{"id":8417,"date":"2025-10-03T13:38:25","date_gmt":"2025-10-03T13:38:25","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-effectiveness-and-side-effects-in-2025\/"},"modified":"2025-12-23T14:25:56","modified_gmt":"2025-12-23T14:25:56","slug":"hmn-jardiance-effectiveness-and-side-effects-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-jardiance-effectiveness-and-side-effects-in-2025\/","title":{"rendered":"HMN: Jardiance , effectiveness, and side effects in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, effectiveness, and side effects in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Jardiance is a medication used to treat Type 2 diabetes as well as kidney disease, cardiovascular disease, and heart failure.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Most patients take 10 mg of Jardiance for treatment, but individuals with diabetes who require additional support may take a 25 mg dose of Jardiance.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">There are no notable differences in side effects, drug interactions, or warnings between a 10 mg and 25 mg dose of Jardiance.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Jardiance<\/span><span style=\"font-weight: 400;\"> is the brand name for empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It\u2019s FDA approved to treat Type 2 diabetes in adults and children, who are at least 10 years of age, in conjunction with diet and exercise. <\/span><span style=\"font-weight: 400;\">Jardiance<\/span><span style=\"font-weight: 400;\"> is also approved to reduce the risk of cardiovascular death in adults with Type 2 diabetes and cardiovascular disease, to reduce the risk of worsening renal function in adults with chronic kidney disease, and to reduce the risk of hospitalization and cardiovascular death in adults with heart failure or chronic kidney disease. Jardiance works by removing excess glucose (sugar) from the body through the kidneys.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance is taken orally once per day at either a 10 mg or 25 mg dose. Wondering what the difference is between Jardiance 10 mg vs. 25 mg? Most people who take Jardiance take a 10 mg dose, but a 25 mg dose is sometimes used in patients with Type 2 diabetes who need more help reducing their blood sugar.<\/span><\/p>\n<h2 id=\"what-s-the-difference-between-jardiance-10-mg-versus-25-mg\"><span style=\"font-weight: 400;\">What\u2019s the difference between Jardiance 10 mg versus 25 mg?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The 10 mg dose of Jardiance is the typical starting dose, says Linda Khoshaba, NMD, naturopathic endocrinologist and founder of<\/span><a href=\"https:\/\/www.nesaz.com\/\"> <span style=\"font-weight: 400;\">Natural Endocrinology Specialists (NES)<\/span><\/a><span style=\"font-weight: 400;\">. \u201cIt\u2019s sort of a \u2018let\u2019s see how your body does with this\u2019 approach,\u201d she says. If your blood sugar levels aren\u2019t being lowered sufficiently with the 10 mg dose, your doctor may bump you up to 25 mg for a more potent effect. \u201cThe higher dose isn\u2019t automatically better for everyone\u2014it\u2019s usually reserved for when the smaller dose isn\u2019t enough,\u201d says Dr. Khoshaba.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When it comes to<\/span> <span style=\"font-weight: 400;\">diabetes management<\/span><span style=\"font-weight: 400;\">, research has shown that higher doses of Jardiance can be more effective for glycemic control. For example, a 2021 study published in the<\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpt.13521\"> <i><span style=\"font-weight: 400;\">Journal of Clinical Pharmacy and Therapeutics<\/span><\/i><\/a><span style=\"font-weight: 400;\"> found that higher doses of empagliflozin (Jardiance) result in more substantial decreases in<\/span> <span style=\"font-weight: 400;\">hemoglobin A1C<\/span><span style=\"font-weight: 400;\">, a blood test that measures your average glucose level from the past three months. Overall, the study found that, over the course of 12 weeks, empagliflozin doses of 10, 25, and 50 mg were more effective at lowering A1C than 1, 2.5, and 5 mg. Among these doses, 25 mg performed the best overall, considering efficacy and side effects.<\/span><\/p>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=faf3dd6a-9cd0-39c2-0d2e-232cb3f67565\"><span style=\"font-weight: 400;\">According to DailyMed,<\/span><\/a><span style=\"font-weight: 400;\"> the 25 mg dose is typically reserved for offering extra support to patients with Type 2 diabetes. However, you can ask your provider if a higher dose is best suited for your specific medical situation.