{"id":8663,"date":"2025-11-14T06:19:21","date_gmt":"2025-11-14T06:19:21","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-and-which-is-better-for-you-in-2025-47\/"},"modified":"2025-12-23T01:43:55","modified_gmt":"2025-12-23T01:43:55","slug":"hmn-differences-similarities-and-which-is-better-for-you-in-2025-47","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-differences-similarities-and-which-is-better-for-you-in-2025-47\/","title":{"rendered":"HMN:  Incruse Ellipta and Spiriva Differences, similarities, and which is better for you in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Differences, similarities, and which is better for you in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Incruse Ellipta and Spiriva are both brand-name, FDA-approved anticholinergic medications used for the long-term maintenance treatment of COPD, but they have some differences.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Incruse Ellipta is more effective than Spiriva in a 12-week study comparing their efficacy and safety in patients with COPD, though both drugs showed meaningful improvements in quality of life.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Both medications are typically covered by insurance and Medicare Part D, with the out-of-pocket price potentially reduced by using a  card or coupon.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Common side effects of both drugs include respiratory infections and cough, with Spiriva also commonly causing sinusitis, chest pain, dry mouth, and urinary tract infection, among others.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">If you or a loved one has <\/span><span style=\"font-weight: 400;\">chronic obstructive pulmonary disease<\/span><span style=\"font-weight: 400;\"> (COPD), you may have heard about Incruse Ellipta and Spiriva. Both are long-acting anticholinergic inhalers (also known as long-acting muscarinic antagonists, or LAMAs) used for the maintenance treatment of COPD, helping to manage symptoms such as shortness of breath, wheezing, and coughing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But which inhaler works better\u2014and which one is more affordable? A 12-week clinical study found that Incruse Ellipta may be slightly more effective than Spiriva, but both improve quality of life and are considered safe. Cost and insurance coverage often play a significant role in determining which option is right for you.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h2 id=\"main-differences-between-incruse-ellipta-and-spiriva\"><span style=\"font-weight: 400;\">Main differences between Incruse Ellipta and Spiriva<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Anticholinergic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anticholinergic<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(Spiriva Handihaler is also available in generic form)<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">The active ingredient is umeclidinium (but a generic version is not yet available)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tiotropium bromide<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Incruse Ellipta Inhaler (inhalation powder)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Spiriva Handihaler (capsules for inhalation), Spiriva Respimat (inhalation mist)\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">One oral inhalation (62.5 mcg) once daily at the same time every day<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Spiriva Handihaler: <\/span><span style=\"font-weight: 400;\">Two oral inhalations of the powder contents of one Spiriva capsule (18 mcg) once daily, with the Handihaler device (capsules are for oral inhalation only; not to be swallowed)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Spiriva Respimat: 2 oral inhalations (of 1.25 mcg or 2.5 mcg) once daily<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Long-term\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Handihaler: Adults (COPD)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Respimat: Adults (COPD, asthma) and children six years and older (asthma)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"conditions-treated-by-incruse-ellipta-and-spiriva\"><span style=\"font-weight: 400;\">Conditions treated by Incruse Ellipta and Spiriva<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Incruse Ellipta and Spiriva are both FDA-approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Spiriva Respimat has one additional indication: maintenance treatment of asthma in patients aged 6 years and older.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Neither drug is a rescue inhaler or to be used for an acute attack.\u00a0<\/span><\/p>\n<h2 id=\"is-incruse-ellipta-or-spiriva-more-effective\"><span style=\"font-weight: 400;\">Is Incruse Ellipta or Spiriva more effective?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is minimal direct data comparing the two drugs. A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4827908\/\"><span style=\"font-weight: 400;\">12-week clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> compared the efficacy and safety of Incruse Ellipta and Spiriva in just over 1,000 people with COPD. <\/span><span style=\"font-weight: 400;\">The primary endpoint was the trough forced expiratory volume in one second (also called FEV1) at day 85. Patients were evaluated using St George\u2019s Respiratory Questionnaire and other assessments. Both drugs showed meaningful improvements in quality of life and were well-tolerated in terms of safety. The study concluded that Incruse Ellipta was more effective than Spiriva.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Only your healthcare provider can determine the most effective medication for you. They can consider the severity of your symptoms and your medical history, along with other medicines you take that could interact with Incruse Ellipta or Spiriva.\u00a0<\/span><\/p>\n<h2 id=\"coverage-and-cost-comparison-of-incruse-ellipta-vs-spiriva\"><span style=\"font-weight: 400;\">Coverage and cost comparison of Incruse Ellipta vs. Spiriva<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Insurance plans and Medicare Part D cover both Incruse Ellipta and Spiriva, but the coverage amount varies by plan. To determine if your specific plan covers either medication, please contact your plan directly for more information about coverage and costs.<\/span><\/p>\n<p><small><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code November 13, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed  price references the price of generic drugs if available.