Harvard University develop ‘Stem cell fillings’ that trigger teeth to repair themselves
- Synthetic biomaterials are used in a similar way to dental fillings
- Material is placed in direct contact with pulp tissue
- This stimulates the native stem cell population for repair and regeneration
Mark Prigg For Dailymail.com
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The horror of a root canal could soon be a thing of the past thanks to a radical new stem cell treatment.
Researchers say the new type of tooth filling can cause teeth to repair and regenerate themselves.
The approach could significantly impact millions of patients each year with dental fillings that help heal teeth when they are injured from dental disease or dental surgery.
Researchers say the new type of tooth filling can cause teeth to repair and regenerate themselves.
HOW THEY WORK
The synthetic biomaterials that can be used similarly to dental fillings.
They are placed in direct contact with pulp tissue
This stimulates the native stem cell population for repair and regeneration of pulp tissue and the surrounding dentin.
Researchers from the University of Nottingham and the Wyss Institute at Harvard University developed the therapeutic synthetic, light-curable, biomaterials.
They allow native dental stem cells inside teeth to repair and regenerate dentin.
Dr Adam Celiz, Marie Curie Research Fellow at the University of Nottingham, said: ‘Existing dental fillings are toxic to cells and are therefore incompatible with pulp tissue inside the tooth.
‘In cases of dental pulp disease and injury a root canal is typically performed to remove the infected tissues.
‘We have designed synthetic biomaterials that can be used similarly to dental fillings but can be placed in direct contact with pulp tissue to stimulate the native stem cell population for repair and regeneration of pulp tissue and the surrounding dentin.
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‘Our approach has great promise to impact the dental field and this prize provides a great platform to develop this technology further with industrial partners.’
The research won second prize in the materials category of the Royal Society of Chemistry’s Emerging Technologies Competition 2016.
David Mooney, the Pinkas Family Professor of Bioengineering at the John Paulson School of Engineering and Applied Sciences at Harvard and the Wyss Institute for Biologically Inspired Engineering, added: ‘These materials may provide an effective and practical approach to allow a patient to regenerate components of their own teeth.’
The synthetic biomaterials that can be used similarly to dental fillings.
Dr Kyle Vining, DDS, Fellow at the Wyss Institute at Harvard University said: ‘We are excited about the promise of therapeutic biomaterials for bringing regenerative medicine to restorative dentistry.’
Applications were judged on the degree of innovation of the technology, its potential impact, and the quality of the science behind it.
Dr Steve Pleasance, Head of Industry at the Royal Society of Chemistry said: ‘Increasing innovation in the chemical sciences is one of the key elements of the Royal Society of Chemistry’s industry strategy. ‘
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