{"id":7026,"date":"2025-02-03T12:08:31","date_gmt":"2025-02-03T12:08:31","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-how-long-does-trintellix-withdrawal-last-in-2025\/"},"modified":"2025-02-03T12:08:31","modified_gmt":"2025-02-03T12:08:31","slug":"hmn-how-long-does-trintellix-withdrawal-last-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-how-long-does-trintellix-withdrawal-last-in-2025\/","title":{"rendered":"HMN: How long does Trintellix withdrawal last? in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  How long does Trintellix withdrawal last? in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Trintellix is an antidepressant used to treat major depressive disorder and, in some cases, anxiety.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Withdrawal is not a common issue with Trintellix, but it\u2019s still important to seek medical advice before quitting this medication.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Abruptly quitting Trintellix has been known to cause intense mood swings and irritability for up to 10 days.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Research shows that abruptly quitting antidepressants can cause flu-like symptoms, nausea, insomnia, and dizziness in about 20% of people. Symptoms usually resolve within two weeks.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Trintellix<\/span><span style=\"font-weight: 400;\"> (vortioxetine) is a brand-name prescription medication that\u2019s approved by the Food and Drug Administration (FDA) to treat major depressive disorder (MDD) in adults. Some healthcare providers also prescribe it <\/span><span style=\"font-weight: 400;\">off-label<\/span><span style=\"font-weight: 400;\"> for <\/span><span style=\"font-weight: 400;\">anxiety<\/span><span style=\"font-weight: 400;\">. Although it\u2019s classified as an atypical antidepressant, Trintellix works similarly to <\/span><span style=\"font-weight: 400;\">selective serotonin reuptake inhibitors (SSRIs)<\/span><span style=\"font-weight: 400;\"> such as fluoxetine or paroxetine. Its active ingredient, vortioxetine, helps balance serotonin levels in the brain, improving mood control and cognitive function.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Trintellix is effective, but may not be right for everyone. Stopping Trintellix should always be done under the medical advice of a healthcare professional. Abruptly quitting Trintellix could result in a type of withdrawal called <\/span><a href=\"https:\/\/www.aafp.org\/afp\/2006\/0801\/p449.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">antidepressant discontinuation syndrome<\/span><\/a><span style=\"font-weight: 400;\">, which triggers common side effects such as headache and nausea. In some cases, stopping Trintellix may cause temporary mood dysfunction.<\/span><\/p>\n<h2 id=\"understanding-trintellix-vortioxetine-withdrawal\"><span style=\"font-weight: 400;\">Understanding Trintellix (vortioxetine) withdrawal<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is limited research on Trintellix withdrawal. A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8151377\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">review published in 2021<\/span><\/a><span style=\"font-weight: 400;\"> included data from only 263 people who had discontinued this drug. Of that group, eight people (3%) experienced negative side effects. However, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449237\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">research on other antidepressant stoppage<\/span><\/a><span style=\"font-weight: 400;\"> has found that about 20% of people develop antidepressant discontinuation syndrome, a constellation of flu-like symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cAbruptly stopping antidepressant medication can lead to withdrawal symptoms and may worsen depression,\u201d confirmed Jodie Pepin, Pharm.D., clinical pharmacy program director at <\/span><a href=\"https:\/\/www.harborhealth.com\/clinicians\/necessitatibus-magni-distinctio\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Harbor Health<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That said, Trintellix is an atypical antidepressant with a long half-life, which means it takes about two weeks for the body to clear the last dose of Trintellix. Board-certified psychiatrist <\/span><a href=\"https:\/\/nevadamentalhealth.com\/our-psychiatrists\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sid Khurana, MD<\/span><\/a><span style=\"font-weight: 400;\">, the medical director of outpatient services at Nevada Mental Health in Las Vegas, says this long half-life allows some patients to stop Trintellix without tapering the dose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Though withdrawal is unlikely and tapering may not be necessary, many providers still take a \u201cbetter safe than sorry\u201d approach. Antidepressants change the activity of chemicals in the brain, after all. A gradual release from the drug further reduces the risk of negative effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cAlways consult your healthcare prescriber before discontinuing any medication, especially those used for mental health challenges due to the risk of suicidal ideations and attempts,\u201d said <\/span><a href=\"https:\/\/www.thepublichealthpharmacist.com\/about\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Christina M. Madison, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, founder of The Public Health Pharmacist.<\/span><\/p>\n<h3 id=\"timeline-for-trintellix-withdrawal\"><span style=\"font-weight: 400;\">Timeline for Trintellix withdrawal<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is no established timeline for Trintellix withdrawal because this drug is not strongly associated with withdrawal. However, the Trintellix research review found that the 3% of patients who experienced withdrawal-like side effects developed them within five days of their last dose. Symptoms resolved within three days for some and up to 10 days for others.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antidepressant discontinuation syndrome has a similar timeline. These symptoms typically occur two to four days after drug cessation and last one to two weeks.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Overall, if a person experiences withdrawal from stopping Trintellix, the symptoms should resolve within a couple of weeks. It\u2019s a good idea to consult a healthcare provider if unexplained symptoms or new depression symptoms persist several weeks after quitting Trintellix.