{"id":7808,"date":"2025-07-14T13:41:50","date_gmt":"2025-07-14T13:41:50","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-fentanyl-vs-oxycodone-differences-similarities-risks-in-2025\/"},"modified":"2025-07-14T13:41:50","modified_gmt":"2025-07-14T13:41:50","slug":"hmn-fentanyl-vs-oxycodone-differences-similarities-risks-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-fentanyl-vs-oxycodone-differences-similarities-risks-in-2025\/","title":{"rendered":"HMN: Fentanyl vs. oxycodone: Differences, similarities &#038; risks in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Fentanyl vs. oxycodone: Differences, similarities &#038; risks in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Fentanyl and oxycodone are potent pain relievers that need to be used with medical supervision.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">These medications are typically used for pain that doesn\u2019t get better with non-opioid painkillers.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Both fentanyl and oxycodone can have serious side effects and can lead to addiction, so they need to be taken exactly as prescribed.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Fentanyl<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">oxycodone<\/span><span style=\"font-weight: 400;\"> are two potent opioid medications used to treat severe pain. These prescription drugs work by binding to opioid receptors in the brain and body to reduce pain signals. If you go through a serious injury or experience chronic pain that won\u2019t respond to regular <\/span><span style=\"font-weight: 400;\">painkillers<\/span><span style=\"font-weight: 400;\">, a healthcare provider may prescribe one of these medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both fentanyl and oxycodone are generic opioid pain relievers that are also available in brand-name versions. They\u2019re meant to be used for a short time. Both drugs are classified as Schedule II <\/span><span style=\"font-weight: 400;\">controlled substances<\/span><span style=\"font-weight: 400;\">, which means they have a high potential for abuse, misuse, and dependence. Therefore, it\u2019s important to use them only with guidance from a healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Read on to learn more about the similarities and differences between fentanyl and oxycodone.\u00a0<\/span><\/p>\n<h2 id=\"fentanyl-vs-oxycodone-key-differences\"><span style=\"font-weight: 400;\">Fentanyl vs. oxycodone: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although fentanyl and oxycodone work similarly as opioid analgesics (painkillers), they have several differences. Fentanyl is a generic synthetic opioid that was <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/019813s081lbl.pdf\"><span style=\"font-weight: 400;\">first approved in 1968<\/span><\/a><span style=\"font-weight: 400;\"> by the Food and Drug Administration (FDA). It\u2019s available as a lozenge, patch, injection, and sublingual (placed under the tongue) or buccal (placed inside the cheek) tablet.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oxycodone is a generic semi-synthetic opioid first <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/209777s009lbl.pdf\"><span style=\"font-weight: 400;\">approved by the FDA in 1950<\/span><\/a><span style=\"font-weight: 400;\">. It\u2019s typically taken as an immediate-release or extended-release tablet or capsule. Oxycodone is also available as a liquid oral solution.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The dosages of fentanyl and oxycodone can vary depending on the type of pain being treated and how a person responds to treatment. Fentanyl is considered more potent than oxycodone and is one of the strongest opioids available. It also has a longer duration of action than oxycodone: A fentanyl patch can <\/span><a href=\"https:\/\/www.hhs.texas.gov\/sites\/default\/files\/documents\/doing-business-with-hhs\/provider-portal\/QMP\/PainMedicationTable.pdf\"><span style=\"font-weight: 400;\">last up to 72 hours<\/span><\/a><span style=\"font-weight: 400;\">, while an oxycodone immediate-release tablet lasts for around three to four hours. However, oxycodone is also available in extended-release versions that can last for up to 12 hours.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-fentanyl-vs-oxycodone-key-differences\"><span class=\"title\">Compare fentanyl vs. oxycodone key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Opioid<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Opioid<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic available<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the brand name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Actiq, Duragesic, Fentora, Sublimaze<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Roxybond, Roxicodone, Percodan, Oxycontin, Xtampza ER<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What forms does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Lozenge, sublingual tablet, buccal tablet, patch, injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tablet, capsule, extended-release tablet, extended-release capsule, liquid oral solution<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Dosage depends on pain severity, response to treatment, previous use of other pain relievers, and potential risk for addiction or misuse<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Dosage depends on pain severity, response to treatment, previous use of other pain relievers, and potential risk for addiction or misuse<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Short-term or long-term with medical supervision<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Short-term or long-term with medical supervision<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"fentanyl-vs-oxycodone-conditions-treated\"><span style=\"font-weight: 400;\">Fentanyl vs. oxycodone: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fentanyl and oxycodone are approved by the FDA to treat moderate to severe pain that doesn\u2019t get better with non-opioid medications. They are usually reserved for situations when other pain relievers, like <\/span><span style=\"font-weight: 400;\">nonsteroidal anti-inflammatory drugs (NSAIDs)<\/span><span style=\"font-weight: 400;\">, aren\u2019t effective enough. Fentanyl, in particular, is often prescribed for patients who have already been using other opioids like morphine or oxycodone for at least a week.