Dec. 14, 2012 ? Scientists during a Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) during Tufts University have detected a new gene resource that appears to umpire triglyceride levels. This pathway competence strengthen carriers of a gene various opposite cardiovascular disease, generally among those with larger intakes of polyunsaturated fat (PUFA).
The findings, published online this week in a American Journal of Human Genetics, minister to examine efforts to rise gene-specific diets that could potentially urge ubiquitous health and element ongoing illness impediment and treatment.
The authors analyzed information from some-more than 27,000 group and women enrolled in 10 epidemiological studies conducted in a United States and Europe that contain a Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Focusing on a Single Nucleotide Polymorphism (SNP) rs13702, they celebrated that a form of tiny RNA famous as microRNA (miR), impacts prolongation of lipoprotein lipase (LPL), an enzyme that mediates a metabolism of present triglycerides.
“We saw no miR activity in carriers of a gene variant,” pronounced comparison author José M. Ordovás, comparison scientist and executive of a Nutritional Genomics Laboratory during a HNRCA during Tufts University. “In a infancy of a subjects a miR seemed to insert to a follower RNA (mRNA), negligence down a production of LPL. Without that interference, people with a various would presumably have some-more LPL accessible to relapse additional triglycerides and forestall them from being deposited in a arteries, that could eventually lead to atherosclerosis and other cardiovascular diseases.”
The authors also remarkable revoke triglyceride levels and aloft concentrations of high-density lipoprotein (HDL) cholesterol, a supposed “healthy” cholesterol in organisation with a gene variant. Furthermore, carriers tended to have even revoke triglyceride blood levels if they had aloft PUFA intake.
“Based on a data, carriers of a gene various competence be means to serve revoke their risk for cardiovascular illness by augmenting their PUFA intake,” pronounced Kris Richardson, Ph.D., a USDA Agricultural Research Service (ARS) post-doctoral associate in a Nutritional Genomics Laboratory and a new connoisseur of a Sackler School of Graduate and Biomedical Sciences during Tufts University. “To build on a observational data, destiny studies competence examine a outcome of treating tellurian cells in enlightenment with PUFA to establish if it will intercede LPL levels by a identified miR.”
PUFA, found in dishes such as salmon and unfeeling oils, is deliberate a healthier fat. The stream U.S. Dietary Guidelines for Americans suggest replacing jam-packed fats with a some-more profitable PUFA and monounsaturated fats whenever possible.
José M. Ordovás is also a highbrow during a Friedman School of Nutrition Science and Policy during Tufts University and a member of a Pharmacology Experimental Therapeutics Faculty during a Sackler School.
This investigate is upheld by grants from USDA and a National Heart, Lung and Blood Institute (NHLBI), and endowment series P50 HL105185-01. A finish list of appropriation sources is accessible in a supplemental information apportionment of a paper.
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Journal Reference:
- Kris Richardson, Jennifer A. Nettleton, Noemi Rotllan, Toshiko Tanaka, Caren E. Smith, Chao-Qiang Lai, Laurence D. Parnell, Yu-Chi Lee, Jari Lahti, Rozenn N. Lemaitre, Ani Manichaikul, Margaux Keller, Vera Mikkilä, Julius Ngwa, Frank J.A. van Rooij, Christie M. Ballentyne, Ingrid B. Borecki, L. Adrienne Cupples, Melissa Garcia, Albert Hofman, Luigi Ferrucci, Dariush Mozaffarian, Mia-Maria Perälä, Olli Raitakari, Russell P. Tracy, Donna K. Arnett, Stefania Bandinelli, Eric Boerwinkle, Johan G. Eriksson, Oscar H. Franco, Mika Kähönen, Michael Nalls, David S. Siscovick, Denise K. Houston, Bruce M. Psaty, Jorma Viikari, Jacqueline C.M. Witteman, Mark O. Goodarzi, Terho Lehtimäki, Yongmei Liu, M. Carola Zillikens, Yii-Der I. Chen, André G. Uitterlinden, Jerome I. Rotter, Carlos Fernandez-Hernando, Jose M. Ordovas. Gain-of-Function Lipoprotein Lipase Variant rs13702 Modulates Lipid Traits by Disruption of a MicroRNA-410 Seed Site. The American Journal of Human Genetics, 2012; DOI: 10.1016/j.ajhg.2012.10.020
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