{"id":7972,"date":"2025-07-28T19:00:02","date_gmt":"2025-07-28T19:00:02","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-how-much-does-spravato-cost-without-insurance-in-2025\/"},"modified":"2025-07-28T19:00:02","modified_gmt":"2025-07-28T19:00:02","slug":"hmn-how-much-does-spravato-cost-without-insurance-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-how-much-does-spravato-cost-without-insurance-in-2025\/","title":{"rendered":"HMN: How much does Spravato cost without insurance? in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  How much does Spravato cost without insurance? in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Spravato (esketamine) is a prescription nasal spray given to people with treatment-resistant depression or depressed people who are at risk of suicide.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Without insurance, Spravato can be expensive. Each dose costs over $1,000, but other fees are incurred as well. <\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">People without insurance can save money on Spravato with alternative treatments, healthcare provider discounts, or payment plans.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Spravato (esketamine) is a prescription nasal spray used for treatment-resistant depression. Spravato is also FDA-approved to relieve depressive symptoms in people with <\/span><span style=\"font-weight: 400;\">major depressive disorder<\/span><span style=\"font-weight: 400;\"> who are actively thinking about killing themselves. The cost can add up to thousands per month.\u00a0<\/span><\/p>\n<p><b> <\/b><b>What is Spravato?<\/b><\/p>\n<h2 id=\"how-much-does-spravato-cost-without-insurance\"><span style=\"font-weight: 400;\">How much does Spravato cost without insurance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For those without insurance, the cost will depend on the dosage and any other additional costs, such as healthcare provider costs. By law, this medication is administered under the supervision of a healthcare provider, generally in an office, clinic, or other healthcare setting. This prescription is not dispensed at the pharmacy or administered by the patient at home.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The average retail price for <\/span><span style=\"font-weight: 400;\">Spravato 56 mg<\/span><span style=\"font-weight: 400;\"> is $1,059 for a 2 28 mg\/device therapy pack, which provides one dose of 56 mg. The average retail price for <\/span><span style=\"font-weight: 400;\">Spravato 84 mg<\/span><span style=\"font-weight: 400;\"> is $1,663 for a 3 28 mg\/device therapy pack, which provides one dose of 84 mg.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If the healthcare professional uses the lowest possible dose (56 mg), the cost of Spravato nasal spray for treatment-resistant depression is:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">First month: $8,473 (8 total doses, given twice-weekly)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Second month: $4,246 (4 total doses, given weekly)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Third month and after: $2,118 or $4,236 per month (given every other week or once a week)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">People without insurance can ask the healthcare professional about alternative treatments. Since oral <\/span><span style=\"font-weight: 400;\">antidepressants<\/span><span style=\"font-weight: 400;\"> are already being used, <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2021\/0101\/p16.html\"><span style=\"font-weight: 400;\">healthcare providers typically add an antipsychotic drug to the treatment plan<\/span><\/a><span style=\"font-weight: 400;\"> for these severe and hard-to-treat forms of depression.<\/span><\/p>\n<h3 id=\"how-much-does-brand-name-spravato-cost\"><span style=\"font-weight: 400;\">How much does brand-name Spravato cost?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Spravato is a premium-priced brand-name medication with no generic alternatives. The earliest a generic may be available is <\/span><a href=\"https:\/\/www.drugpatentwatch.com\/p\/tradename\/SPRAVATO\"><span style=\"font-weight: 400;\">2028<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-spravato-prices-to-related-drugs\">Compare Spravato prices to related drugs<\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Spravato<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(esketamine)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">$1,059 for a 2, 28 mg\/device therapy pack (56 mg dose)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">$1,663 for a 3, 28 mg\/device therapy pack (84 mg dose)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">$761 for a 2, 28 mg\/device therapy pack (56 mg dose) of