Jan. 15, 2013 ? In vitro fertilization (IVF) is compared with an increasing risk of pulmonary embolism (blockage of a categorical artery of a lung) and venous thromboembolism (blood clots) during a initial trimester of pregnancy, a investigate published currently on bmj.com suggests.
IVF has been used given 1978 for a 10% of couples worldwide influenced by infertility. Approximately 5 million people have so distant been innate after IVF.
It is good famous that a risk of blood clots is increasing during normal pregnancy, inspiring around one in 1000 in a early 1990s.
Blood clots have been reported in some-more IVF pregnancies than normal pregnancies, though so distant there is no information on a risk of artery blockage following IVF, that is critical given this is a heading means of maternal deaths.
Researchers from a Karolinska Institute in Sweden therefore compared a risk of both pulmonary embolism (PE) and venous thromboembolism (VTE) in women undergoing an IVF pregnancy (23,498) and women undergoing normal pregnancy (116,960). Women were matched for age and time duration (births between 1990 and 2008). The women had an normal age of 33 for both groups.
The suit of IVF women who were diagnosed with VTE was 4.2 in 1000 compared with 2.5 in 1000 of a unexposed women. Risk was increasing during a initial trimester (1.5 in unprotected and 0.3 in unexposed). There was no disproportion in risk before to pregnancy or during a year after delivery.
Researchers identified 19 women with PE in a IVF organisation (0.08%) compared with 70 women in a unexposed organisation (0.05%). The risk of PE in a IVF women was increasing during a whole pregnancy and quite in a initial trimester.
Absolute risks for PE were low however with 2-3 additional cases per 10,000 IVF women. However, a researchers contend that PE is a formidable condition to diagnose and still represents a heading means of maternal genocide and so these commentary are critical to physicians.
Results were not influenced when adjustments were done for: maternal age, calendar years of delivery, BMI, parity, smoking, nation of birth, family conditions and education.
The researchers interpretation that there is an increasing risk of blood clots and importantly an increasing risk of artery blockage in pregnancy after IVF. They contend all physicians should be wakeful of these formula as it is a potentially deadly condition and suggest that “efforts should concentration on a marker of women during risk.â€
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The above story is reprinted from materials supposing by BMJ-British Medical Journal.
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Journal Reference:
- P. Henriksson, E. Westerlund, H. Wallen, L. Brandt, O. Hovatta, A. Ekbom. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cranky sectional study. BMJ, 2013; 346 (jan15 3): e8632 DOI: 10.1136/bmj.e8632
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