{"id":7041,"date":"2025-02-03T12:11:19","date_gmt":"2025-02-03T12:11:19","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-is-tramadol-a-nonsteroidal-anti-inflammatory-drug-nsaid-in-2025\/"},"modified":"2025-02-03T12:11:19","modified_gmt":"2025-02-03T12:11:19","slug":"hmn-is-tramadol-a-nonsteroidal-anti-inflammatory-drug-nsaid-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-is-tramadol-a-nonsteroidal-anti-inflammatory-drug-nsaid-in-2025\/","title":{"rendered":"HMN: Is tramadol a nonsteroidal anti-inflammatory drug (NSAID)? in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Is tramadol a nonsteroidal anti-inflammatory drug (NSAID)? in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Tramadol is a medication used to treat moderate to severe pain.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Tramadol can be used for conditions such as nerve pain, cancer pain, postoperative pain, or pain from injuries<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Although tramadol can be taken along with anti-inflammatory medication, it does not have known anti-inflammatory properties<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Tramadol is not an NSAID; it is an opioid analgesic drug<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Pain in the body often goes hand in hand with inflammation. That\u2019s why many people are looking for a medication that can knock out both pain and inflammation at the same time.<\/span> <span style=\"font-weight: 400;\">Tramadol<\/span><span style=\"font-weight: 400;\"> is a well-known, powerful pain medication. But does tramadol help with inflammation? Tramadol isn\u2019t an anti-inflammatory but can be combined with NSAIDs to address both pain and inflammation.\u00a0<\/span><\/p>\n<h2 id=\"is-tramadol-an-anti-inflammatory-drug\"><span style=\"font-weight: 400;\">Is tramadol an anti-inflammatory drug?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Tramadol<\/span><span style=\"font-weight: 400;\"> is not classified as an anti-inflammatory drug. \u201cWhile tramadol is indicated as a second-line agent for pain management, it does not possess anti-inflammatory properties,\u201d says <\/span><span style=\"font-weight: 400;\">Reema Hammoud Pharm.D., BCPS, AVP Clinical Pharmacy at<\/span> <a href=\"https:\/\/www.sedgwick.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sedgwick<\/span><\/a><span style=\"font-weight: 400;\">. As such, while it\u2019s useful for managing pain, tramadol is not used for inflammation, and it\u2019s not for use in pain conditions where inflammation is the primary concern, <\/span><span style=\"font-weight: 400;\">Hammoud<\/span><span style=\"font-weight: 400;\"> says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A 2018 paper published in the<\/span> <a href=\"https:\/\/calonmedical.com\/Pharmacology\/pharmacology-6-1131.pdf\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">Journal of Pharmacology &amp; Clinical Toxicology<\/span><\/i><\/a><span style=\"font-weight: 400;\"> reviewed data on tramadol to explore if it has anti-inflammatory properties. Researchers reviewed all available data and concluded that there is no evidence of any noteworthy anti-inflammatory effects of tramadol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tramadol is<\/span> <a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/tramadol-information\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">sold under the brand names<\/span><\/a><span style=\"font-weight: 400;\"> Ultram, Ultram ER, and Conzip, and also in generic form. In 2014, the U.S. Food and Drug Administration (<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537060\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FDA<\/span><\/a><span style=\"font-weight: 400;\">) approved it to treat cases of moderate to severe pain. Tramadol is often prescribed by healthcare providers to treat advanced cancer pain, postoperative pain, trauma, and intractable pain caused by disease, according to <\/span><a href=\"https:\/\/www.mwpain.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Dr. Thomas Pontinen<\/span><\/a><span style=\"font-weight: 400;\">, a double-board certified anesthesiologist and pain management specialist.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tramadol is a potent pain reliever and is prescribed when people aren\u2019t experiencing relief from first-line pain treatments, notes <\/span><a href=\"https:\/\/www.leiarispolimd.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Leia Rispoli, MD<\/span><\/a><span style=\"font-weight: 400;\">, a double-board-certified interventional pain management specialist and physiatrist at<\/span> <a href=\"https:\/\/www.discmdgroup.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">DISC Sports &amp; Spine Center<\/span><\/a><span style=\"font-weight: 400;\">. \u201cTypically, tramadol is used for acute pain that is severe and may involve a neuropathic source, meaning a pain that may be derived from a nerve pain,\u201d Dr. Rispoli states.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For the management of pain with inflammation, non-steroidal anti-inflammatory drugs (<\/span><span style=\"font-weight: 400;\">NSAIDs<\/span><span style=\"font-weight: 400;\">) are usually the first-line agents, says <\/span><span style=\"font-weight: 400;\">Hammoud<\/span><span style=\"font-weight: 400;\">. NSAIDs are available as both a prescription (in higher strengths) and over-the-counter. While tramadol isn\u2019t an NSAID, it can be taken with one. \u201cTramadol is safe to be taken together with standard anti-inflammatory medications such as NSAIDs,\u201d says Dr. Pontinen.<\/span><\/p>\n<h2 id=\"is-tramadol-an-nsaid\"><span style=\"font-weight: 400;\">Is tramadol an NSAID?<\/span><b>\u00a0<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Many people wonder if tramadol is an NSAID. The answer is that tramadol is not an NSAID. Tramadol <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a695011.