{"id":8610,"date":"2025-11-05T03:25:54","date_gmt":"2025-11-05T03:25:54","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-generic-entresto-sacubitril-valsartan-availability-and-price-in-2025\/"},"modified":"2025-11-05T03:25:54","modified_gmt":"2025-11-05T03:25:54","slug":"hmn-generic-entresto-sacubitril-valsartan-availability-and-price-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-generic-entresto-sacubitril-valsartan-availability-and-price-in-2025\/","title":{"rendered":"HMN: Generic Entresto (sacubitril-valsartan) availability and price in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Generic Entresto (sacubitril-valsartan) availability and price in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Generic Entresto is now available and FDA approved.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Brand-name and generic Entresto are equally effectiv<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">The Entreso generic offers significant cost savings.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">Entresto<\/span><span style=\"font-weight: 400;\"> is a brand-name prescription drug that is FDA-approved to treat<\/span> <span style=\"font-weight: 400;\">congestive heart failure<\/span><span style=\"font-weight: 400;\">. Entresto contains two active ingredients, sacubitril and<\/span> <span style=\"font-weight: 400;\">valsartan<\/span><span style=\"font-weight: 400;\">, that work by relaxing blood vessels and reducing blood pressure. The combination of these two components is unique, making Entresto the first medication in a new class of drugs called angiotensin receptor neprilysin inhibitors (ARNIs).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like most brand-name drugs, Entresto is more expensive than generic alternatives. Fortunately, generic Entresto was recently approved by the FDA and is now available at pharmacies across the country. Continue reading to learn more about Entresto and its generic version, which is often significantly cheaper than the brand-name version.<\/span><\/p>\n<h2 id=\"is-there-a-generic-for-entresto\"><span style=\"font-weight: 400;\">Is there a generic for Entresto?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Yes, generic Entresto is now available. <\/span><span style=\"font-weight: 400;\">Entresto generics, sold simply as <\/span><span style=\"font-weight: 400;\">sacubitril-valsartan<\/span><span style=\"font-weight: 400;\"> tablets, were <\/span><a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-roundup-may-31-2024\"><span style=\"font-weight: 400;\">approved in May 2024<\/span><\/a><span style=\"font-weight: 400;\"> but only hit U.S. pharmacy shelves <\/span><a href=\"https:\/\/www.reuters.com\/legal\/litigation\/novartis-cannot-block-generic-version-entresto-judge-rules-2025-07-16\/\"><span style=\"font-weight: 400;\">in July 2025<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\"> \u201cIt has very good supply with a couple of different generic drug companies,\u201d says<\/span> <span style=\"font-weight: 400;\">Blair Gingerich<\/span><span style=\"font-weight: 400;\">, Pharm.D., an ambulatory care pharmacist in northern Indiana and a member of the  Medical Board.\u00a0<\/span><\/p>\n<h2 id=\"what-are-the-differences-between-brand-name-and-generic-entresto\"><span style=\"font-weight: 400;\">What are the differences between brand-name and generic Entresto?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Minor differences between brand-name and generic Entresto may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>The drug manufacturer. <\/b><span style=\"font-weight: 400;\">Novartis Pharmaceuticals Corporation makes Entresto. Generic Entresto is made by a variety of drug companies.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cost. <\/b><span style=\"font-weight: 400;\">Generic drugs usually cost less than brand-name drugs.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Appearance. <\/b><span style=\"font-weight: 400;\">\u201cTablets <\/span><a href=\"https:\/\/www.uclahealth.org\/news\/publication\/same-medicine-can-come-different-shapes-and-sizes\"><span style=\"font-weight: 400;\">may look different<\/span><\/a><span style=\"font-weight: 400;\">, but the active meds are the same,\u201d says <\/span><span style=\"font-weight: 400;\">Barbara Sparacino, MD, a triple board-certified geriatric psychiatrist, addiction medicine specialist, and founder of <\/span><a href=\"https:\/\/www.theagingparentcoach.com\/\"><span style=\"font-weight: 400;\">The Aging Parent Coach<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">There is very little difference between brand-name and generic Entresto. The FDA<\/span><a href=\"https:\/\/www.fda.gov\/drugs\/frequently-asked-questions-popular-topics\/generic-drugs-questions-answers#q2\"> <span style=\"font-weight: 400;\">requires<\/span><\/a><span style=\"font-weight: 400;\"> generic drugs to have the same<\/span> <span style=\"font-weight: 400;\">dosage<\/span><span style=\"font-weight: 400;\">,<\/span> <span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, safety, and effectiveness as their brand-name equivalents. Like<\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/207620s025,218591s000lbl.pdf\"> <span style=\"font-weight: 400;\">brand-name Entresto<\/span><\/a><span style=\"font-weight: 400;\">,<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2c39c326-34a2-b7f4-e063-6294a90a6732\"> <span style=\"font-weight: 400;\">generic Entresto<\/span><\/a><span style=\"font-weight: 400;\"> is still an<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507904\/\"> <span style=\"font-weight: 400;\">ARNI<\/span><\/a><span style=\"font-weight: 400;\"> that combines the neprilysin inhibitor sacubitril with the angiotensin receptor blocker (ARB) valsartan and is FDA approved to reduce the risk of <\/span><span style=\"font-weight: 400;\">cardiovascular events<\/span><span style=\"font-weight: 400;\"> in adult patients with chronic heart failure and to treat certain types of symptomatic heart failure in children and adolescents 1 year and older.