Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

1 Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

2 Department of Biostatistics, Vanderbilt University, Nashville, TN, USA

3 Division of Epidemiology, Vanderbilt University, Nashville, TN, USA

4 Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA

5 Department of Medicine, Vanderbilt University, Nashville, TN, USA

6 Department of Pediatrics, Maternal and Child Health Care Hospital of Hainan Province, Haikou, China

7 Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

8 Laboratory of Nuclear Receptors and Cancer Research, Center for Basic Medical Research, Nantong University School of Medicine, Nantong, Jiangsu, China

9 Pediatric Surgery Department, Qilu Hospital of Shandong University, Jinan, Shangdong, China

10 Department of Cardiovascular Disease, Hainan General Hospital, Haikou, Hainan, China

11 Department of Dermatology, Hainan General Hospital, Haikou, Hainan, China

12 Division of Genetic Medicine, 536A Light Hall, Vanderbilt University, 2215 Garland Avenue, Nashville 37232-0275, TN, USA