{"id":7704,"date":"2025-06-27T10:08:01","date_gmt":"2025-06-27T10:08:01","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-effect-on-appetite-mood-more-in-2025\/"},"modified":"2025-06-27T10:08:01","modified_gmt":"2025-06-27T10:08:01","slug":"hmn-effect-on-appetite-mood-more-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-effect-on-appetite-mood-more-in-2025\/","title":{"rendered":"HMN: Effect on appetite, mood &#038; more in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Effect on appetite, mood &#038; more in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Ozempic (semaglutide) is a glucagon-like peptide-1 agonist (GLP-1) used for Type 2 diabetes, cardiovascular risk reduction, and kidney disease. It is often prescribed off-label for weight loss.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Ozempic works by acting like a hormone called GLP-1, helping you feel full faster and satisfied for longer, so you eat less. It also slows stomach emptying.\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Social media users often report positive effects of Ozempic and other GLP-1 drugs, such as clearer thinking, more energy, less anxiety and depression, and better control over compulsive behaviors like smoking and shopping, although some people report negative effects.\u00a0\u00a0<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Ozempic may have other potential benefits, such as <\/span><span style=\"font-weight: 400;\">slowing or delaying the development of Alzheimer\u2019s disease, but more research is needed.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Consult your primary healthcare provider or endocrinologist for more information and medical advice about Ozempic or other treatment options.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Ozempic<\/span><span style=\"font-weight: 400;\"> (semaglutide) is part of the <\/span><span style=\"font-weight: 400;\">glucagon-like peptide-1 agonist<\/span><span style=\"font-weight: 400;\"> (GLP-1) class of drugs and is made by Novo Nordisk. It is approved by the Food and Drug Administration (FDA) for blood glucose control in people with <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\">. It is also used for cardiovascular risk reduction and kidney disease. Although it is often thought of as a diabetes drug, Ozempic is often prescribed <\/span><span style=\"font-weight: 400;\">off-label<\/span><span style=\"font-weight: 400;\"> for weight loss, but it is not FDA approved for this use. Recently, there has been growing interest in other potential benefits of Ozempic and other GLP-1 medications. <\/span><span style=\"font-weight: 400;\">Ozempic<\/span><span style=\"font-weight: 400;\"> has various effects on the body, including the brain, and more research is continuously finding potential new benefits of this drug.\u00a0\u00a0<\/span><\/p>\n<h2 id=\"how-does-ozempic-work-for-weight-loss\"><span style=\"font-weight: 400;\">How does Ozempic work for weight loss?<\/span><\/h2>\n<p><a href=\"https:\/\/health.ucdavis.edu\/blog\/cultivating-health\/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend\/2023\/07\"><span style=\"font-weight: 400;\">Ozempic works for weight loss<\/span><\/a><span style=\"font-weight: 400;\"> by mimicking a natural hormone (GLP-1) in the body, enhancing satiety by helping you feel full faster and satisfied for longer, so you eat less. Ozempic also slows down how fast food leaves the stomach, which can further reduce appetite.\u00a0<\/span><\/p>\n<p><b> <\/b><b>How much weight can you lose in a month with Ozempic?<\/b><\/p>\n<h2 id=\"ozempic-s-effect-on-the-brain-s-reward-pathways\"><span style=\"font-weight: 400;\">Ozempic\u2019s effect on the brain\u2019s reward pathways<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People who take Ozempic often rave about how the medicine helps quiet <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10674813\/\"><span style=\"font-weight: 400;\">food noise<\/span><\/a><span style=\"font-weight: 400;\">, which is when you have constant and persistent thoughts of foods that are hard to ignore. Examples include constantly thinking about the next meal or craving sweet or salty foods. These food-related intrusive thoughts can interfere with even the best dieting efforts.