{"id":8580,"date":"2025-10-28T02:15:45","date_gmt":"2025-10-28T02:15:45","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-7-safe-and-effective-weight-loss-pills-in-2025\/"},"modified":"2025-10-28T02:15:45","modified_gmt":"2025-10-28T02:15:45","slug":"hmn-7-safe-and-effective-weight-loss-pills-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-7-safe-and-effective-weight-loss-pills-in-2025\/","title":{"rendered":"HMN: 7 safe and effective weight-loss pills in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  7 safe and effective weight-loss pills in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p>When combined with a healthy diet and exercise, prescription weight-loss pills can contribute to significant weight loss, reducing the risk of heart attack, stroke, and diabetes.<\/p>\n<\/li>\n<li>\n<p>The effectiveness and safety of prescription weight-loss medications varies. Standard options include Phentermine, Qsymia, Saxenda, Contrave, Plenity, Orlistat, and Wegovy, each working through different mechanisms and having distinct side effects.<\/p>\n<\/li>\n<li>\n<p>Prescription weight-loss medications are typically reserved for individuals with a BMI of 27 or greater with weight-related health issues or those with a BMI of 30 or greater. Due to the potential side effects, patients should use them under medical supervision.<\/p>\n<\/li>\n<li>\n<p>You can maximize the effectiveness of FDA-approved weight-loss medications with lifestyle changes like diet and exercise. The best choice of medication depends on your health conditions and potential side effects.<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><span style=\"font-weight: 400;\"><a href=\"#weightlosspills\">FDA-approved weight loss pills<\/a> | <a href=\"#phentermine\">Phentermine<\/a> | <a href=\"#qsymia\">Qsymia<\/a> | <a href=\"#saxenda\">Saxenda<\/a> | <a href=\"#contrave\">Contrave<\/a> | <a href=\"#plenity\">Plenity<\/a> | <a href=\"#orlistat\">Orlistat<\/a> | <a href=\"#wegovy\">Wegovy<\/a> | <a href=\"#safety\">Safety information<\/a> | <a href=\"#bestweightlosspill\">What\u2019s the best weight-loss pill?<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Just over <\/span><span style=\"font-weight: 400;\">42% of adult Americans<\/span><span style=\"font-weight: 400;\"> are obese (defined by having a body mass index over 30)\u2014and that number is expected to grow to <\/span><a href=\"https:\/\/www.hsph.harvard.edu\/news\/press-releases\/half-of-us-to-have-obesity-by-2030\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">50% by 2030<\/span><\/a><span style=\"font-weight: 400;\">. Because of the myriad health conditions that all those extra pounds can cause, many are wondering: Can losing weight be as simple as taking a pill?<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prescription weight-loss pills aren\u2019t a magic bullet. But when used in conjunction with a <\/span><span style=\"font-weight: 400;\">healthy diet<\/span><span style=\"font-weight: 400;\">, restricting calorie intake, and exercise, they can help some people on their weight loss journey. On average, after one year of use, people taking prescription weight-loss medication <\/span><a href=\"https:\/\/www.niddk.nih.gov\/health-information\/weight-management\/prescription-medications-treat-overweight-obesity\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">lose 3% to 12% more body weight<\/span><\/a><span style=\"font-weight: 400;\"> than people who use diet and exercise alone. This may not sound that impressive, but that difference can be enough to help reduce your risk of heart attack, stroke, and diabetes<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cWe live in what we now call an obesogenic environment,\u201d says <\/span><a href=\"https:\/\/healthcare.utah.edu\/fad\/mddetail.php?physicianID=u0492920&amp;name=juliana-s-simonetti\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Juliana Simonetti, MD<\/span><\/a><span style=\"font-weight: 400;\">, co- director of the Comprehensive Weight Management Program at the University of Utah. \u201cPhysiologically speaking, we\u2019re built to hold on to calories so we can survive things like famine and war. We also eat many calorie-dense foods and have 24\/7 access to food. All these things promote weight gain. Weight-loss medications can help us overcome some of that physiology and control our appetites so we can lose weight.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So, what are the best weight loss pills out there? Read on to find out.<\/span><\/p>\n<h2 id=\"weightlosspills\">7 FDA-approved weight-loss pills<\/h2>\n<p><span style=\"font-weight: 400;\">Prescription medications for weight loss work in different ways. Some work by targeting areas of the brain that regulate appetite. By altering certain brain chemicals, these drugs act as an appetite suppressant and\/or increase feelings of fullness. Some drugs use a different pathway, helping to interfere with your body\u2019s absorption of fat. Because obesity can be a chronic health issue, many of these drugs are meant to be used long term, even after you reach your ideal weight\u2014assuming you\u2019re responding to the medication in the first place.