{"id":8326,"date":"2025-09-13T21:20:10","date_gmt":"2025-09-13T21:20:10","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-side-effects-in-2025-36\/"},"modified":"2025-12-23T14:21:43","modified_gmt":"2025-12-23T14:21:43","slug":"hmn-latuda-lurasidone-and-zyprexa-differences-similarities-side-effects-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-latuda-lurasidone-and-zyprexa-differences-similarities-side-effects-in-2025\/","title":{"rendered":"HMN:  Latuda (lurasidone) and Zyprexa Differences, similarities &#038; side effects in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, similarities &#038; side effects in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Latuda (lurasidone) and Zyprexa (olanzapine) are second-generation antipsychotics used to treat schizophrenia and bipolar disorder. Latuda is available in tablet form, while Zyprexa is available in tablet, dissolving tablet, and injectable form.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Both medications can cause side effects such as drowsiness, dizziness, and weight gain. They may also lead to movement disorders and metabolic changes.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Consult your healthcare provider to determine the best medication for your condition and to discuss any potential interactions or side effects.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Latuda<\/span><span style=\"font-weight: 400;\"> (lurasidone) and <\/span><span style=\"font-weight: 400;\">Zyprexa<\/span><span style=\"font-weight: 400;\"> (olanzapine) are brand-name antipsychotic medications. Latuda is used for treating schizophrenia and bipolar depression. Zyprexa is used for managing schizophrenia and manic episodes of bipolar disorder. It can also be combined with antidepressants to treat depression or bipolar depression. Both medications work by affecting certain brain chemicals called dopamine and serotonin. However, Latuda and Zyprexa are not exactly the same. Continue reading to learn more about these medicines.<\/span><\/p>\n<h2 id=\"latuda-vs-zyprexa-key-differences\"><span style=\"font-weight: 400;\">Latuda vs. Zyprexa: Key differences<\/span><\/h2>\n<p><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/24692-antipsychotic-medications\"><span style=\"font-weight: 400;\">Antipsychotic medications<\/span><\/a><span style=\"font-weight: 400;\"> manage conditions related to psychosis, such as <\/span><span style=\"font-weight: 400;\">schizophrenia<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">bipolar disorder<\/span><span style=\"font-weight: 400;\">, and delirium. These medications are typically prescribed by psychiatrists, who specialize in diagnosing and treating mental health conditions. There are two main types of antipsychotics.<\/span><\/p>\n<p><b>First-generation antipsychotics<\/b><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">typical antipsychotics<\/span><span style=\"font-weight: 400;\">), such as Haldol (<\/span><span style=\"font-weight: 400;\">haloperidol<\/span><span style=\"font-weight: 400;\">), were the earliest developed and are less commonly used today due to their more bothersome side effects compared to newer medications.<\/span><\/p>\n<p><b>Second-generation antipsychotics<\/b><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><span style=\"font-weight: 400;\">) are now more commonly prescribed for psychosis. They tend to have fewer side effects than first-generation options. Latuda and Zyprexa are both atypical antipsychotics. Other examples include <\/span><span style=\"font-weight: 400;\">Abilify<\/span><span style=\"font-weight: 400;\"> (aripiprazole), <\/span><span style=\"font-weight: 400;\">Caplyta<\/span><span style=\"font-weight: 400;\"> (lumateperone), Clozaril (<\/span><span style=\"font-weight: 400;\">clozapine<\/span><span style=\"font-weight: 400;\">), <\/span><span style=\"font-weight: 400;\">Fanapt<\/span><span style=\"font-weight: 400;\"> (iloperidone), <\/span><span style=\"font-weight: 400;\">Geodon<\/span><span style=\"font-weight: 400;\"> (ziprasidone), <\/span><span style=\"font-weight: 400;\">Invega<\/span><span style=\"font-weight: 400;\"> (paliperidone), <\/span><span style=\"font-weight: 400;\">Risperdal<\/span><span style=\"font-weight: 400;\"> (risperidone), <\/span><span style=\"font-weight: 400;\">Rexulti<\/span><span style=\"font-weight: 400;\"> (brexpiprazole), <\/span><span style=\"font-weight: 400;\">Saphris<\/span><span style=\"font-weight: 400;\"> (asenapine), <\/span><span style=\"font-weight: 400;\">Seroquel<\/span><span style=\"font-weight: 400;\"> (quetiapine), and <\/span><span style=\"font-weight: 400;\">Vraylar<\/span><span style=\"font-weight: 400;\"> (cariprazine).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although Zyprexa and Latuda are in the same drug class and come in both brand and generic versions, they have a few key differences, including their active ingredients and dosage forms.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-latuda-vs-zyprexa-key-differences\"><span class=\"title\">Compare Latuda vs. Zyprexa key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Second-generation antipsychotic; atypical antipsychotic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Lurasidone\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Olanzapine\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets: <\/span><span style=\"font-weight: 400;\">20 mg, 40 mg, 60 mg, 80 mg, and 120 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablets (Zyprexa): <\/span><span style=\"font-weight: 400;\">2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Orally disintegrating tablets (<\/span><span style=\"font-weight: 400;\">Zyprexa Zydis<\/span><span style=\"font-weight: 400;\">): 5 mg, 10 mg, 15 mg, and 20 mg<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Injection (<\/span><span style=\"font-weight: 400;\">Zyprexa Relprevv<\/span><span style=\"font-weight: 400;\">)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Schizophrenia: 40 to 160 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bipolar depression: 20 to 120 