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Drugs like semaglutide affect parts of the brain involved in the regulation of appetite, as well as reward-seeking behaviors. Research is ongoing about GLP-1s and food noise, but there seems to be a connection (based on anecdotal evidence) between using semaglutide and noticing less food noise. Researchers think that the satiety effects of GLP-1s may be related to their actions on the brain\u2019s dopamine reward system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Interestingly, some people also find that semaglutide reduces other compulsive behaviors, such as smoking, drinking alcohol, and even shopping. While these effects are mostly anecdotal, they suggest that GLP-1s may influence reward pathways beyond appetite control.\u00a0\u00a0<\/span><\/p>\n<h2 id=\"ozempic-s-effect-on-mood-and-behavior\"><span style=\"font-weight: 400;\">Ozempic\u2019s effect on mood and behavior<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Have you heard the term Ozempic personality? Will this drug give you a whole new personality, for better or worse? The prescribing information for Ozempic does not list any mood or personality changes as a side effect. Some personality-related effects,\u00a0 like anxiety, irritability, or mood changes, could be a symptom of low blood sugar, which Ozempic may cause\u2014especially when combined with insulin or certain diabetes medicines.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ozempic\u2019s <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=adec4fd2-6858-4c99-91d4-531f5f2a2d79#\"><span style=\"font-weight: 400;\">prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> does not specifically mention depression or suicidal thoughts. The prescribing information for <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98\"><span style=\"font-weight: 400;\">Rybelsus<\/span><\/a><span style=\"font-weight: 400;\"> (a brand-name drug that also contains semaglutide) also does not. However, the prescribing information for <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=ee06186f-2aa3-4990-a760-757579d8f77b#ID_447bccea-f565-49f6-b2c5-99530fc2cff7\"><span style=\"font-weight: 400;\">Wegovy<\/span><\/a><span style=\"font-weight: 400;\"> (another semaglutide product) does have a warning about avoiding use of the drug in people with a history of suicidal thoughts or behaviors. It also warns that people who use Wegovy should be closely monitored. Interestingly, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=487cd7e7-434c-4925-99fa-aa80b1cc776b\"><span style=\"font-weight: 400;\">Zepbound<\/span><\/a><span style=\"font-weight: 400;\"> has this suicide warning while <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d2d7da5d-ad07-4228-955f-cf7e355c8cc0\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> does not\u2014and both contain the same active ingredient, tirzepatide.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Regardless, the FDA has reported that there has been no connection found between GLP-1s and suicidal thoughts or behaviors\u2014but they are still researching the topic.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10669484\/\"><span style=\"font-weight: 400;\">new study published in 2024<\/span><\/a><span style=\"font-weight: 400;\"> looked at social media discussions to explore the effects of GLP-1s on mood and behavior. Many people reported positive effects, such as reduced <\/span><span style=\"font-weight: 400;\">anxiety<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">depression<\/span><span style=\"font-weight: 400;\"> symptoms, increased energy, clearer thinking, and better control over compulsive behaviors like smoking and shopping. People noted an improved sense of control around food\u2014not just eating less, but also feeling more in control. However, some individuals reported negative effects as well. The study researchers noted, however, that these reports do not establish a direct cause-and-effect relationship, and more new research is needed.<\/span><\/p>\n<h3 id=\"is-there-a-connection-between-ozempic-and-suicidal-thoughts\"><span style=\"font-weight: 400;\">Is there a connection between Ozempic and suicidal thoughts?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In January 2024, the <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/fda-drug-safety-podcasts\/update-fdas-ongoing-evaluation-reports-suicidal-thoughts-or-actions-patients-taking-certain-type\"><span style=\"font-weight: 400;\">FDA reported<\/span><\/a><span style=\"font-weight: 400;\"> that it had not found evidence of Ozempic and other GLP-1s causing suicidal thoughts or actions. They came to this conclusion by reviewing cases of suicidal thoughts or actions reported to the FDA Adverse Event Reporting System. From this, as well as reviews of clinical studies, the FDA found that there was not a clear relationship between GLP-1s and suicidal thoughts. However, the FDA noted that it cannot definitively rule out that there is a small risk and that it will continue to research the connection.