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important to understand that the interchangeability of brand-name and generic drugs is backed by science. A<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6415809\/\"> <span style=\"font-weight: 400;\">research analysis<\/span><\/a><span style=\"font-weight: 400;\"> of eight brand-name and prescription medications and 2,264,774 matched pairs of patients found that generics resulted in \u201ccomparable clinical outcomes\u201d to their brand-name counterparts. However,<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8061123\/\"> <span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\"> of antidepressants did find that brand-name drugs outperformed their generic equivalents.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bottom line: Talk to your healthcare provider if you are interested in switching from brand-name Entresto to its generic form. Your prescriber can talk through any questions or concerns. When her own patients make the switch, Dr. Sparacino double-checks dosage and asks patients to report back if anything feels \u201coff.\u201d \u201c<\/span><span style=\"font-weight: 400;\">If a patient had a very specific clinical response [to the brand-name medication] and is anxious about a switch, we can individualize\u2014but most do well switching to save money,\u201d she says.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Uses<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce the risk of cardiovascular death and hospitalization in adults with chronic heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Treat symptomatic heart failure with left ventricular systolic dysfunction in pediatric patients 1 year and older<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Adults: 97\/103 mg tablet taken twice per day<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pediatric patients: Dosage is based on body weight<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Common side effects<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood pressure (hypotension)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Impaired kidney function<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood potassium<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Contraindications<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergy to sacubitril or valsartan<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hereditary angioedema or previous angioedema related to ACE inhibitors or ARBs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use with ACE inhibitors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Other considerations<\/span><\/td>\n<td>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Entresto has a <\/span><span style=\"font-weight: 400;\">black box warning<\/span><span style=\"font-weight: 400;\"> for fetal toxicity, which means it can seriously harm an unborn baby. <\/span><b>This drug should never be taken while pregnant.<\/b><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"how-much-is-generic-entresto\"><span style=\"font-weight: 400;\">How much is generic Entresto?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The price of generic Entresto varies depending on dosage, quantity, insurance coverage, pharmacy, and location. In general, generic versions of Entresto can be cheaper than brand-name Entresto even when insurance doesn\u2019t cover some or all of the cost.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Currently, the average retail price of generic Entresto is $459 for 60, 24-26 mg tablets, whereas the average price of brand-name Entresto is $969 for 60, 24-26 mg tablets, which is a one-month supply of a starting dose. Cash payers can pay as little as $50 for 60, 24-26mg tablets of generic sacubitril-valsartan by using  coupons or a <\/span><span style=\"font-weight: 400;\"> discount card<\/span><span style=\"font-weight: 400;\"> at CVS.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 id=\"brand-vs-generic-entresto-prices\"><span style=\"font-weight: 400;\">Brand vs. generic Entresto prices<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Average cost without insurance<\/span><\/td>\n<td><span style=\"font-weight: 400;\"> $969 for 60, 24-26 mg tablets of Entresto<\/span><\/td>\n<td><span style=\"font-weight: 400;\"> $459 per 60, 24-26 mg tablets of sacubitril-valsartan<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">\u2019s lowest price<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$691 for 60, 24-26 mg tablets of Entresto at Walgreens<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$50 for 60, 24-26 mg tablets of sacubitril-valsartan at CVS<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Free coupons<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Entresto coupons<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Sacubitril-Valsartan coupons<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><small>Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of November 4, 2005. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed  price references the price of generic drugs if available.