{"id":7133,"date":"2025-02-03T12:47:18","date_gmt":"2025-02-03T12:47:18","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-what-happens-if-you-take-jardiance-at-night-in-2025\/"},"modified":"2025-02-03T12:47:18","modified_gmt":"2025-02-03T12:47:18","slug":"hmn-what-happens-if-you-take-jardiance-at-night-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-what-happens-if-you-take-jardiance-at-night-in-2025\/","title":{"rendered":"HMN: What happens if you take Jardiance at night? in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  What happens if you take Jardiance at night? in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Jardiance is a medication for diabetes that helps clear blood sugar through the urine.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Jardiance is generally prescribed to be taken once daily in the morning, with or without food. However, some people may wish to take it later in the day or at night.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Research explores how Jardiance\u2019s timing relates to our body\u2019s internal clock, but it seems there\u2019s no big difference whether you take it in the morning or evening.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Potential side effects of taking Jardiance at night include nocturnal hypoglycemia and other potentially serious complications like dehydration.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Jardiance, known generically as empagliflozin, is an oral medication often prescribed to manage blood sugar levels in people with Type 2 diabetes. It works as a <\/span><span style=\"font-weight: 400;\">sodium-glucose cotransporter 2 (SGLT2) inhibitor<\/span><span style=\"font-weight: 400;\"> that helps the kidneys remove blood sugar or glucose from the bloodstream through the urine. It\u2019s typically recommended to take Jardiance in the morning.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you take Jardiance at night, it could cause you to wake frequently to urinate. As a result, Jardiance might also disrupt your sleep patterns. Some studies suggest that the timing of Jardiance doses may also affect the drug\u2019s metabolism, with the effects of Jardiance on blood sugar levels varying between morning and evening doses.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read on to learn more about what happens if you take Jardiance at night.<\/span><\/p>\n<h2 id=\"the-circadian-rhythm-and-timing-of-medications\"><b>The circadian rhythm and timing of medications<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The field of chronopharmacology explores how our body\u2019s internal clock, known as its <\/span><a href=\"https:\/\/www.nigms.nih.gov\/education\/fact-sheets\/Pages\/circadian-rhythms.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">circadian rhythm<\/span><\/a><span style=\"font-weight: 400;\">, affects the effectiveness and safety of medications. This rhythm regulates various bodily functions, including blood pressure and blood sugar levels. Medications can have different effects depending on the time they are taken, as our bodies respond differently to treatment throughout the day.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The body\u2019s circadian rhythm also <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8803319\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">affects how the kidneys work<\/span><\/a><span style=\"font-weight: 400;\">. The kidneys have different functions, such as filtering the blood and helping control blood pressure. This natural rhythm guides when these functions are most active or slow. Understanding this timing can help healthcare providers choose the best times to give medications for better results in treating kidney-related issues.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Researchers are studying how the timing of Jardiance aligns with our biological clock, especially as it relates to <\/span><span style=\"font-weight: 400;\">managing blood sugar levels<\/span><span style=\"font-weight: 400;\">. By considering the natural fluctuations in our body\u2019s functions throughout the day, healthcare providers may be able to personalize treatment plans for better outcomes.<\/span><\/p>\n<h2 id=\"how-is-jardiance-administered\"><b>How is Jardiance administered?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance is a brand-name drug available as oral tablets in strengths of <\/span><span style=\"font-weight: 400;\">10 and 25 milligrams (<\/span><span style=\"font-weight: 400;\">mg<\/span><span style=\"font-weight: 400;\">). People typically take Jardiance once daily in the morning, with or without food. Taking it at the same time every day may help maintain a consistent level of the medication in the bloodstream.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The typical starting dose of Jardiance is 10 mg, which healthcare providers may increase to 25 mg based on how well a patient\u2019s blood sugar levels are controlled and their overall tolerance to the medication. As it works in the kidneys, it\u2019s recommended to have kidney function assessed before taking the drug. Like all medications, following the prescribed dosing instructions is important to ensure the best results.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This diabetes medication is recommended to be taken along with diet and exercise to lower blood sugar levels. Although it\u2019s mainly prescribed for diabetes, it can also help reduce the risk of death from <\/span><span style=\"font-weight: 400;\">heart failure<\/span><span style=\"font-weight: 400;\"> or heart disease. It has also been approved to reduce the risk of worsening kidney function that could lead to hospital visits or death in people with chronic kidney disease.\u00a0<\/span><\/p>\n<h2 id=\"what-happens-when-you-take-jardiance-at-night\"><b>What happens when you take Jardiance at night?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">While Jardiance is generally recommended in the morning, taking it in the evening could still help manage blood sugar levels. Recent studies suggest that the timing of the dose does not significantly alter the efficacy of Jardiance.<\/span><\/p>\n<h2 id=\"studies-on-the-effects-of-jardiance-at-night\"><b>Studies on the effects of Jardiance at night<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The recommendation to take Jardiance in the morning comes from its drug label and is based on clinical research about the drug\u2019s peak action times and its potential effects on the circadian rhythm. Taking this medication in the morning may be beneficial because <\/span><a href=\"https:\/\/diabetes.org\/living-with-diabetes\/high-morning-blood-glucose\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">blood sugar levels tend to rise early in the day<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8167502\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recent study<\/span><\/a><span style=\"font-weight: 400;\"> looked at the effects of taking Jardiance in the evening versus the morning in healthy adults. The study found that after taking a single 10 mg dose of Jardiance, the time it took for the medication to reach its peak concentration (T max) was slightly shorter in the morning compared to the evening.