{"id":7857,"date":"2025-07-23T02:00:04","date_gmt":"2025-07-23T02:00:04","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-is-trulicity-insulin-in-2025\/"},"modified":"2025-07-23T02:00:04","modified_gmt":"2025-07-23T02:00:04","slug":"hmn-is-trulicity-insulin-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-is-trulicity-insulin-in-2025\/","title":{"rendered":"HMN: Is Trulicity insulin? in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Is Trulicity insulin? in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p>Trulicity (dulaglutide) is a non-insulin medication used to control blood sugar levels in adults with Type 2 diabetes, working by slowing food\u2019s exit from the stomach and stimulating insulin release after meals.<\/p>\n<\/li>\n<li>\n<p>Trulicity is part of a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists, which are not insulin replacements but can be used alongside insulin to improve blood glucose control.<\/p>\n<\/li>\n<li>\n<p>It is recommended for use in combination with diet and exercise and may also reduce the risk of major cardiovascular events in adults with Type 2 diabetes who have cardiovascular disease or multiple risk factors.<\/p>\n<\/li>\n<li>\n<p>Trulicity is a prescription medication administered via a self-injectable pen once a week, designed to be easy to use to aid in maintaining consistent treatment adherence.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Diabetes can be a difficult condition to manage. With many medical options available, and companies with high advertising budgets, it can be challenging to know which medication may be the best addition to a healthful diet and exercise. , we will talk about Trulicity, a non-insulin medication that can help with diabetes management.<\/span><\/p>\n<h2 id=\"how-trulicity-works\"><span style=\"font-weight: 400;\">How Trulicity works\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Trulicity (dulaglutide) can help control <\/span><span style=\"font-weight: 400;\">blood sugar levels<\/span><span style=\"font-weight: 400;\"> in adults with Type 2 diabetes. Trulicity works by slowing down how quickly food leaves the stomach and helping the pancreas release insulin in response to high blood sugar levels after a meal.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Type 2 diabetes mellitus can be <\/span><span style=\"font-weight: 400;\">reversed with weight loss and a healthful diet<\/span><span style=\"font-weight: 400;\">. Adults with Type 2 diabetes may use Trulicity as an addition to diet and exercise to improve blood glucose control. Trulicity is also used to reduce the risk of major adverse cardiovascular events, such as heart attack, in adults with Type 2 diabetes who have cardiovascular disease or multiple risk factors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Trulicity is not an over-the-counter medication. It is a prescription drug manufactured by Eli Lilly and Company that should only be used under the care of a healthcare provider.\u00a0<\/span><\/p>\n<h2 id=\"is-trulicity-insulin\"><span style=\"font-weight: 400;\">Is Trulicity insulin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Trulicity is not insulin. Trulicity is in a class of medications called <\/span><span style=\"font-weight: 400;\">glucagon-like peptide-1 (GLP-1) receptor agonists<\/span><span style=\"font-weight: 400;\">. GLP-1 agonists are medications that stimulate insulin secretion after a meal. The stomach releases its contents more slowly, the production of glucagon (the hormone that increases blood glucose levels) decreases, and the cells in the pancreas that produce insulin are better protected.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551568\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">GLP-1 agonists<\/span><\/a><span style=\"font-weight: 400;\"> have also been shown to improve outcomes in people who have cardiovascular disease and Type 2 diabetes by promoting weight loss, lowering blood pressure, improving blood flow to the heart, and improving overall cardiac function. GLP-1 agonists have also been shown to lower glucose production by the liver, protect nerve cells, and act on the part of the brain that sends hunger signals to the body.<\/span><\/p>\n<h2 id=\"does-trulicity-replace-insulin\"><span style=\"font-weight: 400;\">Does Trulicity replace insulin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Trulicity is not an insulin replacement. Insulin is used in the management of both <\/span><span style=\"font-weight: 400;\">Type 1 diabetes and Type 2 diabetes<\/span><span style=\"font-weight: 400;\">. People with Type 1 diabetes do not produce insulin or they produce it in extremely low amounts. They are dependent on insulin injections to maintain blood glucose levels that are safe. Other types of medications, like Trulicity, cannot be used in Type 1 diabetes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Insulin is not a first-line treatment for most individuals with Type 2 diabetes. People with Type 2 diabetes may or may not use insulin in addition to other medications and <\/span><span style=\"font-weight: 400;\">diet and weight loss strategies<\/span><span style=\"font-weight: 400;\"> to control blood sugar.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In clinical trials for long-acting diabetes medications, it is common to compare newer medications like Trulicity to a form of long-acting insulin called insulin glargine. This comparison is not to determine if the new medication is a replacement for insulin, but instead provides a known and acceptable set of parameters to evaluate it.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Trulicity is not better than insulin and insulin is not better than Trulicity. They are different classes of medications that are prescribed based on the needs of the person with diabetes. However, if there are no symptoms of hyperglycemia or very high blood glucose levels, the <\/span><a href=\"https:\/\/diabetesjournals.org\/care\/article\/45\/Supplement_1\/S125\/138908\/9-Pharmacologic-Approaches-to-Glycemic-Treatment\"><span style=\"font-weight: 400;\">American Diabetes Association<\/span><\/a><span style=\"font-weight: 400;\"> has recommended the use of a GLP-1 receptor agonist over insulin when possible.