{"id":8589,"date":"2025-10-29T11:59:34","date_gmt":"2025-10-29T11:59:34","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-side-effects-in-2025-43\/"},"modified":"2025-12-23T01:46:17","modified_gmt":"2025-12-23T01:46:17","slug":"hmn-differences-similarities-side-effects-in-2025-43","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-side-effects-in-2025-43\/","title":{"rendered":"HMN: Jardiance and glipizide Differences, similarities &#038; side effects in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, similarities &#038; side effects in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Jardiance and glipizide are diabetes drugs that help control blood sugar in people with Type 2 diabetes. Jardiance can also be used to reduce cardiovascular risks and treat heart failure and chronic kidney disease.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Jardiance can commonly cause urinary tract and yeast infections. Glipizide is more likely to cause low blood sugar, especially when combined with other medications or certain medical conditions.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Because there are many factors to consider when choosing the best medication for your condition, you should consult your healthcare provider for more information and medical advice.\u00a0<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Jardiance<\/span><span style=\"font-weight: 400;\"> (empagliflozin) and glipizide are prescription medications that are approved by the Food and Drug Administration (FDA) for <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Although both medicines are used for Type 2 diabetes, they belong to different drug classes and have different active ingredients and various other differences. Continue reading to learn more about Jardiance and glipizide.<\/span><\/p>\n<h2 id=\"jardiance-vs-glipizide-key-differences\"><span style=\"font-weight: 400;\">Jardiance vs. glipizide: Key differences<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance is a brand-name drug that contains the active ingredient <\/span><span style=\"font-weight: 400;\">empagliflozin. It is part of a group of drugs called <\/span><span style=\"font-weight: 400;\">sodium-glucose cotransporter 2 (SGLT2) inhibitors<\/span><span style=\"font-weight: 400;\">. Examples of other drugs in the SGLT2 inhibitor class include <\/span><span style=\"font-weight: 400;\">Farxiga<\/span><span style=\"font-weight: 400;\"> (dapagliflozin) and <\/span><span style=\"font-weight: 400;\">Invokana<\/span><span style=\"font-weight: 400;\"> (canagliflozin). Jardiance <\/span><span style=\"font-weight: 400;\">works by helping the kidneys eliminate sugar in the urine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Glipizide<\/span><span style=\"font-weight: 400;\"> is a generic medication that is part of a group of drugs called <\/span><span style=\"font-weight: 400;\">sulfonylureas<\/span><span style=\"font-weight: 400;\">. It works by helping the pancreas make more insulin (which helps lower blood sugar) and helping the body use insulin more efficiently. Glipizide is available in brand-name form as Glucotrol and Glucotrol XL (an extended-release formulation of glipizide). Other sulfonylurea drugs include <\/span><span style=\"font-weight: 400;\">glyburide<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">glimepiride<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both medications are also available as combination drugs, as one ingredient in a medication that contains more than one ingredient. However, this article will focus on the single-ingredient products Jardiance and glipizide.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-jardiance-vs-glipizide-key-differences\"><span class=\"title\">Compare Jardiance vs. glipizide: Key differences<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">SGLT2 inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Sulfonylurea\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Generic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/p>\n<p><b>Or<\/b><\/p>\n<p><b>What is the brand name?<\/b><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is called empagliflozin, but a generic is not available at this time<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Glucotrol, Glucotrol XL<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet: 10 mg, 25 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet: 2.5 mg, 5 mg, 10 mg<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral extended-release tablet: 2.5 mg, 5 mg, 10 mg<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">10 mg or 25 mg by mouth once daily in the morning<\/span><\/td>\n<td><span style=\"font-weight: 400;\">The starting dose<\/span><span style=\"font-weight: 400;\"> is usually 5 mg by mouth once daily, and the healthcare provider may gradually increase the dose if needed<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults and pediatric patients 10 years and older for Type 2 diabetes; adults only for all other uses<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"jardiance-vs-glipizide-conditions-treated\"><span style=\"font-weight: 400;\">Jardiance vs. glipizide: Conditions treated<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance is FDA approved for the following uses:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">To improve blood sugar control in adults and pediatric patients 10 years and older with Type 2 diabetes; usually in combination with diet and exercise<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">To lower the risk of cardiovascular death and heart failure