with high potency SSRIs, which includes sertraline. Similarly, the use of COX-2 selective NSAIDs may reduce the risk.\u00a0<\/span><\/p>\nNSAIDs are a class of medications that include:\u00a0<\/span><\/p>\n\n- Diclofenac<\/span><\/li>\n
- Etodolac<\/span><\/li>\n
- Ibuprofen<\/span><\/li>\n
- Indomethacin<\/span><\/li>\n
- Ketorolac<\/span><\/li>\n
- Meloxicam<\/span><\/li>\n
- Nabumetone<\/span><\/li>\n
- Naproxen<\/span><\/li>\n
- Sulindac<\/span><\/li>\n<\/ul>\n
Amphetamines<\/span><\/h2>\nMedications known as amphetamines, which are a type of <\/span>central nervous system (CNS) stimulants<\/span> that increase the levels of dopamine, norepinephrine, and serotonin in the body to improve focus and increase alertness. These medications may also enhance the serotonergic effects of sertraline, which could result in serotonin syndrome. Patients on both medications should be monitored closely, and a lower amphetamine dose should be considered if they need to be used in combination.\u00a0<\/span><\/p>\nAmphetamines include:<\/span><\/p>\n\n- Amphetamine<\/span><\/li>\n
- Benzphetamine<\/span><\/li>\n
- Dextroamphetamine<\/span><\/li>\n
- Lisdexamfetamine<\/span><\/li>\n
- Phentermine<\/span><\/li>\n<\/ul>\n
Many sertraline drug interactions occur due to medications referred to as \u201cCYP3A4 inducers,\u201d\u2014which are medications that increase the activity of a common enzyme (cytochrome P450)\u2014involved in the metabolism of many medications, including sertraline. CYP3A4 inducers are ubiquitous and rev up the enzyme to varying degrees. Strong CYP3A4 inducers include <\/span>anticonvulsant<\/span> medications like <\/span>phenobarbital<\/span>, <\/span>phenytoin<\/span>, and <\/span>carbamazepine<\/span>. These medications will decrease the blood levels of sertraline, which may necessitate dose increases, but minimally close monitoring for reduced antidepressant effects.\u00a0<\/span><\/p>\nOther strong CYP3A4 inducers include:\u00a0<\/span><\/p>\nModerate CYP3A4 inducers include:<\/span><\/p>\n\n- Diltiazem<\/span><\/li>\n
- Erythromycin<\/span><\/li>\n
- Medications for fungal infections, such as fluconazole, isavuconazole, and posaconazole<\/span><\/li>\n
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