China’s community-based strategy of universal preconception care in rural areas at a population level using a novel risk classification system for stratifying couples´ preconception health status

^aincluding 20,647 not eating fresh vegetables (0.96%), 16,435 pesticide exposure (0.77%), 16,049 organic solvent exposure (0.75%), 12,540 radiation exposure (0.59%), 9,717 smoking (0.45%), 5,582 raw meat eating habit (0.26%) and 1,765 heavy metal exposure (0.08%)

^bAnemia referred to hemoglobin ranging from 60–109g/L

^cVaginitis included 27,657 Candida infection, 11,398 Bacterial vaginitis and 10,107 Trichomonasis

^dincluding 10,107 Trichomoniasis (0.47%), 7,672 Toxoplasma gondiiIgM positive (0.36%), 4,545Gonococcal infection (0.21%) and 40 history of psychological disease (0.00%)

^eincluding 20,705 Rh negative (0.97%), 9,290 Cytomegalovirus IgM positive (0.43%), 9,266 Chlamydia positive (0.43%), 8,482 Syphilis screening positive (0.40%), 4,395 history of preterm birth (0.21%), 14,383 diabetes (0.67%), 1,830 reported hypertension (0.09%), 1,655 reported history of tuberculosis (0.08%), 1,392 anesthetic drug use (0.07%), 1,327 congenital heart disease (0.06%), 1,018 reported tumor history (0.05%), 897 reported chronic renal disease history (0.04%) and 882 reported epilepsy history (0.04%)

^fAdverse pregnancy history included 16,824 with history of stillbirth and 7,054 with history of birth defects

^gincluding 4,515 with birth defects (0.21%), 1,527 family history of neonatal death (0.07%), 1,416 mental retardation (0.07%), 923 family history of Mediterranean anemia (0.04%), 254 family history of G6PD deficiency (0.01%), 138 family history of Albinism (0.01%), 92 family history of Down’s syndrome (0.00%), 5 family history of hearing impairment (0.00%), 2 family history of mental retardation (0.00%) and 1family history of visual impairment (0.00%)

^hincluding 2,707 severe thrombocytopenia (0.13%) and 2,552 severe anemia (0.12%). Severe thrombocytopenia referred to platelet less than 50*10⁹/L. Severe anemia referred to hemoglobin less than 60g/L

ⁱincluding 18,726 not eating fresh vegetables (0.87%), 9,734 radiation exposure (0.45%), 9,454 raw meat eating habit (0.44%) and 3,578 exposure to heavy metals (0.17%)

^jincluding 5,325 spermatic cord varicocele (0.25%), 2,432 hypertension (0.11%), 1,052 congenital heart disease (0.05%), 598 chronic renal disease history (0.03%), 404 epilepsy (0.02%), 159 history of cancer (0.01%) and 3 history of psychological disease (0.00%)

^kincluding 7,771 Syphilis screening positive (0.36%), 1,348 anesthetic drug use (0.06%) and 992 reported thyroid disease (0.05%)

^lincluding 2,344 with birth defects (0.11%), 658 family history of neonatal death (0.03%), 603 family history of Mediterranean anemia (0.03%), 274 family history of G6PD deficiency (0.01%), 248 mental retardation (0.01%), 138 family history of Albinism (0.01%), 78 family history of Down’s syndrome (0.00%), 4 family history of hearing impairment (0.00%), 1family history of hemophilia (0.00%) and 1family history of visual impairment (0.00%)