{"id":8754,"date":"2025-12-12T04:50:38","date_gmt":"2025-12-12T04:50:38","guid":{"rendered":"https:\/\/healthmedicinet.com\/review\/hmn-can-you-avoid-weight-gain-on-pregabalin-experts-weigh-in-in-2025\/"},"modified":"2025-12-12T04:50:38","modified_gmt":"2025-12-12T04:50:38","slug":"hmn-can-you-avoid-weight-gain-on-pregabalin-experts-weigh-in-in-2025","status":"publish","type":"post","link":"https:\/\/healthmedicinet.com\/review\/hmn-can-you-avoid-weight-gain-on-pregabalin-experts-weigh-in-in-2025\/","title":{"rendered":"HMN: Can you avoid weight gain on pregabalin? Experts weigh in in 2025"},"content":{"rendered":"<p>\n<br \/>Do you know:  Can you avoid weight gain on pregabalin? Experts weigh in in 2025<\/p>\n<div id=\"main-content\">\n<div id=\"post-intro\">\n<div id=\"takeaways\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>\n<p><span style=\"font-weight: 400;\">Weight gain is a common side effect of pregabalin, although there are several steps you can take to mitigate the risks.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">Maintaining a healthy diet, exercising regularly, drinking plenty of water, and getting enough sleep can help reduce significant weight gain.<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-weight: 400;\">If you experience rapid and excessive weight gain, accompanied by other symptoms, consult your healthcare provider immediately.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<section class=\"table-of-contents\">\n<div class=\"anchorLinks\">\n<div class=\"mobile-only\">\n<div class=\"dropdownLists\">\n<div tabindex=\"0\" class=\"dropdownBtn\"><span class=\"listsIcon\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/union.svg\" width=\"14\" height=\"20\"\/><\/span><br \/>\n\t\t\t\t\t\t\t<label><\/label><br \/>\n\t\t\t\t\t\t\t<span class=\"downArrow\"><br \/>\n\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.singlecare.com\/blog\/wp-content\/themes\/singlecare\/images\/dropDownArrow.svg\" width=\"24\" height=\"24\"\/><br \/>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<p><span style=\"font-weight: 400;\">An estimated 1.7 million people in the United States <\/span><a href=\"https:\/\/clincalc.com\/DrugStats\/Drugs\/Pregabalin\"><span style=\"font-weight: 400;\">take pregabalin<\/span><\/a><span style=\"font-weight: 400;\">, which is FDA approved for the treatment of nerve pain in people with diabetic neuropathy, postherpetic neuralgia, spinal cord injuries, and <\/span><span style=\"font-weight: 400;\">fibromyalgia<\/span><span style=\"font-weight: 400;\">. Pregabalin may also be prescribed as an adjunct therapy for epilepsy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some people report gaining weight on <\/span><span style=\"font-weight: 400;\">pregabalin<\/span><span style=\"font-weight: 400;\">, also sold under the brand name Lyrica. Fortunately, there are several steps you can take to avoid that side effect.<\/span><\/p>\n<h2 id=\"why-does-pregabalin-cause-weight-gain\"><span style=\"font-weight: 400;\">Why does pregabalin cause weight gain?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Pregabalin (<\/span><span style=\"font-weight: 400;\">Lyrica<\/span><span style=\"font-weight: 400;\">) is a gabapentinoid, which is a class of drugs that reduce nerve pain by binding to alpha-2-delta subunits of what are called voltage-gated calcium channels (VGCCs) to decrease the release of several neurotransmitters to reduce pain signaling in the pain pathway.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are a few main reasons why <\/span><span style=\"font-weight: 400;\">pregabalin<\/span><span style=\"font-weight: 400;\"> could lead to weight gain. Peripheral edema, characterized by swelling in the extremities, is a known <\/span><span style=\"font-weight: 400;\">side effect of pregabalin<\/span><span style=\"font-weight: 400;\">. This occurs because when the drug binds to those VGCCs, it can lead to dilation of your small arteries, but there is no dilation in your small veins. This results in fluid leakage into your body tissues, causing the swelling.<\/span><\/p>\n<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n<p id=\"headline\">Save up to 80% on Lyrica with <\/p>\n<p id=\"subheadline\">Different pharmacies offer different prices for the same medication.  helps find the best price for you.<\/p>\n<div class=\"details-wrap\">\n<p>\n\t\t\t\t\tLyrica 75 mg (60 Capsules)\t\t\t\t<\/p>\n<p>\n\t\t\t\t\t23666 &#8211; Hampton, VA\t\t\t\t<\/p>\n<\/p><\/div>\n<div class=\"api-response\">\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<div class=\"coupon\">\n<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\"\/>\t\t\t<\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>\t\t\tSee Lyrica prices at all pharmacies\n\t\t<\/p><\/div>\n<p><span style=\"font-weight: 400;\">A study found that <\/span><a href=\"https:\/\/bmcprimcare.biomedcentral.com\/articles\/10.1186\/1471-2296-11-85\"><span style=\"font-weight: 400;\">peripheral edema<\/span><\/a><span style=\"font-weight: 400;\"> is one of the most common side effects of pregabalin, with an incidence rate of 10% or higher. That fluid retention could cause the number on your scale to rise.