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Should always be taken with at least 350 calories of food for optimal absorption<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Varies by indication; a <\/span><span style=\"font-weight: 400;\">typical dose<\/span><span style=\"font-weight: 400;\"> is 5 to 20 mg by mouth once daily<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Can be taken with or without food<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adolescents (for some uses)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adolescents (for some uses)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"latuda-vs-zyprexa-conditions-treated\"><span style=\"font-weight: 400;\">Latuda vs. Zyprexa: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Latuda is approved by the Food and Drug Administration (FDA) to treat adult and adolescent patients (13\u201317 years old) with <\/span><span style=\"font-weight: 400;\">schizophrenia<\/span><span style=\"font-weight: 400;\">. It can also be used alone to treat bipolar depression associated with bipolar I disorder in adults and pediatric patients ages 10\u201317 years old. It can be used in combination with lithium or valproate in adults with bipolar depression.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zyprexa is FDA approved to treat schizophrenia in adults and adolescents 13\u201317 years old. It can be used to treat acute manic or mixed episodes associated with bipolar I disorder as well as maintenance treatment of <\/span><span style=\"font-weight: 400;\">bipolar I disorder<\/span><span style=\"font-weight: 400;\"> in adults and adolescents 13 years and older. The table below outlines the FDA-approved uses for each medication.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-latuda-vs-zyprexa-conditions-treated\"><span class=\"title\">Compare Latuda vs. Zyprexa conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Condition<\/b><\/td>\n<td><b>Latuda<\/b><\/td>\n<td><b>Zyprexa<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Schizophrenia\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bipolar depression\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (associated with bipolar I disorder)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (when used as a combination medicine called <\/span><span style=\"font-weight: 400;\">Symbyax<\/span><span style=\"font-weight: 400;\"> that contains both olanzapine and <\/span><span style=\"font-weight: 400;\">fluoxetine<\/span><span style=\"font-weight: 400;\">)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acute treatment of manic episodes or mixed episodes associated with bipolar I disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (adults and adolescents), can be used alone or in combination with a mood stabilizer such as valproate or lithium<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Maintenance treatment of bipolar I disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Add-on medication to antidepressants such as Prozac (fluoxetine) to treat depression<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Symbyax)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acute agitation associated with schizophrenia or bipolar I mania<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (injection only)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"is-zyprexa-better-than-latuda\"><span style=\"font-weight: 400;\">Is Zyprexa better than Latuda?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is not a lot of data comparing the two drugs directly. In <\/span><a href=\"https:\/\/www.psychiatrist.com\/jcp\/effectiveness-lurasidone-patients-schizophrenia-following\/\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\"> comparing Latuda and Zyprexa, both medicines significantly improved symptoms in patients with schizophrenia during a six-week period. In a six-month extension study, Latuda maintained these improvements and showed benefits like sustained symptom control, reduced weight gain, and better cholesterol levels compared to Zyprexa. Switching from Zyprexa to Latuda led to further improvements in weight and cholesterol levels, though there was a slight increase in a movement disorder called akathisia.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.thelancet.com\/article\/S0140-6736(19)31135-3\/fulltext\"><span style=\"font-weight: 400;\">meta-analysis published in 2019<\/span><\/a><span style=\"font-weight: 400;\"> reviewed 32 oral antipsychotics, including Latuda and Zyprexa, to compare the efficacy and side effects. <\/span><span style=\"font-weight: 400;\">Latuda was found to have a minimal effect on heart rhythm, suggesting a lower risk for this cardiac side effect. Zyprexa was associated with an average weight gain of about 7 pounds, indicating a higher likelihood of weight-related issues. Latuda, on the other hand, was linked to less weight gain. Both medications were effective in reducing symptoms of schizophrenia compared to placebo (inactive medicine).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A more recent <\/span><a href=\"https:\/\/www.cambridge.org\/core\/journals\/european-psychiatry\/article\/efficacy-and-tolerability-of-fdaapproved-atypical-antipsychotics-for-the-treatment-of-bipolar-depression-a-systematic-review-and-network-metaanalysis\/9DEFC4464EBB6E4730A1D89654C6F2AB\"><span style=\"font-weight: 400;\">meta-analysis published in 2024<\/span><\/a><span style=\"font-weight: 400;\"> evaluated the efficacy and tolerability of five FDA-approved atypical antipsychotics for acute bipolar depression. Among the five drugs studied, all were more effective than placebo in improving depressive symptoms. Both Latuda and Zyprexa were effective, but Zyprexa was associated with significant weight gain and increases in total cholesterol and triglycerides. In contrast, Latuda was associated with less weight gain and fewer metabolic side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because treatment is individualized to each patient based on many individual factors, it is important to discuss the best treatment options for your condition with your healthcare provider.