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here\u2019s what to know about conditions that Jardiance treats and 10 mg vs 25 mg dosing.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"conditions-treated-by-jardiance-10-mg-and-25-mg\"><span style=\"font-weight: 400;\">Conditions treated by Jardiance 10 mg and 25 mg<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Reduction in the risk of cardiovascular death and hospitalization in adults with heart failure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Reduction in the risk of kidney failure, hospitalization, and death in adults with chronic kidney disease<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Reduction in the risk of cardiovascular death in adults with Type 2 diabetes and cardiovascular disease<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Blood glucose control in people with Type 2 diabetes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, if well tolerated and if further glycemic control is needed<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"jardiance-10-mg-vs-25-mg-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">\u00a0<\/span><span style=\"font-weight: 400;\">Jardiance 10 mg vs. 25 mg: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most<\/span> <span style=\"font-weight: 400;\">major health insurance plans cover Jardiance<\/span><span style=\"font-weight: 400;\">, though coverage will depend on your plan, and some providers may require<\/span> <span style=\"font-weight: 400;\">step therapy<\/span><span style=\"font-weight: 400;\">, meaning that you must try other less expensive medications first to prove that Jardiance is a better match for your health needs. What about Medicare and Medicaid? \u201cMedicare Part D and Medicaid also usually cover Jardiance, though the exact out-of-pocket cost can depend on your plan and state,\u201d Dr. Khoshaba says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As for whether coverage varies based on a 10 mg vs. 25 mg dose of Jardiance, that shouldn\u2019t make much of a difference. \u201cIn most cases, both 10 mg and 25 mg doses are covered since they\u2019re the same medication in different strengths,\u201d Dr. Khoshaba explains. \u201cSometimes it requires <\/span><span style=\"font-weight: 400;\">prior approval<\/span><span style=\"font-weight: 400;\">, but typically, patients can get access to either dose.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In terms of out-of-pocket costs, <\/span><span style=\"font-weight: 400;\">copays<\/span><span style=\"font-weight: 400;\"> for Jardiance vary from one insurance company to another. Medicaid recipients typically do not have copayments for medications. People on Medicare Part D may have Jardiance copayments ranging from<\/span> <span style=\"font-weight: 400;\">$0 to $170 a month<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance without insurance can be costly. For example, the average cost of Jardiance is about $867 for 30, 25 mg tablets. However, with a<\/span> <span style=\"font-weight: 400;\"> savings card<\/span><span style=\"font-weight: 400;\">, you can pay around $529 for 30, 25 mg tablets.<\/span><\/p>\n<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n<p id=\"headline\">Save up to 80% on Jardiance with <\/p>\n<p id=\"subheadline\">Different pharmacies offer different prices for the same medication.  helps find the best price for you.<\/p>\n<div class=\"details-wrap\">\n<p>\n\t\t\t\t\tJardiance 25 mg (30 Tablets)\t\t\t\t<\/p>\n<p>\n\t\t\t\t\t23666 &#8211; Hampton, VA\t\t\t\t<\/p>\n<\/p><\/div>\n<div class=\"api-response\">\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>\t\t\t<a target=\"_blank\" href=\"#\" class=\"coupon-see-all-btn\">See Jardiance prices at all pharmacies<\/a>\n\t\t<\/div>\n<h2 id=\"10-mg-and-25-mg-jardiance-side-effects\"><span style=\"font-weight: 400;\">10 mg and 25 mg Jardiance side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like all medications, Jardiance can have side effects. The<\/span> <span style=\"font-weight: 400;\">most common side effects of Jardiance<\/span><span style=\"font-weight: 400;\"> are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infections (UTIs)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased urination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yeast infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increases in blood cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint aches and pains<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney issues<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Less commonly, Jardiance can cause dehydration and hypotension (low blood pressure).