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another reason pregabalin could lead to weight gain is that it <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S000689931830492X\"><span style=\"font-weight: 400;\">inhibits dopaminergic function<\/span><\/a><span style=\"font-weight: 400;\"> in your brain when you eat food. This makes eating more enjoyable and actually encourages you to continue eating. Many people report an increased appetite while on pregabalin. The more calories you consume without burning, the more likely it is that you may gain weight.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lastly, some people experience fatigue and drowsiness while taking pregabalin. Research suggests that older adults who also <\/span><a href=\"https:\/\/jphcs.biomedcentral.com\/articles\/10.1186\/s40780-015-0022-7\"><span style=\"font-weight: 400;\">take strong opioids<\/span><\/a><span style=\"font-weight: 400;\"> are at risk of experiencing this effect. (It should be noted that people with fibromyalgia have actually experienced a <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4710099\/\"><span style=\"font-weight: 400;\">reduction in fatigue-related symptoms<\/span><\/a><span style=\"font-weight: 400;\"> while on pregabalin. ) Any kind of fatigue or sleepiness could make it more challenging to exercise and burn calories, which can lead to weight gain.\u00a0<\/span><\/p>\n<h2 id=\"is-weight-gain-inevitable-on-pregabalin\"><span style=\"font-weight: 400;\">Is weight gain inevitable on pregabalin?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some weight gain is a common side effect of pregabalin, but <\/span><i><span style=\"font-weight: 400;\">significant<\/span><\/i><span style=\"font-weight: 400;\"> weight gain is not inevitable. In fact, an analysis of studies involving more than 43,000 people taking the drug found that more than 80% remained <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22494020\/\"><span style=\"font-weight: 400;\">within 7% of their starting weight<\/span><\/a><span style=\"font-weight: 400;\"> for close to a year. Only 1 in 6 people had an average weight gain of more than 7% two months or longer after starting to take the drug.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Several factors may increase the likelihood of weight gain with pregabalin.\u00a0<\/span><\/p>\n<h3 id=\"dosage\"><span style=\"font-weight: 400;\">Dosage<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201c<\/span><span style=\"font-weight: 400;\">Studies indicate that the longer usage and\/or higher dosages tend to increase the likelihood of weight gain,\u201d explains <\/span><a href=\"https:\/\/www.mytoolboxgenomics.com\/about-us\/erika-gray\/\"><span style=\"font-weight: 400;\">Erika Gray, Pharm.D<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><span style=\"font-weight: 400;\">, founder and chief medical officer at ToolBox Genomics.com.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While dosage varies from patient to patient, most people <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/pregabalin-oral-route\/description\/drg-20067411\"><span style=\"font-weight: 400;\">starting pregabalin<\/span><\/a><span style=\"font-weight: 400;\"> take an initial total daily dose of 150 milligrams. The length of time you may be on it depends on your condition and your healthcare provider\u2019s advice.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One study found that people who were on the drug for more than 12 months for neuropathic pain <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8221832\/\"><span style=\"font-weight: 400;\">gained an average of 3.6 pounds<\/span><\/a><span style=\"font-weight: 400;\">. This study also found that more weight was gained at higher doses, specifically those exceeding 300 milligrams a day.\u00a0<\/span><\/p>\n<h3 id=\"renal-function\"><span style=\"font-weight: 400;\">Renal function<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People with kidney disease or infections may have elevated serum creatinine levels. Your kidneys filter serum creatinine. If they are damaged or if you\u2019re dehydrated, your kidneys aren\u2019t able to perform this function. A study found that people with higher serum creatinine levels were <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2014\/280549\"><span style=\"font-weight: 400;\">more likely to gain weight<\/span><\/a><span style=\"font-weight: 400;\"> while on pregabalin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<\/p>\n<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our weight management newsletter<\/span><\/p><\/div>\n<p>\t<\/span><\/p>\n<h3 id=\"pre-existing-medical-conditions\"><span style=\"font-weight: 400;\">Pre-existing medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain health conditions could <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/pregabalin-oral-route\/description\/drg-20067411\"><span style=\"font-weight: 400;\">exacerbate pregabalin\u2019s side effects<\/span><\/a><span style=\"font-weight: 400;\">, including weight gain. These conditions include severe swelling, obesity, bleeding disorders, depression, respiratory issues, congestive heart failure, heart disease, diabetes, and substance abuse. It\u2019s imperative to alert your provider to any conditions you may have.