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cA common analogy is blood pressure medication,\u201d says <\/span><a href=\"https:\/\/www.ethosendo.com\/about-aleem-kanji-md\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Aleem Kanji, MD<\/span><\/a><span style=\"font-weight: 400;\">, a board-certified endocrinologist and obesity medicine specialist with Ethos Endocrinology in Houston, Texas. \u201cMost would expect high blood pressure to return if medication is discontinued. Obesity is the same. It is a chronic disease that requires chronic therapy.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<\/p>\n<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our weight management newsletter<\/span><\/p><\/div>\n<p>\t<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But not everyone is a candidate for weight-loss drugs. Use of prescription weight-loss medications is typically reserved for people who:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have <\/span><span style=\"font-weight: 400;\">a BMI (body mass index) of 27 or greater with the presence of a weight-related disease or complication\u2014for example, Type 2 diabetes, high cholesterol, or high blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a BMI of 30 or greater<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">A BMI of 25-30 puts a person in the overweight category. A BMI over 30 is considered obese. Your primary care physician can prescribe a weight-loss medication, as can an obesity medicine doctor or endocrinologist, who treats weight-related health conditions like diabetes. Currently, there are only a handful of weight-loss medications approved by the Food and Drug Administration (FDA). The most commonly used ones include the following.<\/span><\/p>\n<h3 id=\"phentermine\">1. Lomaira, Adipex (phentermine)<\/h3>\n<p><span style=\"font-weight: 400;\">Phentermine<\/span><span style=\"font-weight: 400;\"> is the <\/span><a href=\"https:\/\/www.kpwashingtonresearch.org\/news-and-events\/blog\/2019\/mar-2019\/Using_phentermine_for_weight_loss_more_than_3_months_seems_safe_and_effective\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most commonly prescribed weight-loss medication<\/span><\/a><span style=\"font-weight: 400;\"> used in this country. It helps suppress appetite and make you feel fuller for longer.<\/span><span style=\"font-weight: 400;\"> Phentermine is an amphetamine-like stimulant drug that can affect your heart. As such, it\u2019s generally used for the short term (usually 12 weeks at a time).\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.stlukesonline.org\/health-services\/health-information\/healthwise\/2017\/06\/27\/13\/09\/phentermine\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Side effects<\/span><\/a><span style=\"font-weight: 400;\"> can run the gamut and may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shortness of breath<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased heart rate\/pounding heart<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness\/problems sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in mood<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itchiness<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3791337\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\"> looking at nearly 800 people with BMIs of over 25, 45.6% of people were able to lose 5% or more of their starting body weight after 12 weeks of phentermine use.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the drug\u2019s <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/085128s065lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FDA prescription information<\/span><\/a><span style=\"font-weight: 400;\">, certain people should not use the drug, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those with cardiovascular disease (including uncontrolled high blood pressure and heart arrythmias)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who have taken a <\/span><span style=\"font-weight: 400;\">monoamine oxidase inhibitor<\/span><span style=\"font-weight: 400;\"> (MAOI\u2014a type of drug that\u2019s sometimes used to treat depression) within 14 days<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant or nursing women<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those with an overactive thyroid<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who have mood disorders, especially manic\/depressive moods or agitation<\/span><\/li>\n<\/ul>\n<h3 id=\"qsymia\">2. Qsymia (phentermine\/topiramate)<\/h3>\n<p><span style=\"font-weight: 400;\">Qsymia<\/span><span style=\"font-weight: 400;\"> combines a low dose of phentermine with <\/span><span style=\"font-weight: 400;\">topiramate<\/span><span style=\"font-weight: 400;\">, a drug used to treat seizures and migraines. \u201cThe phentermine helps suppress appetite and the topiramate appears to reduce cravings,\u201d says Dr. Simonetti. \u201cBecause we use a low dose of phentermine, Qsymia can be used over a long period of time and typically produces good results.