{"id":7065,"date":"2025-02-03T12:15:24","date_gmt":"2025-02-03T12:15:24","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-side-effects-in-2025-24\/"},"modified":"2025-12-23T14:39:50","modified_gmt":"2025-12-23T14:39:50","slug":"hmn-emgality-and-aimovig-differences-similarities-side-effects-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-emgality-and-aimovig-differences-similarities-side-effects-in-2025\/","title":{"rendered":"HMN: Emgality and Aimovig Differences, similarities &#038; side effects in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, similarities &#038; side effects in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Emgality and Aimovig, both CGRP antagonists, are used for migraine prevention but differ in active ingredients and dosing requirements.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Emgality requires a loading dose and is also approved for episodic cluster headaches, unlike Aimovig.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Both medications are generally effective in reducing migraine frequency, with Emgality showing slightly better consistency in being taken as directed.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">While both drugs have similar side effects, like injection site reactions, Aimovig may also cause constipation and high blood pressure.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Emgality<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Aimovig<\/span><span style=\"font-weight: 400;\"> are two medications used as preventive treatments for <\/span><span style=\"font-weight: 400;\">migraine<\/span><span style=\"font-weight: 400;\">, a condition characterized by intense, debilitating headaches. These medications belong to a class of drugs called calcitonin gene-related peptide (CGRP) antagonists. They work by blocking the CGRP molecule, which is involved in pain and inflammation associated with migraine attacks.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both Emgality and Aimovig are brand-name drugs given by injection, typically once a month. As subcutaneous injections, these medications are administered just under the skin of the stomach area, thigh, or upper arm. While they share similarities in how they work and are used, they differ in various ways, including cost and potential side effects. Therefore, it\u2019s important to consult a healthcare provider to determine the most appropriate option.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read on to learn more about the similarities and differences between Emgality and Aimovig.\u00a0<\/span><\/p>\n<h2 id=\"emgality-vs-aimovig-key-differences\"><span style=\"font-weight: 400;\">Emgality vs. Aimovig: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The main difference between Emgality and Aimovig is in their active ingredients. Emgality, developed by Eli Lilly &amp; Co., contains the active ingredient galcanezumab-gnlm. Aimovig is manufactured by Amgen Inc. and contains the active ingredient erenumab-aooe. Despite their different active components, both drugs target the calcitonin gene-related peptide (CGRP) pathway to prevent migraine headaches.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Regarding administration, both drugs are injected once per month. However, they differ in their dosage forms and delivery devices. Emgality is available as a <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/761063s006lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">prefilled pen or syringe<\/span><\/a><span style=\"font-weight: 400;\">. It requires a loading dose of 240 milligrams (mg) before switching to a monthly dose of 120 mg for migraine prevention. A loading dose is an initial higher dose of medication given to quickly achieve a therapeutic level in the bloodstream.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aimovig comes as a <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/761077s015lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">prefilled autoinjector or syringe<\/span><\/a><span style=\"font-weight: 400;\">. Unlike Emgality, Aimovig does not require a loading dose. Instead, Aimovig can be started as a monthly dose from the first use. The typical dosage is 70 or 140 mg, injected once monthly.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"emgality-vs-aimovig-compare-key-differences\"><span class=\"title\">Emgality vs. Aimovig: Compare key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">CGRP receptor antagonists, monoclonal antibody<\/span><\/td>\n<td><span style=\"font-weight: 400;\">CGRP receptor antagonists, monoclonal antibody<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Galcanezumab-gnlm<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Erenumab-aooe<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Injection under the skin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection under the skin<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Migraine prevention: Two 120 mg injections administered once, followed by 120 mg per month<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Episodic cluster headache treatment: Three 100 mg injections administered consecutively, followed by three, 100 mg injections each month until the end of the cluster period<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Migraine prevention: 70 or 140 mg injection once per month<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"emgality-vs-aimovig-conditions-treated\"><span style=\"font-weight: 400;\">Emgality vs. Aimovig: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Emgality and Aimovig are both approved by the Food and Drug Administration (FDA) to prevent migraine in adults. This approval includes the prevention of episodic migraines\u2014defined as fewer than 15 headache days per month\u2014and chronic migraines\u2014defined as 15 or more headache days a month, with at least eight being migrainous.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Emgality has also received FDA approval for the treatment of episodic <\/span><span style=\"font-weight: 400;\">cluster headaches<\/span><span style=\"font-weight: 400;\"> in adults. People with episodic cluster headaches experience periods of frequent headache attacks, known as \u201ccluster periods,\u201d followed by headache-free intervals. During these cluster periods, individuals may face multiple excruciating headaches per day. Unlike migraines, which often cause throbbing pain on both sides of the head and can be triggered by various factors like light or noise sensitivity, cluster headaches are typically <\/span><span style=\"font-weight: 400;\">one-sided<\/span><span style=\"font-weight: 400;\"> and have a more intense and debilitating pain intensity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Neither Emgality nor Aimovig is a cure for migraines or cluster headaches. Rather, they are used to reduce the frequency, severity, and duration of headache episodes. Unlike Emgality, Aimovig has not been approved to treat cluster headaches.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"emgality-vs-aimovig-compare-conditions-treated\"><span class=\"title\">Emgality vs. Aimovig: Compare conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Preventive treatment of migraine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Treatment of episodic cluster headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"is-aimovig-better-than-emgality\"><span style=\"font-weight: 400;\">Is Aimovig better than Emgality?