{"id":7031,"date":"2025-02-03T12:09:28","date_gmt":"2025-02-03T12:09:28","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-levothyroxine-for-dogs-dosage-and-safety-in-2025\/"},"modified":"2025-02-03T12:09:28","modified_gmt":"2025-02-03T12:09:28","slug":"hmn-levothyroxine-for-dogs-dosage-and-safety-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-levothyroxine-for-dogs-dosage-and-safety-in-2025\/","title":{"rendered":"HMN: Levothyroxine for dogs: Dosage and safety in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Levothyroxine for dogs: Dosage and safety in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Levothyroxine is used to treat underactive thyroid in dogs.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">The standard levothyroxine dosage for dogs is variable and depends on the dog\u2019s response to the dosage.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Once the correct dosage is established, levothyroxine usually does not cause side effects.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Do not give levothyroxine to dogs who have overactive thyroid, untreated adrenal gland problems, or who have had a recent heart attack.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Levothyroxine<\/span><span style=\"font-weight: 400;\"> is used by veterinarians in dogs that don\u2019t produce enough thyroid hormone, a condition called hypothyroidism. Since thyroid hormones control many processes throughout the body, low thyroid hormones can cause many symptoms and medical issues. Levothyroxine is a synthetic formulation of the thyroid hormone thyroxine (T4) and replaces the missing thyroid hormone. Because levothyroxine is similar to a natural hormone in the dog, it is safe to give dogs with an underactive thyroid under the direction of a veterinarian.\u00a0<\/span><\/p>\n<p><b> <\/b><b>Save up to 80% on levothyroxine<\/b><\/p>\n<h2 id=\"what-is-levothyroxine-used-for-in-dogs\"><span style=\"font-weight: 400;\">What is levothyroxine used for in dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Veterinarians use levothyroxine in dogs whose thyroid glands aren\u2019t producing enough thyroid hormone.<\/span><\/p>\n<h3 id=\"hypothyroidism\"><span style=\"font-weight: 400;\">Hypothyroidism<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Thyroid hormones\u2014thyroxine (T4) and triiodothyronine (T3)\u2014are critical for animal health. Thyroxine regulates metabolism, energy use, oxygen consumption, protein synthesis, blood volume, body temperature, heart rate, growth, and many other chemical processes in the body. Dogs with an <\/span><span style=\"font-weight: 400;\">underactive thyroid<\/span><span style=\"font-weight: 400;\"> will experience a number of problems.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The thyroid gland produces thyroid hormones. Two structures in the brain\u2014the hypothalamus and the pituitary gland\u2014regulate thyroid hormone production by producing thyroid-stimulating hormone (TSH). When the whole system works as it should, TSH is produced when thyroid hormones are low, and the thyroid gland releases the right amount of thyroid hormone to compensate.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hypothyroidism is a condition where the body doesn\u2019t have enough thyroid hormone. Either the thyroid gland isn\u2019t working right (primary hypothyroidism), or the body isn\u2019t producing enough TSH (secondary hypothyroidism). It\u2019s a common problem in people and dogs, particularly middle-aged and older dogs between <\/span><a href=\"https:\/\/www.vet.cornell.edu\/departments\/riney-canine-health-center\/canine-health-information\/hypothyroidism\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">4 and 10 years of age<\/span><\/a><span style=\"font-weight: 400;\">. Some breeds, such as golden retrievers, Labrador retrievers, Doberman pinschers, beagles, border collies, and boxers, are more likely to have the condition.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hypothyroidism affects every system in the body, causing noticeable symptoms and potentially serious health problems such as weight gain or high cholesterol. Signs of hypothyroidism in a dog include lack of energy, sluggishness, weight gain, poor hair coat quality, \u201crat tail,\u201d and hair loss. The dog becomes more sensitive to cold, as evidenced by shivering or efforts to keep warm.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Whether in people or pets, primary hypothyroidism and secondary hypothyroidism are always treated with thyroid hormone replacement therapy. The first choice is oral levothyroxine. It allows for precise and predictable doses to stabilize thyroid hormone concentrations.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hypothyroidism is usually a lifelong condition in pets. Levothyroxine doses must be faithfully given every day for the rest of the dog\u2019s life.<\/span><\/p>\n<h2 id=\"is-levothyroxine-safe-for-dogs\"><span style=\"font-weight: 400;\">Is levothyroxine safe for dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most dogs will have no problems with levothyroxine once the correct dose is established.