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These drugs are commonly used to manage acute pain following surgery or a major injury. In addition to postoperative pain, they may also be prescribed for <\/span><span style=\"font-weight: 400;\">chronic pain<\/span><span style=\"font-weight: 400;\"> associated with conditions like cancer. However, they are not generally recommended for long-term use due to the risk of addiction and potential overdose. Healthcare providers try to prescribe the smallest effective dose for pain control and for the shortest time necessary to minimize risks.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-fentanyl-vs-oxycodone-conditions-treated\"><span class=\"title\">Compare fentanyl vs. oxycodone conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Pain so severe that it requires the use of an opioid, and when other treatments are inadequate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"is-fentanyl-stronger-than-oxycodone\"><span style=\"font-weight: 400;\">Is fentanyl stronger than oxycodone?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both opioids are potent and effective for pain relief. However, fentanyl may have a stronger analgesic effect than oxycodone. For comparison, oxycodone is up to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482226\/\"><span style=\"font-weight: 400;\">two times<\/span><\/a><span style=\"font-weight: 400;\"> stronger than morphine. On the other hand, fentanyl is around <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459275\/\"><span style=\"font-weight: 400;\">50\u2013100 times<\/span><\/a><span style=\"font-weight: 400;\"> stronger than morphine. Therefore, after doing the math, fentanyl could be 25 to 50 times stronger than oxycodone.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Still, some studies suggest that fentanyl and oxycodone provide similar pain relief in real-world applications. In <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4025163\/\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\">, patients who used oxycodone for pain relief after laparoscopic cholecystectomy, a procedure to remove the gallbladder, required less medication than those who used fentanyl. However, the oxycodone group experienced more nausea between six and 24 hours post-operation. Despite these differences, there were no significant differences in overall patient satisfaction or other side effects between the two groups.<\/span><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-024-71708-5\"><span style=\"font-weight: 400;\">Another study<\/span><\/a><span style=\"font-weight: 400;\"> looked at the use of oxycodone and fentanyl after laparoscopic hysteromyomectomy, a minimally invasive surgery to remove uterine fibroids. Both medications provided similar pain scores, but more patients were more satisfied with oxycodone (73.3%) than fentanyl (36.7%). In addition, patients taking oxycodone had fewer headaches after the surgery.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Effectiveness can also depend on the amount of fentanyl or oxycodone taken and how each person reacts to the medication. It\u2019s important to use these opioids only with medical guidance to ensure they are safe and effective.<\/span><\/p>\n<h2 id=\"fentanyl-vs-oxycodone-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Fentanyl vs. oxycodone: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fentanyl and oxycodone are available in both generic and brand-name forms. Many insurance and Medicare plans usually cover these drugs, but coverage can vary based on the insurance plan. Prices may also vary depending on the pharmacy location and whether a person has met their deductible. Patients may need prior authorization from their healthcare provider, especially for fentanyl, due to its high potency.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Retail prices for prescription opioids can change based on the pharmacy, dosage form, and the quantity purchased. Without insurance, the <\/span><span style=\"font-weight: 400;\">cost of oxycodone<\/span><span style=\"font-weight: 400;\"> is roughly $310 per month, while <\/span><span style=\"font-weight: 400;\">fentanyl\u2019s average cost<\/span><span style=\"font-weight: 400;\"> can hover around $178. The availability of these medicines can depend on the demand and supply at your local pharmacy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may be able to save on retail prescription costs with discount cards like <\/span><span style=\"font-weight: 400;\"><\/span><span style=\"font-weight: 400;\">. These cards often provide helpful savings on pain medicine, especially for those without insurance. With your  card or the  app, you can access coupons for <\/span><span style=\"font-weight: 400;\">fentanyl<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">oxycodone<\/span><span style=\"font-weight: 400;\"> to bring the cost down to $39 and $77, respectively.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Compare fentanyl vs. oxycodone cost &amp; coverage<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td\/>\n<td><b>Fentanyl<\/b><\/td>\n<td><b>Oxycodone<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">2 boxes of 5 patches each<\/span><\/td>\n<td><span style=\"font-weight: 400;\">20, 5 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b> cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$39<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$77<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"fentanyl-vs-oxycodone-side-effects\"><span style=\"font-weight: 400;\">Fentanyl vs. oxycodone side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As part of the same drug class, fentanyl and oxycodone share many of the same side effects. The most common side effects of opioid pain medications include <\/span><span style=\"font-weight: 400;\">central nervous system (CNS) depressant effects<\/span><span style=\"font-weight: 400;\"> like drowsiness, dizziness, insomnia, weakness, fatigue, and headaches. These medications can also cause gastrointestinal side effects such as nausea, vomiting, constipation, and diarrhea. In addition, increased sweating and itching are possible while using opiates like fentanyl and oxycodone.