<\/small><\/p>\n<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n<p id=\"headline\">Save up to 80% on Entresto with <\/p>\n<p id=\"subheadline\">Different pharmacies offer different prices for the same medication.  helps find the best price for you.<\/p>\n<div class=\"details-wrap\">\n<p>\n\t\t\t\t\tEntresto 24-26 mg (60 Tablets)\t\t\t\t<\/p>\n<p>\n\t\t\t\t\t23666 &#8211; Hampton, VA\t\t\t\t<\/p>\n<\/p><\/div>\n<div class=\"api-response\">\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-cvs.svg\" alt=\"CVS Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/walgreens-logo.svg\" alt=\"Walgreens\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>\t\t\tSee Entresto prices at all pharmacies\n\t\t<\/p><\/div>\n<h2 id=\"is-entresto-covered-by-insurance\"><span style=\"font-weight: 400;\">Is Entresto covered by insurance?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Insurance coverage can drastically reduce the out-of-pocket cost of<\/span> <span style=\"font-weight: 400;\">brand-name and generic prescription drugs<\/span><span style=\"font-weight: 400;\">. The good news is that many commercial insurance plans and Medicare Part D plans cover Entresto, though each person\u2019s final price will depend on their plan\u2019s deductible and copay.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Heart failure patients<\/span> <span style=\"font-weight: 400;\">without insurance coverage for Entresto<\/span><span style=\"font-weight: 400;\"> may still be able to<\/span> <span style=\"font-weight: 400;\">save on Entresto<\/span><span style=\"font-weight: 400;\"> by switching to the generic form, using coupons, or participating in financial assistance programs. \u201c<\/span><span style=\"font-weight: 400;\">I advise patients to ask the pharmacist to order by the generic name, not \u2018Entresto,\u2019 and to check coupon pricing while they wait,\u201d Dr. Sparacino says.<\/span><\/p>\n<h2 id=\"generic-alternatives-to-entresto\"><span style=\"font-weight: 400;\">Generic alternatives to Entresto<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Entresto is a first-of-its-kind medication, so the only true<\/span> <span style=\"font-weight: 400;\">Entresto alternative<\/span><span style=\"font-weight: 400;\"> is sacubitril-valsartan, which is generic Entresto itself. Other generic heart medications include<\/span> <span style=\"font-weight: 400;\">beta blockers<\/span><span style=\"font-weight: 400;\">,<\/span> <span style=\"font-weight: 400;\">ACE inhibitors<\/span><span style=\"font-weight: 400;\">, and<\/span> <span style=\"font-weight: 400;\">ARBs<\/span><span style=\"font-weight: 400;\"> such as:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The good news is that with the new availability of generic Entresto, patients with a prescription for Entresto can now ask their pharmacists to dispense sacubitril-valsartan instead. \u201cIf a pharmacy can order it, the order will arrive next business day, \u201c says Dr. Gingerich. \u201cWith how many people need this medication, pharmacies should have sufficient supply on the shelves at any given time.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A <\/span><span style=\"font-weight: 400;\">drug shortage<\/span><span style=\"font-weight: 400;\"> of Entresto is unlikely since several pharmaceutical companies are manufacturing the generic form. Anyone who thinks they might have trouble filling their prescription or accessing more Entresto when their current supply runs out should contact their prescriber. Stopping Entresto should not cause withdrawal symptoms, but there is a risk of<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33690130\/\"> <span style=\"font-weight: 400;\">worsening cardiovascular symptoms<\/span><\/a><span style=\"font-weight: 400;\"> and rebound <\/span><span style=\"font-weight: 400;\">high blood pressure<\/span><span style=\"font-weight: 400;\">, which can be dangerous and even deadly in people with chronic heart failure.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bottom line: Entresto was the first drug in a new class of powerful heart failure drugs, but as a brand-name drug, it came at a high price. Fortunately, a lower-cost generic version of Entresto is now available. If you\u2019re interested in switching from brand-name Entresto to generic Entresto, seek medical advice from a healthcare provider who knows your medical history, health conditions, and other prescription and over-the-counter medications.<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 9.27138 25.45 8.3206C24.6436 8.80066 23.7608 9.1389 22.84 9.3206C22.2245 8.65317 21.405 8.2089 20.5098 8.05745C19.6147 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Brand-name and generic Entresto are equally effectiv The Entreso generic offers significant cost savings. Entresto is a brand-name prescription drug that is FDA-approved to treat congestive heart failure. Entresto contains two active ingredients, sacubitril [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8610","post","type-post","status-publish","format-standard","hentry","category-health-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/comments?post=8610"}],"version-history":[{"count":0,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/posts\/8610\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/media?parent=8610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/categories?post=8610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthmedicinet.com\/review\/wp-json\/wp\/v2\/tags?post=8610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}