HMN 2026: How Tiny worm reveals secret to protecting skin sensations

A tiny roundworm has helped University of Queensland scientists uncover minuscule structures in skin tissue that may protect the body’s ability to feel temperature, touch and pain. The research is published in Science Advances.

How skin scaffolds protect nerves

The research changes a decade of scientific thinking on the way sensory nerve connections remain strong throughout a lifetime.

Dr. Sean Coakley from UQ’s School of Biomedical Sciences said the discovery of an external protective “scaffold” in the skin that surrounds sensory nerves has given a glimpse of how the skin and nervous system work together to protect the cable-like structures which receive and transmit messages back to the brain.

“If these axons are damaged, signals that transmit sensory information like touch, temperature and pain are disrupted with potentially devastating impact, as we see in both traumatic injuries and neurodegenerative diseases,” Dr. Coakley said. “Axons are very long and thin, and in humans they can reach up to a meter in length, but they’re only one-fiftieth of the width of a hair.

“This should make them extremely vulnerable to damage, yet they withstand a lifetime of constant strain as our body moves, flexes and absorbs impacts in everyday tasks.

“Understanding how they are protected is important for future therapies to treat nervous-system injuries and disease.”

Insights from tiny roundworm studies

Like in the roundworm C. elegans, humans and other species have sensory axons embedded in the skin, the body’s largest organ.

The roundworm is only about one millimeter long, and the research team was able to reveal an internal scaffolding structure in the skin around the axons with super resolution microscopy.

Professor Massimo Hilliard from UQ’s Queensland Brain Institute said the scaffold of nano-scale trusses and beams was made from protein molecules known as spectrins. “This scaffold appears to shield the axons in a similar way to a plaster cast protecting a broken arm,” Professor Hilliard said.

“Until now, we thought that axons were robust because they had an internal scaffold that made them elastic and able to stretch when needed.

“Now, we think that this is not enough.

“The external scaffold present in the skin that we have discovered appears to be critically important for maintaining the integrity of these tiny underlying cables.”

What this could mean for therapies

Dr. Igor Bonacossa Pereira from UQ’s Institute for Molecular Bioscience said this knowledge may inform and re-direct existing and new therapies aimed at protecting axonal structure and function. “Focusing on the tissue surrounding the axon might uncover new ways of treating and preventing injury and disease,” Dr. Pereira said.

“All animals have spectrins, which suggests these molecules are a key building block and will now be the subject of significant further study.”

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