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-fentanyl-vs-oxycodone-side-effects\"><span class=\"title\">Compare fentanyl vs. oxycodone side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Itching<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Constipation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Increased sweating<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weakness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fatigue<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diarrhea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&gt;5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">Source: DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=bf02ffd0-cc5d-446b-b648-378f6885052f\"><span style=\"font-weight: 400;\">Fentanyl<\/span><\/a><span style=\"font-weight: 400;\">), DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=72398542-8e0a-47b2-afeb-9ca5a1f15083\"><span style=\"font-weight: 400;\">Oxycodone<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/h5>\n<h5><i><span style=\"font-weight: 400;\">This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more.<\/span><\/i><\/h5>\n<h2 id=\"fentanyl-and-oxycodone-drug-interactions\"><span style=\"font-weight: 400;\">Fentanyl and oxycodone drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fentanyl and oxycodone can interact with similar medications, including the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liver enzyme inhibitors or inducers:<\/b><span style=\"font-weight: 400;\"> Both fentanyl and oxycodone are processed by the <\/span><span style=\"font-weight: 400;\">liver enzyme CYP3A4<\/span><span style=\"font-weight: 400;\">. Certain medications, like certain macrolide antibiotics and azole-antifungal drugs, can slow this process, leading to higher opioid levels in the body and an increased risk of an opioid overdose. Other drugs, like certain anticonvulsants, speed up metabolism, potentially making these opioids less effective or causing withdrawal symptoms.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>CNS depressants:<\/b><span style=\"font-weight: 400;\"> Combining fentanyl or oxycodone with other CNS depressants, such as <\/span><span style=\"font-weight: 400;\">benzodiazepines<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">muscle relaxants<\/span><span style=\"font-weight: 400;\">, or <\/span><span style=\"font-weight: 400;\">antipsychotics<\/span><span style=\"font-weight: 400;\">, can increase the risk of extreme drowsiness, slowed breathing, coma, or death. If these drugs need to be used together, dosages should be carefully managed by a healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Serotonergic drugs:<\/b><span style=\"font-weight: 400;\"> Both opioids can increase the risk of serotonin syndrome, a dangerous condition that affects mood and nervous system function, especially when taken with certain antidepressants. These <\/span><span style=\"font-weight: 400;\">antidepressants<\/span><span style=\"font-weight: 400;\"> may include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs). Symptoms include confusion, rapid heart rate, and high blood pressure.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monoamine oxidase inhibitors (MAOIs):<\/b><span style=\"font-weight: 400;\"> Using fentanyl or oxycodone with <\/span><span style=\"font-weight: 400;\">MAOIs<\/span><span style=\"font-weight: 400;\">, such as phenelzine or tranylcypromine, can lead to severe side effects, such as dangerous changes in blood pressure or respiratory depression. These opioids should not be used with MAOIs or within 14 days of stopping an MAOI.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diuretics:<\/b><span style=\"font-weight: 400;\"> Opioids can make <\/span><span style=\"font-weight: 400;\">diuretics<\/span><span style=\"font-weight: 400;\"> less effective by increasing the release of antidiuretic hormone, which reduces urination. Those on diuretics should be monitored for fluid retention.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Anticholinergic drugs:<\/b><span style=\"font-weight: 400;\"> Medications that affect the nervous system, such as those used for bladder issues or allergies, can increase the risk of severe constipation and urinary retention when taken with fentanyl or oxycodone.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Always consult a healthcare provider before taking an opioid if you take other medications. Provide a list of prescription medications, over-the-counter drugs, and herbal supplements you may be taking.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-fentanyl-vs-oxycodone-drug-interactions\"><span class=\"title\">Compare fentanyl vs. oxycodone drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Zithromax (azithromycin)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Biaxin (clarithromycin)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ery-Tab (erythromycin)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Macrolide antibiotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diflucan (fluconazole)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nizoral (ketoconazole)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sporanox (itraconazole)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Azole antifungal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Norvir (ritonavir)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Reyataz (atazanavir)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prezista (darunavir)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Protease inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dilantin (phenytoin)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tegretol (carbamazepine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Depakote (valproate)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Anticonvulsant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Xanax (alprazolam)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Valium (diazepam)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ativan (lorazepam)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Benzodiazepine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Flexeril (cyclobenzaprine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Soma (carisoprodol)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Baclofen (baclofen)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Muscle