hospitalization in adults with <\/span><span style=\"font-weight: 400;\">heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">To lower the risk of kidney complications, hospitalization, and cardiovascular death in adults with <\/span><span style=\"font-weight: 400;\">chronic kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">To lower the risk of cardiovascular death in adults who have both Type 2 diabetes and <\/span><span style=\"font-weight: 400;\">heart disease<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Glipizide, on the other hand, is only FDA approved to improve blood sugar control in people with <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\">. It is only approved for use in adults. Like Jardiance, healthcare providers generally recommend combining <\/span><span style=\"font-weight: 400;\">diet<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">exercise<\/span><span style=\"font-weight: 400;\"> changes with this medicine.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-jardiance-vs-glipizide-conditions-treated\"><span class=\"title\">Compare Jardiance vs. glipizide conditions treated<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Type 2 diabetes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Heart failure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Kidney disease\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Type 2 diabetes plus cardiovascular disease\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*<\/span><i><span style=\"font-weight: 400;\">Shortened in table for clarity<\/span><\/i><\/h5>\n<h2 id=\"is-glipizide-better-than-jardiance\"><span style=\"font-weight: 400;\">Is glipizide better than Jardiance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no clinical trials directly comparing the two medications. Only your healthcare provider can determine the best drug for you, taking into account many individual factors, such as your medical conditions, other medications you take, cost, and potential side effects.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For example, Jardiance may be better tolerated and can treat additional conditions besides diabetes, but it has some potential side effects to consider, such as urinary tract infections and yeast infections. Jardiance is also more likely to help with <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6318231\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">weight loss<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On the other hand, if cost is a concern, glipizide is quite affordable. However, it comes with a higher risk of <\/span><span style=\"font-weight: 400;\">low blood sugar<\/span><span style=\"font-weight: 400;\"> episodes and may be associated with weight gain.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/diabetesjournals.org\/care\/article\/47\/Supplement_1\/S158\/153955\/9-Pharmacologic-Approaches-to-Glycemic-Treatment\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Clinical guidelines<\/span><\/a><span style=\"font-weight: 400;\"> recommend metformin over sulfonylureas, such as glipizide. <\/span><span style=\"font-weight: 400;\">Metformin <\/span><span style=\"font-weight: 400;\">is also affordable but has several advantages over glipizide. For example, it does not tend to cause low blood sugar, and it also reduces deaths caused by heart attacks and <\/span><span style=\"font-weight: 400;\">strokes<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Again, it is important to consult your healthcare provider for medical advice regarding your condition and treatment.\u00a0<\/span><\/p>\n<h2 id=\"jardiance-vs-glipizide-insurance-coverage-and-cost-comparison\"><span style=\"font-weight: 400;\">Jardiance vs. glipizide: Insurance coverage and cost comparison<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Jardiance and glipizide are typically covered by insurance and Medicare prescription plans. Out-of-pocket costs vary by plan. You can contact your insurance provider for the most recent information on pricing estimates.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For those without insurance, a one-month supply of Jardiance costs about $847. However, you can use a <\/span><span style=\"font-weight: 400;\">free  coupon<\/span><span style=\"font-weight: 400;\"> to pay a reduced price of $487, saving $360 per month.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For uninsured patients, a one-month supply of glipizide costs about $10. However, a <\/span><span style=\"font-weight: 400;\">free  coupon<\/span><span style=\"font-weight: 400;\"> can lower the price to $4 per month.<\/span><\/p>\n<p><b> <\/b><b>Jardiance copay assistance: Eligibility &amp; more<\/b><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"compare-jardiance-vs-glipizide-cost-coverage\"><span class=\"title\">Compare Jardiance vs. glipizide cost &amp; coverage<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">30, 25 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">60, 5 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><b> cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$487<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$4<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"jardiance-vs-glipizide-side-effects\"><span style=\"font-weight: 400;\">Jardiance vs. glipizide side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common <\/span><span style=\"font-weight: 400;\">Jardiance side effects<\/span><span style=\"font-weight: 400;\"> include genital yeast infections in females and <\/span><span style=\"font-weight: 400;\">urinary tract infections (UTIs)<\/span><span style=\"font-weight: 400;\">. The most common <\/span><span style=\"font-weight: 400;\">side effects of glipizide<\/span><span style=\"font-weight: 400;\"> are gastrointestinal and include nausea and diarrhea. Other common glipizide side effects include dizziness, drowsiness, and headache. Glipizide can also cause severely low blood sugar.