<\/span><\/p>\n<h2 id=\"latuda-vs-zyprexa-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Latuda vs. Zyprexa: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most commercial health insurance plans and Medicare prescription plans, such as Medicare Part D and Medicare Advantage plans, typically cover Latuda and Zyprexa. However, the copays and out-of-pocket expenses can differ depending on your plan. Choosing brand-name medications might result in higher costs or limited coverage compared with generic drugs. For the most accurate pricing information, contact your insurance provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Without insurance or discounts, the cost of a one-month supply of brand-name Latuda is approximately $1,863. Using a <\/span><span style=\"font-weight: 400;\"> coupon<\/span><span style=\"font-weight: 400;\"> for generic lurasidone can reduce this cost to as low as $22.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Without insurance, a one-month supply of brand-name Zyprexa costs about $573, but a <\/span><span style=\"font-weight: 400;\"> coupon<\/span><span style=\"font-weight: 400;\"> for generic olanzapine can lower the price to as little as $10. Drug prices fluctuate and vary by pharmacy, so these prices are just estimates.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-latuda-vs-zyprexa-cost-coverage\"><span class=\"title\">Compare Latuda vs. Zyprexa cost &amp; coverage<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (generic)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 20 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 5 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b> cost*<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$22 (generic)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$10 (generic)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*Drug prices fluctuate and vary by pharmacy.<\/span><\/h5>\n<p><strong>Save on schizophrenia medication<\/strong><\/p>\n<h2 id=\"latuda-vs-zyprexa-side-effects\"><span style=\"font-weight: 400;\">Latuda vs. Zyprexa side effects<\/span><\/h2>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534115\/\"><span style=\"font-weight: 400;\">Extrapyramidal symptoms (EPS)<\/span><\/a><span style=\"font-weight: 400;\"> refer to a range of movement disorders often associated with antipsychotic medications. These symptoms can occur in several ways, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dystonia<\/b><span style=\"font-weight: 400;\">: This is characterized by involuntary muscle contractions leading to abnormal postures and repetitive movements. Dystonia can impact various body parts, such as the back, pelvis, stomach, neck, jaw, eyes, face, and tongue.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Akathisia<\/b><span style=\"font-weight: 400;\">: This condition involves a persistent feeling of restlessness and an uncontrollable urge to move. Individuals with akathisia might frequently shift their weight or fidget.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Parkinsonism<\/b><span style=\"font-weight: 400;\">: Symptoms resemble those of Parkinson\u2019s disease and include tremors, muscle stiffness, a slow and shuffling walk, a hunched posture, balance issues, and difficulty rising from a seated position.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tardive dyskinesia<\/b><span style=\"font-weight: 400;\">: This disorder involves involuntary movements primarily affecting the face and tongue, including grimacing, lip smacking, and excessive blinking.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Common <\/span><span style=\"font-weight: 400;\">side effects of Latuda<\/span><span style=\"font-weight: 400;\"> include nausea, vomiting, drowsiness, and EPS, such as tremors or rigidity. Latuda can also lead to increased prolactin levels, which may cause men to experience swollen breast tissue or <\/span><span style=\"font-weight: 400;\">erectile dysfunction<\/span><span style=\"font-weight: 400;\">. In women, elevated prolactin levels might lead to breast milk secretion, even in those not breastfeeding, and can affect menstrual cycles.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For adults, common side effects of Zyprexa include decreased energy, dry mouth, increased appetite, sleepiness, shaking, constipation, dizziness, restlessness, and behavioral changes. In pediatric patients (ages 13\u201317), additional side effects include headaches, stomach pain, limb pain, and increased tiredness. Pediatric patients may experience more pronounced sleepiness and higher increases in prolactin levels and liver enzymes compared to adults.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zyprexa is also linked to Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), a potentially life-threatening condition. Symptoms of DRESS include rash, fever, and swollen glands, requiring emergency medical care.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although less common, serious adverse effects may occur with both medications. Individuals experiencing signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, should seek emergency medical attention right away.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For more information about common side effects, see the table below. Note that side effect frequency may vary with dosage. This is not a complete list, and other side effects may occur. For more information, consult your healthcare provider or pharmacist.