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The side effects shouldn\u2019t vary too much between a Jardiance 10 mg vs. 25 mg. The drug\u2019s label on DailyMed cites similar incidence rates for the most common adverse reactions. \u201cThe side effects don\u2019t really change between the two doses\u2014it\u2019s the same drug,\u201d Dr. Khoshaba says. \u201cAt the 25 mg dose, some people may feel these effects a little more strongly, but many tolerate both doses without much issue.\u201d<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Research backs this up. A<\/span> <span style=\"font-weight: 400;\">2018 systematic review and meta-analysis published in <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29524188\/\"><i><span style=\"font-weight: 400;\">Diabetes Therapy<\/span><\/i><\/a><span style=\"font-weight: 400;\"> examined the adverse effects associated with a 10 mg versus a 25 mg dose of empagliflozin, the generic form of Jardiance. After reviewing side effects in 8514 patients who used Jardiance for Type 2 diabetes, the researchers found no significant difference in adverse drug events (ADEs) between patients taking 10 mg of empagliflozin and those taking 25 mg.<\/span><\/p>\n<h2 id=\"jardiance-10-mg-vs-25-mg-interactions-and-warnings\"><span style=\"font-weight: 400;\">Jardiance 10 mg vs. 25 mg interactions and warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Certain people shouldn\u2019t take Jardiance. Importantly, Jardiance should be<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=faf3dd6a-9cd0-39c2-0d2e-232cb3f67565\"> <span style=\"font-weight: 400;\">avoided by people who have Type 1 diabetes<\/span><\/a><span style=\"font-weight: 400;\">, as taking it can increase their risk of diabetic <\/span><span style=\"font-weight: 400;\">ketoacidosis<\/span><span style=\"font-weight: 400;\">, a life-threatening condition.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally,<\/span> <span style=\"font-weight: 400;\">if you have any of the following conditions<\/span><span style=\"font-weight: 400;\">, you should talk to your healthcare provider before taking Jardiance:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant or breastfeeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amputation history<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alcoholism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of a pancreas issue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of genital yeast infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of urinary tract infections<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Finally, there are certain<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=faf3dd6a-9cd0-39c2-0d2e-232cb3f67565\"> <span style=\"font-weight: 400;\">drug interactions<\/span><\/a><span style=\"font-weight: 400;\"> to watch for with Jardiance, including:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to<\/span><a href=\"https:\/\/www.linkedin.com\/in\/jessicairoanya\/\"> <span style=\"font-weight: 400;\">Jessica Iroanya<\/span><\/a><span style=\"font-weight: 400;\">, Pharm.D., BCMTMS, drug interactions and warnings are generally the same for both doses of Jardiance\u201410 mg and 25 mg. \u201c<\/span><span style=\"font-weight: 400;\">Both doses carry warnings for low blood pressure, dehydration, and rare risks like diabetic<\/span> <span style=\"font-weight: 400;\">ketoacidosis,\u201d she explains. As such, she recommends having your kidney function checked before starting Jardiance and making sure your healthcare provider monitors it regularly while you take Jardiance. She also encourages patients to watch for signs of dehydration and low blood pressure, such as dizziness.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. <\/span><span style=\"font-weight: 400;\">Khoshaba agrees that dosing of Jardiance shouldn\u2019t impact drug interactions and warnings. \u201cThe warnings are the same no matter the dose: things like staying hydrated, watching kidney function, and being mindful of low blood sugar if you\u2019re also on insulin or certain other diabetes meds,\u201d she says. \u201cThe higher dose doesn\u2019t introduce new risks\u2014it just means your doctor may keep a closer eye on labs or symptoms.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Above all, regardless of the dose of Jardiance you take\u2014whether 10 mg or 25 mg\u2014you should maintain close contact with your healthcare provider. 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