<\/span><\/p>\n<h3 id=\"concurrent-medications\"><span style=\"font-weight: 400;\">Concurrent medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Combining certain medications or even supplements with pregabalin could lead to weight gain. For example, in a study of veterans taking either or both duloxetine and pregabalin, those taking a combination experienced the <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8221832\/\"><span style=\"font-weight: 400;\">most amount of weight gain<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are other drugs commonly taken alongside pregabalin that may cause weight gain on their own. These include antidiabetic drugs like rosiglitazone and pioglitazone; <\/span><span style=\"font-weight: 400;\">anticonvulsants<\/span><span style=\"font-weight: 400;\"> or antiepileptics like gabapentin and carbamazepine; antipsychotics; antidepressants; and corticosteroids.<\/span><\/p>\n<h3 id=\"genetic-predispositions\"><span style=\"font-weight: 400;\">Genetic predispositions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your own genetics could play a role in how your body uses and metabolizes pregabalin. If you have a genetic predisposition that adversely affects your ability to break down the drug, you could end up with elevated levels of it in your body. Those elevated levels could then lead to weight gain.\u00a0\u00a0<\/span><\/p>\n<h3 id=\"lifestyle-factors\"><span style=\"font-weight: 400;\">Lifestyle factors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your everyday lifestyle could affect weight gain while on pregabalin. For example, if you don\u2019t maintain a healthy diet or exercise prior to starting the drug, you may be less likely to do so based on pregabalin side effects like fatigue.\u00a0<\/span><\/p>\n<h2 id=\"6-ways-to-avoid-weight-gain-on-pregabalin\"><span style=\"font-weight: 400;\">6 ways to avoid weight gain on pregabalin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Follow these steps to sidestep potential weight gain while taking pregabalin:<\/span><\/p>\n<h3 id=\"1-maintain-a-healthy-diet\"><span style=\"font-weight: 400;\">1. Maintain a healthy diet<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your diet\u2014what you consume\u2014is a cornerstone of weight management.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPregabalin can increase appetite and trigger cravings, but it\u2019s important to manage these changes without increasing portion sizes,\u201d says <\/span><a href=\"https:\/\/www.atlanticare.org\/services\/cancer-care\"><span style=\"font-weight: 400;\">David Borrone, RPh<\/span><\/a><span style=\"font-weight: 400;\">, Oral Oncology Specialty Pharmacist at the AtlantiCare Cancer Care Institute.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Borrone has spent more than 35 years in a retail pharmacy setting and is well-acquainted with the side effects of pregabalin. He suggests several steps to keep a healthy, balanced diet:<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Choose lean meats, such as poultry and fish, over pork and red meats.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eat plenty of fruits and vegetables to load up on micronutrients that help you feel full and satisfied.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opt for whole grains and high-fiber carbohydrates, such as brown rice and whole-wheat bread, instead of white bread and pasta.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Limit your portion size on high-calorie foods.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Minimize snacks, especially those high in sugar and unhealthy fats.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you\u2019re unsure where to start, consider working with a registered dietitian who can tailor a meal plan to your specific needs.<\/span><\/p>\n<h3 id=\"2-exercise\"><span style=\"font-weight: 400;\">2. Exercise<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Physical activity plays a crucial role in maintaining a healthy weight because it helps burn calories. The Centers for Disease Control and Prevention suggests you do about 150 minutes of <\/span><a href=\"https:\/\/www.cdc.gov\/physical-activity-basics\/guidelines\/adults.html\"><span style=\"font-weight: 400;\">moderate-intensity aerobic activity<\/span><\/a><span style=\"font-weight: 400;\"> or 75 minutes of intense aerobic activity and two days of strength training per week. A plan for regular exercise could look like:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Five brisk walks a week, followed by strength training two days a week<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Three one-hour aerobics classes and two strength classes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Two intense 30-minute runs each week and two days a week dedicated to weights<\/span>3. Hydrate<\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Drinking water is associated with weight loss and <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0031938425001544\"><span style=\"font-weight: 400;\">long-term weight management<\/span><\/a><span style=\"font-weight: 400;\">, and consuming water before meals may also help reduce hunger. This is particularly important for individuals taking pregabalin who may experience increased hunger.