Transient elastography (TE) is widely used for non-invasive assessment of liver fibrosis in HIV-HCV co-infected patients. TE, however, cannot determine liver morphology.
Acoustic radiation force impulse (ARFI) imaging is a novel procedure enabling assessment of liver fibrosis during a conventional ultrasonographic examination. This study evaluated the correlation between liver fibrosis measurements by TE and ARFI.
Methods:
Each of 46 HIV-HCV patients underwent both ARFI and TE within 6 months.
Patients were evaluated by the “equivalent METAVIRâ€scoring system, using previously established cut-off values. Agreements between the ARFI and TE scores were estimated by Kappa coefficients, with Kappa values =0.40, =0.60, and =0.80 defined as moderate, good and very good agreement, respectively.
Results:
ARFI and TE yielded “Equivalent Metavirâ€fibrosis scores of F1 in 26 and 31 patients, respectively; F2 in nine and seven, respectively; F3 in three and two, respectively; and F4 in eight and six, respectively.
The two methods showed very good agreement in predicting overall stages [Kappa = 0.82] and for F =3 [Kappa = 0.80] and moderate agreement in predicting significant fibrosis F =2 [Kappa = 0.50]. Morphologic ultrasound analysis concomitant to ARFI detected two hepatocarcinomas.
Conclusions:
ARFI showed promising results in the non-invasive assessment of liver fibrosis in HIV-HCV patients, with liver fibrosis staging similar to that of TE.
Moreover, ARFI can assess morphology and fibrosis during the same session.
Author: Nora FrulioHervé TrillaudPaul PerezJulien AsselineauMarianne VandenhendeMojgan HessamfarFabrice BonnetFlorent MaireJean DelauneVictor De LedinghenPhilippe Morlat
Credits/Source: BMC Infectious Diseases 2014, 14:405
Published on: 2014-07-21
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