relaxant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Abilify (aripiprazole)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zyprexa (olanzapine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Seroquel (quetiapine)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Prozac (fluoxetine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zoloft (sertraline)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro (escitalopram)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">SSRI<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Effexor XR (venlafaxine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cymbalta (duloxetine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pristiq (desvenlafaxine)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">SNRI<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Elavil (amitriptyline)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tofranil (imipramine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Norpramin (desipramine)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">TCA<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Imitrex (sumatriptan)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Maxalt (rizatriptan)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zomig (zolmitriptan)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Triptan<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nardil (phenelzine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Parnate (tranylcypromine)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Marplan (isocarboxazid)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">MAOI<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lasix (furosemide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hydrodiuril (hydrochlorothiazide)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aldactone (spironolactone)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Diuretic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Atrovent (ipratropium)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ditropan (oxybutynin)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bentyl (dicyclomine)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Anticholinergic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><i><span style=\"font-weight: 400;\">Consult a healthcare professional for other possible drug interactions<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/h5>\n<h2 id=\"fentanyl-and-oxycodone-drug-warnings\"><span style=\"font-weight: 400;\">Fentanyl and oxycodone drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fentanyl and oxycodone carry many of the same warnings and precautions. You may need to work with a healthcare provider to watch for the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Risk of addiction and dependence:<\/b><span style=\"font-weight: 400;\"> Fentanyl and oxycodone have a high potential for <\/span><a href=\"https:\/\/nida.nih.gov\/research-topics\/opioids\"><span style=\"font-weight: 400;\">addiction and dependence<\/span><\/a><span style=\"font-weight: 400;\">. Even when taken as prescribed, there is a risk of developing physical and psychological dependence when taking either drug. Always follow a healthcare provider\u2019s instructions and discuss any history of substance abuse.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Neonatal opioid withdrawal syndrome (NOWS):<\/b><span style=\"font-weight: 400;\"> The use of opioids during pregnancy can carry risks to an unborn child, such as <\/span><a href=\"https:\/\/kidshealth.org\/en\/parents\/nows.html\"><span style=\"font-weight: 400;\">NOWS<\/span><\/a><span style=\"font-weight: 400;\">. This condition can cause withdrawal symptoms in the newborn. Pregnant individuals should consult a healthcare provider to weigh the risks and benefits of pain medications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Opioid-induced hyperalgesia:<\/b><span style=\"font-weight: 400;\"> In some cases, opioids can actually make pain worse instead of relieving it. If this happens, your healthcare provider may lower your dose or switch you to a different medication.\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Breathing problems in certain individuals:<\/b><span style=\"font-weight: 400;\"> Those with lung disease, who are frail, or who are of advanced age should be watched closely when starting an opioid or adjusting the dose. Opioids can cause respiratory depression, which is a serious condition in which breathing becomes inadequate, potentially leading to life-threatening complications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Adrenal gland issues:<\/b><span style=\"font-weight: 400;\"> Opioids can cause adrenal insufficiency, which can lead to low blood pressure, fatigue, and weakness. If this happens, treatment with steroids may be needed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Severe low blood pressure (hypotension):<\/b><span style=\"font-weight: 400;\"> Opioids can cause a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26461073\/\"><span style=\"font-weight: 400;\">dangerous drop in blood pressure<\/span><\/a><span style=\"font-weight: 400;\">, especially in people with circulatory problems. This can lead to complications such as dizziness or fainting if not managed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Risks with brain conditions:<\/b><span style=\"font-weight: 400;\"> People with head injuries, brain tumors, or impaired consciousness may be more vulnerable to the sedative effects of opioids, which can increase the risk of breathing problems.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Consult a healthcare provider for other possible warnings and precautions before starting pain management with an opioid. 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These medications are typically used for pain that doesn\u2019t get better with non-opioid painkillers. Both fentanyl and oxycodone can have serious side effects and can lead [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7808","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=7808"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/7808\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=7808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=7808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=7808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}