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<\/p>\n<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our diabetes newsletter<\/span><\/p><\/div>\n<p>\t<\/span><\/p>\n<h2 id=\"can-you-take-trulicity-and-insulin-together\"><span style=\"font-weight: 400;\">Can you take Trulicity and insulin together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Yes. Trulicity may be used with insulin if adequate glucose management is not obtained after using Trulicity with other classes of medications first. Insulin is often used early in the treatment of individuals with complications or symptoms of extremely high blood glucose levels. If insulin is used together with GLP-1 receptor agonists, there is often greater efficacy of both medications and improved treatment outcomes. If glycemic control is not adequately obtained in a relatively short period of time with GLP-1 agonists alone, the addition of insulin or other medications should not be delayed.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are several <\/span><span style=\"font-weight: 400;\">types of insulin<\/span><span style=\"font-weight: 400;\"> available. The Food and Drug Administration <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/125469s007s008lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">(FDA) has approved Trulicity<\/span><\/a><span style=\"font-weight: 400;\"> as a treatment for those who use mealtime insulin or basal insulin. Basal insulin, which is sometimes called bedtime insulin, is long-acting and usually taken once a day. Mealtime insulin is short-acting and taken before meals. Insulin doses and schedules may need to be adjusted with Trulicity to avoid low blood glucose levels. Examples of short- and long-acting insulins include:<\/span><\/p>\n<p><b>Mealtime, short-acting insulin:<\/b><\/p>\n<p><b>Bedtime, long-acting insulin:<\/b><\/p>\n<h2 id=\"which-other-medications-may-be-taken-with-trulicity\"><span style=\"font-weight: 400;\">Which other medications may be taken with Trulicity?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Type 2 diabetes is often a progressive disease where <\/span><a href=\"https:\/\/www.acpjournals.org\/doi\/10.7326\/M15-2650\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">monotherapy<\/span><\/a><span style=\"font-weight: 400;\"> (taking only one medication) is effective only for a few years. Combination therapy is often needed to adequately control blood glucose. According to the <\/span><a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/2042018820980225\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">American Diabetes Association<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">metformin<\/span><span style=\"font-weight: 400;\"> is the preferred first-line medical therapy in the treatment of Type 2 diabetes. Metformin is safe, inexpensive, and may reduce the risk of cardiovascular events and death. Compared to other classes of medications, metformin as first-line therapy has known beneficial effects on <\/span><span style=\"font-weight: 400;\">A1C<\/span><span style=\"font-weight: 400;\">, weight, and cardiovascular mortality.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to comprehensive lifestyle modifications, a GLP-1 receptor agonist such as Trulicity should be considered for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those with a contraindication or inability to take metformin,\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individuals with a hemoglobin A1C (a long term marker of glucose control) greater than 1.5% over target, or<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Individuals who do not reach their target A1C in three months, especially if they have cardiovascular risk factors.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">GLP-1 receptor agonists, including medications like Trulicity, may be used as first-line therapy in individuals with Type 2 diabetes who have or are at high risk for atherosclerotic cardiovascular disease and heart failure. It may be used with caution in people who have <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29910024\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">chronic kidney disease<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Emerging data from <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31542292\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">clinical trials<\/span><\/a><span style=\"font-weight: 400;\"> suggest that initial combination therapy may be more beneficial in blood glucose control.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other classes of medications that have been used with Trulicity include:<\/span><\/p>\n<p><b> <\/b><b>Is it safe to take Trulicity and metformin together?<\/b><b>\u00a0<\/b><\/p>\n<h2 id=\"more-about-trulicity\"><span style=\"font-weight: 400;\">More about Trulicity<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to Stephanie Redmond, Pharm.D., a cofounder of <\/span><a href=\"https:\/\/diabetesdoctor.com\/pages\/about-us\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">diabetesdoctor.com<\/span><\/a><span style=\"font-weight: 400;\">, the ease of use of Trulicity is one of the main reasons it may be considered over another medication in its class. \u201cIt\u2019s the easiest pen on the market,\u201d Dr. Redmond says. \u201cYou don\u2019t have to screw a needle cap on or dial up a dose. You take the cap off, set it on your abdomen, and press a button.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are some other helpful tips for taking this medication.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trulicity is used as an injectable pen. The Trulicity pen is self-administered as a subcutaneous injection in the upper arm, abdomen, or thigh. Each pen contains either a 0.75 mg, 1.5 mg, 3.0 mg, or 4.5 mg single-dose of Trulicity to be injected as a once-weekly dose.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trulicity may be taken at any time of day but should be taken on the same day of the week, every week. Take it on the day that you will remember and will fit in best with your schedule.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A missed dose should be taken as soon as you remember. If you need to switch the day you take your medication, that is okay, as long as you do not take two doses of Trulicity within three days.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mild irritation at the injection site is a common side effect of Trulicity, therefore rotating sites may be helpful.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It is important to follow medical advice while taking this medication. Your healthcare provider may adjust the dose of this medication to achieve adequate glycemic control.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This medication works best when combined with healthy lifestyle changes which may include weight loss, exercise, and maintaining a healthful diet.\u00a0<\/span><\/li>\n<\/ul>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 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