<\/span><\/i><\/small><\/p>\n<h2 id=\"common-side-effects-of-incruse-ellipta-vs-spiriva\"><span style=\"font-weight: 400;\">Common side effects of Incruse Ellipta vs. Spiriva<\/span><\/h2>\n<h3 id=\"incruse-ellipta\"><b>Incruse Ellipta<\/b><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory tract infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny or stuffy nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mouth or throat pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taste changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle or joint pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tooth pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bruising or dark areas of skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast or irregular heartbeat<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/li>\n<\/ul>\n<h3 id=\"spiriva\"><b>Spiriva<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Spiriva side effects may vary depending on the formulation (i.e., Handihaler vs. Respimat).<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Runny nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sore throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sinusitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bronchitis\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cough\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infection<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This is not a complete list. Always discuss side effects with your healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Source: DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=dbb64747-1505-49d7-9a33-99dd402e96d3\"><span style=\"font-weight: 400;\">Incruse Ellipta<\/span><\/a><span style=\"font-weight: 400;\">), DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=820839ef-e53d-47e8-a3b9-d911ff92e6a9\"><span style=\"font-weight: 400;\">Spiriva<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h2 id=\"drug-interactions-of-incruse-ellipta-vs-spiriva\"><span style=\"font-weight: 400;\">Drug interactions of Incruse Ellipta vs. Spiriva<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Since both inhalers are anticholinergic medications, they should not be combined with other anticholinergics, as this increases the risk of side effects like urinary retention or worsening glaucoma. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK555893\/\"><span style=\"font-weight: 400;\">Examples of anticholinergics<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before using Incruse Ellipta or Spiriva, check with your healthcare provider to ensure there are no drug interactions. Be sure your provider knows about all the medicines you take, including Rx and OTC drugs, vitamins, and supplements.\u00a0<\/span><\/p>\n<h2 id=\"warnings-of-incruse-ellipta-and-spiriva\"><span style=\"font-weight: 400;\">Warnings of Incruse Ellipta and Spiriva<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not use Incruse Ellipta or Spiriva Handihaler if you have a severe milk protein allergy. Spiriva Respimat does not contain this warning.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Not for acute episodes of COPD (use a rescue inhaler instead).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">May cause paradoxical bronchospasm (sudden worsening of breathing). Discontinue and seek emergency care if this occurs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">May trigger allergic reactions such as rash, swelling, or difficulty breathing. Get emergency medical help if this occurs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tell your healthcare provider about any medical conditions you have, including if you have glaucoma, bladder or prostate problems, heart conditions, or are pregnant or breastfeeding.<\/span><\/li>\n<\/ul>\n<h2 id=\"frequently-asked-questions-about-incruse-ellipta-vs-spiriva\"><span style=\"font-weight: 400;\">Frequently asked questions about Incruse Ellipta vs. Spiriva<\/span><\/h2>\n<h3 id=\"are-incruse-ellipta-and-spiriva-the-same\"><span style=\"font-weight: 400;\">Are Incruse Ellipta and Spiriva the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">No. Both are LAMAs and work similarly, but they contain different active ingredients, come in various forms, and may cause slightly different side effects.<\/span><\/p>\n<h3 id=\"is-incruse-ellipta-or-spiriva-better\"><span style=\"font-weight: 400;\">Is Incruse Ellipta or Spiriva better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Limited data is available comparing Incruse Ellipta to Spiriva. One study showed Incruse Ellipta to be more effective, but both medications were found to be equally safe. Your healthcare provider can determine which drug is better for you.\u00a0<\/span><\/p>\n<h3 id=\"can-i-use-incruse-ellipta-or-spiriva-while-pregnant\"><span style=\"font-weight: 400;\">Can I use Incruse Ellipta or Spiriva while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is not enough information on the effects of Incruse Ellipta or Spiriva in pregnancy. Consult your obstetrician or gynecologist for medical advice. If you are already taking Incruse Ellipta or Spiriva and find out that you are pregnant, consult your Ob\/Gyn.\u00a0<\/span><\/p>\n<h3 id=\"can-i-use-incruse-ellipta-or-spiriva-with-alcohol\"><span style=\"font-weight: 400;\">Can I use Incruse Ellipta or Spiriva with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Although Incruse Ellipta or Spiriva does not interact with alcohol, drinking alcohol over a long time can increase COPD symptoms and weaken your immune system, worsening your COPD symptoms. Consult your healthcare provider for more information about alcohol and COPD.\u00a0<\/span><\/p>\n<h3 id=\"is-incruse-ellipta-a-steroid\"><span style=\"font-weight: 400;\">Is Incruse Ellipta a steroid?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">No. Incruse Ellipta is not a steroid. It is classified as an anticholinergic medication. It relaxes the muscles in the airways, making breathing easier.\u00a0<\/span><\/p>\n<h3 id=\"what-inhaler-is-equivalent-to-spiriva\"><span style=\"font-weight: 400;\">What inhaler is equivalent to Spiriva?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tudorza Pressair (aclidinium) is another inhaler in the same category as Spiriva and Incruse Ellipta. Multiple inhalers contain more than one active ingredient, including a LAMA. If you are looking for an alternative to Spiriva, discuss options with your healthcare provider.<\/span><\/p>\n<h3 id=\"what-s-the-best-inhaler-for-copd\"><span style=\"font-weight: 400;\">What\u2019s the best inhaler for COPD?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is no single \u201cbest\u201d inhaler. The choice depends on your medical condition, symptoms, lung function, other health conditions, and insurance coverage. 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