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Qsymia comes in a variety of <\/span><a href=\"https:\/\/qsymia.com\/patient\/resources\/taking-qsymia\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">dosages<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">For the first two weeks, your provider will prescribe a dose of 3.75\/23 mg (3.75 mg of phentermine, 23 mg of topiramate) taken in capsule form once a day.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Starting in week three, you\u2019ll be prescribed a 7.5\/46 mg capsule. If you\u2019ve lost at least 3% of your overall body weight by the end of 12 weeks, you\u2019ll stay on this dose indefinitely.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If not, your healthcare provider may up the dose to a maximum of 15\/92 mg.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Qsymia may cause some of the same <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2012\/022580s000lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> as other medications containing phentermine, as well as possible additional side effects due to the topiramate. One of the biggest dangers of Qsymia is its link to birth defects. It\u2019s imperative that you talk to your doctor about preventing pregnancy if you want to try Qsymia and to take monthly pregnancy tests if you\u2019re at risk for pregnancy. And while Qsymia can have other serious side effects, including suicidal thoughts, increased irritability, worsening depression\/anxiety and heart and eye problems, the most common ones include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tingling or numbness in hands, feet, arms, and face<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in the way food tastes<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Research shows that Qsymia can help people lose weight, even at low doses (although the higher doses produce more weight loss). In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3814438\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\">, people who took the average dose of Qsymia (7.5\/46 mg) lost 7.8% of their body weight and those taking the highest dose (15\/92 mg) lost nearly 10%.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Qsymia may not be right for certain groups of people, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant\/nursing women or women trying to conceive<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with cardiovascular problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those with glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who drink heavily<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with an anxiety disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those with uncontrolled hyperthyroidism (an overactive thyroid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Those with prior issues of kidney stones<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who have taken an MAOI within 14 days<\/span><\/li>\n<\/ul>\n<h3 id=\"saxenda\">3. Saxenda (liraglutide)<\/h3>\n<p><span style=\"font-weight: 400;\">The active ingredient in <\/span><span style=\"font-weight: 400;\">Saxenda<\/span><span style=\"font-weight: 400;\"> is a <\/span><span style=\"font-weight: 400;\">glucagon-like peptide-1 (GLP-1) receptor agonist<\/span><span style=\"font-weight: 400;\">, a class of drugs used to treat Type 2 diabetes and keep blood sugar levels in check. GLP-1 is a hormone your body naturally makes that\u2019s released in response to food and helps regulate your appetite. <\/span><a href=\"https:\/\/www.novomedlink.com\/obesity\/products\/treatments\/saxenda\/about\/how-saxenda-works.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Saxenda<\/span><\/a><span style=\"font-weight: 400;\"> mimics the action of GLP-1 in your body, but it lasts much longer than naturally occurring GLP-1. As such, it can help suppress hunger longer and slow the movement of food emptying from your stomach. Both factors can help you eat less overall and lose weight.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cI have patients tell me that they never left food on their plates before, but with Saxenda, they\u2019re eating less and getting full quickly,\u201d comments Dr. Simonetti. In late 2020, Saxenda was <\/span><a href=\"https:\/\/www.prnewswire.com\/news-releases\/fda-approves-saxenda-for-the-treatment-of-obesity-in-adolescents-aged-12-17-301186800.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">approved<\/span><\/a><span style=\"font-weight: 400;\"> for use in adolescents.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Saxenda is a daily injectable with dosing increasing from 0.6 mg in week one to 3.0 mg by week five. While Saxenda can cause some serious <\/span><a href=\"https:\/\/www.saxenda.com\/about-saxenda\/dosing-schedule.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\">, such as inflammation of the pancreas (called pancreatitis), gallbladder problems, and mood changes, the most common side effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood sugar (hypoglycemia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tiredness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5358074\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> following more than 500 people found that 50.5% of those taking liraglutide were able to lose at least 5% of their body weight during the study period versus 21.8% who took a placebo. Even more impressive, 26.1% of the drug group were able to lose 10% of their body weight compared to just 6.3% in the placebo group.