Key protein behind brain asymmetry uncovered by scientists

Morpholino knockdown of cachd1 results in bilateral symmetry. (A-B) Dorsal views of 4 dpf uninjected wildtype and cachd1 morpholino-injected larvae after wholemount in situ hybridization using antisense riboprobes against asymmetric dorsal habenula markers kctd12.1. (C) Semi-quantitative RT-PCR for cachd1 transcripts. Credit: Science (2024). DOI: 10.1126/science.ade6970 Genetic mechanisms behind the brain’s unique left–right differences are now better understood with new research, paving the way for better understanding of human disorders where brain asymmetry is disrupted. The protein, called Cachd1, plays a crucial role in establishing the distinct neural wiring and functions Read More