brand-name Spravato<\/span><\/p>\n<p><span style=\"font-weight: 400;\">$1,131 for a 3, 28 mg\/device therapy pack (84 mg dose) of brand-name Spravato<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">See latest prices<\/span><span style=\"font-weight: 400;\"> (56 mg)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">See latest prices<\/span><span style=\"font-weight: 400;\">(84 mg)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Abilify<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><span style=\"font-weight: 400;\">aripiprazole<\/span><span style=\"font-weight: 400;\">)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">$895 for 30, 5 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$13 <\/span><span style=\"font-weight: 400;\">for 30, 5 mg tablets<\/span><span style=\"font-weight: 400;\"> of generic Abilify<\/span><\/td>\n<td><span style=\"font-weight: 400;\">See latest prices<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Geodon<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">ziprasidone<\/span><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$884 for 30, 40 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$13 for 30, 40 mg capsules of generic Geodon<\/span><\/td>\n<td><span style=\"font-weight: 400;\">See latest prices<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Rexulti<\/span><span style=\"font-weight: 400;\"> (brexpiprazole)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$2,024 for 30, 1 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1,420 for 30, 1 mg tablets of brand-name Rexulti<\/span><\/td>\n<td><span style=\"font-weight: 400;\">See latest prices<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Seroquel<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">quetiapine<\/span><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$154 for 30, 25 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 30, 25 mg tablets of generic Seroquel<\/span><\/td>\n<td><span style=\"font-weight: 400;\">See latest prices<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vraylar<\/span><span style=\"font-weight: 400;\"> (cariprazine)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$2,069 for 30, 1.5 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1,371 for 30, 1.5 mg capsules of brand-name Vraylar<\/span><\/td>\n<td><span style=\"font-weight: 400;\">See latest prices<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs. The listed  price references the price of generic drugs if available. Click the link under \u201cSavings options\u201d to see updated drug prices.<\/span><\/i><\/p>\n<h2 id=\"spravato-costs-by-dose\"><span style=\"font-weight: 400;\">Spravato costs by dose<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Spravato prices vary by dose. Spravato is sold only to the clinic or healthcare provider, so pricing may vary significantly by clinic. However, the medication cost is only part of the total cost. Administrative and provider costs add additional costs.<\/span><\/p>\n<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n<p id=\"headline\">Save up to 80% on Spravato with <\/p>\n<p id=\"subheadline\">Different pharmacies offer different prices for the same medication.  helps find the best price for you.<\/p>\n<div class=\"details-wrap\">\n<p>\n\t\t\t\t\tSpravato 56 Mg (2 Nasal spray)\t\t\t\t<\/p>\n<p>\n\t\t\t\t\t23666 &#8211; Hampton, VA\t\t\t\t<\/p>\n<\/p><\/div>\n<div class=\"api-response\">\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>\t\t\tSee Spravato prices at all pharmacies\n\t\t<\/p><\/div>\n<h2 id=\"is-spravato-covered-by-insurance\"><span style=\"font-weight: 400;\">Is Spravato covered by insurance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Spravato is different from other prescription drugs. This medicine cannot be purchased at your local pharmacy or by mail order. You can only get Spravato at <\/span><a href=\"https:\/\/www.spravato.com\/find-treatment-center\/\"><span style=\"font-weight: 400;\">treatment centers<\/span><\/a><span style=\"font-weight: 400;\"> from specific healthcare providers who are enrolled in the Spravato REMS program.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In terms of health <\/span><a href=\"https:\/\/www.spravato.com\/insurance-coverage\/#insurance-qustions\"><span style=\"font-weight: 400;\">insurance coverage<\/span><\/a><span style=\"font-weight: 400;\">, Spravato may be covered <\/span><a href=\"https:\/\/www.spravato.com\/insurance-coverage\/#insurance-qustions\"><span style=\"font-weight: 400;\">under your medical benefits or your pharmacy benefits<\/span><\/a><span style=\"font-weight: 400;\">. Check with your insurance company or ask your healthcare provider to verify coverage. The insurance provider can also estimate any out-of-pocket costs due after a deductible has been met. Not all Spravato-certified treatment centers may be in-network with your insurance plan, so choose an in-network provider to reduce the copay and other additional costs.