Validated Classification Criteria for Calcium Pyrophosphate Deposition (CPPD) Disease

Validated Classification Criteria for Calcium Pyrophosphate Deposition (CPPD) Disease

Calcium Pyrophosphate Deposition (CPPD) disease, also known as pseudogout, is a common form of arthritis caused by the accumulation of calcium pyrophosphate crystals in the joints. Accurate diagnosis of CPPD disease is crucial for effective management and treatment. To aid in the classification of this condition, validated criteria have been developed.

What are Classification Criteria?

Classification criteria are a set of guidelines or rules used to categorize and identify specific diseases or conditions. They help healthcare professionals in diagnosing and classifying patients based on certain clinical features or laboratory findings.

Validated Classification Criteria for CPPD Disease

The validated classification criteria for CPPD disease were developed by the European League Against Rheumatism (EULAR) in 2015. These criteria are based on clinical and radiographic features and aim to differentiate CPPD disease from other forms of arthritis.

Key Features of the Classification Criteria

  • Age: The criteria consider patients aged 60 years or older.
  • Joint Involvement: Presence of knee, wrist, or 1st metatarsophalangeal joint involvement.
  • Imaging Findings: Radiographic evidence of chondrocalcinosis (calcium pyrophosphate crystal deposition) in at least one joint.
  • Acute Inflammatory Signs: Presence of acute inflammatory signs, such as joint swelling, redness, and warmth.
  • Exclusion of Other Causes: Exclusion of other causes of joint inflammation, such as infection or other crystal-induced arthropathies.

Benefits of Validated Classification Criteria

The use of validated classification criteria for CPPD disease offers several benefits:

  • Improved Diagnosis: The criteria help healthcare professionals accurately diagnose CPPD disease, reducing misdiagnosis and ensuring appropriate treatment.
  • Standardization: By following standardized criteria, healthcare professionals can ensure consistency in diagnosing and classifying patients with CPPD disease.
  • Research and Clinical Trials: Validated criteria enable researchers to select appropriate study participants and ensure homogeneity in clinical trials, leading to more reliable results.


The validated classification criteria for CPPD disease provide a standardized approach to diagnose and classify patients with this condition. By considering age, joint involvement, imaging findings, acute inflammatory signs, and exclusion of other causes, healthcare professionals can accurately identify and manage CPPD disease. These criteria not only improve patient care but also contribute to research and clinical trials in the field of rheumatology.