{"id":7064,"date":"2025-02-03T12:15:15","date_gmt":"2025-02-03T12:15:15","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-side-effects-in-2025-23\/"},"modified":"2025-12-23T14:42:47","modified_gmt":"2025-12-23T14:42:47","slug":"hmn-rinvoq-and-dupixent-rinvoq-and-dupixent-differences-similarities-side-effects-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-rinvoq-and-dupixent-rinvoq-and-dupixent-differences-similarities-side-effects-in-2025\/","title":{"rendered":"HMN: Rinvoq and Dupixent Rinvoq and Dupixent  Differences, similarities &#038; side effects in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, similarities &#038; side effects in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Rinvoq and Dupixent are prescription drugs for moderate-to-severe atopic dermatitis. However, they also have other FDA-approved uses.\u00a0\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Rinvoq, a JAK inhibitor, is taken orally, while Dupixent, a monoclonal antibody, is administered via injection.\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Both drugs are effective for atopic dermatitis, but clinical trials show Rinvoq might provide better skin improvement.\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Common side effects of Rinvoq include infections, nausea, and acne; Dupixent\u2019s common side effects are injection site reactions and eye problems.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Rinvoq<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Dupixent<\/span><span style=\"font-weight: 400;\"> are brand-name prescription drugs that have become popular treatment options for <\/span><span style=\"font-weight: 400;\">eczema<\/span><span style=\"font-weight: 400;\"> (atopic dermatitis) and other chronic inflammatory diseases. They may be especially useful when other medications have not effectively controlled symptoms such as itching, inflammation, and skin irritation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While both drugs share similar treatment goals, they may differ in other uses, mechanisms of action, and potential side effects. As these medications are only available with a prescription, it\u2019s recommended to consult a healthcare provider for the most suitable medication for your condition.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read on to learn more about the differences and similarities between Rinvoq and Dupixent.\u00a0<\/span><\/p>\n<h2 id=\"rinvoq-vs-dupixent-key-differences\"><span style=\"font-weight: 400;\">Rinvoq vs. Dupixent: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The main difference between Rinvoq and Dupixent lies in their active ingredients and how they work. Rinvoq is a product of AbbVie Inc. and contains the active ingredient upadacitinib. It belongs to a class of drugs known as Janus kinase (JAK) inhibitors. By targeting JAK1, Rinvoq interferes with the function of certain substances involved in inflammation. It is available as an <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/211675s019lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">extended-release pill<\/span><\/a><span style=\"font-weight: 400;\"> and is approved for adults and adolescents with moderate to severe atopic dermatitis. Rinvoq is typically taken as a 15- or 30-milligram (mg) tablet once daily.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dupixent, developed by Regeneron Pharmaceuticals, Inc., is a monoclonal antibody that blocks the signaling of two key proteins, IL-4 and IL-13, which are believed to play key roles in inflammation associated with atopic dermatitis. It is <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/761055s059lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">approved for use in patients ages six months and older<\/span><\/a><span style=\"font-weight: 400;\"> and is administered as a subcutaneous injection. Treatment with Dupixent usually starts with two 300 mg injections, followed by one 300 mg injection every other week.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-rinvoq-vs-dupixent-key-differences\"><span class=\"title\">Compare Rinvoq vs. Dupixent key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">JAK inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Monoclonal antibody, interleukin-4 receptor alpha antagonist<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Upadacitinib<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Dupilumab<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Extended-release tablet<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection under the skin<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">15 or 30 mg once daily<\/span><\/td>\n<td><span style=\"font-weight: 400;\">600 mg followed by 300 mg every 2 weeks<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults and children 12 years and older, depending on the indication<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults and children 6 months and older, depending on the indication\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"rinvoq-vs-dupixent-conditions-treated\"><span style=\"font-weight: 400;\">Rinvoq vs. Dupixent: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Rinvoq and Dupixent are approved by the Food and Drug Administration (FDA) to treat atopic dermatitis. However, apart from this similarity, these drugs differ in their other approved indications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to atopic dermatitis, Rinvoq treats different forms of arthritis, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It is also approved to treat <\/span><span style=\"font-weight: 400;\">ulcerative colitis and Crohn\u2019s disease<\/span><span style=\"font-weight: 400;\">, which are types of inflammatory bowel disease (IBD). Still, Rinvoq may only be prescribed after certain medications, such as TNF blockers, have been tried first.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dupixent\u2019s indications, other than atopic dermatitis, are as an add-on treatment for <\/span><span style=\"font-weight: 400;\">asthma<\/span><span style=\"font-weight: 400;\"> and sinus inflammation (chronic rhinosinusitis) that leads to nasal polyps. It can also treat a certain type of inflammation of the esophagus (eosinophilic esophagitis) and a chronic skin disorder called prurigo nodularis, which is characterized by itchy nodules on the skin.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-conditions-treated-by-rinvoq-vs-dupixent\"><span class=\"title\">Compare conditions treated by Rinvoq vs. Dupixent<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Atopic dermatitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Asthma<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ulcerative colitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Crohn\u2019s disease<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Rheumatoid arthritis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Psoriatic arthritis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ankylosing spondylitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Non-radiographic axial spondyloarthritis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Chronic rhinosinusitis with nasal polyposis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Eosinophilic esophagitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Prurigo nodularis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"is-dupixent-better-than-rinvoq\"><span style=\"font-weight: 400;\">Is Dupixent better than Rinvoq?