e., sleepiness or drowsiness)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of falling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased rate of breathing<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u201cThese symptoms can occur fairly quickly,\u201d Dr. Dimitriu said. \u201cSomeone taking this medication who drinks would immediately experience the effects of alcohol in addition to Rexulti, which is already in their system.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In general, these effects go away once the <\/span><a href=\"https:\/\/health.clevelandclinic.org\/how-long-does-alcohol-stay-in-your-system\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">alcohol is metabolized in your body<\/span><\/a><span style=\"font-weight: 400;\">, but that timing depends on how much alcohol was consumed along with other factors such as your overall health, body weight, and gender. Meanwhile, <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-fda-warns-about-serious-risks-and-death-when-combining-opioid-pain-or\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">serious side effects of CNS depression<\/span><\/a><span style=\"font-weight: 400;\"> could occur, causing difficulty breathing, irregular heart rate, seizure, and loss of consciousness.<\/span><\/p>\n<h2 id=\"are-certain-people-at-greater-risk\"><span style=\"font-weight: 400;\">Are certain people at greater risk?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dr. Gray says anyone taking Rexulti should make every attempt to avoid alcohol, but some groups of people should be even more cautious, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anyone over the age of 65<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anyone with impaired kidney or liver function\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anyone who is a poor metabolizer of <\/span><a href=\"https:\/\/www.stjude.org\/treatment\/clinical-trials\/pg4kds-pharmaceutical-science\/implemented-genes\/cytochrome-p450-2d6-cyp2d6.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">CYP2D6<\/span><\/a><span style=\"font-weight: 400;\">, an enzyme that breaks down many pharmaceutical drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anyone experiencing serious symptoms of the psychiatric illness being treated by Rexulti, since alcohol may make their symptoms worse\u00a0\u00a0<\/span><\/li>\n<\/ul>\n<h2 id=\"how-long-after-taking-rexulti-can-i-drink-alcohol\"><span style=\"font-weight: 400;\">How long after taking Rexulti can I drink alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to Dr. Dimitriu, Rexulti reaches peak levels in your blood around four hours after you take it, but the drug has a very long half-life of 91 hours. The <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554498\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">half-life of a drug<\/span><\/a><span style=\"font-weight: 400;\"> is the amount of time it takes for your body to remove 50% of the dosage you last took. That means the half-life of Rexulti won\u2019t be reached for almost four days, so you can\u2019t just wait a day or two after taking it to start drinking alcohol.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, Dr. Gray says Rexulti isn\u2019t considered clinically eliminated (i.e., at least 90% removed) from your system until 12.5 days after your last dose, regardless of <\/span><span style=\"font-weight: 400;\">how many milligrams you take per day<\/span><span style=\"font-weight: 400;\">. Until the drug is clinically eliminated from your system, you could experience serious side effects from drinking while taking Rexulti.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cTechnically, larger doses could extend this timeline,\u201d said Dr. Gray, although the dosing doesn\u2019t play as big of a role as you might think. \u201cLarger doses do increase the amount of Rexulti your body is exposed to and how much drug the body has to break down.\u201d But, it ultimately depends on how much Rexulti your liver can metabolize at a time.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of the other factors that affect how long a drug remains in your system include your body size, metabolic function, and liver function, according to Dr. Gray.<\/span><\/p>\n<h2 id=\"which-antipsychotic-medications-are-not-affected-by-alcohol\"><span style=\"font-weight: 400;\">Which antipsychotic medications are not affected by alcohol?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cAll medications prescribed for psychiatric conditions can interact with alcohol,\u201d said Dr. Gray. This means mixing alcohol with one of these drugs increases your risk of CNS depression and can also counteract the effects of your medication, leading to worsening symptoms. Therefore, healthcare experts recommend avoiding alcohol when taking <\/span><span style=\"font-weight: 400;\">Rexulti or any of its alternatives<\/span><span style=\"font-weight: 400;\">, like <\/span><span style=\"font-weight: 400;\">Abilify<\/span><span style=\"font-weight: 400;\"> (aripiprazole), <\/span><span style=\"font-weight: 400;\">Vraylar<\/span><span style=\"font-weight: 400;\"> (cariprazine), <\/span><span style=\"font-weight: 400;\">Seroquel<\/span><span style=\"font-weight: 400;\"> (quetiapine), or <\/span><span style=\"font-weight: 400;\">Risperdal<\/span><span style=\"font-weight: 400;\"> (risperidone).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Gray says Rexulti alternatives with a shorter half-life may give you some flexibility with timing when it comes to consuming alcohol. For example, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7520903\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Risperdal<\/span><\/a><span style=\"font-weight: 400;\"> has a half-life of less than 24 hours, and <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2846118\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Seroquel\u2019s half-life<\/span><\/a><span style=\"font-weight: 400;\"> is about six to seven hours, so they are eliminated from your system sooner.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That said, just because a Rexulti alternative has a shorter half-life doesn\u2019t make it safe to combine with alcohol. Dr. Dimitriu says it\u2019s important to remember that alcohol is a neurotoxin (especially in larger doses) that disrupts sleep and often leads to more drinking: \u201cThere is a slippery slope with alcohol, and when people are told they can drink lightly, it can easily become too much.\u201d\u00a0<\/span><\/p>\n<p><b> <\/b><b>Rexulti generic availability, cost &amp; more<\/b><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Rexulti and alcohol are both central nervous system depressants, so mixing them together increases your risk for serious side effects like sedation, injury, and decreased respiration. Rexulti also has a long half-life and stays in your system for several weeks, which makes it riskier than other drugs to combine with alcohol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s possible that a small amount of alcohol wouldn\u2019t harm you while taking Rexulti, but Dr. Dimitriu strongly suggests avoiding it entirely.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you don\u2019t think you can completely abstain from alcohol while taking Rexulti, talk to a healthcare provider who knows your whole medical history and can make a more informed recommendation.<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 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Anyone taking any kind of antipsychotic medication should be careful to avoid alcohol as much as possible because it can worsen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6991","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/6991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=6991"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/6991\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=6991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=6991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=6991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}