Rationale and Design of the CREDENCE Trial: computed TomogRaphic evaluation of atherosclerotic DEtermiNants of myocardial IsChEmia

Acknowledgements

We would like to acknowledge and thank all the members of the laboratory teams.

Principal Investigators: Andrejs Erglis, MD, Paul Stradins Clinical University Hospital, Riga, Latvia; Erick Avelar, MD, Oconee Heart and Vascular Center at St Mary’s Hospital, Athens, GA; U Joseph Schoepf, MD, Medical University of South Carolina, Charleston, SC; Randall Thompson, MD, St. Luke’s Mid America Heart Institute, Kansas City, MO; Bin Lu, MD, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China; Atizazul Mansoor, MD, PinnacleHealth Cardiovascular Institute, Wormleysburg, PA; Chris Rowan, MD, Renown Heart and Vascular, Reno, NV; Philippe Généreux, MD, Cardiovascular Research Foundation, New York, NY.

Other Investigators: Hiroyuki Niinuma, MD PhD, Cardiovascular Imaging Lab, St. Luke’s International Hospital, Tokyo, Japan; Ae-Young Her, MD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Joon-Hyung Doh, MD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Jung Hyun Choi, MD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; So-Yeon Choi, MD PhD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Bon-Kwon Koo, MD PhD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Chang-Wook Nam, MD PhD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Sanghoon Shin, MD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Hyung-Bok Park, MD, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Daniel H. Steinberg, MD, Medical University of South Carolina, Charleston, SC; Irfan Ullah, MD CCRP, Cardiac Center of Texas, Mczkinney, TX; Ahmed Ladak, MD CCRP, Cardiac Center of Texas, Mczkinney, TX; Venkata S. Chilakapati, MD FACC, Cardiac Center of Texas, Mczkinney, TX; Dante Chiappino, MD, Fondazione Toscana/CNR Gabriele Monasterio, Pisa PI, Italy; Yang Gao, MD, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China; Chaowei Mu, MD, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing, China.

Funding

This study was supported in part by a grant from the National Institutes of Health (R01HL118019). This study was also funded, in part, by a generous gift from the Dalio Institute of Cardiovascular Imaging and the Michael Wolk Foundation.

Availability of data and materials

Not applicable.

Authors’ contributions

AR drafted the manuscript. BH, FL, and JM critically revised the manuscript. JS contributed to the statistical analysis. All authors made a contribution to the design and conception of the study. All authors read and approved the final manuscript.

Competing interests

Dr. Min serves as a consultant to HeartFlow, is on the scientific advisory board of Arineta, has ownership in Autoplaq and MDDX, and has a research agreement with GE Healthcare. All other authors have no disclosures to report.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The study protocol was approved by the Weill Cornell Medicine Institutional Review Board (IRB 1309014313). The study was also registered with the ClinicalTrials.gov (Registration No. NCT02173275). Written informed consent will be obtained and documented for all study participants.