{"id":7175,"date":"2025-02-03T13:41:13","date_gmt":"2025-02-03T13:41:13","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-rexulti-generic-availability-cost-more-in-2025\/"},"modified":"2025-02-03T13:41:13","modified_gmt":"2025-02-03T13:41:13","slug":"hmn-rexulti-generic-availability-cost-more-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-rexulti-generic-availability-cost-more-in-2025\/","title":{"rendered":"HMN: Rexulti generic availability, cost &#038; more in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Rexulti generic availability, cost &#038; more in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Rexulti is a brand-name second-generation antipsychotic that contains the active ingredient brexpiprazole.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Rexulti is currently only available under its brand name. There is not a generic formulation available at this time.\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Consult your healthcare provider for more information about Rexulti or other alternatives that may work for you.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Rexulti<\/span><span style=\"font-weight: 400;\"> is a prescription medication that contains the active ingredient brexpiprazole. The brand-name drug is <\/span><span style=\"font-weight: 400;\">a member of a drug class called <\/span><span style=\"font-weight: 400;\">atypical antipsychotic drugs<\/span><span style=\"font-weight: 400;\">, or second-generation antipsychotics. <\/span><span style=\"font-weight: 400;\">Made by <\/span><span style=\"font-weight: 400;\">Otsuka America Pharmaceutical, Inc., Rexulti is <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2d301358-6291-4ec1-bd87-37b4ad9bd850\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">approved by the Food &amp; Drug Administration (FDA)<\/span><\/a><span style=\"font-weight: 400;\"> for the following uses:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Adjunctive therapy (an add-on medication) to antidepressant medication for the treatment of major depressive disorder (<\/span><span style=\"font-weight: 400;\">depression<\/span><span style=\"font-weight: 400;\">) in adults<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment of <\/span><span style=\"font-weight: 400;\">schizophrenia<\/span><span style=\"font-weight: 400;\"> in adults and pediatric patients ages 13 and older<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment of agitation associated with <\/span><span style=\"font-weight: 400;\">dementia<\/span><span style=\"font-weight: 400;\"> due to <\/span><span style=\"font-weight: 400;\">Alzheimer\u2019s disease<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Brand-name drugs can be costly. For people who pay out of pocket with no insurance coverage or discounts, <\/span><span style=\"font-weight: 400;\">a one-month supply of Rexulti<\/span><span style=\"font-weight: 400;\"> costs about $1,924. That\u2019s over $23,000 per year. Because of these high prices, patients who take Rexulti may want to know if a lower-cost generic is available.\u00a0<\/span><\/p>\n<h2 id=\"is-generic-rexulti-available\"><span style=\"font-weight: 400;\">Is generic Rexulti available?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Generic Rexulti is not yet available in pharmacies. Several generic formulations of brexpiprazole have received <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/drug-approvals-and-databases\/drugsfda-glossary-terms\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">tentative approval<\/span><\/a><span style=\"font-weight: 400;\"> from the FDA. A tentative approval means that the generic formulation is ready to be approved, but the brand name product still has patents that have not yet expired. These patents allow only the manufacturer to make and market the drug until the patents expire. The FDA does not give final approval until all patent or exclusivity issues are resolved. Companies with tentative approval cannot sell the generic drug yet. So, if you see generic brexpiprazole advertised or in the news, know that these are tentative approvals, and the generic formulations are not yet available in pharmacies.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although you cannot get generic Rexulti at the moment, you may want to know more about generics in general\u2014<\/span><span style=\"font-weight: 400;\">are they as good as their brand-name counterparts<\/span><span style=\"font-weight: 400;\">? This general information applies to all prescription and over-the-counter (OTC) drugs (but not dietary supplements, which are not as strictly regulated). Here are some key facts about generics:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Although a generic drug may look different from a brand-name drug, it contains the same active ingredient and works the same way. However, there is usually a significant difference in cost, as generics can cost up to 80% less than their brand-name counterparts.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Because brand-name and generic medications contain the same active ingredient and have the same FDA-approved uses, they are the same in terms of safety and efficacy. Since generics offer the benefit of significant cost savings, many patients choose generics when available.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The FDA requires generics to be <\/span><a href=\"https:\/\/www.merckmanuals.com\/home\/drugs\/brand-name-and-generic-drugs\/bioequivalence-and-interchangeability-of-generic-drugs\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">bioequivalent<\/span><\/a><span style=\"font-weight: 400;\"> to the brand. This means that the generic drug results in the same blood levels in the body over the same period of time as the brand.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">According to the FDA, <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/generic-drugs\/office-generic-drugs-2022-annual-report\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">91% of all prescriptions in the United States are filled as generics<\/span><\/a><span style=\"font-weight: 400;\"> instead of their brand-name versions.<\/span><\/li>\n<\/ul>\n<h2 id=\"rexulti-important-information\"><span style=\"font-weight: 400;\">Rexulti: Important information<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following table summarizes information about Rexulti, such as its uses, side effects, and warnings.