B cell subtypes’ kinetics over a 6 monthxs period in CVID patients submitted to influenza and H1N1 immunization

Common Variable Immunodeficiency (CVID) is characterized by hypogammaglobulinaemia
and impaired specific antibody production, resulting in increased susceptibility to
infections, mainly of the respiratory tract. In an attempt to minimize the recurrent
episodes of infections, some studies have recommended immunization with inactivated
pathogens or subunits, however, experience with vaccine administration in immunodeficient
patients is limited.