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are exceptions. Levothyroxine is never used in dogs that have:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Normal thyroid hormone levels and a healthy thyroid gland (euthyroid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High thyroid hormone levels (hyperthyroidism)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Addison\u2019s disease (underactive adrenal gland and low levels of cortisol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Recently had a heart attack<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Veterinarians will need to regularly monitor dogs taking levothyroxine who also have:<\/span><\/p>\n<h3 id=\"side-effects-of-levothyroxine-in-dogs\"><span style=\"font-weight: 400;\">Side effects of levothyroxine in dogs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When the correct dose is established, levothyroxine should not cause adverse reactions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If the dose is too high, dogs may show symptoms of hyperthyroidism, such as weight loss, hunger, excessive peeing, excessive drinking, and aggressiveness. When a dog shows any symptoms of hyperthyroidism, call the veterinarian. High thyroid hormone levels can\u2019t be definitively established without a blood test. They are easily fixed by reducing the levothyroxine dose.<\/span><\/p>\n<h3 id=\"interactions-of-levothyroxine-with-other-pet-meds\"><span style=\"font-weight: 400;\">Interactions of levothyroxine with other pet meds<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Make sure the prescribing veterinarian knows about all prescription medications, over-the-counter remedies, supplements, and foods the dog receives, particularly:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High-fiber foods<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Iron supplements<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heartburn and ulcer medications such as antacids, sucralfate, or stomach acid reducer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insulin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High-dose <\/span><span style=\"font-weight: 400;\">corticosteroid<\/span> <span style=\"font-weight: 400;\">treatment\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The heart rhythm drug amiodarone<\/span><\/li>\n<\/ul>\n<h2 id=\"levothyroxine-dosage-for-dogs\"><span style=\"font-weight: 400;\">Levothyroxine dosage for dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is no fixed levothyroxine dosage for dogs. Instead, veterinarians will prescribe the dose that results in normal thyroid hormone levels and clears up the symptoms of hypothyroidism.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/todaysveterinarypractice.com\/endocrinology\/canine-hypothyroidism-diagnosis-and-treatment\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recommended starting dosage<\/span><\/a><span style=\"font-weight: 400;\"> in dogs is 0.02 milligrams (mg) of levothyroxine per kilogram (kg) of body weight (0.01 mg\/lb) daily. The full dose can be given once daily or half doses twice daily. Veterinarians will most likely use once-daily dosing since it <\/span><a href=\"https:\/\/www.dvm360.com\/view\/canine-hypothyroidism-supplementation-and-monitoring-updates\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">conforms to current guidelines<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The starting dose is not the final dose. Veterinarians usually increase the dose in steady increments every two to four weeks. They use clinical signs and blood tests to determine how well each dosage is working. They continue to modify the dosage until thyroid hormone levels are normal and the dog no longer has clinical signs of low thyroid hormone.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Human versions of levothyroxine, such as <\/span><span style=\"font-weight: 400;\">Synthroid<\/span><span style=\"font-weight: 400;\"> or Euthyrox, are inappropriate for dogs\u2019 use. The dosage strengths are too low. Dogs require substantially more thyroid hormone than people because they eliminate levothyroxine faster. The half-life of levothyroxine in people is seven days, but it takes a dog 10 to 16 hours to eliminate half a dose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dogs are given levothyroxine tablets that range from 0.1 mg per pill to 1 mg. For people, levothyroxine tablets range from 0.013 mg to 0.3 mg. Veterinarians will then prescribe levothyroxine tablets formulated for dogs that contain high-delivery doses. Thyro-Tabs Canine is a brand name for levothyroxine that has been FDA-approved for use in dogs.<\/span><\/p>\n<h3 id=\"can-dogs-overdose-on-levothyroxine\"><span style=\"font-weight: 400;\">Can dogs overdose on levothyroxine?