Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke

1 School of Biomedical Sciences Pharmacy, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia

2 Heart and Brain Research Group, Justus-Liebig-University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany

3 Department of Neurology, Justus-Liebig-University, Giessen, Germany

4 Department of Cardiac Surgery, Kerckhoff Clinic, Bad Nauheim, Germany

5 Hunter New England Local Health District, Newcastle, Australia

6 School of Medicine and Public Health, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia

7 Sana Regio Klinkum, Pinneberg, Germany

8 Department of Neurology, University Hospital Center Hamburg-Eppendorf, Hamburg, Germany