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Clinical trials have shown that Dupixent and Rinvoq are effective treatment options for atopic dermatitis. The better option may depend on the individual\u2019s age and overall condition.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34347860\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">double-blind, randomized clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> comparing these drugs, Rinvoq (upadacitinib) was found to be more effective than Dupixent (dupilumab) in improving atopic dermatitis. After 16 weeks of treatment, 71% of patients on Rinvoq showed significant improvement in their skin condition versus 61% of those taking dupilumab. However, those on Dupixent experienced higher rates of certain infections and other adverse events, while those on dupilumab had more issues with eye irritation and injection-site reactions.<\/span><\/p>\n<p><a href=\"https:\/\/www.jaad.org\/article\/S0190-9622(23)00966-0\/fulltext\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Another study<\/span><\/a><span style=\"font-weight: 400;\"> followed patients with moderate-to-severe atopic dermatitis who switched from Dupixent (dupilumab) to Rinvoq (upadacitinib). It was found that those who continued with Rinvoq maintained high levels of skin and itch improvement. However, patients who switched from Dupixent to Rinvoq experienced additional improvements in their skin condition within just four weeks. Most patients who didn\u2019t respond well to Dupixent showed better results with Rinvoq, and the safety of Rinvoq over 40 weeks was consistent with previous studies, showing no new safety concerns.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always consult a healthcare provider to determine the most appropriate treatment option for your condition.\u00a0<\/span><\/p>\n<h2 id=\"rinvoq-vs-dupixent-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Rinvoq vs. Dupixent: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most insurance plans typically cover Rinvoq and Dupixent. However, the extent of coverage can vary based on the specifics of your health plan. Medicare Part D coverage for these drugs may also differ and should be confirmed with your insurance provider. Rinvoq, being a newer treatment, may have lower coverage rates across different plans than Dupixent.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The average retail cost of Rinvoq and Dupixent without insurance can vary widely, but with discounts or assistance programs, the price may be reduced. A one-month supply of Rinvoq without insurance may cost around $8,000, while a one-month supply of Dupixent without insurance is around $5,000. Using a <\/span><span style=\"font-weight: 400;\"> discount card<\/span><span style=\"font-weight: 400;\"> may help offset the out-of-pocket costs of these medications.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-coverage-cost-of-rinvoq-vs-dupixent\"><span class=\"title\">Compare coverage &amp; cost of Rinvoq vs. Dupixent<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 15 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2, 2 ml of 300 mg\/2 ml pens<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Average retail price<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$8,291<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$5,139<\/span><\/td>\n<\/tr>\n<tr>\n<td><b> cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$5,900<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$3,603<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"dupixent-vs-rinvoq-side-effects\"><span style=\"font-weight: 400;\">Dupixent vs. Rinvoq side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dupixent and Rinvoq carry a risk of various side effects. The types of side effects and their severity can depend on the medication and dosage.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common side effects of Rinvoq include upper respiratory infections, such as the common cold, nausea, acne, headache, cough, fatigue, weight gain, muscle pain, and fever. On the other hand, the most common side effects of Dupixent include injection site reactions, which can cause redness, swelling, itching, and joint pain. Dupixent can also cause eye problems, such as inflammation, redness, itching, and dryness in the eyes.\u00a0<\/span><\/p>\n<p><b> <\/b><b>Dupixent face rash and redness: Causes and treatment<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Both medications have been linked to an increased risk of <\/span><span style=\"font-weight: 400;\">herpes simplex<\/span><span style=\"font-weight: 400;\"> virus reactivation, which includes cold sores and herpes keratitis, particularly in individuals who carry the virus. Both medications can also lead to serious, although less frequent, side effects. For example, Rinvoq may increase the risk of serious infections, while Dupixent has been linked to severe allergic reactions.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-side-effects-of-rinvoq-vs-dupixent\"><span class=\"title\">Compare side effects of Rinvoq vs. Dupixent<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Upper respiratory tract infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">23%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">18%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Injection site reactions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Joint pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acne<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Herpes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%-4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Pink eye<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dry eye<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;1%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Eye itching<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cough<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Stomach pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fever<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight gain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Muscle pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fatigue<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><i><span style=\"font-weight: 400;\">Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more.