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">is classified as an opioid analgesic<\/span><\/a><span style=\"font-weight: 400;\">. It is classified as a <\/span><a href=\"https:\/\/www.federalregister.gov\/documents\/2014\/07\/02\/2014-15548\/schedules-of-controlled-substances-placement-of-tramadol-into-schedule-iv\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Schedule IV <\/span><\/a><span style=\"font-weight: 400;\">controlled substance, according to the Controlled Substances Act. This means that it has a low risk of addiction compared to other controlled substances, but it still has the potential to be addictive and misused.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tramadol works by changing how the nervous system and brain respond to pain in the body. \u201cTramadol is an opioid\u2014a potent painkiller that produces its analgesic effect by blocking nociceptive afferent neurons and the release of neurotransmitters that cause nociception such as substance P and glutamate,\u201d explains Dr. Pontinen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tramadol is not similar to anti-inflammatory drugs or NSAIDs in terms of mechanism of action because \u201cThere are different mechanisms of action that work by binding to opioid receptors,\u201d Dr. Rispoli says. \u201cThere\u2019s also a component of tramadol that is an SNRI, a serotonin-norepinephrine reuptake inhibitor, which means that it increases the level of serotonin and norepinephrine in the brain and may have a role in helping with some of the nerve pain that we discussed earlier,\u201d notes Dr. Rispoli.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So what are NSAID drugs, then? NSAIDs are a group of medicines called anti-inflammatory drugs. They can be used to treat fever, inflammation, and pain.<\/span> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547742\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Conditions frequently treated by NSAIDs<\/span><\/a><span style=\"font-weight: 400;\"> include muscle pain, sore throat, menstrual pain, arthritis pain, gout, and migraines. NSAIDs work by \u201cinhibiting cyclooxygenase (COX), the enzyme that produces prostaglandins,\u201d Dr. Pontinen explains. \u201cTwo involved COX isoenzymes produce prostaglandins that have antagonistic (pain-relieving) effects on the body.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Examples of<\/span> <a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/nonsteroidal-anti-inflammatory-drugs-nsaids\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">commonly used NSAIDs include<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<h2 id=\"what-are-the-best-medications-for-inflammation\"><span style=\"font-weight: 400;\">What are the best medications for inflammation?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Individuals experiencing pain and <\/span><a href=\"https:\/\/www.niehs.nih.gov\/health\/topics\/conditions\/inflammation\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">inflammation<\/span><\/a><span style=\"font-weight: 400;\"> associated with chronic conditions like arthritis, gout, or colitis may seek <\/span><span style=\"font-weight: 400;\">anti-inflammatory medications<\/span><span style=\"font-weight: 400;\"> to manage their symptoms. While there are many anti-inflammation medications on the market, the best medication is the one that works for you and is recommended by your healthcare provider. The most common medications for inflammation include NSAIDs and steroids.<\/span><\/p>\n<h3 id=\"prescription-anti-inflammatories-nsaids\"><span style=\"font-weight: 400;\">Prescription anti-inflammatories (NSAIDs)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prescription anti-inflammatory drugs must be prescribed by a physician. These drugs are usually more potent and cause more side effects than over-the-counter anti-inflammatories. In most cases, both brand and generic versions of these drugs are available. However, generic versions tend to be less expensive than prescription drugs. Follow your doctor\u2019s guidance for prescribed anti-inflammatories and start with the lowest effective dose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are some anti-inflammatories available by prescription:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Naprosyn (naproxen)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Celebrex (celecoxib)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ponstel (mefenamic acid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acular (ketorolac tromethamine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anaprox (naproxen sodium)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clinoril (sulindac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Daypro (oxaprozin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Feldene (piroxicam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nalfon (fenoprofen calcium)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Voltaren (diclofenac sodium)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indocin (indomethacin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mobic (meloxicam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ocufen (flurbiprofen)<\/span><\/li>\n<\/ul>\n<h3 id=\"best-otc-anti-inflammatory-medications-nsaids\"><span style=\"font-weight: 400;\">Best OTC anti-inflammatory medications (NSAIDs)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are many over-the-counter anti-inflammatory medications you can purchase. Even though you don\u2019t need a prescription from a doctor to buy these drugs, it\u2019s always best to talk to your healthcare provider before taking any medication. Make sure to follow the instructions in the provided drug information included on the medication bottle carefully, and don\u2019t take more medication than the instructions suggest. Follow any boxed warning on the medication and seek medical attention immediately if any signs of an allergic reaction or drug interaction occur.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other over-the-counter anti-inflammatory medications to consider include:<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 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