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Saxenda carries a <\/span><span style=\"font-weight: 400;\">black box warning<\/span><span style=\"font-weight: 400;\"> (the FDA\u2019s strongest alert to consumers and healthcare providers about very serious side effects) due to the fact that animal studies have linked liraglutide and medicines like it to certain <\/span><span style=\"font-weight: 400;\">thyroid tumors and thyroid cancer<\/span><span style=\"font-weight: 400;\">. It\u2019s important that you not use Saxenda if you have had these conditions or have a family history of them. Saxenda isn\u2019t appropriate for pregnant or nursing women. Talk to your healthcare provider if you\u2019re taking medicines that act like GLP-1 receptor agonists. Because Saxenda can slow stomach emptying, it\u2019s also important to ask your doctor how that may affect other prescription and over-the-counter medicines you take.<\/span><\/p>\n<h3 id=\"contrave\">4. Contrave (naltrexone and bupropion)<\/h3>\n<p><span style=\"font-weight: 400;\">Contrave<\/span><span style=\"font-weight: 400;\"> combines <\/span><span style=\"font-weight: 400;\">naltrexone<\/span><span style=\"font-weight: 400;\"> (used to treat substance abuse) and <\/span><span style=\"font-weight: 400;\">bupropion<\/span><span style=\"font-weight: 400;\"> (an antidepressant that\u2019s marketed under the brand name Wellbutrin). It\u2019s thought to work on the brain to regulate appetite and cravings.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like a lot of weight-loss medications, your dose of Contrave will start out low and increase over time.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Week one: One pill in the morning.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Week two: Two pills, one in the morning and the other at night.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Week three: Two pills in the morning and one in the evening.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Week four and beyond: Four pills per day\u2014two in the morning, two in the evening<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Contrave can potentially produce serious side effects, such as suicidal thoughts and seizures, but the most common side effects are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">One <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4459776\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> examined how Contrave contributed to weight loss when used in conjunction with behavior therapy (sessions with registered dietitians, exercise specialists, and psychologists). Compared to those receiving a placebo and therapy, 1.5 times as many people in the Contrave\/therapy group were able to lose at least 5% of their body weight compared to those in the placebo group.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Contrave should <\/span><a href=\"https:\/\/www.contravehcp.com\/dosing\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">not be used<\/span><\/a><span style=\"font-weight: 400;\"> in people who:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have uncontrolled hypertension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are pregnant<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use other drugs containing bupropion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are withdrawing from alcohol and certain other drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have used an MAOI within 14 days<\/span><\/li>\n<\/ul>\n<h3 id=\"plenity\">5. Plenity<\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7364464\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Plenity<\/span><\/a><span style=\"font-weight: 400;\"> is technically a medical device, not a medication. It\u2019s a capsule that contains superabsorbent hydrogel particles. When the capsule is swallowed, the particles are released, helping to fill up to one fourth of the stomach (when a person is fully hydrated). With the stomach at least partially full, you\u2019re apt to eat less.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You take <\/span><a href=\"https:\/\/www.myplenity.com\/faq\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">three Plenity capsules<\/span><\/a><span style=\"font-weight: 400;\"> with 16 ounces of water before lunch and dinner. The particles absorb the water and mix with the food in your stomach, helping you feel fuller so you eat less.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common side effects are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flatulence<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6587502\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> showed that 59% of those taking Plenity lost 5% or more of their body weight and 27% lost more than 10% of their weight. That\u2019s compared to 42% and 15%, respectively, in the placebo group.