<\/span><\/i><\/h6>\n<h6><span style=\"font-weight: 400;\">Source: DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2966aec7-2ef0-923c-d8ff-fe1a957bf095\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Rinvoq<\/span><\/a><span style=\"font-weight: 400;\">), DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=595f437d-2729-40bb-9c62-c8ece1f82780\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Dupixent<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/h6>\n<h2 id=\"rinvoq-and-dupixent-drug-interactions\"><span style=\"font-weight: 400;\">Rinvoq and Dupixent drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Rinvoq is mainly metabolized or processed in the liver by CYP3A4 enzymes. Taking Rinvoq with other medications that can block or increase the activity of these enzymes may increase Rinvoq blood levels, leading to increased side effects or decreasing its effectiveness. Medications that can affect the metabolism of Rinvoq include certain antibiotics, antifungals, antivirals, and anticonvulsants, among others.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dupixent may have the potential to interact with certain substances that are metabolized by the CYP3A4 enzymes, such as warfarin and cyclosporine. However, some studies indicate that taking Dupixent with other medications metabolized by these liver enzymes has <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7202577\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">no significant effects<\/span><\/a><span style=\"font-weight: 400;\">. Caution may be recommended while taking certain drugs.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As Rinvoq and Dupixent can dampen certain signals of inflammation in the immune system, it\u2019s recommended to avoid live vaccines right before and during treatment. Always consult a healthcare provider before starting treatment if you take other medications, including over-the-counter medicines, prescription drugs, and herbal supplements.\u00a0<\/span><\/p>\n<p><strong> Important information about Dupixent and vaccines<\/strong><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-rinvoq-vs-dupixent-drug-interactions\"><span class=\"title\">Compare Rinvoq vs. Dupixent drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Biaxin (clarithromycin)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ketek (telithromycin)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Erythrocin (erythromycin)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rifadin (rifampin)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Antibiotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nizoral (ketoconazole)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sporanox (itraconazole)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vfend (voriconazole)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Noxafil (posaconazole)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Antifungal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cardizem (diltiazem)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Calan (verapamil)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Calcium channel blocker<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Norvir (ritonavir)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prezista (darunavir)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Reyataz (atazanavir)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Antiviral<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Tegretol (carbamazepine)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dilantin (phenytoin)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Luminal (phenobarbital)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Anticonvulsant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">St. John\u2019s wort\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Herbal supplement<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">MMR (Measles, Mumps, Rubella)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Varivax (Varicella)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rotarix (Rotavirus)\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zostavax (Herpes Zoster)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Live vaccines<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><i><span style=\"font-weight: 400;\">Consult a healthcare professional for other possible drug interactions.<\/span><\/i><\/h6>\n<h2 id=\"rinvoq-and-dupixent-drug-warnings\"><span style=\"font-weight: 400;\">Rinvoq and Dupixent drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Various warnings are associated with Rinvoq and Dupixent, as they each come with their own set of risk factors for serious side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People taking Rinvoq may be at an increased risk of serious infections, such as bacterial, viral, and fungal infections. They also face an increased risk of thrombosis or <\/span><span style=\"font-weight: 400;\">blood clots<\/span><span style=\"font-weight: 400;\">, including deep vein thrombosis, pulmonary embolism, and arterial thrombosis. The medication carries warnings related to malignancies, including reports of lymphoma and lung cancer, and the potential for major adverse cardiovascular events, such as heart attacks and strokes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dupixent carries warnings mainly related to hypersensitivity reactions, which could develop as a severe allergic reaction requiring medical attention. Eye problems, including <\/span><span style=\"font-weight: 400;\">conjunctivitis<\/span><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.aoa.org\/healthy-eyes\/eye-and-vision-conditions\/keratitis?sso=y\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">keratitis<\/span><\/a><span style=\"font-weight: 400;\">, have been reported, especially in people with predisposed conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is unknown whether Rinvoq or Dupixent can harm an unborn baby. Therefore, they should only be used during pregnancy if the potential benefits outweigh the potential risks. 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<\/g>\n<\/svg>\t\t\t\t\t\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Do you know: Differences, similarities &#038; side effects in 2025 Key takeaways Rinvoq and Dupixent are prescription drugs for moderate-to-severe atopic dermatitis. However, they also have other FDA-approved uses.\u00a0\u00a0 Rinvoq, a JAK inhibitor, is taken orally, while Dupixent, a monoclonal antibody, is administered via injection.\u00a0 Both drugs are effective for atopic dermatitis, but clinical trials [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7064","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=7064"}],"version-history":[{"count":2,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7064\/revisions"}],"predecessor-version":[{"id":8903,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7064\/revisions\/8903"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=7064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=7064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=7064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}