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A levothyroxine overdose is the same as having too much thyroid hormone, so it produces the same problems as an overactive thyroid. Symptoms appear about <\/span><a href=\"https:\/\/aspcapro.org\/sites\/default\/files\/oxbrief_0601.pdf\"><span style=\"font-weight: 400;\">one to nine hours<\/span><\/a><span style=\"font-weight: 400;\"> after the overdose. The <\/span><a href=\"https:\/\/www.merckvetmanual.com\/endocrine-system\/the-thyroid-gland\/hyperthyroidism-in-animals\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most common side effects<\/span><\/a><span style=\"font-weight: 400;\"> of a levothyroxine overdose in a dog include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive thirst<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased urination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive panting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excitability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperactivity<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aggressive behavior<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Fortunately, dogs are more resistant to levothyroxine overdoses than people and other animals. They eliminate the drug much more quickly from the body than other animals.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">No maximum dosage has been established. Blood tests and clinical signs will determine the appropriate dose. Any dose that produces normal thyroid hormone levels and resolves hypothyroid symptoms is the maximum dose for that particular dog.<\/span><\/p>\n<h3 id=\"can-i-give-my-dog-levothyroxine-every-day\"><span style=\"font-weight: 400;\">Can I give my dog levothyroxine every day?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Most dogs will need daily levothyroxine for the rest of their lives. Daily levothyroxine doses are not only safe but necessary.\u00a0<\/span><\/p>\n<h3 id=\"how-to-give-your-dog-levothyroxine\"><span style=\"font-weight: 400;\">How to give your dog levothyroxine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pet parents can give their dog levothyroxine in three ways: as a tablet, liquid, or powder (though levothyroxine powder is intended for horses). Pet parents should provide the dog with levothyroxine formulated for dogs rather than human versions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Veterinarians are most likely to prescribe levothyroxine tablets. It\u2019s important to give every dose as instructed by the veterinarian:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not give more levothyroxine than prescribed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">You can give the dog the dose with or without food, but it must be given the same way every time. Food affects how much levothyroxine is absorbed, so changing how you deliver it will change the dose.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you don\u2019t know how to give a dog a tablet, a veterinary technician or the veterinarian can show you the appropriate technique.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you give the dog an oral solution, always measure the dose with a calibrated oral syringe. If one is missing from the package, ask the veterinarian for one.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not miss a dose. If a levothyroxine dose is missed, <\/span><a href=\"https:\/\/vcahospitals.com\/know-your-pet\/levothyroxine\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">give it when remembered<\/span><\/a><span style=\"font-weight: 400;\">.<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">If the dog is getting once-daily doses, skip the missed dose if it\u2019s the next day. Give that day\u2019s dose as scheduled.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">If the dog gets twice-daily doses, skip the missed dose if it\u2019s almost time for the second dose.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Never give two doses to make up for a missed dose.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not stop giving the dog levothyroxine unless advised to do so by a veterinarian.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Store levothyroxine tablets at room temperature, protected from light and moisture.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Keep levothyroxine out of the reach of children.<\/span><\/li>\n<\/ul>\n<h2 id=\"levothyroxine-alternatives-for-dogs\"><span style=\"font-weight: 400;\">Levothyroxine alternatives for dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Veterinarians choose levothyroxine as the drug of choice for hypothyroid medications. Unlike the alternatives, levothyroxine can be precisely and predictably dosed. The only alternative is desiccated thyroid hormone with dried and powdered pig thyroid glands as its active ingredient. However, the amount of thyroid hormone can vary from product to product and pill to pill. The U.S. Food and Drug Administration (FDA) does not regulate them, so poor quality is a possibility. Veterinary professionals do not recommend their use.<\/span><\/p>\n<h2 id=\"summary\"><span style=\"font-weight: 400;\">Summary<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Companion animals commonly experience low thyroid hormone levels as they age. Daily doses of levothyroxine help return them to their normal selves, but they must be given levothyroxine formulated in doses appropriate for dogs. 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The standard levothyroxine dosage for dogs is variable and depends on the dog\u2019s response to the dosage. Once the correct dosage is established, levothyroxine usually does not cause side effects. 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