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Plenity is not approved for use in those under the age of 22. You also shouldn\u2019t take it if you\u2019re allergic to citric acid, cellulose, gelatin, and other ingredients of the gel.<\/span><\/p>\n<h3 id=\"orlistat\">6. Xenical, Alli (orlistat)<\/h3>\n<p><span style=\"font-weight: 400;\">Orlistat is a lipase inhibitor, meaning it blocks the enzyme that helps absorb some of the fats in the foods you eat. Meaning, less of the fat you consume makes it into fat cells to become stubborn belly fat. Orlistat comes in two different strengths\u2014an over-the-counter 60mg strength marketed as Alli and a prescription-strength (120mg) marketed as Xenical.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Xencal is taken by mouth three times a day, with or within one hour of a meal that contains fat.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common <\/span><a href=\"https:\/\/xenical.com\/patients.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects<\/span><\/a><span style=\"font-weight: 400;\"> of Xenical are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oily stools\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas with an oily discharge<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loose stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urgent need to have a bowel movement\/unable to control bowel movement<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">More frequent bowel movements<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Xenical is not as effective as some other weight-loss prescriptions. <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/ijcp.13399\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> comparing orlistat with liraglutide found that those using the latter were able to lose more than twice as much weight as those taking orlistat.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People who should not take Xenical are people who:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are pregnant or breastfeeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have gallbladder problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have food absorption issues<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Xenical can affect the absorption of not just fat, but also of vitamins from the foods you eat. Make sure you talk to your healthcare provider about taking a multivitamin supplement.<\/span><\/p>\n<h3 id=\"wegovy\">7. Wegovy (semaglutide)<\/h3>\n<p><span style=\"font-weight: 400;\">Wegovy<\/span><span style=\"font-weight: 400;\"> is the newest FDA-approved weight-loss medication and works much the same way as Saxenda, by mimicking the action of the hormone GLP-1 to suppress hunger.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wegovy is a <\/span><a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-new-drug-treatment-chronic-weight-management-first-2014\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">once-a-week injectable<\/span><\/a><span style=\"font-weight: 400;\">. Dosage is increased over the course of several weeks-to-months, until a 2.4 mg dose is achieved.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of the most common side effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Belching\/flatulence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood sugar (if you have Type 2 diabetes)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2032183\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\">, the mean change in body weight was -14.9% in the Wegovy group versus -2.4% in the placebo one. Eighty-four percent of those in the Wegovy group lost 5% or more of their body weight compared to 31.5% of those taking a placebo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like Saxenda, Wegovy carries a black box warning due to the possibility that it may increase your risk of certain thyroid tumors and cancer. Pancreatitis, gallbladder disease, kidney injury, low blood sugar, and other conditions have also been reported with <\/span><a href=\"https:\/\/www.novomedlink.com\/obesity\/products\/treatments\/wegovy.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Wegovy use<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"safety\">Safety information<\/h2>\n<p><span style=\"font-weight: 400;\">Prescription weight loss drugs can be effective, but they aren\u2019t risk free. While most side effects are mild, some can be very serious and will vary based on the drug and the person using it. According to <\/span><a href=\"https:\/\/hartfordhospital.org\/find-a-doctor\/physician-detail?id=003j000000GCyb5AAD\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Devika Umashanker, MD<\/span><\/a><span style=\"font-weight: 400;\">, an obesity medicine specialist with Hartford HealthCare\u2019s Medical and Surgical Weight Loss Program, some red flags that require a doctor\u2019s attention are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased heart rate that doesn\u2019t slow down<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shortness of breath<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney stones (symptoms include abdominal pain, back pain, and\/or blood in the urine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood sugar (symptoms are dizziness, feeling clammy, and increased heart rate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bumps\u2014aka nodules\u2014around the front of your neck (this can indicate a thyroid problem)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">All-over severe stomach pain (this could signal pancreatitis)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Of course, your physician should be monitoring you while you\u2019re on the medication, but if something is worrying you, reach out. \u201cI tell my patients, you know your body best,\u201d Dr. Umashanker explains. \u201cIf something feels off, give us a call.