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you or a family member or caregiver notice that you have any changes in mood or behavior, you should call your healthcare provider right away. For urgent situations, such as suicidal thoughts or behaviors, you should call 911 and go to the emergency room or call or text 988 for the <\/span><a href=\"https:\/\/988lifeline.org\/\"><span style=\"font-weight: 400;\">Suicide &amp; Crisis Lifeline<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"do-glp-1s-give-you-brain-fog\"><span style=\"font-weight: 400;\">Do GLP-1s give you brain fog?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some people report experiencing \u201cOzempic <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/symptoms\/brain-fog\"><span style=\"font-weight: 400;\">brain fog<\/span><\/a><span style=\"font-weight: 400;\">.\u201d But what is brain fog, and is it really caused by Ozempic?\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Brain fog is a term used to describe problems with thinking clearly, focusing, concentrating, remembering things, and paying attention. It may feel like you have a cloud (or fog) over your brain.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ozempic and other GLP-1s are not typically associated with brain fog. However, brain fog can occur from a number of causes. For example, Ozempic can cause <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> (low blood sugar), especially when combined with insulin or certain diabetes medications. Low blood sugar can cause symptoms like confusion, which may make people think they are experiencing brain fog due to Ozempic. So, while Ozempic is not associated with causing brain fog directly, it may cause low blood sugar, which could contribute to brain fog.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are various other causes of brain fog as well, such as stress, lack of sleep, and certain other medical conditions. Any of these may contribute to brain fog. If you experience brain fog, consult your healthcare provider for medical advice.\u00a0<\/span><\/p>\n<h2 id=\"does-ozempic-protect-against-alzheimer-s\"><span style=\"font-weight: 400;\">Does Ozempic protect against Alzheimer\u2019s?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some people ask about the connection between Ozempic and <\/span><span style=\"font-weight: 400;\">Alzheimer\u2019s disease<\/span><span style=\"font-weight: 400;\">. While clinical trials are ongoing, a study published in <\/span><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.14313\"><i><span style=\"font-weight: 400;\">Alzheimer\u2019s &amp; Dementia<\/span><\/i><\/a><span style=\"font-weight: 400;\"> in October 2024 found that people with Type 2 diabetes who used semaglutide (the active ingredient in Ozempic, <\/span><span style=\"font-weight: 400;\">Wegovy<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">Rybelsus<\/span><span style=\"font-weight: 400;\">) had a lower risk of a first-time diagnosis of Alzheimer\u2019s disease, compared to people who used insulin, other GLP-1s, or other diabetes medicines. The researchers believe semaglutide may play a role in slowing or delaying the development of Alzheimer\u2019s disease, but more research is needed to confirm this potential benefit.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In the study\u2019s discussion, the researchers note that their findings support previous research suggesting that semaglutide may protect the brain by decreasing inflammation and helping with cell function. Semaglutide may also lower Alzheimer\u2019s risk by improving conditions like Type 2 diabetes, obesity, and heart disease and by helping with depression, smoking, and alcohol use\u2014all of which can affect Alzheimer\u2019s development.<\/span><\/p>\n<h2 id=\"bottom-line\"><span style=\"font-weight: 400;\">Bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Ozempic is a popularly prescribed weight loss drug with various potential benefits being discovered often. We know that it mimics a natural hormone called GLP-1, but many people also report that it helps quiet food noise\u2014one of the biggest roadblocks for dieters. As research continues, we will likely learn even more about how Ozempic and other GLP-1s affect the body and brain. <\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 8.2089 20.5098 8.05745C19.6147 7.90601 18.6945 8.05596 17.8938 8.48379C17.093 8.91162 16.4569 9.59313 16.0852 10.4214C15.7135 11.2497 15.6273 12.178 15.84 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