Newly discovered beneficial mutation in mitochondrial DNA seems to help Alzheimer’s gene carriers live longer
HMN 2024 – The humanin variant P3S is enriched in APOE4 centenarians. (a) Mitochondrial genomic location of the humanin smORF and the P3S mutation. The frequency of P3S is below the location schematic. Below the frequency is the amino acid sequence of humanin and the 3rd residue change caused by P3S; n?=?146. (b) APOE4 frequency as a function […]