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you were assigned male at birth, you should <\/span><a href=\"https:\/\/www.mayoclinic.org\/healthy-lifestyle\/nutrition-and-healthy-eating\/in-depth\/water\/art-20044256\"><span style=\"font-weight: 400;\">drink<\/span><\/a> <span style=\"font-weight: 400;\">approximately 15.5 cups of water per day; if you were assigned female at birth, the recommended amount is about 11.5 cups a day.<\/span><\/p>\n<h3 id=\"3-improve-sleep-quality\"><span style=\"font-weight: 400;\">3. Improve sleep quality\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Sleep and weight have a reciprocal relationship; that is, they can influence each other. If you aren\u2019t at a healthy weight, your sleep may suffer; if your sleep suffers, you may be more prone to gaining weight. In fact, one study found that people who sleep less are more likely to snack, and those who get good sleep have <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9031614\/\"><span style=\"font-weight: 400;\">more success with weight loss.<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Experts recommend that adults get between seven to nine hours of sleep at night. Making your room dark and cool, eliminating screens before bedtime, and avoiding caffeine after noon may improve your sleep.<\/span><\/p>\n<h3 id=\"4-minimize-or-eliminate-alcohol\"><span style=\"font-weight: 400;\">4. Minimize or eliminate alcohol\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol<\/span><span style=\"font-weight: 400;\"> is already contraindicated if you take pregabalin because it can increase side effects that include dizziness and fatigue. Beyond that, alcoholic drinks are what are known as \u201cempty calories\u201d; they provide little to no nutritional value. Do your best to avoid alcohol while taking pregabalin to avoid unnecessary caloric intake and potentially serious side effects.<\/span><\/p>\n<h3 id=\"5-consult-your-provider\"><span style=\"font-weight: 400;\">5. Consult your provider\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is no shortage of reasons you may gain weight. Hormones, genetics, lifestyle, diet\u2014the list goes on. If weight gain is a concern of yours, consult with your healthcare provider to discuss all the factors at play and get sound medical advice.<\/span><\/p>\n<h2 id=\"when-to-see-your-healthcare-provider\"><span style=\"font-weight: 400;\">When to see your healthcare provider<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you have concerns about any side effects you may be experiencing while on pregabalin, consult with your provider. While some weight gain is common, rapid or excessive weight gain may be a sign that something is amiss.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201c<\/span><span style=\"font-weight: 400;\">Because weight gain can point to other medical conditions, it\u2019s important to tell your healthcare provider if your weight increases by about 5 pounds in 2-3 weeks,\u201d says Dr. Gray.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, Dr. Gray says you should contact a healthcare professional if you have any of the following, alongside weight gain:<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coughing or shortness of breath<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling in the ankles or legs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased fatigue<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you\u2019re having trouble maintaining your weight, your healthcare team may recommend several steps to help you achieve your goal. They may prescribe a low <\/span><span style=\"font-weight: 400;\">dose of pregabalin<\/span><span style=\"font-weight: 400;\"> or suggest certain lifestyle changes. If these do not work, you may be switched to a different medication.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cNever stop taking pregabalin or reduce your dosage abruptly without consulting with your healthcare provider,\u201d Borrone warns. \u201cDoing so can cause withdrawal symptoms such as anxiety, nausea, and headaches.\u201d\u00a0<\/span><\/p>\n<p><svg style=\"display:none\">\n  <g id=\"facebook\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M19.51 9.32003H21.39V6.14003C20.4798 6.04538 19.5652 5.99865 18.65 6.00003C15.93 6.00003 14.07 7.66003 14.07 10.7V13.32H11V16.88H14.07V26H17.75V16.88H20.81L21.27 13.32H17.75V11.05C17.75 10 18.03 9.32003 19.51 9.32003Z\"\/>\n  <\/g>\n  <g id=\"twitter\">\n    <rect width=\"32\" height=\"32\" rx=\"4\" fill=\"var(--social-bg)\"\/>\n    <path fill=\"var(--social-ico)\" d=\"M26 9.9506C25.2483 10.2767 24.4534 10.4923 23.64 10.5906C24.4982 10.0779 25.1413 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