Machine learning classifier accelerates the development of cellular immunotherapies
HMN 2024 – PredicTCR50 classifier training strategy. ScRNA data from healthy donors, as well as scRNA?+?VDJ and experimentally derived tumor-reactivity data for the 50 most frequent TCR TIL clonotypes from sample BT21, were used to train an intermediate model using XGBoost. Due to the sparse nature of scRNA data, we optimized this intermediate model by first performing Bayesian […]