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Interestingly, the total exposure of the drug measured through AUC (area under the curve) was slightly higher for the evening dose than for the morning dose. In other words, there were differences in how the body processed the medication depending on the time it was given.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The study also looked at the amount of blood sugar excreted in urine (UGE) over 24 hours after taking Jardiance. Surprisingly, the study found that more blood sugar was excreted after the evening dose than after the morning dose. However, despite these differences between evening and morning doses, the study concluded that there was no significant statistical difference in the effects of Jardiance when taken at night versus in the morning.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important to follow the advice of a healthcare provider since factors like kidney function, blood sugar levels, and other medications can affect the timing.<\/span><\/p>\n<h3 id=\"potential-side-effects-during-sleep\"><b>Potential side effects during sleep<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Jardiance works to lower blood sugar the same way at nighttime as it does in the morning. However, there may still be <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> associated with taking it at night. For example, taking Jardiance at night may increase the risk of nocturnal hypoglycemia (low blood sugar during sleep), especially if it\u2019s taken with other glucose-lowering medications such as insulin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Symptoms of low blood sugar<\/span><span style=\"font-weight: 400;\"> to be aware of include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trembling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapid heartbeat\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tingling or numbness in the lips, tongue, or cheeks<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Hypoglycemia can lead to sleep disturbances, and since signs of low blood sugar may go unnoticed during sleep, it poses a risk that may need to be monitored.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other side effects may be associated with Jardiance, no matter when it\u2019s taken. The most common side effects include <\/span><span style=\"font-weight: 400;\">urinary tract infections<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">yeast infections<\/span><span style=\"font-weight: 400;\"> (in women). Serious side effects are possible and may include the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diabetic ketoacidosis<\/b><span style=\"font-weight: 400;\">: <\/span><span style=\"font-weight: 400;\">Diabetic ketoacidosis<\/span><span style=\"font-weight: 400;\"> is a serious condition where the body produces high levels of ketones, which can be life-threatening. It mainly affects people with Type 1 diabetes but can also occur in people with Type 2 diabetes or pancreas problems. Factors like illness, diet changes, alcohol consumption, dehydration, or missed insulin doses can trigger it. Symptoms include nausea, vomiting, tiredness, abdominal pain, and trouble breathing.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dehydration<\/b><span style=\"font-weight: 400;\">: <\/span><span style=\"font-weight: 400;\">Dehydration<\/span><span style=\"font-weight: 400;\"> can happen after taking Jardiance, causing the body to lose water and salt. Signs of dehydration include dizziness, fainting, and weakness, especially when standing up. Those at higher risk include people who are on blood pressure medications, are following a low-sodium diet, have kidney issues, or are age 65 or older.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Amputations<\/b><span style=\"font-weight: 400;\">: Certain medications may increase the risk of lower limb amputations. People with a history of amputation, narrowed blood vessels, or diabetic foot problems are at higher risk while taking Jardiance. Immediate medical attention is necessary for new pain, sores, ulcers, or infections in the leg or foot.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Serious allergic reactions<\/b><span style=\"font-weight: 400;\">: If signs of a serious allergic reaction develop, stopping the medication and seeking medical help are key. Symptoms of a serious allergic reaction may require urgent attention and include severe hives, itching, swelling of the face or throat, and trouble breathing.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Taking Jardiance at night can be safe and effective. Although the time of taking Jardiance may be adjusted based on your routine and healthcare provider\u2019s recommendations, it may be advised to watch blood sugar levels and keep an eye on potential side effects.<\/span><\/p>\n<h2 id=\"guidance-for-proper-use-of-jardiance\"><b>Guidance for proper use of Jardiance<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance should be taken daily, preferably at the same time every day. You may want to include the medication in your daily routine, such as before or after breakfast, to help you remember to take it.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you miss a dose, it\u2019s important to take it as soon as you remember unless it\u2019s almost time for the next dose; in that case, skip the missed dose. Do not double up on doses.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance works best as part of a <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/204629s040lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">well-rounded treatment plan<\/span><\/a><span style=\"font-weight: 400;\"> that includes a healthy diet, regular exercise, and regular blood sugar monitoring. Combining Jardiance with lifestyle changes helps maximize its effectiveness and can help promote improved overall health.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Serious side effects should not be overlooked. Seek immediate medical attention if you experience symptoms of an allergic reaction, severe urinary infection, or diabetic ketoacidosis. Serious bacterial infections and an increased risk of lower-limb amputations have been associated with Jardiance use in rare cases.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consult a healthcare provider for proper dosage instructions, and never make changes to your medication regimen without medical advice. You should also tell your healthcare provider about other medical conditions you might have or other medications you take, as these can affect how Jardiance works or increase the risk of side effects.\u00a0<\/span><\/p>\n<h2 id=\"bottom-line\"><b>Bottom line<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Taking Jardiance at night is not based on typical dosing recommendations. It\u2019s usually recommended to take Jardiance in the morning, with or without food. However, Jardiance may still be effective for managing blood sugar levels if it is taken at night. Whether you take Jardiance in the morning or at night, aim to take it at the same time every day.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Studies suggest that there is no significant difference in the effects of Jardiance in the morning or at night. Still, the effects of Jardiance can vary by individual. 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