New hope in battle to find cystic fibrosis cure
- Experts say combining three drugs has major positive impact on lung condition
- Two agents helped slow down lung damage in 40% of cystic fibrosis patients
- Adding third element produces similar benefits in up to 90 per cent of patients
Mail on Sunday Reporter
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Cystic fibrosis sufferers have been given hope by a radical new treatment that could save thousands of people from an early death.
Scientists have found that combining three drugs has a major positive impact on the lung condition.
Researchers had earlier achieved success in combining two agents, which helped slow down lung damage in 40 per cent of cystic fibrosis patients.
Cystic fibrosis sufferers have been given hope by a radical new treatment that could save thousands of people from an early death (file photo)
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Now they have shown that adding a third element produces similar benefits in up to 90 per cent of patients.
Drugs company Vertex, behind the research, said the results were ‘clear and compelling, indicating significant potential benefit’.
Cystic fibrosis affects 10,000 people in the UK – among them former PM Gordon Brown’s son, Fraser, 11. Sufferers’ lungs produce too much mucus, leading to scarring, and they often require transplants.
Scientists have found that combining three drugs has a major positive impact on the lung condition (file photo)
Life expectancy has been growing, but half die before the age of 41.
Professor Jane Davies, honorary consultant in paediatric medicine at London’s Royal Brompton Hospital, said if the ‘very, very early’ results held up in further trials, and the method proved to be safe, the triple-therapies could be used in ‘between 70 and 90 per cent of patients globally’.
Beyond larger trials, the next hurdle is cost. One of the drugs, Orkambi, has a ‘list price’ of £104,000 per patient per year and is not yet available on the NHS.
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