<\/span><\/p>\n<h3 id=\"common-symptoms-of-trintellix-withdrawal\"><span style=\"font-weight: 400;\">Common symptoms of Trintellix withdrawal<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Temporary <\/span><a href=\"https:\/\/us.trintellix.com\/frequently-asked-questions#accordion-017819d6f1-item-c6c232f694\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects of Trintellix discontinuation<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Emotional lability (dramatic mood swings, which may include uncontrollable laughing or crying)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sudden worsening of mood<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nervousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The above symptoms are specific to Trintellix. But abruptly quitting any antidepressant comes with an increased risk of antidepressant discontinuation syndrome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Withdrawal symptoms of antidepressants<\/span><span style=\"font-weight: 400;\"> often include:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cBased upon results from multiple studies, the most common discontinuation symptoms appear to be dizziness, fatigue, headache, and nausea,\u201d Dr. Madison said.<\/span><\/p>\n<h2 id=\"dealing-with-side-effects-of-trintellix-withdrawal\"><span style=\"font-weight: 400;\">Dealing with side effects of Trintellix withdrawal<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Remember, many people have successfully quit Trintellix without experiencing withdrawal symptoms. Dr. Khurana emphasizes that Trintellix\u2019s long half-life limits the potential for withdrawal-like symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The experts agree about the importance of working closely with a healthcare professional while quitting Trintellix. Even though severe side effects during withdrawal are unlikely, every patient\u2019s situation and condition are unique. Dr. Pepin says the general guideline is to decrease Trintellix dosage by 25% to 50% every one to two weeks.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aside from seeking the guidance of a medical professional, there are also a few lifestyle practices and supplements that may improve mood instability or symptoms of depression while withdrawing from Trintellix. <\/span><span style=\"font-weight: 400;\">Natural remedies<\/span><span style=\"font-weight: 400;\"> are not a substitute for prescription antidepressants, but they may ease the transition while quitting or switching medications under a doctor\u2019s supervision. Examples include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Regular exercise \u2013<\/b> <span style=\"font-weight: 400;\">Physical activity<\/span><span style=\"font-weight: 400;\"> can improve mental health in many ways. Aerobic exercise and resistance training are both helpful for depression, and hitting the gym is a great way to release tension from stress and anxiety.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Meditation \u2013<\/b><span style=\"font-weight: 400;\"> Research shows that <\/span><span style=\"font-weight: 400;\">meditation<\/span><span style=\"font-weight: 400;\"> can help lower stress, calm anxious thoughts, and improve mood awareness. It\u2019s not a cure for severe depression, but it can be a helpful tool in a patient\u2019s transition away from Trintellix.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Social and emotional support \u2013<\/b><span style=\"font-weight: 400;\"> On top of making a person feel loved and supported, a strong network of supporters can act as a lookout for severe symptoms of antidepressant withdrawal or depression relapse.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Supplements and herbs \u2013<\/b><span style=\"font-weight: 400;\"> Natural remedies are not approved by the FDA for depression or anxiety, so it\u2019s important to discuss them with a doctor before trying them. That being said, there are a few that may be worth discussing:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>St. John\u2019s wort \u2013<\/b><span style=\"font-weight: 400;\"> Some people report a boost in mood from taking <\/span><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><span style=\"font-weight: 400;\">. However, it can interfere with several prescription drugs, so it\u2019s important to ask your healthcare provider before taking it.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>Omega-3 fatty acids \u2013<\/b><span style=\"font-weight: 400;\"> Limited research suggests that omega-3 fatty acids have <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5481805\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">anti-inflammatory effects<\/span><\/a><span style=\"font-weight: 400;\"> that may help alleviate symptoms of depression. However, more research is needed to understand this effect fully.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><b>5-hydroxytryptophan (5-HTP) \u2013 <\/b><span style=\"font-weight: 400;\">5-HTP<\/span><span style=\"font-weight: 400;\"> is a chemical that the body can convert into serotonin. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7796270\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> suggests that 5-HTP supplementation may boost serotonin levels, improving symptoms of depression.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"long-term-effects-of-trintellix-withdrawal\"><span style=\"font-weight: 400;\">Long-term effects of Trintellix withdrawal<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no known long-term effects of Trintellix withdrawal. Some patients may not even experience short-term side effects of quitting this medication. However, discontinuing an antidepressant like Trintellix can have a significant impact on mental health and daily functioning if the lack of treatment causes a depression relapse.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7082055\/#:~:text=Individuals%20with%20a%20higher%20score,9.209%3B%20p%20%3D%200.010).\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> shows that social avoidance and severe previous major depressive episodes are the most significant predictors of MDD relapse. Simple awareness of the potential for depression relapse can help a patient or patient\u2019s support network prevent recurrence from developing into severe MDD. Ultimately, it\u2019s important to stay in contact with a healthcare provider during and after Trintellix discontinuation.<\/span><\/p>\n<h2 id=\"bottom-line-how-to-navigate-a-safe-trintellix-withdrawal\"><span style=\"font-weight: 400;\">Bottom line: How to navigate a safe Trintellix withdrawal\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although Trintellix is not typically associated with withdrawal, some people experience unpleasant mood instability or flu-like symptoms when quitting this drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cTapering off Trintellix should be done under the guidance of a healthcare professional to minimize the risk of withdrawal symptoms and to ensure a safe and effective transition,\u201d Dr. Pepin emphasized.<\/span><\/p>\n<p><b> <\/b><b>Trintellix alternatives: What can I take instead of Trintellix?<\/b><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" 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cases, anxiety. Withdrawal is not a common issue with Trintellix, but it\u2019s still important to seek medical advice before quitting this medication. 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