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"rexulti-brexpiprazole-key-information\"><span class=\"title\">Rexulti (brexpiprazole): Key information<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Uses<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Add-on therapy, in addition to an antidepressant, to treat depression in adults<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment of schizophrenia in adults and children ages 13 and older<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treatment of agitation associated with dementia due to Alzheimer\u2019s disease<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rexulti is taken <\/span><span style=\"font-weight: 400;\">once daily<\/span><span style=\"font-weight: 400;\">, with or without food, as an oral tablet available in the following strengths: <\/span><span style=\"font-weight: 400;\">0.25 milligrams (mg), 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For depression use in adults, the starting dose is 0.5 or 1 mg, the recommended target dosage is 2 mg, and the maximum dosage is 3 mg.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For schizophrenia in adults, the starting dose is 1 mg, the recommended target dose is 2\u20134 mg, and the maximum dosage is 4 mg.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For schizophrenia in pediatric patients ages 13\u201317, the starting dose is 0.5 mg, the recommended target dose is 2\u20134 mg, and the maximum dosage is 4 mg.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For agitation associated with dementia due to Alzheimer\u2019s disease, the starting dose is 0.5 mg, the recommended target dose is 2 mg, and the maximum dosage is 3 mg.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Common side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach problems like constipation, diarrhea, and heartburn<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Uncontrollable shaking of a body part<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness, unsteadiness,\u00a0 and balance problems<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Contraindications<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who are allergic to brexpiprazole or any ingredient in Rexulti should not take this medication.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rexulti should not be used as an as-needed treatment for agitation associated with dementia due to Alzheimer\u2019s disease.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tell your healthcare provider about your medical conditions before taking Rexulti, including whether you are pregnant, planning to become pregnant, or breastfeeding. Also, tell your healthcare provider about all the medications you take, including prescription and OTC drugs, vitamins, and supplements\u2014so your healthcare provider can screen for drug interactions.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Other considerations<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Older adult patients with dementia-related psychosis who take antipsychotic medication are at increased risk of death. People who have dementia-related psychosis without agitation associated with dementia due to Alzheimer\u2019s disease should not take Rexulti.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In clinical trials, antidepressants increased the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. People of any age should be closely monitored for mood and behavior changes while taking Rexulti.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious side effects may occur, such as neuroleptic malignant syndrome (a serious condition that can lead to death; symptoms include high fever, muscle stiffness, confusion, sweating, and changes in pulse, heart rate, <\/span><span style=\"font-weight: 400;\">blood pressure<\/span><span style=\"font-weight: 400;\">, and breathing), <\/span><span style=\"font-weight: 400;\">tardive dyskinesia<\/span><span style=\"font-weight: 400;\"> (uncontrolled body movements), weight gain, <\/span><span style=\"font-weight: 400;\">high blood sugar<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">high cholesterol<\/span><span style=\"font-weight: 400;\">, compulsive behaviors, low blood cell counts, orthostatic hypotension (a drop in blood pressure when standing up), fainting, seizures, and others.<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"rexulti-alternatives\"><span style=\"font-weight: 400;\">Rexulti alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you are interested in switching to a different medication, the best way to do so is to consult your healthcare provider for medical advice. Only your healthcare provider can decide which medication is appropriate for you based on individual factors such as the condition being treated, your medical history, and other medicines you take. Some examples of <\/span><span style=\"font-weight: 400;\">Rexulti alternatives<\/span><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Until generic Rexulti is available, there are ways to save on this brand-name drug if cost is a concern:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use a <\/span><span style=\"font-weight: 400;\"> prescription discount card<\/span><span style=\"font-weight: 400;\">. The average out-of-pocket cost for a one-month supply of 1 mg Rexulti is $1,930, but you can pay as low as $1,370 per month with a <\/span><span style=\"font-weight: 400;\">Rexulti  coupon<\/span><span style=\"font-weight: 400;\">, depending on the pharmacy you choose to fill your prescription. That\u2019s a savings of $560 per month and $6,720 per year.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Look into the manufacturer\u2019s <\/span><a href=\"https:\/\/www.rexulti.com\/savings-cost\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">copay card<\/span><\/a><span style=\"font-weight: 400;\">. Eligible patients with commercial insurance may sign up for the Rexulti Savings Card and pay $0 for the first two months of Rexulti and $5 for each refill, including a 90-day supply. Check with the manufacturer for more information and eligibility requirements.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Find out if you are eligible for the <\/span><a href=\"https:\/\/www.otsukapatientassistance.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Otsuka patient assistance program<\/span><\/a><span style=\"font-weight: 400;\">. The <\/span><span style=\"font-weight: 400;\">Otsuka Patient Assistance Foundation, Inc. (OPAF) is a nonprofit organization that provides free medication (prescribed by a healthcare provider and made by Otsuka) to eligible uninsured or underinsured patients.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 8.2089 20.5098 8.05745C19.6147 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Rexulti is currently only available under its brand name. There is not a generic formulation available at this time.\u00a0 Consult your healthcare provider for more information about Rexulti or other [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7175","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=7175"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7175\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=7175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=7175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=7175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}