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you decide to stop taking the drug for any reason, speak to your doctor about how to do so safely. Quitting cold turkey can be dangerous with some of these drugs. \u201cContrave, for example, has to be gradually reduced,\u201d cautions Dr. Umashanker, \u201cto reduce the risk of seizures.\u201d<\/span><\/p>\n<h2 id=\"bestweightlosspill\">What is the best prescription weight-loss pill for you?<\/h2>\n<p><span style=\"font-weight: 400;\">And now for the million dollar question: Given the choices, which are the best diet pills based on safety and effectiveness? Turns out there\u2019s no one best answer.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cLooking strictly at the studies, Wegovy has the highest percent of body weight loss,\u201d Dr. Kanji notes. \u201cHowever, we have to keep in mind that each study had a different patient population and method. It\u2019s also difficult to generalize safety profiles as it should come down to each individual\u2019s situation. For example, a person with a history of pancreatitis would want to avoid Wegovy and Saxenda but may be fine with Qsymia. On the other hand, a person with a history of kidney stones may want to avoid Qsymia.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important to remember that these drugs should be used in combination with natural weight-loss strategies, like diet and exercise, for optimal results. Some tips to help you get to a healthy weight?<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Eat high-fiber, protein-rich foods <\/b><span style=\"font-weight: 400;\">to feel more satisfied. Consider trying a low-carb, low-fat diet\u2014or limiting your intake of processed <\/span><span style=\"font-weight: 400;\">carbohydrates<\/span><span style=\"font-weight: 400;\"> (think white bread, sweets, pasta).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Focus on making plant-based diet choices.<\/b> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7533223\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Research<\/span><\/a><span style=\"font-weight: 400;\"> shows that it can be beneficial for weight loss, and they contain lots of healthy antioxidants.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Don\u2019t label foods good or bad. <\/b><span style=\"font-weight: 400;\">Instead, aim to make 80% to 90% of what you eat healthy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Get regular exercise<\/b><span style=\"font-weight: 400;\"> to burn calories, decrease body fat, boost metabolism, and increase muscle mass. Experts say you should aim for 150 minutes of moderate- intensity activity (for example, brisk walking or biking) a week.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">And steer clear of any pill or herbal remedy that claims to be the best weight-loss supplement such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Green coffee bean extract<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Konjac (a root)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">L-carnitine (an amino acid derivative)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Green tea extract<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Garcinia cambogia (a fruit)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Conjugated linoleic acid (CLA)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">While these dietary supplements may claim to promote fat loss and fat burning and help you lose weight, well-conducted scientific studies don\u2019t always bear this out. What\u2019s more, these diet supplements are not regulated by the FDA, which means you can\u2019t be sure of exactly what\u2019s in them. Even natural ingredients at certain levels can be toxic to some people.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lastly, many of these prescription medications can be prohibitively expensive, and not all are covered by insurance. 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The effectiveness and safety of prescription weight-loss medications varies. Standard options include Phentermine, Qsymia, Saxenda, Contrave, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8580","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=8580"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8580\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=8580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=8580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=8580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}