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">With any medication, serious allergic reactions may occur in rare cases. If you have symptoms such as hives, difficulty breathing, or swelling, seek emergency medical attention.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The table below lists some of the common adverse effects of both drugs. This is not a full list of side effects, and others may occur. Consult your healthcare provider for more information and questions about side effects.\u00a0<\/span><\/p>\n<p>\u00a0<\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-jardiance-vs-glipizide-side-effects\"><span class=\"title\">Compare Jardiance vs. glipizide side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">UTI<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7.6\u20139.3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Yeast infection (female)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5.4\u20136.4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Yeast infection (male)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.6\u20133.1%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Upper respiratory tract infection\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3.1\u20134%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Increased cholesterol<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2.9\u20133.9%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Joint pain\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2.3\u20132.4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.1\u20132.3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diarrhea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drowsiness\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><span style=\"font-weight: 400;\">*<\/span><i><span style=\"font-weight: 400;\">Range varies by dosage<\/span><\/i><\/h5>\n<h5><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=faf3dd6a-9cd0-39c2-0d2e-232cb3f67565\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\"> (DailyMed), <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=ad55dfd7-ffb5-478a-aa84-1009fa921e22\"><span style=\"font-weight: 400;\">Glipizide<\/span><\/a><span style=\"font-weight: 400;\"> (DailyMed)<\/span><\/h5>\n<h2 id=\"jardiance-and-glipizide-drug-interactions\"><span style=\"font-weight: 400;\">Jardiance and glipizide drug interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before you take Jardiance or glipizide, be sure to tell your healthcare provider about all the medications you take, including prescription drugs, over-the-counter medicines, vitamins, and supplements.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Jardiance interacts with certain medications, such as <\/span><span style=\"font-weight: 400;\">lithium<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">diuretics<\/span><span style=\"font-weight: 400;\"> (water pills). When taken with <\/span><span style=\"font-weight: 400;\">insulin<\/span><span style=\"font-weight: 400;\"> or certain diabetes medications, hypoglycemia (low blood sugar) could occur.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Glipizide is more likely to cause low blood sugar when combined with certain drugs, such as <\/span><span style=\"font-weight: 400;\">nonsteroidal anti-inflammatory drugs<\/span><span style=\"font-weight: 400;\"> (NSAIDs), certain antifungals, <\/span><span style=\"font-weight: 400;\">beta blockers<\/span><span style=\"font-weight: 400;\"> (commonly used to treat high blood pressure), quinolone or sulfa antibiotics, and <\/span><span style=\"font-weight: 400;\">monoamine oxidase inhibitors (MAOIs)<\/span><span style=\"font-weight: 400;\">. On the other hand, certain drugs combined with glipizide can result in hyperglycemia, also called high blood sugar. Examples include diuretics, steroids, hormonal medicines, <\/span><span style=\"font-weight: 400;\">phenytoin<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">calcium channel blockers<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is not a full list of drug interactions. Consult your healthcare provider for more information about drug interactions and how they may affect you.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h3 id=\"compare-jardiance-vs-glipizide-drug-interactions\"><span class=\"title\">Compare Jardiance vs. Glipizide drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Hydrochlorothiazide\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lasix (furosemide)<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Diuretics\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lithium\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Mood stabilizer \/ antimanic drug<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lantus<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Novolog<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tresiba<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Insulin\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Glimepiride\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Glipizide\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Glyburide\u00a0<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Sulfonylureas\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">NSAIDs<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Certain