Exercising in early life may prevent future cancer
- Exercise before maturation turns down genes even if a high-fat diet is eaten
- These effects continue in mice even once the animals have reached adulthood
- Past research has linked fatty diets to increased activity of inflammation genes
- Inflammation has been associated with obesity, heart disease and cancer
Alexandra Thompson Health Reporter For Mailonline
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Children who exercise may be at less risk of heart disease and even cancer in later life, new research suggests.
Mice who are physically active before reaching sexual maturity have ‘turned down’ genes for inflammation, even if they eat a high-fat diet, a study found.
These effects continue even once the mice reach adulthood, the research adds.
Past research demonstrates eating a fatty diet increases the activity of genes that cause inflammation.
Inflammation has previously been linked to an increased risk of obesity, heart disease and cancer.
Children who exercise may be at less risk of heart disease and even cancer in later life (stock)
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WATCHING TELEVISION FOR THREE HOURS A DAY MAY INCREASE A CHILD’S DIABETES RISK
Watching television for three or more hours a day may increase a child’s risk of diabetes, research suggested last month.
Children who spend at least three hours in front of a screen are heavier and have greater insulin resistance, a study found. Both of these are risk factors for type 2 diabetes.
Such youngsters also produce impaired amounts of the hormone leptin, the research adds. Leptin is involved in regulating appetite.
These results remained even after the study’s participant’s activity levels were taken into account, the study found.
Study author Dr Claire Nightingale from St George’s, University of London, said: ‘Our findings suggest that reducing screen time may be beneficial in reducing type 2 diabetes risk factors, in both boys and girls, from an early age.’
Exercise ‘turns down’ inflammation genes
Researchers from the University of Auckland analysed 80 male mice at around six weeks of age, before they reached sexual maturity.
The rats were either given a high-fat diet alongside being given an exercise wheel in their cage, a high-fat diet and no wheel or a standard diet and no wheel.
Results reveal that inflammation-related genes are ‘turned down’ in mice fed a high-fat diet who have access to an exercise wheel.
The findings were published in the journal Frontiers in Physiology.
Effects last into mid-life
Study author Dr Justin O’Sullivan said: ‘What was remarkable was that these changes lasted long after the rats stopped doing that extra exercise – into their mid-life.
‘The bone marrow carried a “memory” of the effects of exercise.
‘The rats still got fat, but that early extra exercise basically set them up so that even though they put on weight they didn’t have the same profile of negative effects that is common with a high fat diet.’
The researchers add their findings strongly demonstrate the health benefits of exercise in children.
Previous research reveals high-fat diets increase the activity of inflammation-related genes.
Inflammation is linked to an increased risk of obesity, heart disease and cancer.
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