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-latuda-vs-zyprexa-side-effects\"><span class=\"title\">Compare Latuda vs. Zyprexa side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Insomnia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%\u201311%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">EPS<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%\u201322%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10%\u201332%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%\u201313%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%\u20139%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%\u20139%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness or sedation\u00a0\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8%\u201326%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies; up to 52% in people who also took lithium or valproate<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%\u20136%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%\u201318%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dry mouth\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%\u20136%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">17%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Increased appetite\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%\u201324%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=afad3051-9df2-4c54-9684-e8262a133af8\"><span style=\"font-weight: 400;\">Latuda (DailyMed)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d5051fbc-846b-4946-82df-341fb1216341\"><span style=\"font-weight: 400;\">Zyprexa (DailyMed)<\/span><\/a><\/h5>\n<h2 id=\"latuda-and-zyprexa-drug-interactions\"><span style=\"font-weight: 400;\">Latuda and Zyprexa drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before starting treatment with Latuda or Zyprexa, tell your healthcare provider about all of the medications you are taking, including prescription drugs, over-the-counter (OTC) medications, vitamins, and dietary supplements. Some drug combinations with Latuda or Zyprexa may need to be avoided or dosages may need to be adjusted. It is also important to avoid alcohol while on these medications. For personalized advice on drug interactions and their effects, consult your prescribing healthcare provider.<\/span><\/p>\n<p>\u00a0<\/p>\n<h2 id=\"latuda-and-zyprexa-drug-warnings\"><span style=\"font-weight: 400;\">Latuda and Zyprexa drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before taking Latuda or Zyprexa, tell your healthcare provider about your medical history and medical conditions, including if you are pregnant, planning to become pregnant, or breastfeeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Latuda and Zyprexa both have a <\/span><span style=\"font-weight: 400;\">black box warning<\/span><span style=\"font-weight: 400;\"> about an increased risk of death in older adults with dementia-related psychosis as well as an increased risk of suicidal thoughts and behaviors\u2014especially in children and young adults. Patients of all ages on Latuda or Zyprexa should be closely monitored for any mood changes or suicidal thoughts.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additional warnings for Latuda and Zyprexa include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Neuroleptic Malignant Syndrome (NMS) is a rare but severe condition that can be fatal and is associated with antipsychotic medications like Zyprexa and Latuda. Symptoms may include severe muscle stiffness, high fever, delirium, and kidney failure. Immediate medical attention is required if these symptoms occur.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tardive dyskinesia (TD)<\/span><span style=\"font-weight: 400;\"> is a type of extrapyramidal symptom (EPS) associated with these medications. It involves repetitive, involuntary movements, such as grimacing, blinking, and lip-smacking.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Metabolic changes, such as weight gain, diabetes, and elevated <\/span><span style=\"font-weight: 400;\">cholesterol levels<\/span><span style=\"font-weight: 400;\"> can occur.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">There\u2019s a risk of decreases in white blood cells, which may require discontinuation of the medication.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">There\u2019s a risk of orthostatic hypotension, which is a drop in blood pressure when standing that can lead to fainting. Avoid alcohol and refrain from driving or operating machinery until you know how the medication affects you.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Both medications may increase sensitivity to high temperatures. Stay hydrated and avoid overheating, especially during physical activity and in hot environments.<\/span><\/li>\n<\/ul>\n<h2 id=\"can-you-take-latuda-and-zyprexa-together\"><span style=\"font-weight: 400;\">Can you take Latuda and Zyprexa together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Combining Latuda and Zyprexa is generally <\/span><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/collections\/choosing-wisely\/111.html\"><span style=\"font-weight: 400;\">not recommended<\/span><\/a><span style=\"font-weight: 400;\">. Routine use of multiple antipsychotic medications is discouraged due to limited evidence supporting their combined efficacy and safety, as well as increased risks for drug interactions and medication errors. Exceptions may be considered in certain scenarios, such as if a patient has not responded to several single therapies, or if there is a plan to eventually transition to a single medicine. 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<\/g>\n<\/svg>\t\t\t\t\t\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Do you know: Differences, similarities &#038; side effects in 2025 Key takeaways Latuda (lurasidone) and Zyprexa (olanzapine) are second-generation antipsychotics used to treat schizophrenia and bipolar disorder. Latuda is available in tablet form, while Zyprexa is available in tablet, dissolving tablet, and injectable form. Both medications can cause side effects such as drowsiness, dizziness, and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8326","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=8326"}],"version-history":[{"count":1,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8326\/revisions"}],"predecessor-version":[{"id":8874,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8326\/revisions\/8874"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=8326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=8326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=8326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}