antifungals Beta blockers Quinolone antibiotics<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sulfa antibiotics<\/span><\/p>\n<p><span style=\"font-weight: 400;\">MAOIs<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Drugs that may interact and lead to low blood sugar\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Corticosteroids<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Hormonal medicines Phenytoin<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Calcium channel blockers<\/span><\/p>\n<\/td>\n<td><span style=\"font-weight: 400;\">Drugs that may interact and lead to high blood sugar\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u00a0<\/p>\n<h2 id=\"jardiance-and-glipizide-drug-warnings\"><span style=\"font-weight: 400;\">Jardiance and glipizide drug warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Before you take Jardiance or glipizide, tell your healthcare professional about all of your medical conditions and family history. Warnings for each drug are listed below.<\/span><\/p>\n<h3 id=\"jardiance-warnings\"><span style=\"font-weight: 400;\">Jardiance warnings<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">You should not take Jardiance if you are breastfeeding. The prescribing information also notes that Jardiance should not be used by individuals in the second or third trimester of pregnancy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Jardiance increases the risk of a life-threatening condition called <\/span><span style=\"font-weight: 400;\">diabetic ketoacidosis (DKA)<\/span><span style=\"font-weight: 400;\">, especially in patients with Type 1 diabetes or certain other risk factors. Jardiance is not approved for use in people with Type 1 diabetes.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Jardiance may cause volume depletion or low fluid volume in the body, which could lead to kidney injury, hospitalization, and dialysis. You may be at higher risk if you have problems with your kidney function, take a <\/span><span style=\"font-weight: 400;\">loop diuretic<\/span><span style=\"font-weight: 400;\">, or if you are an older adult.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious UTIs may occur and should be immediately treated by a healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Genital yeast infections may occur in men or women and require medical attention. Women may experience vaginal itching, odor, and a cottage cheese-like discharge. Men may notice a rash, pain, redness, itching, or swelling of the penis, as well as a bad-smelling discharge.\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fournier\u2019s Gangrene, also called necrotizing fasciitis of the perineum, is a rare but life-threatening infection associated with SGLT2 inhibitors like Jardiance. Symptoms that require emergency medical attention include fever along with pain, redness, or swelling around the genitals or perineal area.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Routine preventive foot care is necessary since SGLT2 inhibitors, like Jardiance, can increase the risk of lower limb amputation. See your healthcare provider right away for symptoms of a diabetic foot infection, such as pain, tenderness, sores, or ulcers.\u00a0<\/span><\/li>\n<\/ul>\n<h3 id=\"glipizide-warnings\"><span style=\"font-weight: 400;\">Glipizide warnings<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Generally, glipizide is not prescribed for people who are pregnant or breastfeeding unless recommended by the healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sulfonylurea drugs, such as glipizide, can lead to severely low blood sugar\u2014especially in people with liver or kidney problems, older adults, or people with certain other medical conditions. Low blood sugar is more likely to occur when you do not eat enough, after intense or prolonged exercise, when you drink alcohol, or when you take more than one medicine that lowers blood sugar.\u00a0<\/span><\/li>\n<\/ul>\n<h2 id=\"can-you-take-jardiance-and-glipizide-together\"><span style=\"font-weight: 400;\">Can you take Jardiance and glipizide together?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many people with Type 2 diabetes mellitus require more than one drug to control blood sugar levels, especially if they have certain co-occurring conditions. It\u2019s important to note, though, that taking glipizide with Jardiance may increase the risk of hypoglycemia. 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<\/g>\n<\/svg>\t\t\t\t\t\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Do you know: Differences, similarities &#038; side effects in 2025 Key takeaways Jardiance and glipizide are diabetes drugs that help control blood sugar in people with Type 2 diabetes. Jardiance can also be used to reduce cardiovascular risks and treat heart failure and chronic kidney disease. Jardiance can commonly cause urinary tract and yeast infections. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8589","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=8589"}],"version-history":[{"count":1,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8589\/revisions"}],"predecessor-version":[{"id":8828,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8589\/revisions\/8828"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=8589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=8589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=8589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}