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Emgality and Aimovig are both effective options for preventing migraines. Clinical studies on Emgality and Eimovig showed they were effective in significantly reducing the number of monthly migraine days (MMDs) compared to a placebo. Specifically, patients receiving these treatments were more likely to achieve at least a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9369309\/\"><span style=\"font-weight: 400;\">50% reduction<\/span><\/a><span style=\"font-weight: 400;\"> in their migraine frequency.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One study <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10787551\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">compared three different migraine prevention drugs<\/span><\/a><span style=\"font-weight: 400;\">: Emgality (galcanezumab), Ajovy (fremanezumab), and Aimovig (erenumab). It found that people who started with galcanezumab tended to stick with their treatment longer and were less likely to stop using it compared to those on the other two drugs. Specifically, 47.8% of patients on galcanezumab discontinued treatment, which is lower than the 51.7% for fremanezumab and 50.2% for erenumab. The results suggest that galcanezumab might be a more effective option for consistent migraine prevention over time.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always consult a healthcare provider for medical advice on the most effective treatment option, as effectiveness can vary.\u00a0<\/span><\/p>\n<p><b> <\/b><b>Aimovig alternatives: What can I take instead?<\/b><\/p>\n<h2 id=\"emgality-vs-aimovig-insurance-coverage-and-cost\"><span style=\"font-weight: 400;\">Emgality vs. Aimovig: Insurance coverage and cost\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many insurance plans cover Emgality and Aimovig, although the extent of coverage can vary based on one\u2019s healthcare provider and the specific insurance plan. Those with Medicare Part D might also find that these medications are covered, but it is recommended to review the plan\u2019s policy details to confirm.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For those without insurance, Emgality and Aimovig may be more expensive than generic options. The cost for a one-month supply of Emgality or Aimovig without insurance may be around $1,000.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients can often reduce their out-of-pocket expenses by using prescription savings programs such as <\/span><span style=\"font-weight: 400;\"><\/span><span style=\"font-weight: 400;\">. Emgality and Aimovig coupons can provide substantial savings, sometimes lowering costs to a fraction of the retail price.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-costs-coverage-of-emgality-vs-aimovig\"><span class=\"title\">Compare costs &amp; coverage of Emgality vs. Aimovig<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">1, 1 ml of 120 mg\/ml pen<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1, 1 ml of 140 mg\/ml pen<\/span><\/td>\n<\/tr>\n<tr>\n<td><b> cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$640<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$738<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"aimovig-vs-emgality-side-effects\"><span style=\"font-weight: 400;\">Aimovig vs. Emgality side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Emgality<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Aimovig<\/span><span style=\"font-weight: 400;\"> share some common side effects. People who use Emgality or Aimovig may experience injection site reactions, such as pain, redness, and swelling around the area of injection. However, injection site reactions may occur more frequently in people using Emgality. Unlike Emgality, Aimovig may also cause constipation, muscle cramps, and high blood pressure.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both drugs can potentially cause serious side effects. For instance, both could trigger an allergic reaction, although this is rare. Symptoms like swelling of the face, severe rash, or difficulty breathing could be signs of a serious allergic reaction requiring immediate medical attention.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-side-effects-of-emgality-vs-aimovig\"><span class=\"title\">Compare side effects of Emgality vs. Aimovig<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Injection site reactions<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">18%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Constipation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">High blood pressure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Muscle cramps or spasms<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">\u2013<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;1%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more.<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">Source: DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=33a147be-233a-40e8-a55e-e40936e28db0\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Emgality<\/span><\/a><span style=\"font-weight: 400;\">), DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b998ed05-94b0-47fd-b28f-cddd1e128fd8\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Aimovig<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h2 id=\"emgality-and-aimovig-drug-interactions\"><span style=\"font-weight: 400;\">Emgality and Aimovig drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Emgality and Aimovig are unlikely to interact with most medications. Neither drug is metabolized or processed in the liver in a way that significantly affects other medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since both drugs work by influencing the CGRP pathway, the key concern is using them with other CGRP receptor antagonists, which may increase the risk of hypersensitivity or compounded effects. Therefore, these medications should not be used together or with other CGRP receptor antagonists.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although these migraine medications do not have extensive drug interactions, it is still important to inform healthcare providers of all medications you take, especially if you have multiple health conditions.\u00a0<\/span><\/p>\n<h2 id=\"emgality-and-aimovig-drug-warnings\"><span style=\"font-weight: 400;\">Emgality and Aimovig drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Emgality and Aimovig carry warnings on their drug labels for potential hypersensitivity reactions. It\u2019s important to report any signs of allergic reactions, such as hives, swelling, or difficulty breathing, which require immediate medical attention. These reactions may occur within hours or days after taking the medications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aimovig carries additional warnings for serious complications related to constipation and the possibility of new-onset or worsening <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33423274\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\">. It is important to monitor your health closely and seek medical attention if you experience any concerning symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is not known whether Emgality or Aimovig can harm an unborn baby or pass into breast milk. 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Emgality requires a loading dose and is also approved for episodic cluster headaches, unlike Aimovig. 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