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People with <\/span><a href=\"https:\/\/www.janssencarepath.com\/patient\/spravato\/withme\/medicare\"><span style=\"font-weight: 400;\">Medicare coverage<\/span><\/a><span style=\"font-weight: 400;\"> are usually covered for Spravato treatment in their Medicare Part B coverage. Not all Medicare Part B plans cover Spravato therapy, but some Medicare Part D drug coverage plans do cover the cost of the drug. If you are unsure, contact your Medicare insurance provider to check your coverage and out-of-pocket costs.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The out-of-pocket cost of Spravato treatment for individuals with health insurance or Medicare coverage will vary depending on the specific plan.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some state Medicaid programs cover Spravato therapy for eligible patients.<\/span><\/p>\n<h3 id=\"how-to-get-spravato-covered-by-insurance\"><span style=\"font-weight: 400;\">How to get Spravato covered by insurance<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before starting Spravato, contact the insurance company to verify coverage. Insurance plans will not cover Spravato for diagnoses other than treatment-resistant depression (TRD) or major depressive disorder (MDD) with acute suicidal ideation. You may be denied coverage if you don\u2019t meet the diagnostic criteria for either of these mental health disorders.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Approval usually requires prior authorization. The clinician will submit this paperwork, but insurance coverage may still be denied. Step therapy is already a requirement based on the diagnosis.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If all these requirements are met and coverage is still denied, you can file an appeal with the insurance company. The healthcare provider must supply a letter of medical necessity to justify the treatment. This process may be cumbersome and take a few weeks.<\/span><\/p>\n<h2 id=\"how-to-get-spravato-without-insurance\"><span style=\"font-weight: 400;\">How to get Spravato without insurance<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It can be difficult to pay for a premium-priced brand-name medicine like Spravato without insurance, especially taking into account associated costs such as healthcare provider visits. The good news is that there are other options:<\/span><\/p>\n<h3 id=\"1-use-a-singlecare-discount-card\"><span style=\"font-weight: 400;\">1. Use a  discount card<\/span><\/h3>\n<p><span style=\"font-weight: 400;\"> can save people up to 80% on prescription medications. However, Spravato is never sold to patients at retail pharmacies. Many retail pharmacies, however, have specialty pharmacies. Talk to the treating clinician about using a  discount.\u00a0<\/span><\/p>\n<h3 id=\"2-talk-with-your-healthcare-provider\"><span style=\"font-weight: 400;\">2. Talk with your healthcare provider<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many healthcare providers will work with patients on financial matters. You can ask your provider if they offer payment plans or other types of financing options. Some healthcare providers may offer a discounted price for patients without insurance.\u00a0<\/span><\/p>\n<h3 id=\"3-ask-your-healthcare-provider-about-an-alternative-medication\"><span style=\"font-weight: 400;\">3. Ask your healthcare provider about an alternative medication<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you have not exhausted all other options, ask your healthcare provider if there is a different medication that may be just as effective. However, you may experience troublesome side effects with some of these medications. Ask the clinician for medical advice before trying alternative drugs.\u00a0<\/span><\/p>\n<h3 id=\"4-ask-the-provider-about-financial-assistance-programs\"><span style=\"font-weight: 400;\">4. Ask the provider about financial assistance programs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The clinician or treatment center staff may know about rebates, <\/span><a href=\"https:\/\/www.jnjwithme.com\/patient\/spravato\/withme\/cost-support\/\"><span style=\"font-weight: 400;\">financial assistance, or patient assistance programs<\/span><\/a><span style=\"font-weight: 400;\"> that can help pay for your treatment.\u00a0<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 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Without insurance, Spravato can be expensive. Each dose costs over $1,000, but other fees are incurred as well. 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